TR200401051T4 - 3-amino-2-kloro-4-etilpiridin yapım işlemi - Google Patents
3-amino-2-kloro-4-etilpiridin yapım işlemiInfo
- Publication number
- TR200401051T4 TR200401051T4 TR2004/01051T TR200401051T TR200401051T4 TR 200401051 T4 TR200401051 T4 TR 200401051T4 TR 2004/01051 T TR2004/01051 T TR 2004/01051T TR 200401051 T TR200401051 T TR 200401051T TR 200401051 T4 TR200401051 T4 TR 200401051T4
- Authority
- TR
- Turkey
- Prior art keywords
- chloro
- methyl
- dicyano
- product
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
2-kloro-3-amino-4-metilpiridin (CAPIC) hazirlanmasi için, asagidaki asaalari kapsayan, gelistirilmis bir islem: (a) asetilasetaldehit dimetil asetal' in, ürün olarak 4,4-disiyano-3-metil-3-butenal dimetil asetal ve 1,1-disiyano-4-metoksi-2-metil-3-butenal dimetil asetal ve 1,1-disiyano-4-metoksi-2-metil-1,3-butadiyen karisimi vermek üzere, malonitril ile reaksiyona sokulmasi, (b) bu sekilde meydana getirilen 4,4-disiyano-3-metil-3-butenal dimetil asteal ve 1,1-disiyano-4-metoksi-2-metil-1,3-butadiyen karisiminin, ürün olarak 3-s,yano-4-metil-2-piridon vermek üzere, kuvvetli bir asit ve su ile muamele edilmesi, (c) 3-siyano-4-metil-2-piridon' un ürün olarak 3-s,yano-2-kloro-4-metilpiridin vermek üzere, kuvvetli bir klorlaa ajani ile muamele edilmesi, (d) 3-siyano-52-kloro-4-metilpiridin' in, ürün olarak 2-kloro-3-amido-4-metilpiridin vermek üzere, kuvvetli bir asit ve su ile muamele edilmesi, ve (e) 2-kloro-3-amido-4-metilpiridin' in, ürün olarak 2-kloro-3-amido-4-DEVAMI VAR...
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23930000P | 2000-10-10 | 2000-10-10 | |
US29184101P | 2001-05-17 | 2001-05-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200401051T4 true TR200401051T4 (tr) | 2004-07-21 |
Family
ID=26932446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2004/01051T TR200401051T4 (tr) | 2000-10-10 | 2001-09-14 | 3-amino-2-kloro-4-etilpiridin yapım işlemi |
Country Status (15)
Country | Link |
---|---|
US (1) | US6399781B1 (tr) |
EP (1) | EP1326836B1 (tr) |
JP (1) | JP4102665B2 (tr) |
AR (1) | AR032369A1 (tr) |
AT (1) | ATE266004T1 (tr) |
AU (1) | AU2001291313A1 (tr) |
CA (1) | CA2425494C (tr) |
DE (1) | DE60103173T2 (tr) |
DK (1) | DK1326836T3 (tr) |
ES (1) | ES2220805T3 (tr) |
MX (1) | MXPA03003177A (tr) |
PT (1) | PT1326836E (tr) |
TR (1) | TR200401051T4 (tr) |
UY (1) | UY26954A1 (tr) |
WO (1) | WO2002030901A1 (tr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA200605471B (en) * | 2003-12-23 | 2007-11-28 | Dow Agrosciences Llc | Process for the preparation of pyridine derivatives |
US8043070B2 (en) | 2004-08-26 | 2011-10-25 | Pentair Water Pool And Spa, Inc. | Speed control |
US8480373B2 (en) | 2004-08-26 | 2013-07-09 | Pentair Water Pool And Spa, Inc. | Filter loading |
US7686589B2 (en) | 2004-08-26 | 2010-03-30 | Pentair Water Pool And Spa, Inc. | Pumping system with power optimization |
CN100358871C (zh) * | 2005-08-02 | 2008-01-02 | 江阴暨阳医药化工有限公司 | 氰乙酰胺和丙酮合成2-氯-3-氨基-4-甲基吡啶法 |
CN103508945A (zh) * | 2012-06-26 | 2014-01-15 | 上海品沃化工有限公司 | 一种2-氯-4-甲基烟腈的制备方法 |
CN102898361B (zh) * | 2012-10-08 | 2014-02-19 | 鲁东大学 | 一种制备2-氯-3-氨基-4-甲基吡啶的方法 |
CN103664772B (zh) * | 2013-11-29 | 2016-08-24 | 齐鲁工业大学 | 5-氯-3-氰基-4-甲氧基-2(1 h)吡啶酮的合成方法 |
CN104592104B (zh) * | 2015-01-13 | 2017-02-22 | 江苏中邦制药有限公司 | 一种制备2‑氯烟酸的方法 |
CN105859614B (zh) * | 2015-01-19 | 2020-05-26 | 盐城迪赛诺制药有限公司 | 一种制备2-氯-3-氰基-4-甲基吡啶的方法 |
WO2016118586A1 (en) * | 2015-01-20 | 2016-07-28 | Virginia Commonwealth University | Lowcost, high yield synthesis of nevirapine |
CN110218211B (zh) * | 2018-03-01 | 2020-06-23 | 新发药业有限公司 | 一种奈韦拉平的简便制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3434921A1 (de) | 1984-09-22 | 1986-05-07 | Sandoz-Patent-GmbH, 7850 Lörrach | Heterocyclische monoazoverbindungen |
US5366972A (en) | 1989-04-20 | 1994-11-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | 5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection |
US5200522A (en) | 1991-06-11 | 1993-04-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for preparing 3-amino-2-chloro-4-alkylpyridines |
WO1992022531A1 (en) | 1991-06-11 | 1992-12-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the preparation of 3-amino-2-chloro-4-alkylpyridines |
US5654429A (en) | 1992-11-18 | 1997-08-05 | Boehringer Ingelheim Pharma | Method for the preparation of 3-amino-2-chloro-4-alkylpyridines |
JP3516454B2 (ja) | 1993-12-02 | 2004-04-05 | ベーリンガー インゲルハイム コマンディトゲゼルシャフト | 3‐アミノ‐2‐クロロ‐4‐アルキルピリジン又は‐4‐アリールピリジンの製造方法 |
DE4403311C1 (de) | 1994-02-03 | 1995-04-20 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von Nevirapine (11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4-diazepin]-6-on) |
CA2318412A1 (en) | 1999-01-22 | 2000-07-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate |
ES2218109T3 (es) | 1999-01-22 | 2004-11-16 | Boehringer Ingelheim Pharmaceuticals Inc. | Sintesis de 3-amino-2-cloro-4-metilpiridina a partir de malononitrilo y acetona. |
-
2001
- 2001-09-12 US US09/950,727 patent/US6399781B1/en not_active Expired - Lifetime
- 2001-09-14 JP JP2002534287A patent/JP4102665B2/ja not_active Expired - Fee Related
- 2001-09-14 DK DK01971424T patent/DK1326836T3/da active
- 2001-09-14 EP EP01971424A patent/EP1326836B1/en not_active Expired - Lifetime
- 2001-09-14 AT AT01971424T patent/ATE266004T1/de active
- 2001-09-14 TR TR2004/01051T patent/TR200401051T4/tr unknown
- 2001-09-14 WO PCT/US2001/042143 patent/WO2002030901A1/en active IP Right Grant
- 2001-09-14 CA CA002425494A patent/CA2425494C/en not_active Expired - Fee Related
- 2001-09-14 MX MXPA03003177A patent/MXPA03003177A/es not_active Application Discontinuation
- 2001-09-14 ES ES01971424T patent/ES2220805T3/es not_active Expired - Lifetime
- 2001-09-14 PT PT01971424T patent/PT1326836E/pt unknown
- 2001-09-14 AU AU2001291313A patent/AU2001291313A1/en not_active Abandoned
- 2001-09-14 DE DE60103173T patent/DE60103173T2/de not_active Expired - Lifetime
- 2001-10-09 UY UY26954A patent/UY26954A1/es not_active Application Discontinuation
- 2001-10-10 AR ARP010104751A patent/AR032369A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE266004T1 (de) | 2004-05-15 |
WO2002030901A1 (en) | 2002-04-18 |
CA2425494A1 (en) | 2002-04-18 |
EP1326836B1 (en) | 2004-05-06 |
DE60103173D1 (de) | 2004-06-09 |
AR032369A1 (es) | 2003-11-05 |
UY26954A1 (es) | 2002-06-20 |
US6399781B1 (en) | 2002-06-04 |
ES2220805T3 (es) | 2004-12-16 |
DK1326836T3 (da) | 2004-06-01 |
US20020052507A1 (en) | 2002-05-02 |
PT1326836E (pt) | 2004-07-30 |
MXPA03003177A (es) | 2004-12-06 |
DE60103173T2 (de) | 2005-05-19 |
JP4102665B2 (ja) | 2008-06-18 |
CA2425494C (en) | 2008-04-29 |
EP1326836A1 (en) | 2003-07-16 |
AU2001291313A1 (en) | 2002-04-22 |
JP2004529856A (ja) | 2004-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR200401051T4 (tr) | 3-amino-2-kloro-4-etilpiridin yapım işlemi | |
ES2186792T3 (es) | Metodos de fabricar liposomas que contienen fotosensibilizantes hidro-monobenzoporfirinicos. | |
GB2361924A (en) | Ion-sensitive hard water dispersible polymers and applications therefor | |
TW341598B (en) | A mild, lathering, low smearing transparent pour molded personal cleansing bar made with mostly insoluble soap | |
BR0016334A (pt) | Composições de polipeptìdeo com estabilidade aperfeiçoada | |
TR200301035T2 (tr) | Sentetik lifler içeren emici malzeme ve bu malzemeyi hazırlamak için işlem | |
MY105045A (en) | Detergent bar. | |
ES2172660T3 (es) | Procedimiento para preparar acido n-fosfonometiliminoacetico. | |
EP0914814A4 (en) | EMULSION COMPOSITION | |
BR9900793A (pt) | Processo para produzir pães por uso de transglutaminase e hidrolisados parciais de proteìna, como as matérias primas, preparação de enzimas, e, pães. | |
UA70296A (uk) | Фармацевтична композиція, що містить ліофілізовані ліпосоми, які енкапсулюють активний інгредієнт з високим ступенем нерозчинності у воді, і спосіб одержання вказаної композиції | |
MXPA03003631A (es) | Material de aislamiento celular procesable de alta velocidad con espumabilidad mejorada. | |
ATE233484T1 (de) | Desinfizierende zusammensetzung | |
DE60031154D1 (de) | Verfahren zur herstellung von clarithromycin | |
ES2170127T3 (es) | Sacarido no reductor, su produccion y su utilizacion. | |
DE60226896D1 (de) | Herstellung von f(ab')2 fragmenten in saügetierzelle | |
MXPA04000227A (es) | Productos de limpieza. | |
MX9705015A (es) | 2-fenilpiridinas sustituidas, su procedimiento de obtencion y las composiciones herbicidas que las contienen. | |
EP0750701A4 (en) | Opaque means for paper | |
ES2197790A1 (es) | Compuesto intermedio de utilidad en la sintesis de macrolidos. | |
ZA983231B (en) | Substituted benzyloxyimino compounds. | |
ES2160085A1 (es) | Dihidrato de eritromicina a oxima | |
MD1262F1 (en) | Process for obtaining Stevia rebaudiana Bertoni seedlings | |
JPS649916A (en) | Shampoo composition | |
MXPA03003466A (es) | Derivados de piranosido. |