DE69624485T2 - Verfahren zur herstellung hydro-monobenzoporhyrin -photosensibilisatoren enthaltender liposomen - Google Patents
Verfahren zur herstellung hydro-monobenzoporhyrin -photosensibilisatoren enthaltender liposomenInfo
- Publication number
- DE69624485T2 DE69624485T2 DE69624485T DE69624485T DE69624485T2 DE 69624485 T2 DE69624485 T2 DE 69624485T2 DE 69624485 T DE69624485 T DE 69624485T DE 69624485 T DE69624485 T DE 69624485T DE 69624485 T2 DE69624485 T2 DE 69624485T2
- Authority
- DE
- Germany
- Prior art keywords
- photosensitizers
- monobenzoporhyrine
- liposomes containing
- producing liposomes
- containing hydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/510,573 US5707608A (en) | 1995-08-02 | 1995-08-02 | Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizer |
PCT/CA1996/000512 WO1997004746A1 (en) | 1995-08-02 | 1996-07-29 | Methods of making liposomes containing hydro-monobenzoporphyrin photosensitizers |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69624485D1 DE69624485D1 (de) | 2002-11-28 |
DE69624485T2 true DE69624485T2 (de) | 2003-06-26 |
Family
ID=24031289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69624485T Expired - Lifetime DE69624485T2 (de) | 1995-08-02 | 1996-07-29 | Verfahren zur herstellung hydro-monobenzoporhyrin -photosensibilisatoren enthaltender liposomen |
Country Status (12)
Country | Link |
---|---|
US (1) | US5707608A (de) |
EP (1) | EP0843547B1 (de) |
JP (1) | JP3782112B2 (de) |
AT (1) | ATE226430T1 (de) |
AU (1) | AU717181B2 (de) |
CA (1) | CA2227761C (de) |
DE (1) | DE69624485T2 (de) |
DK (1) | DK0843547T3 (de) |
ES (1) | ES2186792T3 (de) |
PT (1) | PT843547E (de) |
TW (1) | TW585785B (de) |
WO (1) | WO1997004746A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69215722T3 (de) * | 1991-03-22 | 2001-03-08 | Katsuro Tachibana | Verstärker zur Ultraschalltherapie von Erkrankungen sowie diesen enthaltende flüssige Arzneimittelzusammensetzungen |
US6890555B1 (en) * | 1992-02-05 | 2005-05-10 | Qlt, Inc. | Liposome compositions of porphyrin photosensitizers |
US6210356B1 (en) * | 1998-08-05 | 2001-04-03 | Ekos Corporation | Ultrasound assembly for use with a catheter |
US6176842B1 (en) | 1995-03-08 | 2001-01-23 | Ekos Corporation | Ultrasound assembly for use with light activated drugs |
US6143287A (en) * | 1996-02-27 | 2000-11-07 | New York Blood Center, Inc. | Method and composition for hair removal |
CA2202103C (en) * | 1996-04-11 | 2007-01-09 | Toshiaki Tagawa | Method for preparing closed vesicles |
JP2001511128A (ja) * | 1997-01-28 | 2001-08-07 | ファルマシア・アンド・アップジョン・カンパニー | 水不溶性ポルフィリンの脂質錯体の凍結乾燥物 |
US6582392B1 (en) | 1998-05-01 | 2003-06-24 | Ekos Corporation | Ultrasound assembly for use with a catheter |
US6676626B1 (en) | 1998-05-01 | 2004-01-13 | Ekos Corporation | Ultrasound assembly with increased efficacy |
WO1999013916A2 (en) * | 1997-09-18 | 1999-03-25 | Nycomed Imaging As | Methods and compositions for medical imaging |
US6183727B1 (en) | 1998-05-19 | 2001-02-06 | Arizona Board Of Regents | Use of long-wavelength electromagnetic radiation and photoprotective tumor localizing agents for diagnosis |
US6608050B2 (en) * | 1999-07-20 | 2003-08-19 | Pharmacia & Upjohn Company | Lyophilizate of lipid complex of water insoluble porphyrins |
US6351663B1 (en) | 1999-09-10 | 2002-02-26 | Akorn, Inc. | Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation |
US6944493B2 (en) * | 1999-09-10 | 2005-09-13 | Akora, Inc. | Indocyanine green (ICG) compositions and related methods of use |
US6443976B1 (en) | 1999-11-30 | 2002-09-03 | Akorn, Inc. | Methods for treating conditions and illnesses associated with abnormal vasculature |
CA2714081C (en) | 2000-02-10 | 2013-08-06 | Massachusetts Eye And Ear Infirmary | Methods and compositions for treating conditions of the eye |
KR20070114856A (ko) * | 2000-03-24 | 2007-12-04 | 노파르티스 아게 | 개선된 혈관신생의 치료 방법 |
AU2002233092A1 (en) | 2001-02-15 | 2002-08-28 | Qlt Inc. | Reduction or prevention of pdt related inflammation |
US6984395B2 (en) * | 2001-04-11 | 2006-01-10 | Qlt, Inc. | Drug delivery system for hydrophobic drugs |
AU2007202603B2 (en) * | 2001-04-11 | 2010-06-10 | Valeant Pharmaceuticals International, Inc. | Drug delivery system for hydrophobic drugs |
DE60225844T2 (de) * | 2001-11-02 | 2009-04-09 | The Governors Of The University Of Alberta, Edmonton | Micelle-zusammensetzungen enthaltend pegylierten phospholipide und einen photosensibilisator |
EP1647232B1 (de) | 2001-12-03 | 2011-08-17 | Ekos Corporation | Katheter mit mehreren Ultraschall-abstrahlenden Teilen |
US8226629B1 (en) | 2002-04-01 | 2012-07-24 | Ekos Corporation | Ultrasonic catheter power control |
US7455858B2 (en) * | 2002-05-16 | 2008-11-25 | Qlt Inc. | Compositions and methods for delivery of photosensitive drugs |
US6921371B2 (en) * | 2002-10-14 | 2005-07-26 | Ekos Corporation | Ultrasound radiating members for catheter |
US20040220167A1 (en) * | 2003-05-02 | 2004-11-04 | Nasrollah Samiy | Methods of treating neuralgic pain |
JP4741205B2 (ja) * | 2003-07-07 | 2011-08-03 | 真 湯浅 | 金属ポルフィリン錯体包埋リポソーム、その製造方法およびこれを利用する医薬 |
US7682603B2 (en) * | 2003-07-25 | 2010-03-23 | The Trustees Of The University Of Pennsylvania | Polymersomes incorporating highly emissive probes |
US20050048109A1 (en) * | 2003-08-26 | 2005-03-03 | Ceramoptec Industries, Inc. | Non-polar photosensitizer formulations for photodynamic therapy |
US7341569B2 (en) * | 2004-01-30 | 2008-03-11 | Ekos Corporation | Treatment of vascular occlusions using ultrasonic energy and microbubbles |
US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
EP1874197A4 (de) * | 2005-04-12 | 2010-02-10 | Ekos Corp | Ultraschallkatheter mit kavitationsfördernder oberfläche |
EP2015846A2 (de) | 2006-04-24 | 2009-01-21 | Ekos Corporation | Ultraschalltherapiesystem |
US10182833B2 (en) | 2007-01-08 | 2019-01-22 | Ekos Corporation | Power parameters for ultrasonic catheter |
WO2008088037A1 (ja) * | 2007-01-18 | 2008-07-24 | National University Corporation Chiba University | 微粒子製剤 |
ES2471118T3 (es) | 2007-06-22 | 2014-06-25 | Ekos Corporation | Método y aparato para el tratamiento de hemorragias intracraneales |
WO2009079415A1 (en) * | 2007-12-14 | 2009-06-25 | Ekos Corporation | Ultrasound pulse shaping |
US9211214B2 (en) | 2012-03-21 | 2015-12-15 | Valeant Pharmaceuticals International, Inc | Photodynamic therapy laser |
WO2016161428A1 (en) * | 2015-04-02 | 2016-10-06 | The Research Foundation For The State University Of New York | Serum-stable compositions and methods for light-triggered release of materials |
EP3307388B1 (de) | 2015-06-10 | 2022-06-22 | Ekos Corporation | Ultraschallkatheter |
KR102434879B1 (ko) | 2016-05-26 | 2022-08-22 | 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 폐혈관 질환 치료용 조성물 및 방법 |
KR102035384B1 (ko) * | 2017-06-26 | 2019-10-22 | 서강대학교산학협력단 | 광감작제를 포함한 마이크로버블-나노입자 복합체 및 이를 포함하는 항암 치료제 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4500507A (en) * | 1981-10-30 | 1985-02-19 | Wong Dennis W | Diagnostic composition for radiologic imaging of neoplasms in the body and method of preparation |
US4649151A (en) * | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
US4577636A (en) * | 1982-11-23 | 1986-03-25 | The Beth Israel Hospital Association | Method for diagnosis of atherosclerosis |
US4517762A (en) * | 1983-07-08 | 1985-05-21 | Venetz Louis M | Animal trap holder |
US4485806A (en) * | 1983-10-24 | 1984-12-04 | Calspan Corporation | Method and apparatus for evacuating contaminated casualties |
US4753958A (en) * | 1985-02-07 | 1988-06-28 | University Of Cal | Photochemotherapy of epithelial diseases with derivatives of hematoporphyrins |
US4776991A (en) * | 1986-08-29 | 1988-10-11 | The United States Of America As Represented By The Secretary Of The Navy | Scaled-up production of liposome-encapsulated hemoglobin |
US4933121A (en) * | 1986-12-10 | 1990-06-12 | Ciba Corning Diagnostics Corp. | Process for forming liposomes |
US4920143A (en) * | 1987-04-23 | 1990-04-24 | University Of British Columbia | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
US4883790A (en) * | 1987-01-20 | 1989-11-28 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US5010073A (en) * | 1989-10-05 | 1991-04-23 | The Rockefeller University | Use of liposomes as carriers for metalloporphyrins |
US5214036A (en) * | 1990-03-08 | 1993-05-25 | University Of British Columbia | Benzoporphyrin derivatives for photodynamic therapy |
US5238940A (en) * | 1990-03-22 | 1993-08-24 | Quadra Logic Technologies Inc. | Compositions for photodynamic therapy |
US5053423A (en) * | 1990-03-22 | 1991-10-01 | Quadra Logic Technologies Inc. | Compositions for photodynamic therapy |
US5270053A (en) * | 1990-04-03 | 1993-12-14 | Ciba-Geigy Corp. | Parenterally administerable liposome formulation comprising synthetic lipid |
CA2047969A1 (en) * | 1990-08-17 | 1992-02-18 | Thomas D. Madden | Benzoporphyrin vesicles |
CA2087902C (en) * | 1992-02-05 | 2006-10-17 | Narendra Raghunathji Desai | Liposome compositions of porphyrin photosensitizers |
US5422362A (en) * | 1993-07-29 | 1995-06-06 | Quadra Logic Technologies, Inc. | Method to inhibit restenosis |
-
1995
- 1995-08-02 US US08/510,573 patent/US5707608A/en not_active Expired - Lifetime
-
1996
- 1996-07-29 JP JP53435996A patent/JP3782112B2/ja not_active Expired - Lifetime
- 1996-07-29 ES ES96925614T patent/ES2186792T3/es not_active Expired - Lifetime
- 1996-07-29 WO PCT/CA1996/000512 patent/WO1997004746A1/en active IP Right Grant
- 1996-07-29 AU AU66083/96A patent/AU717181B2/en not_active Expired
- 1996-07-29 CA CA002227761A patent/CA2227761C/en not_active Expired - Lifetime
- 1996-07-29 DE DE69624485T patent/DE69624485T2/de not_active Expired - Lifetime
- 1996-07-29 EP EP96925614A patent/EP0843547B1/de not_active Expired - Lifetime
- 1996-07-29 PT PT96925614T patent/PT843547E/pt unknown
- 1996-07-29 AT AT96925614T patent/ATE226430T1/de active
- 1996-07-29 DK DK96925614T patent/DK0843547T3/da active
- 1996-07-30 TW TW085109287A patent/TW585785B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69624485D1 (de) | 2002-11-28 |
ATE226430T1 (de) | 2002-11-15 |
PT843547E (pt) | 2003-03-31 |
EP0843547B1 (de) | 2002-10-23 |
WO1997004746A1 (en) | 1997-02-13 |
EP0843547A1 (de) | 1998-05-27 |
CA2227761C (en) | 2004-01-06 |
AU6608396A (en) | 1997-02-26 |
JP3782112B2 (ja) | 2006-06-07 |
ES2186792T3 (es) | 2003-05-16 |
CA2227761A1 (en) | 1997-02-13 |
AU717181B2 (en) | 2000-03-16 |
US5707608A (en) | 1998-01-13 |
TW585785B (en) | 2004-05-01 |
DK0843547T3 (da) | 2003-02-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |