EA202092892A1 - Ингаляционные композиции, содержащие макроциклические иммуносупрессанты - Google Patents

Ингаляционные композиции, содержащие макроциклические иммуносупрессанты

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Publication number
EA202092892A1
EA202092892A1 EA202092892A EA202092892A EA202092892A1 EA 202092892 A1 EA202092892 A1 EA 202092892A1 EA 202092892 A EA202092892 A EA 202092892A EA 202092892 A EA202092892 A EA 202092892A EA 202092892 A1 EA202092892 A1 EA 202092892A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aerosol
pharmaceutical composition
subject
nebulizer
mouthpiece
Prior art date
Application number
EA202092892A
Other languages
English (en)
Inventor
Оливер Денк
Original Assignee
Брес Терапьютикс Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Брес Терапьютикс Гмбх filed Critical Брес Терапьютикс Гмбх
Priority claimed from PCT/EP2019/066872 external-priority patent/WO2020002351A1/en
Publication of EA202092892A1 publication Critical patent/EA202092892A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0018—Details of inhalators; Constructional features thereof with exhalation check valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к фармацевтической композиции, содержащей ингаляционный иммуносупрессивный макроциклический активный ингредиент, для применения для предотвращения или лечения легочного заболевания или состояния у субъекта, причем обеспечена возможность введения фармацевтической композиции субъекту путем ингаляции в виде аэрозоля, и обеспечена возможность выработки аэрозоля распылением фармацевтической композиции с применением небулайзера (100), содержащего a) генератор (101) аэрозоля, содержащий резервуар (103) для текучей среды для хранения фармацевтической композиции или переходник, предназначенный для соединения резервуара для текучей среды, и выполненную с возможностью вибрации мембрану (110), имеющую множество отверстий, предназначенных для получения аэрозоля, содержащего капельки, имеющие массовый медианный аэродинамический диаметр (ММАД) вплоть до примерно 4,0 мкм при измерении с использованием 0,9% (мас./об.) водного раствора хлорида натрия; b) камеру (105) для временного размещения аэрозоля, вырабатываемого в генераторе (101) аэрозоля, имеющую внутреннюю полость объемом в диапазоне от примерно 50 до примерно 150 мл; и c) мундштук (40) для доставки субъекту аэрозоля, подаваемого небулайзером (100), при этом мундштук (40) имеет фильтр (30) выдоха.
EA202092892A 2018-12-04 2019-06-25 Ингаляционные композиции, содержащие макроциклические иммуносупрессанты EA202092892A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18210255 2018-12-04
PCT/EP2019/066872 WO2020002351A1 (en) 2018-06-27 2019-06-25 Inhalable compositions comprising macrocyclic immunosuppressants

Publications (1)

Publication Number Publication Date
EA202092892A1 true EA202092892A1 (ru) 2021-05-27

Family

ID=64606777

Family Applications (2)

Application Number Title Priority Date Filing Date
EA202092892A EA202092892A1 (ru) 2018-12-04 2019-06-25 Ингаляционные композиции, содержащие макроциклические иммуносупрессанты
EA202191307A EA202191307A1 (ru) 2018-12-04 2019-12-03 Композиции для ингаляции для применения для лечения заболеваний легких

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202191307A EA202191307A1 (ru) 2018-12-04 2019-12-03 Композиции для ингаляции для применения для лечения заболеваний легких

Country Status (22)

Country Link
US (3) US11419819B2 (ru)
EP (1) EP3890767B1 (ru)
JP (1) JP7285930B2 (ru)
KR (1) KR102475644B1 (ru)
CN (3) CN116688093A (ru)
AU (1) AU2019392626B2 (ru)
BR (1) BR112021010756A2 (ru)
CA (1) CA3121362C (ru)
CO (1) CO2021007141A2 (ru)
EA (2) EA202092892A1 (ru)
ES (1) ES2932966T3 (ru)
FI (1) FI3890767T3 (ru)
HR (1) HRP20221529T1 (ru)
HU (1) HUE060322T2 (ru)
IL (1) IL283469B (ru)
LT (1) LT3890767T (ru)
MX (1) MX2021006585A (ru)
PL (1) PL3890767T3 (ru)
PT (1) PT3890767T (ru)
RS (1) RS63847B1 (ru)
SI (1) SI3890767T1 (ru)
WO (1) WO2020115032A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3069711A1 (en) * 2015-03-16 2016-09-21 PARI Pharma GmbH Cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection
EP4249022A1 (en) * 2022-03-21 2023-09-27 PARI Pharma GmbH Drug-device combination
CN115006656A (zh) * 2022-05-18 2022-09-06 苏州易合医药有限公司 一种可连续提供肺部活性剂粉雾剂的给药装置

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857319A (en) 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US5049388A (en) * 1986-11-06 1991-09-17 Research Development Foundation Small particle aerosol liposome and liposome-drug combinations for medical use
TW497974B (en) * 1996-07-03 2002-08-11 Res Dev Foundation High dose liposomal aerosol formulations
US5958378A (en) * 1996-07-03 1999-09-28 Research Development Foundation High dose liposomal aerosol formulations containing cyclosporin A or budesonide
IT1289938B1 (it) 1997-02-20 1998-10-19 Angelini Ricerche Spa Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e
CA2348455A1 (en) * 1998-11-06 2000-05-18 Walter Van Horn Nebulizer mouthpiece and accessories
US6962151B1 (en) * 1999-11-05 2005-11-08 Pari GmbH Spezialisten für effektive Inhalation Inhalation nebulizer
US7971588B2 (en) 2000-05-05 2011-07-05 Novartis Ag Methods and systems for operating an aerosol generator
DE10102846B4 (de) 2001-01-23 2012-04-12 Pari Pharma Gmbh Aerosolgenerator
DE10347994A1 (de) * 2003-10-15 2005-06-16 Pari GmbH Spezialisten für effektive Inhalation Wässrige Aerosol-Zubereitung
US7452524B2 (en) * 2004-01-27 2008-11-18 Gilead Sciences, Inc. Method for improvement of tolerance for therapeutically effective agents delivered by inhalation
AU2005302255A1 (en) * 2004-10-28 2006-05-11 Alza Corporation Lyophilized liposome formulations and method
DE102005038619A1 (de) 2005-08-16 2007-02-22 Pari GmbH Spezialisten für effektive Inhalation Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments
DE102006051512A1 (de) * 2005-12-06 2007-06-14 Pari GmbH Spezialisten für effektive Inhalation Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin
WO2007067784A2 (en) 2005-12-08 2007-06-14 Wyeth Liposomal compositions
EP1927373B1 (en) 2006-11-30 2012-08-22 PARI Pharma GmbH Inhalation nebulizer
PT2285439E (pt) * 2008-04-04 2014-03-25 Nektar Therapeutics Dispositivo de aerossolização
WO2012026963A2 (en) 2010-08-23 2012-03-01 Darren Rubin Systems and methods of aerosol delivery with airflow regulation
CN103415398B (zh) * 2010-12-28 2016-08-10 斯坦福设备有限公司 光限定孔板以及其制备方法
NZ700983A (en) * 2012-05-21 2016-10-28 Insmed Inc Systems for treating pulmonary infections
US9677919B2 (en) 2014-11-26 2017-06-13 Rosemount Inc. Gauge display system
EP3069711A1 (en) * 2015-03-16 2016-09-21 PARI Pharma GmbH Cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection
US9566399B1 (en) * 2015-04-14 2017-02-14 Clempharma LLC Deep lung alveolar aerosol targeted drug delivery

Also Published As

Publication number Publication date
EP3890767A1 (en) 2021-10-13
FI3890767T3 (fi) 2023-01-13
PT3890767T (pt) 2022-11-29
CA3121362C (en) 2024-01-02
KR20210110312A (ko) 2021-09-07
CN116688093A (zh) 2023-09-05
CO2021007141A2 (es) 2021-08-19
US11890376B2 (en) 2024-02-06
SI3890767T1 (sl) 2023-02-28
CN113164553B (zh) 2023-04-21
WO2020115032A1 (en) 2020-06-11
US20220347098A1 (en) 2022-11-03
PL3890767T3 (pl) 2023-05-08
JP7285930B2 (ja) 2023-06-02
EP3890767B1 (en) 2022-10-12
CA3121362A1 (en) 2020-06-11
RS63847B1 (sr) 2023-01-31
CN113164553A (zh) 2021-07-23
EA202191307A1 (ru) 2021-08-09
CN116726146A (zh) 2023-09-12
AU2019392626B2 (en) 2022-02-10
US11419819B2 (en) 2022-08-23
JP2022510953A (ja) 2022-01-28
HRP20221529T1 (hr) 2023-02-17
LT3890767T (lt) 2022-12-12
AU2019392626A1 (en) 2021-06-24
US20240122852A1 (en) 2024-04-18
MX2021006585A (es) 2022-07-04
US20220023211A1 (en) 2022-01-27
ES2932966T3 (es) 2023-01-30
IL283469A (en) 2021-07-29
HUE060322T2 (hu) 2023-02-28
IL283469B (en) 2022-07-01
KR102475644B1 (ko) 2022-12-07
BR112021010756A2 (pt) 2021-08-31

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