CO2021007141A2 - Composiciones inhalables para usarse en el tratamiento de enfermedades pulmonares - Google Patents
Composiciones inhalables para usarse en el tratamiento de enfermedades pulmonaresInfo
- Publication number
- CO2021007141A2 CO2021007141A2 CONC2021/0007141A CO2021007141A CO2021007141A2 CO 2021007141 A2 CO2021007141 A2 CO 2021007141A2 CO 2021007141 A CO2021007141 A CO 2021007141A CO 2021007141 A2 CO2021007141 A2 CO 2021007141A2
- Authority
- CO
- Colombia
- Prior art keywords
- aerosol
- pharmaceutical composition
- nebulizer
- subject
- treatment
- Prior art date
Links
- 208000019693 Lung disease Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 239000000443 aerosol Substances 0.000 abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 abstract 4
- 239000006199 nebulizer Substances 0.000 abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000002663 nebulization Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0018—Details of inhalators; Constructional features thereof with exhalation check valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a una composición farmacéutica que comprende un ingrediente activo macrocíclico inmunosupresor inhalable para usarse en la prevención o el tratamiento de una enfermedad o afección pulmonar en un sujeto, en donde la composición farmacéutica se administra al sujeto por inhalación en forma de aerosol, y en donde el aerosol se genera por nebulización de la composición farmacéutica usando un nebulizador (100), comprendiendo el nebulizador: a) un generador de aerosol (101) que comprende: - un depósito de fluido (103) para contener la composición farmacéutica o una interfaz configurada para conectar un depósito de fluido, y - una membrana vibratoria (110) que tiene una pluralidad de aberturas, estando adaptadas las aberturas para producir un aerosol que comprende gotas que tienen un diámetro aerodinámico medio de masa (MMAD) de hasta aproximadamente 4,0 µm medido con una solución acuosa al 0,9% (p/v) de cloruro de sodio; b) una cámara (105) para alojar temporalmente el aerosol generado por el generador de aerosol (101), teniendo la cámara un lumen interior con un volumen en el intervalo de aproximadamente 50 a aproximadamente 150 mL; y c) una boquilla (40) para administrar el aerosol suministrado por el nebulizador (100) al sujeto, teniendo la boquilla un filtro de exhalación (30).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18210255 | 2018-12-04 | ||
| PCT/EP2019/083470 WO2020115032A1 (en) | 2018-12-04 | 2019-12-03 | Inhalable compositions for use in the treatment of pulmonary diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2021007141A2 true CO2021007141A2 (es) | 2021-08-19 |
Family
ID=64606777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2021/0007141A CO2021007141A2 (es) | 2018-12-04 | 2021-05-31 | Composiciones inhalables para usarse en el tratamiento de enfermedades pulmonares |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US11419819B2 (es) |
| EP (1) | EP3890767B1 (es) |
| JP (1) | JP7285930B2 (es) |
| KR (1) | KR102475644B1 (es) |
| CN (3) | CN116726146A (es) |
| AU (1) | AU2019392626B2 (es) |
| BR (1) | BR112021010756A2 (es) |
| CA (1) | CA3121362C (es) |
| CO (1) | CO2021007141A2 (es) |
| EA (2) | EA202092892A1 (es) |
| ES (1) | ES2932966T3 (es) |
| FI (1) | FI3890767T3 (es) |
| HR (1) | HRP20221529T1 (es) |
| HU (1) | HUE060322T2 (es) |
| IL (1) | IL283469B (es) |
| LT (1) | LT3890767T (es) |
| MX (1) | MX2021006585A (es) |
| PL (1) | PL3890767T3 (es) |
| PT (1) | PT3890767T (es) |
| RS (1) | RS63847B1 (es) |
| SI (1) | SI3890767T1 (es) |
| WO (1) | WO2020115032A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3069711A1 (en) * | 2015-03-16 | 2016-09-21 | PARI Pharma GmbH | Cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection |
| CN116348170A (zh) * | 2020-09-22 | 2023-06-27 | 艾弗林制药有限公司 | 用于改善气雾剂参数amarknd的雾化器装置优化和其用途 |
| EP4249022A1 (en) * | 2022-03-21 | 2023-09-27 | PARI Pharma GmbH | Drug-device combination |
| CN115006656A (zh) * | 2022-05-18 | 2022-09-06 | 苏州易合医药有限公司 | 一种可连续提供肺部活性剂粉雾剂的给药装置 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4857319A (en) | 1985-01-11 | 1989-08-15 | The Regents Of The University Of California | Method for preserving liposomes |
| US5049388A (en) * | 1986-11-06 | 1991-09-17 | Research Development Foundation | Small particle aerosol liposome and liposome-drug combinations for medical use |
| US5958378A (en) | 1996-07-03 | 1999-09-28 | Research Development Foundation | High dose liposomal aerosol formulations containing cyclosporin A or budesonide |
| TW497974B (en) | 1996-07-03 | 2002-08-11 | Res Dev Foundation | High dose liposomal aerosol formulations |
| IT1289938B1 (it) | 1997-02-20 | 1998-10-19 | Angelini Ricerche Spa | Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e |
| US6631721B1 (en) * | 1998-11-06 | 2003-10-14 | Salter Labs | Nebulizer mouthpiece and accessories |
| US6962151B1 (en) | 1999-11-05 | 2005-11-08 | Pari GmbH Spezialisten für effektive Inhalation | Inhalation nebulizer |
| US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
| DE10102846B4 (de) | 2001-01-23 | 2012-04-12 | Pari Pharma Gmbh | Aerosolgenerator |
| DE10347994A1 (de) | 2003-10-15 | 2005-06-16 | Pari GmbH Spezialisten für effektive Inhalation | Wässrige Aerosol-Zubereitung |
| US7452524B2 (en) | 2004-01-27 | 2008-11-18 | Gilead Sciences, Inc. | Method for improvement of tolerance for therapeutically effective agents delivered by inhalation |
| US20060110441A1 (en) * | 2004-10-28 | 2006-05-25 | Harry Wong | Lyophilized liposome formulations and method |
| DE102005038619A1 (de) | 2005-08-16 | 2007-02-22 | Pari GmbH Spezialisten für effektive Inhalation | Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments |
| DE102006051512A1 (de) | 2005-12-06 | 2007-06-14 | Pari GmbH Spezialisten für effektive Inhalation | Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin |
| WO2007067784A2 (en) | 2005-12-08 | 2007-06-14 | Wyeth | Liposomal compositions |
| EP1927373B1 (en) * | 2006-11-30 | 2012-08-22 | PARI Pharma GmbH | Inhalation nebulizer |
| SI2285439T1 (sl) * | 2008-04-04 | 2014-05-30 | Nektar Therapeutics | Naprava za aerosolizacijo |
| CA3071911C (en) | 2010-08-23 | 2023-01-17 | Darren Rubin | Systems and methods of aerosol delivery with airflow regulation |
| RU2593254C2 (ru) * | 2010-12-28 | 2016-08-10 | Стэмфорд Девайсиз Лтд. | Полученная фотолитографическим способом дырчатая пластина и способ ее изготовления |
| KR102092361B1 (ko) | 2012-05-21 | 2020-03-23 | 인스메드 인코포레이티드 | 폐 감염을 치료하기 위한 시스템 |
| US9677919B2 (en) * | 2014-11-26 | 2017-06-13 | Rosemount Inc. | Gauge display system |
| EP3069711A1 (en) * | 2015-03-16 | 2016-09-21 | PARI Pharma GmbH | Cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection |
| US9566399B1 (en) * | 2015-04-14 | 2017-02-14 | Clempharma LLC | Deep lung alveolar aerosol targeted drug delivery |
-
2019
- 2019-06-25 EA EA202092892A patent/EA202092892A1/ru unknown
- 2019-12-03 MX MX2021006585A patent/MX2021006585A/es unknown
- 2019-12-03 FI FIEP19813329.0T patent/FI3890767T3/fi active
- 2019-12-03 AU AU2019392626A patent/AU2019392626B2/en active Active
- 2019-12-03 IL IL283469A patent/IL283469B/en unknown
- 2019-12-03 CN CN202310328774.6A patent/CN116726146A/zh active Pending
- 2019-12-03 CA CA3121362A patent/CA3121362C/en active Active
- 2019-12-03 BR BR112021010756-8A patent/BR112021010756A2/pt not_active Application Discontinuation
- 2019-12-03 CN CN201980080782.5A patent/CN113164553B/zh active Active
- 2019-12-03 EA EA202191307A patent/EA202191307A1/ru unknown
- 2019-12-03 SI SI201930419T patent/SI3890767T1/sl unknown
- 2019-12-03 CN CN202310312402.4A patent/CN116688093A/zh active Pending
- 2019-12-03 PL PL19813329.0T patent/PL3890767T3/pl unknown
- 2019-12-03 PT PT198133290T patent/PT3890767T/pt unknown
- 2019-12-03 LT LTEPPCT/EP2019/083470T patent/LT3890767T/lt unknown
- 2019-12-03 HU HUE19813329A patent/HUE060322T2/hu unknown
- 2019-12-03 RS RS20221172A patent/RS63847B1/sr unknown
- 2019-12-03 ES ES19813329T patent/ES2932966T3/es active Active
- 2019-12-03 JP JP2021531031A patent/JP7285930B2/ja active Active
- 2019-12-03 HR HRP20221529TT patent/HRP20221529T1/hr unknown
- 2019-12-03 WO PCT/EP2019/083470 patent/WO2020115032A1/en active Search and Examination
- 2019-12-03 US US17/298,603 patent/US11419819B2/en active Active
- 2019-12-03 EP EP19813329.0A patent/EP3890767B1/en active Active
- 2019-12-03 KR KR1020217020795A patent/KR102475644B1/ko active IP Right Grant
-
2021
- 2021-05-31 CO CONC2021/0007141A patent/CO2021007141A2/es unknown
-
2022
- 2022-07-15 US US17/865,426 patent/US11890376B2/en active Active
-
2023
- 2023-12-21 US US18/391,712 patent/US20240122852A1/en active Pending
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