MX2021006585A - Ciclosporina a en forma solubilizada en liposomas (l-csa) para usarse en el tratamiento de enfermedades pulmonares mediante la inhalación de un aerosol generado por un nebulizador. - Google Patents
Ciclosporina a en forma solubilizada en liposomas (l-csa) para usarse en el tratamiento de enfermedades pulmonares mediante la inhalación de un aerosol generado por un nebulizador.Info
- Publication number
- MX2021006585A MX2021006585A MX2021006585A MX2021006585A MX2021006585A MX 2021006585 A MX2021006585 A MX 2021006585A MX 2021006585 A MX2021006585 A MX 2021006585A MX 2021006585 A MX2021006585 A MX 2021006585A MX 2021006585 A MX2021006585 A MX 2021006585A
- Authority
- MX
- Mexico
- Prior art keywords
- aerosol
- pharmaceutical composition
- nebulizer
- subject
- treatment
- Prior art date
Links
- 208000019693 Lung disease Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 239000000443 aerosol Substances 0.000 abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 abstract 4
- 239000006199 nebulizer Substances 0.000 abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000012530 fluid Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000002663 nebulization Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0018—Details of inhalators; Constructional features thereof with exhalation check valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0085—Inhalators using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a una composición farmacéutica que comprende un ingrediente activo macrocíclico inmunosupresor inhalable para usarse en la prevención o el tratamiento de una enfermedad o afección pulmonar en un sujeto, en donde la composición farmacéutica se administra al sujeto por inhalación en forma de aerosol, y en donde el aerosol se genera por nebulización de la composición farmacéutica usando un nebulizador (100), comprendiendo el nebulizador: a) un generador de aerosol (101) que comprende: - un depósito de fluido (103) para contener la composición farmacéutica o una interfaz configurada para conectar un depósito de fluido, y - una membrana vibratoria (110) que tiene una pluralidad de aberturas, estando adaptadas las aberturas para producir un aerosol que comprende gotas que tienen un diámetro aerodinámico medio de masa (MMAD) de hasta aproximadamente 4.0 µm medido con una solución acuosa al 0.9% (p/v) de cloruro de sodio; b) una cámara (105) para alojar temporalmente el aerosol generado por el generador de aerosol (101), teniendo la cámara un lumen interior con un volumen en el intervalo de aproximadamente 50 a aproximadamente 150 mL; y c) una boquilla (40) para administrar el aerosol suministrado por el nebulizador (100) al sujeto, teniendo la boquilla un filtro de exhalación (30).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18210255 | 2018-12-04 | ||
PCT/EP2019/083470 WO2020115032A1 (en) | 2018-12-04 | 2019-12-03 | Inhalable compositions for use in the treatment of pulmonary diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021006585A true MX2021006585A (es) | 2022-07-04 |
Family
ID=64606777
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021006585A MX2021006585A (es) | 2018-12-04 | 2019-12-03 | Ciclosporina a en forma solubilizada en liposomas (l-csa) para usarse en el tratamiento de enfermedades pulmonares mediante la inhalación de un aerosol generado por un nebulizador. |
Country Status (22)
Country | Link |
---|---|
US (3) | US11419819B2 (es) |
EP (1) | EP3890767B1 (es) |
JP (1) | JP7285930B2 (es) |
KR (1) | KR102475644B1 (es) |
CN (3) | CN116726146A (es) |
AU (1) | AU2019392626B2 (es) |
BR (1) | BR112021010756A2 (es) |
CA (1) | CA3121362C (es) |
CO (1) | CO2021007141A2 (es) |
EA (2) | EA202092892A1 (es) |
ES (1) | ES2932966T3 (es) |
FI (1) | FI3890767T3 (es) |
HR (1) | HRP20221529T1 (es) |
HU (1) | HUE060322T2 (es) |
IL (1) | IL283469B (es) |
LT (1) | LT3890767T (es) |
MX (1) | MX2021006585A (es) |
PL (1) | PL3890767T3 (es) |
PT (1) | PT3890767T (es) |
RS (1) | RS63847B1 (es) |
SI (1) | SI3890767T1 (es) |
WO (1) | WO2020115032A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3069711A1 (en) * | 2015-03-16 | 2016-09-21 | PARI Pharma GmbH | Cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection |
EP4249022A1 (en) * | 2022-03-21 | 2023-09-27 | PARI Pharma GmbH | Drug-device combination |
CN115006656A (zh) * | 2022-05-18 | 2022-09-06 | 苏州易合医药有限公司 | 一种可连续提供肺部活性剂粉雾剂的给药装置 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857319A (en) | 1985-01-11 | 1989-08-15 | The Regents Of The University Of California | Method for preserving liposomes |
US5049388A (en) * | 1986-11-06 | 1991-09-17 | Research Development Foundation | Small particle aerosol liposome and liposome-drug combinations for medical use |
TW497974B (en) * | 1996-07-03 | 2002-08-11 | Res Dev Foundation | High dose liposomal aerosol formulations |
US5958378A (en) * | 1996-07-03 | 1999-09-28 | Research Development Foundation | High dose liposomal aerosol formulations containing cyclosporin A or budesonide |
IT1289938B1 (it) | 1997-02-20 | 1998-10-19 | Angelini Ricerche Spa | Preparazione farmaceutica comprendente liposomi liofilizzati in cui e' incapsulato un principio attivo altamente insolubile in acqua e |
US6631721B1 (en) * | 1998-11-06 | 2003-10-14 | Salter Labs | Nebulizer mouthpiece and accessories |
US6962151B1 (en) * | 1999-11-05 | 2005-11-08 | Pari GmbH Spezialisten für effektive Inhalation | Inhalation nebulizer |
US7971588B2 (en) | 2000-05-05 | 2011-07-05 | Novartis Ag | Methods and systems for operating an aerosol generator |
DE10102846B4 (de) | 2001-01-23 | 2012-04-12 | Pari Pharma Gmbh | Aerosolgenerator |
DE10347994A1 (de) * | 2003-10-15 | 2005-06-16 | Pari GmbH Spezialisten für effektive Inhalation | Wässrige Aerosol-Zubereitung |
US7452524B2 (en) * | 2004-01-27 | 2008-11-18 | Gilead Sciences, Inc. | Method for improvement of tolerance for therapeutically effective agents delivered by inhalation |
JP2008518951A (ja) * | 2004-10-28 | 2008-06-05 | アルザ コーポレイション | 凍結乾燥リポソーム配合物及び方法 |
DE102005038619A1 (de) | 2005-08-16 | 2007-02-22 | Pari GmbH Spezialisten für effektive Inhalation | Inhalationstherapievorrichtung mit einer Ampulle für die Bevorratung eines zu vernebelnden Medikaments |
DE102006051512A1 (de) * | 2005-12-06 | 2007-06-14 | Pari GmbH Spezialisten für effektive Inhalation | Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin |
EP2007355A2 (en) | 2005-12-08 | 2008-12-31 | Wyeth a Corporation of the State of Delaware | Liposomal compositions |
EP1927373B1 (en) | 2006-11-30 | 2012-08-22 | PARI Pharma GmbH | Inhalation nebulizer |
PT2285439E (pt) * | 2008-04-04 | 2014-03-25 | Nektar Therapeutics | Dispositivo de aerossolização |
EP3950028A1 (en) | 2010-08-23 | 2022-02-09 | Darren Rubin | Systems and methods of aerosol delivery with airflow regulation |
CN103415398B (zh) * | 2010-12-28 | 2016-08-10 | 斯坦福设备有限公司 | 光限定孔板以及其制备方法 |
EP2852391B1 (en) * | 2012-05-21 | 2021-11-17 | Insmed Incorporated | Systems for treating pulmonary infections |
US9677919B2 (en) * | 2014-11-26 | 2017-06-13 | Rosemount Inc. | Gauge display system |
EP3069711A1 (en) * | 2015-03-16 | 2016-09-21 | PARI Pharma GmbH | Cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection |
US9566399B1 (en) * | 2015-04-14 | 2017-02-14 | Clempharma LLC | Deep lung alveolar aerosol targeted drug delivery |
-
2019
- 2019-06-25 EA EA202092892A patent/EA202092892A1/ru unknown
- 2019-12-03 PL PL19813329.0T patent/PL3890767T3/pl unknown
- 2019-12-03 PT PT198133290T patent/PT3890767T/pt unknown
- 2019-12-03 RS RS20221172A patent/RS63847B1/sr unknown
- 2019-12-03 SI SI201930419T patent/SI3890767T1/sl unknown
- 2019-12-03 BR BR112021010756-8A patent/BR112021010756A2/pt not_active Application Discontinuation
- 2019-12-03 CA CA3121362A patent/CA3121362C/en active Active
- 2019-12-03 HR HRP20221529TT patent/HRP20221529T1/hr unknown
- 2019-12-03 JP JP2021531031A patent/JP7285930B2/ja active Active
- 2019-12-03 WO PCT/EP2019/083470 patent/WO2020115032A1/en active Search and Examination
- 2019-12-03 LT LTEPPCT/EP2019/083470T patent/LT3890767T/lt unknown
- 2019-12-03 CN CN202310328774.6A patent/CN116726146A/zh active Pending
- 2019-12-03 CN CN201980080782.5A patent/CN113164553B/zh active Active
- 2019-12-03 CN CN202310312402.4A patent/CN116688093A/zh active Pending
- 2019-12-03 FI FIEP19813329.0T patent/FI3890767T3/fi active
- 2019-12-03 EP EP19813329.0A patent/EP3890767B1/en active Active
- 2019-12-03 AU AU2019392626A patent/AU2019392626B2/en active Active
- 2019-12-03 KR KR1020217020795A patent/KR102475644B1/ko active IP Right Grant
- 2019-12-03 ES ES19813329T patent/ES2932966T3/es active Active
- 2019-12-03 HU HUE19813329A patent/HUE060322T2/hu unknown
- 2019-12-03 IL IL283469A patent/IL283469B/en unknown
- 2019-12-03 US US17/298,603 patent/US11419819B2/en active Active
- 2019-12-03 MX MX2021006585A patent/MX2021006585A/es unknown
- 2019-12-03 EA EA202191307A patent/EA202191307A1/ru unknown
-
2021
- 2021-05-31 CO CONC2021/0007141A patent/CO2021007141A2/es unknown
-
2022
- 2022-07-15 US US17/865,426 patent/US11890376B2/en active Active
-
2023
- 2023-12-21 US US18/391,712 patent/US20240122852A1/en active Pending
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