EA202191307A1 - Композиции для ингаляции для применения для лечения заболеваний легких - Google Patents

Композиции для ингаляции для применения для лечения заболеваний легких

Info

Publication number
EA202191307A1
EA202191307A1 EA202191307A EA202191307A EA202191307A1 EA 202191307 A1 EA202191307 A1 EA 202191307A1 EA 202191307 A EA202191307 A EA 202191307A EA 202191307 A EA202191307 A EA 202191307A EA 202191307 A1 EA202191307 A1 EA 202191307A1
Authority
EA
Eurasian Patent Office
Prior art keywords
aerosol
pharmaceutical composition
subject
nebulizer
mouthpiece
Prior art date
Application number
EA202191307A
Other languages
English (en)
Inventor
Оливер Денк
Original Assignee
Брес Терапьютикс Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Брес Терапьютикс Гмбх filed Critical Брес Терапьютикс Гмбх
Publication of EA202191307A1 publication Critical patent/EA202191307A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0018—Details of inhalators; Constructional features thereof with exhalation check valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Transplantation (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

В изобретении предложена фармацевтическая композиция, содержащая ингаляционный иммуносупрессивный макроциклический активный ингредиент, для применения для предотвращения или лечения заболевания или состояния легких у субъекта, где фармацевтическую композицию вводят субъекту путем ингаляции в виде аэрозоля и где аэрозоль вырабатывается распылением фармацевтической композиции с применением небулайзера (100), содержащего: a) генератор (101) аэрозоля, содержащий резервуар (103) для текучей среды для хранения фармацевтической композиции или переходник, выполненный с возможностью соединения резервуара для текучей среды, и выполненную с возможностью вибрации мембрану (110), имеющую множество отверстий, предназначенных для получения аэрозоля, содержащего капли, имеющие массовый медианный аэродинамический диаметр (ММАД) вплоть до примерно 4,0 мкм при измерении с использованием 0,9% (мас./об.) водного раствора хлорида натрия; b) камеру (105) для временного размещения аэрозоля, вырабатываемого генератором (101) аэрозоля, имеющую внутреннюю полость объемом в диапазоне от примерно 50 до примерно 150 мл; и c) мундштук (40) для доставки субъекту аэрозоля, подаваемого небулайзером (100), где мундштук имеет фильтр (30) выдоха.
EA202191307A 2018-12-04 2019-12-03 Композиции для ингаляции для применения для лечения заболеваний легких EA202191307A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18210255 2018-12-04
PCT/EP2019/083470 WO2020115032A1 (en) 2018-12-04 2019-12-03 Inhalable compositions for use in the treatment of pulmonary diseases

Publications (1)

Publication Number Publication Date
EA202191307A1 true EA202191307A1 (ru) 2021-08-09

Family

ID=64606777

Family Applications (2)

Application Number Title Priority Date Filing Date
EA202092892A EA202092892A1 (ru) 2018-12-04 2019-06-25 Ингаляционные композиции, содержащие макроциклические иммуносупрессанты
EA202191307A EA202191307A1 (ru) 2018-12-04 2019-12-03 Композиции для ингаляции для применения для лечения заболеваний легких

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA202092892A EA202092892A1 (ru) 2018-12-04 2019-06-25 Ингаляционные композиции, содержащие макроциклические иммуносупрессанты

Country Status (22)

Country Link
US (3) US11419819B2 (ru)
EP (1) EP3890767B1 (ru)
JP (1) JP7285930B2 (ru)
KR (1) KR102475644B1 (ru)
CN (3) CN116688093A (ru)
AU (1) AU2019392626B2 (ru)
BR (1) BR112021010756A2 (ru)
CA (1) CA3121362C (ru)
CO (1) CO2021007141A2 (ru)
EA (2) EA202092892A1 (ru)
ES (1) ES2932966T3 (ru)
FI (1) FI3890767T3 (ru)
HR (1) HRP20221529T1 (ru)
HU (1) HUE060322T2 (ru)
IL (1) IL283469B (ru)
LT (1) LT3890767T (ru)
MX (1) MX2021006585A (ru)
PL (1) PL3890767T3 (ru)
PT (1) PT3890767T (ru)
RS (1) RS63847B1 (ru)
SI (1) SI3890767T1 (ru)
WO (1) WO2020115032A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3069711A1 (en) * 2015-03-16 2016-09-21 PARI Pharma GmbH Cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection
EP4249022A1 (en) * 2022-03-21 2023-09-27 PARI Pharma GmbH Drug-device combination
CN115006656A (zh) * 2022-05-18 2022-09-06 苏州易合医药有限公司 一种可连续提供肺部活性剂粉雾剂的给药装置

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US4857319A (en) 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US5049388A (en) * 1986-11-06 1991-09-17 Research Development Foundation Small particle aerosol liposome and liposome-drug combinations for medical use
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US5958378A (en) * 1996-07-03 1999-09-28 Research Development Foundation High dose liposomal aerosol formulations containing cyclosporin A or budesonide
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Also Published As

Publication number Publication date
JP2022510953A (ja) 2022-01-28
MX2021006585A (es) 2022-07-04
CN116726146A (zh) 2023-09-12
CO2021007141A2 (es) 2021-08-19
BR112021010756A2 (pt) 2021-08-31
EP3890767A1 (en) 2021-10-13
JP7285930B2 (ja) 2023-06-02
ES2932966T3 (es) 2023-01-30
CN116688093A (zh) 2023-09-05
EA202092892A1 (ru) 2021-05-27
RS63847B1 (sr) 2023-01-31
EP3890767B1 (en) 2022-10-12
US20240122852A1 (en) 2024-04-18
PT3890767T (pt) 2022-11-29
LT3890767T (lt) 2022-12-12
PL3890767T3 (pl) 2023-05-08
FI3890767T3 (fi) 2023-01-13
HRP20221529T1 (hr) 2023-02-17
WO2020115032A1 (en) 2020-06-11
US11419819B2 (en) 2022-08-23
CA3121362C (en) 2024-01-02
CN113164553B (zh) 2023-04-21
IL283469B (en) 2022-07-01
US20220347098A1 (en) 2022-11-03
KR102475644B1 (ko) 2022-12-07
SI3890767T1 (sl) 2023-02-28
US11890376B2 (en) 2024-02-06
AU2019392626A1 (en) 2021-06-24
AU2019392626B2 (en) 2022-02-10
KR20210110312A (ko) 2021-09-07
CA3121362A1 (en) 2020-06-11
US20220023211A1 (en) 2022-01-27
HUE060322T2 (hu) 2023-02-28
CN113164553A (zh) 2021-07-23
IL283469A (en) 2021-07-29

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