CN107529337B - 二去水卫矛醇中杂质的hplc分析 - Google Patents

二去水卫矛醇中杂质的hplc分析 Download PDF

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Publication number
CN107529337B
CN107529337B CN201480073454.XA CN201480073454A CN107529337B CN 107529337 B CN107529337 B CN 107529337B CN 201480073454 A CN201480073454 A CN 201480073454A CN 107529337 B CN107529337 B CN 107529337B
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Prior art keywords
dianhydrogalactitol
dulcitol
minutes
hplc
impurities
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Expired - Fee Related
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CN201480073454.XA
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English (en)
Chinese (zh)
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CN107529337A (zh
Inventor
刘晓云
李作斌
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Del Mar Pharmaceuticals
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Del Mar Pharmaceuticals
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Priority claimed from US14/083,135 external-priority patent/US9029164B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8447—Nebulising, aerosol formation or ionisation
    • G01N2030/8494—Desolvation chambers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8872—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample impurities

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN201480073454.XA 2013-11-18 2014-11-18 二去水卫矛醇中杂质的hplc分析 Expired - Fee Related CN107529337B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/083,135 2013-11-18
US14/083,135 US9029164B2 (en) 2012-02-27 2013-11-18 Analytical methods for analyzing and determining impurities in dianhydrogalactitol
PCT/US2014/066087 WO2015074025A1 (en) 2013-11-18 2014-11-18 Hplc analysis of impurities in dianhydrogalactitol

Publications (2)

Publication Number Publication Date
CN107529337A CN107529337A (zh) 2017-12-29
CN107529337B true CN107529337B (zh) 2021-11-16

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CN201480073454.XA Expired - Fee Related CN107529337B (zh) 2013-11-18 2014-11-18 二去水卫矛醇中杂质的hplc分析

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Country Link
EP (1) EP3071555A4 (https=)
JP (1) JP2016538574A (https=)
KR (1) KR20160108315A (https=)
CN (1) CN107529337B (https=)
AU (1) AU2014348232A1 (https=)
CA (1) CA2931088A1 (https=)
CL (1) CL2016001197A1 (https=)
IL (1) IL245713A0 (https=)
MX (1) MX2016006457A (https=)
WO (1) WO2015074025A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106397360A (zh) * 2015-07-29 2017-02-15 广西梧州制药（集团）股份有限公司 叔丁醇在去水卫矛醇或其组合物冷冻干燥过程中的应用
MX379918B (es) * 2015-11-25 2025-03-11 Del Mar Pharmaceuticals Bc Ltd Metodos para analisis y resolucion de preparaciones de dianhidrogalactitol y derivados o analogos del mismo.
CN105445407B (zh) * 2015-12-29 2017-04-19 成都普思生物科技股份有限公司 一种山桐子中脂肪酸和维生素e的检测方法
US10927363B2 (en) 2016-04-04 2021-02-23 Mie University DNA sequence and expression vector for alginate lyase
KR102270026B1 (ko) * 2020-01-31 2021-06-28 현대약품 주식회사 (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법
CN114113352A (zh) * 2020-08-28 2022-03-01 深圳波顿香料有限公司 发酵液中内酯型槐糖酯含量的测定方法
US12295919B2 (en) 2022-03-16 2025-05-13 Mie University Methods of treatment and prevention using 4-deoxy-L-erythro-5-hexoseulose uronic acid
CN120741731B (zh) * 2025-09-08 2025-11-14 天津中医药大学 一种基于uplc-qtrap-ms/ms检测扶芳藤或复方扶芳藤合剂中化学成分的方法

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JPH04297868A (ja) * 1991-03-27 1992-10-21 Tonen Corp オリゴ糖の分析方法
JPH09229920A (ja) * 1996-02-26 1997-09-05 Kao Corp グラジェント液体クロマトグラフィー溶離液の処理方法
US6060525A (en) * 1996-03-01 2000-05-09 Dionix Corporation Removal of borate in chromatography
WO2000042225A1 (en) * 1999-01-14 2000-07-20 Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College Process for the separation of sugars
US20060148732A1 (en) * 2000-11-17 2006-07-06 Gutterman Jordan U Inhibition of NF-kappaB by triterpene compositions
JP2004294384A (ja) * 2003-03-28 2004-10-21 National Agriculture & Bio-Oriented Research Organization １−デオキシノジリマイシンの測定方法
WO2005007122A2 (en) * 2003-07-18 2005-01-27 Oakwood Laboratories, L.L.C. Polymer stabilization
EP1747457B1 (en) * 2004-05-20 2011-11-30 Novartis AG Analysis of liquid chromatography eluates
JP2008076340A (ja) * 2006-09-25 2008-04-03 Toppan Printing Co Ltd 高感度検出方法およびその検出装置
CA2703477C (en) * 2007-10-25 2016-10-11 Exelixis, Inc. Pyridinyl substituted tropane compounds and uses thereof
EP2528918B1 (en) * 2010-01-29 2014-09-10 Nerviano Medical Sciences S.r.l. 6,7-dihydroimidazo[1,5-a]pyrazin-8(5h)-one derivatives as protein kinase modulators
CA2808629C (en) * 2010-08-18 2020-06-16 Del Mar Pharmaceuticals Method of synthesis of substituted hexitols such as dianhydrogalactitol
CN102008541B (zh) * 2010-10-08 2012-07-04 广西中医学院 无糖型复方扶芳藤制剂中3种主要活性成分的同时检测方法
MX2014010312A (es) * 2012-02-27 2015-04-14 Del Mar Pharmaceuticals Metodos analiticos mejorados para analizar y determinar impurezas en dianhidrogalactitol.
BE1020835A5 (nl) * 2012-03-20 2014-06-03 Maes Francis N V Werkwijze voor het vervaardigen van een plantenextract, i.h.b. uit desmodium.

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Publication number Publication date
CA2931088A1 (en) 2015-05-21
MX2016006457A (es) 2017-01-06
KR20160108315A (ko) 2016-09-19
CN107529337A (zh) 2017-12-29
WO2015074025A9 (en) 2015-12-17
AU2014348232A1 (en) 2016-06-30
WO2015074025A1 (en) 2015-05-21
IL245713A0 (en) 2016-08-02
JP2016538574A (ja) 2016-12-08
CL2016001197A1 (es) 2017-06-30
EP3071555A1 (en) 2016-09-28
EP3071555A4 (en) 2017-05-31

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