MX2016006457A - Analisis de cromatografia liquida de alto rendimiento (hplc) de impurezas en dianhidrogalactitol. - Google Patents

Analisis de cromatografia liquida de alto rendimiento (hplc) de impurezas en dianhidrogalactitol.

Info

Publication number
MX2016006457A
MX2016006457A MX2016006457A MX2016006457A MX2016006457A MX 2016006457 A MX2016006457 A MX 2016006457A MX 2016006457 A MX2016006457 A MX 2016006457A MX 2016006457 A MX2016006457 A MX 2016006457A MX 2016006457 A MX2016006457 A MX 2016006457A
Authority
MX
Mexico
Prior art keywords
dianhydrogalactitol
hplc
impurities
preparations
hplc analysis
Prior art date
Application number
MX2016006457A
Other languages
English (en)
Inventor
Tso- Ping Li Mike
Lu Xiaoyun
Original Assignee
Del Mar Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/083,135 external-priority patent/US9029164B2/en
Application filed by Del Mar Pharmaceuticals filed Critical Del Mar Pharmaceuticals
Publication of MX2016006457A publication Critical patent/MX2016006457A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8447—Nebulising, aerosol formation or ionisation
    • G01N2030/8494—Desolvation chambers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8872—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample impurities

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Un método analítico mejorado para el análisis de las preparaciones de dianhidrogalactitol proporciona un método para determinar la pureza de dianhidrogalactitol y detectar impurezas en preparaciones de dianhidrogalactitol, así como identificar cualquiera de dichas impurezas; el método emplea la cromatografía líquida de alto rendimiento (HPLC), en particular, HPLC con detección de difracción de luz evaporativa (ELSD); la HPCL puede ser seguido por espectroscopía de masa en tándem; el método puede comprender además el paso de realizar la recolección de HPLC preparativa de al menos un pico de la sustancia específica presente en una preparación de dianhidrogalactitol.
MX2016006457A 2013-11-18 2014-11-18 Analisis de cromatografia liquida de alto rendimiento (hplc) de impurezas en dianhidrogalactitol. MX2016006457A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/083,135 US9029164B2 (en) 2012-02-27 2013-11-18 Analytical methods for analyzing and determining impurities in dianhydrogalactitol
PCT/US2014/066087 WO2015074025A1 (en) 2013-11-18 2014-11-18 Hplc analysis of impurities in dianhydrogalactitol

Publications (1)

Publication Number Publication Date
MX2016006457A true MX2016006457A (es) 2017-01-06

Family

ID=53058168

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016006457A MX2016006457A (es) 2013-11-18 2014-11-18 Analisis de cromatografia liquida de alto rendimiento (hplc) de impurezas en dianhidrogalactitol.

Country Status (10)

Country Link
EP (1) EP3071555A4 (es)
JP (1) JP2016538574A (es)
KR (1) KR20160108315A (es)
CN (1) CN107529337B (es)
AU (1) AU2014348232A1 (es)
CA (1) CA2931088A1 (es)
CL (1) CL2016001197A1 (es)
IL (1) IL245713A0 (es)
MX (1) MX2016006457A (es)
WO (1) WO2015074025A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106397360A (zh) * 2015-07-29 2017-02-15 广西梧州制药（集团）股份有限公司 叔丁醇在去水卫矛醇或其组合物冷冻干燥过程中的应用
MX2018006425A (es) 2015-11-25 2018-11-09 Del Mar Pharmaceuticals Bc Ltd Metodos para analisis y resolucion de preparaciones de dianhidrogalactitol y derivados o analogos del mismo.
CN105445407B (zh) * 2015-12-29 2017-04-19 成都普思生物科技股份有限公司 一种山桐子中脂肪酸和维生素e的检测方法
JP6954644B2 (ja) 2016-04-04 2021-10-27 国立大学法人三重大学 アルギン酸リアーゼ及び当該酵素を用いる不飽和ウロン酸単糖の製造方法
KR102270026B1 (ko) * 2020-01-31 2021-06-28 현대약품 주식회사 (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법
CN114113352A (zh) * 2020-08-28 2022-03-01 深圳波顿香料有限公司 发酵液中内酯型槐糖酯含量的测定方法

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JPH04297868A (ja) * 1991-03-27 1992-10-21 Tonen Corp オリゴ糖の分析方法
JPH09229920A (ja) * 1996-02-26 1997-09-05 Kao Corp グラジェント液体クロマトグラフィー溶離液の処理方法
US6060525A (en) * 1996-03-01 2000-05-09 Dionix Corporation Removal of borate in chromatography
WO2000042225A1 (en) * 1999-01-14 2000-07-20 Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College Process for the separation of sugars
US20060148732A1 (en) * 2000-11-17 2006-07-06 Gutterman Jordan U Inhibition of NF-kappaB by triterpene compositions
JP2004294384A (ja) * 2003-03-28 2004-10-21 National Agriculture & Bio-Oriented Research Organization １−デオキシノジリマイシンの測定方法
CA2819769C (en) * 2003-07-18 2016-06-28 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
CA2567528A1 (en) * 2004-05-20 2005-12-01 Chiron S.R.L. Analysis of liquid chromatography eluates
JP2008076340A (ja) * 2006-09-25 2008-04-03 Toppan Printing Co Ltd 高感度検出方法およびその検出装置
BRPI0818893B8 (pt) * 2007-10-25 2021-05-25 Exelixis Inc compostos de tropano, suas composições farmacêuticas, seus usos e método in vitro de inibição de hsp90 em uma célula
WO2011092120A1 (en) * 2010-01-29 2011-08-04 Nerviano Medical Sciences S.R.L. 6,7- dihydroimidazo [1,5-a] pyrazin-8 (5h) - one derivatives as protein kinase modulators
SG188235A1 (en) * 2010-08-18 2013-04-30 Del Mar Pharmaceuticals Method of synthesis of substituted hexitols such as dianhydrogalactitol
CN102008541B (zh) * 2010-10-08 2012-07-04 广西中医学院 无糖型复方扶芳藤制剂中3种主要活性成分的同时检测方法
MX2014010312A (es) * 2012-02-27 2015-04-14 Del Mar Pharmaceuticals Metodos analiticos mejorados para analizar y determinar impurezas en dianhidrogalactitol.
BE1020835A5 (nl) * 2012-03-20 2014-06-03 Maes Francis N V Werkwijze voor het vervaardigen van een plantenextract, i.h.b. uit desmodium.

Also Published As

Publication number Publication date
KR20160108315A (ko) 2016-09-19
AU2014348232A1 (en) 2016-06-30
WO2015074025A9 (en) 2015-12-17
IL245713A0 (en) 2016-08-02
CL2016001197A1 (es) 2017-06-30
EP3071555A1 (en) 2016-09-28
CA2931088A1 (en) 2015-05-21
CN107529337A (zh) 2017-12-29
EP3071555A4 (en) 2017-05-31
WO2015074025A1 (en) 2015-05-21
CN107529337B (zh) 2021-11-16
JP2016538574A (ja) 2016-12-08

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