WO2013170011A3 - Method for determining biospecimen quality - Google Patents

Method for determining biospecimen quality Download PDF

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Publication number
WO2013170011A3
WO2013170011A3 PCT/US2013/040323 US2013040323W WO2013170011A3 WO 2013170011 A3 WO2013170011 A3 WO 2013170011A3 US 2013040323 W US2013040323 W US 2013040323W WO 2013170011 A3 WO2013170011 A3 WO 2013170011A3
Authority
WO
WIPO (PCT)
Prior art keywords
specimen
protein
degraded
biospecimen
quality
Prior art date
Application number
PCT/US2013/040323
Other languages
French (fr)
Other versions
WO2013170011A2 (en
Inventor
Timothy J. GEDDS
Original Assignee
William Beaumont Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Beaumont Hospital filed Critical William Beaumont Hospital
Publication of WO2013170011A2 publication Critical patent/WO2013170011A2/en
Publication of WO2013170011A3 publication Critical patent/WO2013170011A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

A method of assigning an index which indicates the degradation of a type-specific sample, comprising: providing a first specimen of a type-specific sample, subjecting the first specimen to condition(s) which degrade protein(s) in the first specimen; performing surface- enhanced laser desorption/ionization time-of-flight mass spectroscopy analysis on the first specimen to determine protein peak intensities for individual proteins in the first specimen; based on the protein peak intensities, identifying protein(s) in the first specimen as having degraded or not degraded; and assigning an index which is derived from a ratio of the degraded protein(s) to the non-degraded protein(s).
PCT/US2013/040323 2012-05-09 2013-05-09 Method for determining biospecimen quality WO2013170011A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261644584P 2012-05-09 2012-05-09
US61/644,584 2012-05-09

Publications (2)

Publication Number Publication Date
WO2013170011A2 WO2013170011A2 (en) 2013-11-14
WO2013170011A3 true WO2013170011A3 (en) 2014-01-03

Family

ID=49551458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/040323 WO2013170011A2 (en) 2012-05-09 2013-05-09 Method for determining biospecimen quality

Country Status (1)

Country Link
WO (1) WO2013170011A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3628068A4 (en) * 2017-05-02 2020-12-30 Liquid Biosciences, Inc. Systems and methods for determining attributes of biological samples
US10453552B2 (en) 2017-05-02 2019-10-22 Liquid Biosciences, Inc. Systems and methods for determining attributes of biological samples
US11039765B2 (en) 2017-09-26 2021-06-22 International Business Machines Corporation Smart pellet for sample testing

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090093010A1 (en) * 2004-09-21 2009-04-09 University Of Manitoba Method of Detecting Kidney Dysfunction

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090093010A1 (en) * 2004-09-21 2009-04-09 University Of Manitoba Method of Detecting Kidney Dysfunction

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BECKER: "Investigations into the Effects of Blood Specimen Handling Procedures on Protein Integrity", 3ND ANNUAL BIOSPECIMEN RESEARCH NETWORK (BRN) SYMPOSIUM, 27 April 2010 (2010-04-27), pages 1 - 20, Retrieved from the Internet <URL:http://biospecimens.cancer.gov/meeting/bmsymposium/2010/docslBecker%20Caprton%20NCI%20OBBR%20March%202010.pdf> *
GEDDES ET AL.: "''The Development of a Protein Integrity Metric for Biorepository Specimens: Introduction of the ''SPIN'' Index,''", 2012 BIOSPECIMEN RESEACH NETWORK SYMPOSIUM, 22 February 2012 (2012-02-22), Retrieved from the Internet <URL:http://biospecimens.cancer.gov/meeting/brnsymposium/2012/posters.asp> *
ISSAQ ET AL.: "SELDI-TOF MS for Diagnostic Proteomics", ANALYTICAL CHEMISTRY, 1 April 2003 (2003-04-01), pages 149 - 155 *

Also Published As

Publication number Publication date
WO2013170011A2 (en) 2013-11-14

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