CN107250373A - 通过微流体递送实现的基因编辑 - Google Patents
通过微流体递送实现的基因编辑 Download PDFInfo
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- CN107250373A CN107250373A CN201680008278.0A CN201680008278A CN107250373A CN 107250373 A CN107250373 A CN 107250373A CN 201680008278 A CN201680008278 A CN 201680008278A CN 107250373 A CN107250373 A CN 107250373A
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108728330A (zh) * | 2018-06-19 | 2018-11-02 | 东台德缘生物科技有限公司 | 一种用于哺乳动物细胞基因编辑载体构建的试剂盒 |
| CN109593743A (zh) * | 2018-12-12 | 2019-04-09 | 广州普世利华科技有限公司 | 新型CRISPR/ScCas12a蛋白及其制备方法 |
| CN109666662A (zh) * | 2018-12-12 | 2019-04-23 | 广州普世利华科技有限公司 | 新型ScCas12a在核酸检测方面的应用 |
| CN109680053A (zh) * | 2018-12-12 | 2019-04-26 | 广州普世利华科技有限公司 | 新型SsCas12a蛋白在核酸检测方面的应用 |
| WO2020207456A1 (en) * | 2019-04-11 | 2020-10-15 | The Chinese University Of Hong Kong | Systems and methods for controlled membrane disruption |
| CN113528483A (zh) * | 2020-04-22 | 2021-10-22 | 复星凯特生物科技有限公司 | Shp2特异性失活突变蛋白及其在car-t治疗中应用 |
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|---|---|---|---|---|
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| CN107058101B (zh) * | 2011-10-17 | 2021-06-01 | 麻省理工学院 | 细胞内传递 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| EP3033184B1 (en) | 2013-08-16 | 2021-03-31 | Massachusetts Institute of Technology | Selective delivery of material to cells |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| JP7523203B2 (ja) | 2014-10-31 | 2024-07-26 | マサチューセッツ インスティテュート オブ テクノロジー | 生体分子の免疫細胞への送達 |
| WO2016077761A1 (en) | 2014-11-14 | 2016-05-19 | Massachusetts Institute Of Technology | Disruption and field enabled delivery of compounds and compositions into cells |
| CN107250373A (zh) | 2015-01-12 | 2017-10-13 | 麻省理工学院 | 通过微流体递送实现的基因编辑 |
| SG10201912910PA (en) | 2015-07-09 | 2020-02-27 | Massachusetts Inst Technology | Delivery of materials to anucleate cells |
| EP3344575B1 (en) | 2015-09-04 | 2020-04-15 | SQZ Biotechnologies Company | Intracellular delivery of biomolecules to cells comprising a cell wall |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したＣａｓ９蛋白質 |
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| CN109666662A (zh) * | 2018-12-12 | 2019-04-23 | 广州普世利华科技有限公司 | 新型ScCas12a在核酸检测方面的应用 |
| CN109680053A (zh) * | 2018-12-12 | 2019-04-26 | 广州普世利华科技有限公司 | 新型SsCas12a蛋白在核酸检测方面的应用 |
| WO2020207456A1 (en) * | 2019-04-11 | 2020-10-15 | The Chinese University Of Hong Kong | Systems and methods for controlled membrane disruption |
| US12465912B2 (en) | 2019-04-11 | 2025-11-11 | The Chinese University Of Hong Kong | Systems and methods for controlled membrane disruption |
| CN113528483A (zh) * | 2020-04-22 | 2021-10-22 | 复星凯特生物科技有限公司 | Shp2特异性失活突变蛋白及其在car-t治疗中应用 |
| CN113528483B (zh) * | 2020-04-22 | 2024-08-16 | 复星凯特生物科技有限公司 | Shp2特异性失活突变蛋白及其在car-t治疗中应用 |
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| JP7278027B2 (ja) | 2023-05-19 |
| US20180003696A1 (en) | 2018-01-04 |
| EP3245294A1 (en) | 2017-11-22 |
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| US11125739B2 (en) | 2021-09-21 |
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| CA2971626A1 (en) | 2016-07-21 |
| JP2021129584A (ja) | 2021-09-09 |
| JP2018500913A (ja) | 2018-01-18 |
| EP3245294A4 (en) | 2018-05-30 |
| US20220091099A1 (en) | 2022-03-24 |
| AU2016206870A1 (en) | 2017-07-13 |
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