CN107074975A - 用于修饰的t细胞的条件活性嵌合抗原受体 - Google Patents

用于修饰的t细胞的条件活性嵌合抗原受体 Download PDF

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CN107074975A
CN107074975A CN201580057728.0A CN201580057728A CN107074975A CN 107074975 A CN107074975 A CN 107074975A CN 201580057728 A CN201580057728 A CN 201580057728A CN 107074975 A CN107074975 A CN 107074975A
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杰·M·肖特
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Bioatla Inc
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Bioatla Inc
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CN201580057728.0A 2014-08-28 2015-08-27 用于修饰的t细胞的条件活性嵌合抗原受体 Pending CN107074975A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462043067P 2014-08-28 2014-08-28
US62/043,067 2014-08-28
PCT/US2015/047197 WO2016033331A1 (en) 2014-08-28 2015-08-27 Conditionally active chimeric antigen receptors for modified t-cells

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CN201680049877.7A Pending CN107922473A (zh) 2014-08-28 2016-02-24 用于修饰的t细胞的条件活性嵌合抗原受体

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US (5) US20170260261A1 (enExample)
EP (3) EP4074735B1 (enExample)
JP (3) JP7286267B2 (enExample)
KR (4) KR102818922B1 (enExample)
CN (2) CN107074975A (enExample)
AU (3) AU2015308818B2 (enExample)
BR (1) BR112018003535A2 (enExample)
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Cited By (13)

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WO2019096115A1 (zh) * 2017-11-14 2019-05-23 杭州康万达医药科技有限公司 分离的t细胞受体、其修饰的细胞、编码核酸、表达载体、制备方法、药物组合物和应用
WO2019096261A1 (zh) * 2017-11-17 2019-05-23 科济生物医药（上海）有限公司 靶向成纤维激活蛋白α的结合单元及其应用
CN109957019A (zh) * 2017-12-25 2019-07-02 深圳宾德生物技术有限公司 一种靶向dr5的单链抗体、嵌合抗原受体t细胞及其制备方法和应用
CN109957025A (zh) * 2017-12-25 2019-07-02 深圳宾德生物技术有限公司 一种靶向dr5的单链抗体、嵌合抗原受体t细胞及其制备方法和应用
WO2019148656A1 (zh) * 2018-02-05 2019-08-08 深圳市默赛尔生物医学科技发展有限公司 多信号嵌合抗原受体及其表达基因、其修饰的nk细胞及抗肿瘤的药物
CN111836827A (zh) * 2017-12-28 2020-10-27 南京传奇生物科技有限公司 包含nkg2d结构域的多特异性嵌合受体和其使用方法
CN111989342A (zh) * 2018-04-18 2020-11-24 艾克隆株式会社 开关分子以及可转换嵌合抗原受体
CN112567025A (zh) * 2018-08-10 2021-03-26 国立大学法人京都大学 Cd3阳性细胞的制造方法
CN114007643A (zh) * 2019-04-19 2022-02-01 中外制药株式会社 识别抗体改变部位的嵌合受体
CN114173822A (zh) * 2019-06-03 2022-03-11 芝加哥大学 用胶原结合药物载体治疗癌症的方法和组合物
CN114450410A (zh) * 2019-05-16 2022-05-06 华盛顿大学 使用从头设计的共定位依赖蛋白开关的超特异性细胞靶向
WO2022166665A1 (zh) * 2021-02-08 2022-08-11 浙江大学 一种以内源性蛋白质分子替代单结构域抗体的嵌合抗原受体
TWI835848B (zh) * 2018-09-07 2024-03-21 美商拜奧亞特拉公司 經改造t細胞之條件活性嵌合抗原受體

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ES3034398T3 (en) 2014-08-28 2025-08-18 Bioatla Inc Conditionally active chimeric antigen receptors for modified t-cells
US11111288B2 (en) * 2014-08-28 2021-09-07 Bioatla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
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WO2016138034A1 (en) 2015-02-24 2016-09-01 The Regents Of The University Of California Binding-triggered transcriptional switches and methods of use thereof
DK3298033T4 (da) 2015-05-18 2023-10-02 Tcr2 Therapeutics Inc Sammensætninger og medicinske anvendelser til tcr-reprogrammering under anvendelse af fusionsproteiner
US10434153B1 (en) 2015-05-20 2019-10-08 Kim Leslie O'Neill Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors
US11173179B2 (en) 2015-06-25 2021-11-16 Icell Gene Therapeutics Llc Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof
TW202444897A (zh) 2015-06-25 2024-11-16 美商生物細胞基因治療有限公司 嵌合抗原受體(car)、組合物及其使用方法
KR102697827B1 (ko) 2015-07-28 2024-08-23 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 키메릭 항원 수용체를 발현하는 변형된 단핵세포/대식세포 및 그의 용도
US11352439B2 (en) * 2015-08-13 2022-06-07 Kim Leslie O'Neill Macrophage CAR (MOTO-CAR) in immunotherapy
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US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
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WO2019055946A1 (en) * 2017-09-18 2019-03-21 F1 Oncology, Inc. METHODS AND COMPOSITIONS FOR THE GENETIC MODIFICATION AND EXPANSION OF LYMPHOCYTES AND THE REGULATION OF THE ACTIVITY THEREOF
WO2017180587A2 (en) 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Regulated biocircuit systems
WO2017180842A1 (en) * 2016-04-15 2017-10-19 Bioatla, Llc Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof
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RU2017109966A (ru) 2018-09-28
US20170260261A1 (en) 2017-09-14
US11584927B2 (en) 2023-02-21
KR102889461B1 (ko) 2025-11-21
EP3341406A4 (en) 2019-03-20
DK4074735T3 (da) 2025-07-14
ES3034398T3 (en) 2025-08-18
BR112017003835A2 (pt) 2018-04-10
ES2913865T3 (es) 2022-06-06
WO2016033331A8 (en) 2017-03-02
KR20240034265A (ko) 2024-03-13
WO2016033331A1 (en) 2016-03-03
AU2015308818A1 (en) 2017-03-09
MX2022009625A (es) 2022-09-07
AU2021203997A1 (en) 2021-07-08
MX2017002605A (es) 2017-05-19
RU2759957C2 (ru) 2021-11-19
AU2021203997B2 (en) 2024-03-28
KR20230172625A (ko) 2023-12-22
CN107922473A (zh) 2018-04-17
EP3186284B1 (en) 2022-04-06
JP7048494B2 (ja) 2022-04-05
JP2021137013A (ja) 2021-09-16
JP7405444B2 (ja) 2023-12-26
KR20170042325A (ko) 2017-04-18
RU2018110553A (ru) 2019-09-27
MX2018002400A (es) 2018-04-11
KR102818922B1 (ko) 2025-06-11
US20190010219A1 (en) 2019-01-10
AU2015308818B2 (en) 2021-02-25
RU2017109966A3 (enExample) 2019-03-11
MX2022007894A (es) 2022-07-19
US20180340021A1 (en) 2018-11-29
EP3341406A1 (en) 2018-07-04
EP4074735B1 (en) 2025-05-21
US20230183679A1 (en) 2023-06-15
JP2018529376A (ja) 2018-10-11
CA2959141A1 (en) 2016-03-03
CA2996514A1 (en) 2017-03-02
EP3186284A1 (en) 2017-07-05
EP3186284A4 (en) 2018-01-24
BR112018003535A2 (pt) 2018-09-25
US20160207989A1 (en) 2016-07-21
KR20180036782A (ko) 2018-04-09
RU2018110553A3 (enExample) 2019-09-27
RU2764074C2 (ru) 2022-01-13
DK3186284T3 (da) 2022-05-09
WO2017034615A1 (en) 2017-03-02
HK1246803A1 (zh) 2018-09-14
EP4074735A1 (en) 2022-10-19

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