CN106794258A - 配体‑细胞毒性药物偶联物、其制备方法及其应用 - Google Patents

配体‑细胞毒性药物偶联物、其制备方法及其应用 Download PDF

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CN106794258A
CN106794258A CN201680001840.7A CN201680001840A CN106794258A CN 106794258 A CN106794258 A CN 106794258A CN 201680001840 A CN201680001840 A CN 201680001840A CN 106794258 A CN106794258 A CN 106794258A
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formula
methyl
compound
methoxyl group
bases
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CN106794258B (zh
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许建烟
章瑛
屈博磊
张富尧
于秀招
梁金栋
蒋贵阳
张连山
李昂
王亚里
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
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Abstract

提供了一种通式(Ⅰ)为PC‑L‑Dr的配体‑细胞毒性药物偶联物，其制备方法以及该配体‑细胞毒性药物偶联物及含有其的药物组合物通过受体调节在制备治疗癌症的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (29)

  1. PCT国内申请，权利要求书已公开。
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EP3251698A4 (en) 2018-10-17
US20180177890A1 (en) 2018-06-28
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