CN1065246C - 棒酸盐的制备方法 - Google Patents
棒酸盐的制备方法 Download PDFInfo
- Publication number
- CN1065246C CN1065246C CN95192179A CN95192179A CN1065246C CN 1065246 C CN1065246 C CN 1065246C CN 95192179 A CN95192179 A CN 95192179A CN 95192179 A CN95192179 A CN 95192179A CN 1065246 C CN1065246 C CN 1065246C
- Authority
- CN
- China
- Prior art keywords
- solution
- clavulanate
- water
- clavulanic acid
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9401969A GB9401969D0 (en) | 1994-02-02 | 1994-02-02 | Process |
| GB9401969.2 | 1994-02-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1144528A CN1144528A (zh) | 1997-03-05 |
| CN1065246C true CN1065246C (zh) | 2001-05-02 |
Family
ID=10749727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95192179A Expired - Fee Related CN1065246C (zh) | 1994-02-02 | 1995-01-31 | 棒酸盐的制备方法 |
Country Status (31)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT400033B (de) | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
| SI9400107A (en) | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
| GB9500977D0 (en) * | 1995-01-19 | 1995-03-08 | Smithkline Beecham Plc | Novel process |
| SI9500134B (sl) | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
| GB9515809D0 (en) * | 1995-08-02 | 1995-10-04 | Smithkline Beecham Plc | Process |
| AT403375B (de) * | 1995-11-15 | 1998-01-26 | Biochemie Gmbh | Verfahren zur fällung von alkalisalzen der clavulansäure |
| US6414142B1 (en) * | 1996-06-13 | 2002-07-02 | Smithkline Beecham Corporation | Process for preparing potassium clavulanate |
| WO1998042858A1 (en) * | 1997-03-24 | 1998-10-01 | Cipan-Companhia Industrial Produtora De Antibióticos, S.A. | Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid |
| DE69700903T2 (de) | 1997-03-24 | 2000-07-06 | Cipan-Companhia Industrial Produtora De Antibioticos, S.A. | Verfahren zur Isolierung eines pharmazeutisch verträglichen Alkalimetallsalzes der Clavulansäure |
| DZ2456A1 (fr) | 1997-04-04 | 2003-01-18 | Smithkline Beecham Plc | Procédé de préparation de sels de l'acide clavulanique. |
| US7199242B2 (en) | 2001-08-02 | 2007-04-03 | Lg Life Sciences Limited | Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof |
| KR20190039137A (ko) | 2016-07-14 | 2019-04-10 | 아카오젠, 인코포레이티드 | 박테리아 감염 치료에서 사용하기 위한 세프티부텐과 클라불란산의 조합 |
| CN108822134B (zh) * | 2018-04-25 | 2021-06-25 | 国药集团威奇达药业有限公司 | 克拉维酸叔丁胺盐的制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0026044A1 (en) * | 1979-08-24 | 1981-04-01 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
| EP0153843A2 (en) * | 1984-02-23 | 1985-09-04 | United Kingdom Atomic Energy Authority | Improvements in and relating to fluidic contactors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1508977A (en) * | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
| ES444195A1 (es) * | 1974-10-09 | 1977-08-01 | Beecham Group Ltd | Un procedimiento para la preparacion de acido clavulanico. |
| GB1543563A (en) * | 1975-02-07 | 1979-04-04 | Glaxo Lab Ltd | Beta-lactam antibiotic in purified form |
| GB1563103A (en) * | 1975-10-13 | 1980-03-19 | Beecham Group Ltd | Process for the preparation of clavulanic acid |
| GB1578739A (en) * | 1976-07-23 | 1980-11-05 | Beecham Group Ltd | Amine salts of clavulanic acid methods for their preparation and compositions containing them |
| ES2010143A6 (es) * | 1989-03-01 | 1989-10-16 | Pharma Mar S A Pharmar | Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp. |
-
1994
- 1994-02-02 GB GB9401969A patent/GB9401969D0/en active Pending
-
1995
- 1995-01-31 HU HU9602128A patent/HU226597B1/hu not_active IP Right Cessation
- 1995-01-31 BR BR9506919A patent/BR9506919A/pt not_active Application Discontinuation
- 1995-01-31 CZ CZ19962294A patent/CZ294005B6/cs not_active IP Right Cessation
- 1995-01-31 PL PL95315782A patent/PL181451B1/pl not_active IP Right Cessation
- 1995-01-31 UA UA96083392A patent/UA48944C2/uk unknown
- 1995-01-31 DK DK95907075T patent/DK0741732T3/da active
- 1995-01-31 RU RU96117347A patent/RU2140418C1/ru not_active IP Right Cessation
- 1995-01-31 SI SI9530525T patent/SI0741732T1/xx unknown
- 1995-01-31 MX MX9603204A patent/MX9603204A/es not_active IP Right Cessation
- 1995-01-31 AT AT95907075T patent/ATE202358T1/de not_active IP Right Cessation
- 1995-01-31 DE DE69521415T patent/DE69521415T2/de not_active Expired - Lifetime
- 1995-01-31 NZ NZ278927A patent/NZ278927A/en not_active IP Right Cessation
- 1995-01-31 WO PCT/GB1995/000191 patent/WO1995021173A1/en not_active Ceased
- 1995-01-31 PT PT95907075T patent/PT741732E/pt unknown
- 1995-01-31 SK SK1003-96A patent/SK282544B6/sk not_active IP Right Cessation
- 1995-01-31 AU AU15412/95A patent/AU688849B2/en not_active Ceased
- 1995-01-31 RO RO96-01582A patent/RO115730B1/ro unknown
- 1995-01-31 CA CA002182504A patent/CA2182504C/en not_active Expired - Fee Related
- 1995-01-31 EP EP95907075A patent/EP0741732B1/en not_active Expired - Lifetime
- 1995-01-31 JP JP52044595A patent/JP4074336B2/ja not_active Expired - Fee Related
- 1995-01-31 ES ES95907075T patent/ES2159626T3/es not_active Expired - Lifetime
- 1995-01-31 KR KR1019960704202A patent/KR100388769B1/ko not_active Expired - Fee Related
- 1995-01-31 US US08/663,158 patent/US5965728A/en not_active Expired - Lifetime
- 1995-01-31 CN CN95192179A patent/CN1065246C/zh not_active Expired - Fee Related
- 1995-01-31 AP APAP/P/1996/000838A patent/AP610A/en active
-
1996
- 1996-08-01 FI FI963050A patent/FI111949B/fi active
- 1996-08-01 BG BG100765A patent/BG63307B1/bg unknown
- 1996-08-01 NO NO19963217A patent/NO314505B1/no not_active IP Right Cessation
- 1996-08-02 OA OA60872A patent/OA10587A/en unknown
-
2001
- 2001-09-12 GR GR20010401463T patent/GR3036602T3/el not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0026044A1 (en) * | 1979-08-24 | 1981-04-01 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
| EP0153843A2 (en) * | 1984-02-23 | 1985-09-04 | United Kingdom Atomic Energy Authority | Improvements in and relating to fluidic contactors |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1065246C (zh) | 棒酸盐的制备方法 | |
| KR100293172B1 (ko) | 스트렙토마이세스sp. P6621 FERM P2804의 발효액으로부터 클라불란산과 제약학적으로 허용가능한 이들의 염을 단리하는 신규한 방법 | |
| CN103555807B (zh) | 一步酶法制备7-氨基头孢霉烷酸并获得α-氨基己二酸的方法 | |
| CN1113656A (zh) | 制备高纯蜜胺的方法 | |
| CN1185155A (zh) | 制造克拉维酸盐的方法 | |
| RU2169151C2 (ru) | Способ получения и/или очистки клавулановой кислоты из ферментационного бульона посредством ультрафильтрации | |
| CN105237600A (zh) | 一种从含红霉素废水中回收红霉素的方法 | |
| CN100344608C (zh) | 一种用离子交换树脂法生产高纯辣椒素晶体的方法 | |
| CN1105724C (zh) | 棒酸的萃取方法 | |
| WO2024233856A1 (en) | Process for preparing lactic acid | |
| CN1110686A (zh) | 青霉素的提取与纯化 | |
| HK1012373B (en) | Process for the preparation of a salt of clavulanic acid | |
| CN118878554A (zh) | 从克拉维酸叔丁胺盐结晶母液中回收有效成分的方法 | |
| RU2188156C1 (ru) | Способ получения фтористого кальция | |
| JPH03147794A (ja) | Ｌ‐トリプトファンの分離法 | |
| CN1432572A (zh) | 一种青霉素的提纯方法 | |
| US20100055749A1 (en) | Process for the production of clavulanic acid | |
| CN104591996A (zh) | 一种有机酸的精制方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20010502 Termination date: 20100131 |