KR100388769B1 - 클라불란산염의제조방법 - Google Patents

클라불란산염의제조방법 Download PDF

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Publication number
KR100388769B1
KR100388769B1 KR1019960704202A KR19960704202A KR100388769B1 KR 100388769 B1 KR100388769 B1 KR 100388769B1 KR 1019960704202 A KR1019960704202 A KR 1019960704202A KR 19960704202 A KR19960704202 A KR 19960704202A KR 100388769 B1 KR100388769 B1 KR 100388769B1
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KR
South Korea
Prior art keywords
solution
clavulanic acid
water
organic solvent
potassium
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Expired - Fee Related
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KR1019960704202A
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English (en)
Korean (ko)
Inventor
마이클 알렌 쿡
제프리 클리브 웹
Original Assignee
스미스클라인비이참피이엘시이
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Application granted granted Critical
Publication of KR100388769B1 publication Critical patent/KR100388769B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
KR1019960704202A 1994-02-02 1995-01-31 클라불란산염의제조방법 Expired - Fee Related KR100388769B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9401969A GB9401969D0 (en) 1994-02-02 1994-02-02 Process
GB9401969.2 1994-02-02

Publications (1)

Publication Number Publication Date
KR100388769B1 true KR100388769B1 (ko) 2003-09-02

Family

ID=10749727

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960704202A Expired - Fee Related KR100388769B1 (ko) 1994-02-02 1995-01-31 클라불란산염의제조방법

Country Status (31)

Country Link
US (1) US5965728A (cg-RX-API-DMAC10.html)
EP (1) EP0741732B1 (cg-RX-API-DMAC10.html)
JP (1) JP4074336B2 (cg-RX-API-DMAC10.html)
KR (1) KR100388769B1 (cg-RX-API-DMAC10.html)
CN (1) CN1065246C (cg-RX-API-DMAC10.html)
AP (1) AP610A (cg-RX-API-DMAC10.html)
AT (1) ATE202358T1 (cg-RX-API-DMAC10.html)
AU (1) AU688849B2 (cg-RX-API-DMAC10.html)
BG (1) BG63307B1 (cg-RX-API-DMAC10.html)
BR (1) BR9506919A (cg-RX-API-DMAC10.html)
CA (1) CA2182504C (cg-RX-API-DMAC10.html)
CZ (1) CZ294005B6 (cg-RX-API-DMAC10.html)
DE (1) DE69521415T2 (cg-RX-API-DMAC10.html)
DK (1) DK0741732T3 (cg-RX-API-DMAC10.html)
ES (1) ES2159626T3 (cg-RX-API-DMAC10.html)
FI (1) FI111949B (cg-RX-API-DMAC10.html)
GB (1) GB9401969D0 (cg-RX-API-DMAC10.html)
GR (1) GR3036602T3 (cg-RX-API-DMAC10.html)
HU (1) HU226597B1 (cg-RX-API-DMAC10.html)
MX (1) MX9603204A (cg-RX-API-DMAC10.html)
NO (1) NO314505B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ278927A (cg-RX-API-DMAC10.html)
OA (1) OA10587A (cg-RX-API-DMAC10.html)
PL (1) PL181451B1 (cg-RX-API-DMAC10.html)
PT (1) PT741732E (cg-RX-API-DMAC10.html)
RO (1) RO115730B1 (cg-RX-API-DMAC10.html)
RU (1) RU2140418C1 (cg-RX-API-DMAC10.html)
SI (1) SI0741732T1 (cg-RX-API-DMAC10.html)
SK (1) SK282544B6 (cg-RX-API-DMAC10.html)
UA (1) UA48944C2 (cg-RX-API-DMAC10.html)
WO (1) WO1995021173A1 (cg-RX-API-DMAC10.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
ZA975198B (en) * 1996-06-13 1997-12-15 Smithkline Beecham Corp Improved process for preparing potassium clavulanate.
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
EP0867515B1 (en) * 1997-03-24 1999-12-08 CIPAN-Companhia Industrial Produtora De Antibioticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DZ2456A1 (fr) 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
DK1412078T3 (da) 2001-08-02 2009-02-02 Lg Life Sciences Ltd Fremgangsmåde til fremstilling af amino-beskyttede derivater af 4-aminomethylen-pyrrolidin-3-on, Gemifloxacin eller salte deraf
CN109715156A (zh) 2016-07-14 2019-05-03 尔察祯有限公司 用于治疗细菌感染的头孢布烯和克拉维酸的组合
CN108822134B (zh) * 2018-04-25 2021-06-25 国药集团威奇达药业有限公司 克拉维酸叔丁胺盐的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072569A (en) * 1975-10-13 1978-02-07 Beecham Group Limited Preparation of clavulanic using Streptomyces jumonjinensis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
ES444195A1 (es) * 1974-10-09 1977-08-01 Beecham Group Ltd Un procedimiento para la preparacion de acido clavulanico.
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB8404749D0 (en) * 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072569A (en) * 1975-10-13 1978-02-07 Beecham Group Limited Preparation of clavulanic using Streptomyces jumonjinensis

Also Published As

Publication number Publication date
CZ229496A3 (en) 1997-01-15
PL181451B1 (en) 2001-07-31
PL315782A1 (en) 1996-12-09
UA48944C2 (uk) 2002-09-16
HU226597B1 (en) 2009-04-28
PT741732E (pt) 2001-11-30
NO314505B1 (no) 2003-03-31
SK282544B6 (sk) 2002-10-08
WO1995021173A1 (en) 1995-08-10
EP0741732A1 (en) 1996-11-13
RO115730B1 (ro) 2000-05-30
JP4074336B2 (ja) 2008-04-09
ES2159626T3 (es) 2001-10-16
RU2140418C1 (ru) 1999-10-27
NZ278927A (en) 1998-02-26
BR9506919A (pt) 1997-09-30
DK0741732T3 (da) 2001-10-15
NO963217D0 (no) 1996-08-01
AP9600838A0 (en) 1996-07-31
EP0741732B1 (en) 2001-06-20
OA10587A (en) 2002-07-10
AU1541295A (en) 1995-08-21
CZ294005B6 (cs) 2004-09-15
BG63307B1 (bg) 2001-09-28
SI0741732T1 (cg-RX-API-DMAC10.html) 2001-10-31
CA2182504A1 (en) 1995-08-10
FI963050A0 (fi) 1996-08-01
GR3036602T3 (en) 2001-12-31
GB9401969D0 (en) 1994-03-30
CA2182504C (en) 2008-04-08
ATE202358T1 (de) 2001-07-15
AP610A (en) 1997-09-04
JPH09508411A (ja) 1997-08-26
DE69521415D1 (de) 2001-07-26
BG100765A (en) 1997-09-30
AU688849B2 (en) 1998-03-19
HK1012373A1 (en) 1999-07-30
CN1065246C (zh) 2001-05-02
US5965728A (en) 1999-10-12
SK100396A3 (en) 1996-12-04
FI111949B (fi) 2003-10-15
HU9602128D0 (en) 1996-09-30
CN1144528A (zh) 1997-03-05
NO963217L (no) 1996-10-01
FI963050L (fi) 1996-10-01
DE69521415T2 (de) 2002-05-29
MX9603204A (es) 1997-03-29
HUT74885A (en) 1997-02-28

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