CN105753968A - Fviii的位点定向修饰 - Google Patents
Fviii的位点定向修饰 Download PDFInfo
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- CN105753968A CN105753968A CN201610201090.XA CN201610201090A CN105753968A CN 105753968 A CN105753968 A CN 105753968A CN 201610201090 A CN201610201090 A CN 201610201090A CN 105753968 A CN105753968 A CN 105753968A
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- pegization
- fviii
- peg
- polypeptide
- separation
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62727704P | 2004-11-12 | 2004-11-12 | |
| US60/627277 | 2004-11-12 |
Related Parent Applications (1)
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| CN2005800464698A Division CN101124331B (zh) | 2004-11-12 | 2005-11-14 | Fvⅲ的位点定向修饰 |
Publications (1)
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| CN105753968A true CN105753968A (zh) | 2016-07-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2005800464698A Active CN101124331B (zh) | 2004-11-12 | 2005-11-14 | Fvⅲ的位点定向修饰 |
| CN201510612184.1A Active CN105148287B (zh) | 2004-11-12 | 2005-11-14 | Fviii的位点定向修饰 |
| CN201310125428.4A Active CN103214569B (zh) | 2004-11-12 | 2005-11-14 | Fviii的位点定向修饰 |
| CN201610838893.6A Pending CN107082806A (zh) | 2004-11-12 | 2005-11-14 | Fviii的位点定向修饰 |
| CN201210455152.1A Active CN103102406B (zh) | 2004-11-12 | 2005-11-14 | Fviii的位点定向修饰 |
| CN201610201090.XA Pending CN105753968A (zh) | 2004-11-12 | 2005-11-14 | Fviii的位点定向修饰 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
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| CN2005800464698A Active CN101124331B (zh) | 2004-11-12 | 2005-11-14 | Fvⅲ的位点定向修饰 |
| CN201510612184.1A Active CN105148287B (zh) | 2004-11-12 | 2005-11-14 | Fviii的位点定向修饰 |
| CN201310125428.4A Active CN103214569B (zh) | 2004-11-12 | 2005-11-14 | Fviii的位点定向修饰 |
| CN201610838893.6A Pending CN107082806A (zh) | 2004-11-12 | 2005-11-14 | Fviii的位点定向修饰 |
| CN201210455152.1A Active CN103102406B (zh) | 2004-11-12 | 2005-11-14 | Fviii的位点定向修饰 |
Country Status (32)
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| EP (9) | EP3130601B1 (fr) |
| JP (5) | JP2008524117A (fr) |
| KR (7) | KR101483917B1 (fr) |
| CN (6) | CN101124331B (fr) |
| AU (1) | AU2005304622B2 (fr) |
| BR (2) | BRPI0517795B8 (fr) |
| CA (1) | CA2586379C (fr) |
| CY (3) | CY1119292T1 (fr) |
| DK (3) | DK1824988T3 (fr) |
| ES (4) | ES2633916T3 (fr) |
| FR (1) | FR19C1031I2 (fr) |
| HK (3) | HK1117875A1 (fr) |
| HN (1) | HN2007015683A (fr) |
| HR (2) | HRP20180481B1 (fr) |
| HU (5) | HUE050542T2 (fr) |
| IL (3) | IL182903A (fr) |
| LT (5) | LT2363414T (fr) |
| LU (1) | LUC00118I2 (fr) |
| MA (1) | MA29663B1 (fr) |
| MX (2) | MX2007005466A (fr) |
| NL (1) | NL300989I2 (fr) |
| NO (3) | NO20210454A1 (fr) |
| NZ (1) | NZ555032A (fr) |
| PH (2) | PH12014500352B1 (fr) |
| PL (3) | PL1824988T3 (fr) |
| PT (4) | PT2363414T (fr) |
| RU (1) | RU2423380C2 (fr) |
| SI (4) | SI2363414T1 (fr) |
| UA (1) | UA95225C2 (fr) |
| WO (1) | WO2006053299A2 (fr) |
| ZA (1) | ZA200703696B (fr) |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
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| SG155777A1 (en) | 2003-04-09 | 2009-10-29 | Neose Technologies Inc | Glycopegylation methods and proteins/peptides produced by the methods |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| AU2005260763B2 (en) | 2004-06-30 | 2011-12-22 | Nektar Therapeutics | Polymer-factor IX moiety conjugates |
| WO2006010143A2 (fr) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Remodelage de peg ramifie et glycosylation de peptide-1 semblable a glucagon [glp-1] |
| EP2586456B1 (fr) | 2004-10-29 | 2016-01-20 | ratiopharm GmbH | Remodelage et glycopégylation de facteur de croissance de fibroblaste (FGF) |
| CN101124331B (zh) | 2004-11-12 | 2013-04-24 | 拜尔健康护理有限责任公司 | Fvⅲ的位点定向修饰 |
| JP4951527B2 (ja) | 2005-01-10 | 2012-06-13 | バイオジェネリックス アーゲー | 糖ｐｅｇ化顆粒球コロニー刺激因子 |
| US20070154992A1 (en) | 2005-04-08 | 2007-07-05 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| WO2006134173A2 (fr) | 2005-06-17 | 2006-12-21 | Novo Nordisk Health Care Ag | Reduction et derivation selectives de proteines conçues par le genie genetique comprenant au moins une cysteine non native |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| US7855279B2 (en) | 2005-09-27 | 2010-12-21 | Amunix Operating, Inc. | Unstructured recombinant polymers and uses thereof |
| US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
| KR20090013816A (ko) * | 2006-05-24 | 2009-02-05 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 반감기를 갖는 인자 ⅸ 유사체 |
| JP2009544327A (ja) | 2006-07-21 | 2009-12-17 | ノヴォ ノルディスク アー／エス | Ｏ−結合型グリコシル化配列によるペプチドのグリコシル化 |
| EP2054521A4 (fr) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | Méthodes de purification de conjugués de polypeptides |
| EP2101821B1 (fr) | 2006-12-15 | 2014-08-13 | Baxter International Inc. | Conjugué du facteur viia et de l'acide (poly)sialique présentant une demi-vie in vivo prolongée |
| NZ580030A (en) | 2007-04-03 | 2012-06-29 | Biogenerix Ag | Methods of treatment using glycopegylated g-csf |
| JP5876649B2 (ja) | 2007-06-12 | 2016-03-02 | ラツィオファルム ゲーエムベーハーｒａｔｉｏｐｈａｒｍ ＧｍｂＨ | ヌクレオチド糖の改良製造法 |
| CA2704234A1 (fr) | 2007-11-09 | 2009-05-14 | Baxter International Inc. | Facteur viii et facteur de von willebrand recombines modifies et procede d'utilisation |
| EP2626080A3 (fr) | 2008-02-27 | 2014-03-05 | Novo Nordisk A/S | Molécules de facteur VIII conjuguées |
| WO2009140598A1 (fr) * | 2008-05-16 | 2009-11-19 | Bayer Healthcare Llc | Facteurs de coagulation ciblés et procédés d'utilisation de ceux-ci |
| MX2010013219A (es) * | 2008-06-04 | 2011-04-11 | Bayer Healthcare Llc | Muteínas de fviii para el tratamiento de la enfermedad de von willebrand. |
| CA2728012C (fr) | 2008-06-24 | 2017-10-31 | Csl Behring Gmbh | Facteur viii, facteur de von willebrand ou leurs complexes avec des durees de vies in vivo prolongees |
| WO2010019263A2 (fr) * | 2008-08-15 | 2010-02-18 | Genzyme Corporation | Produits de construction de flt soluble pour traiter des cancers |
| LT2349342T (lt) * | 2008-10-17 | 2018-10-10 | Baxalta GmbH | Modifikuoti kraujo faktoriai, apimantys nedidelį vandenyje tirpaus polimero kiekį |
| KR20110093775A (ko) * | 2008-11-03 | 2011-08-18 | 바이엘 헬스케어 엘엘씨 | 혈우병 치료 방법 |
| WO2010060081A1 (fr) * | 2008-11-24 | 2010-05-27 | Bayer Healthcare Llc | Procédé de détermination d’activité de facteur de coagulation sanguine pégylé dans un essai de temps de thromboplastine partielle activée à base de silice |
| WO2010083536A1 (fr) * | 2009-01-19 | 2010-07-22 | Bayer Healthcare Llc | Conjugué protéique ayant une fraction bio-protectrice pouvant être clivée par une endopeptidase |
| CN102348715B (zh) | 2009-02-03 | 2017-12-08 | 阿穆尼克斯运营公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
| CN102333788A (zh) * | 2009-02-19 | 2012-01-25 | 诺沃—诺迪斯克有限公司 | 因子viii的修饰 |
| PT2408800T (pt) * | 2009-03-20 | 2016-08-23 | Hanmi Science Co Ltd | Método para preparar um conjugado específico de local de um polipéptido fisiologicamente ativo |
| EP2411024A4 (fr) * | 2009-03-24 | 2013-02-27 | Bayer Healthcare Llc | Variants du facteur viii et procédés d'utilisation associés |
| DK2459224T3 (en) | 2009-07-27 | 2016-07-25 | Baxalta GmbH | Blodstørkningsproteinkonjugater |
| KR101912335B1 (ko) | 2009-07-27 | 2018-10-26 | 리폭센 테크놀로지즈 리미티드 | 비혈액 응고 단백질의 글리코폴리시알화 |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| ES2856055T3 (es) | 2009-07-27 | 2021-09-27 | Baxalta GmbH | Glicopolisialilación de proteínas diferentes de las proteínas de coagulación de la sangre |
| CN102741275B (zh) * | 2009-08-24 | 2016-08-03 | 阿穆尼克斯运营公司 | 凝血因子ix组合物及其制备和使用方法 |
| ME02964B (fr) | 2009-12-06 | 2018-07-20 | Polypeptides chimériques et hybrides de facteur viii-fc, et procédés d'utilisation de ceux-ci | |
| US8765432B2 (en) | 2009-12-18 | 2014-07-01 | Oligasis, Llc | Targeted drug phosphorylcholine polymer conjugates |
| CN105524164A (zh) | 2010-02-16 | 2016-04-27 | 诺沃—诺迪斯克有限公司 | 具有降低的vwf结合的因子viii分子 |
| SG183309A1 (en) * | 2010-02-21 | 2012-09-27 | Bayer Healthcare Llc | Method for activation and conjugation of biomolecules |
| KR20130097636A (ko) | 2010-04-15 | 2013-09-03 | 올리가시스 | 고분자량 쌍성이온-함유 중합체 |
| GB201007357D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
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