ATE485331T1 - Thiolselektive wasserlösliche polymerderivate - Google Patents
Thiolselektive wasserlösliche polymerderivateInfo
- Publication number
- ATE485331T1 ATE485331T1 AT04700409T AT04700409T ATE485331T1 AT E485331 T1 ATE485331 T1 AT E485331T1 AT 04700409 T AT04700409 T AT 04700409T AT 04700409 T AT04700409 T AT 04700409T AT E485331 T1 ATE485331 T1 AT E485331T1
- Authority
- AT
- Austria
- Prior art keywords
- thiol
- polymer derivatives
- soluble polymer
- selective water
- selective
- Prior art date
Links
- 229920003169 water-soluble polymer Polymers 0.000 title 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G75/00—Macromolecular compounds obtained by reactions forming a linkage containing sulfur with or without nitrogen, oxygen, or carbon in the main chain of the macromolecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/06—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols from sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
- C08F22/36—Amides or imides
- C08F22/38—Amides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2636—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing sulfur
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G75/00—Macromolecular compounds obtained by reactions forming a linkage containing sulfur with or without nitrogen, oxygen, or carbon in the main chain of the macromolecule
- C08G75/20—Polysulfones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
- Peptides Or Proteins (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43855503P | 2003-01-06 | 2003-01-06 | |
| US45508403P | 2003-03-14 | 2003-03-14 | |
| PCT/US2004/001190 WO2004063250A1 (en) | 2003-01-06 | 2004-01-06 | Thiol-selective water-soluble polmer derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE485331T1 true ATE485331T1 (de) | 2010-11-15 |
Family
ID=32717985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04700409T ATE485331T1 (de) | 2003-01-06 | 2004-01-06 | Thiolselektive wasserlösliche polymerderivate |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US7910661B2 (de) |
| EP (1) | EP1581582B2 (de) |
| JP (1) | JP4490413B2 (de) |
| KR (2) | KR101177340B1 (de) |
| AT (1) | ATE485331T1 (de) |
| AU (1) | AU2004204136B2 (de) |
| CA (1) | CA2509939C (de) |
| DE (1) | DE602004029646D1 (de) |
| MX (1) | MXPA05007348A (de) |
| WO (1) | WO2004063250A1 (de) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7432331B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| US7432330B2 (en) * | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| ATE485331T1 (de) | 2003-01-06 | 2010-11-15 | Nektar Therapeutics | Thiolselektive wasserlösliche polymerderivate |
| HUE058897T2 (hu) | 2003-02-26 | 2022-09-28 | Nektar Therapeutics | Polimer VIII-as faktor egység konjugátumok |
| EP1725262B1 (de) | 2004-03-15 | 2021-05-26 | Nektar Therapeutics | Polymerische Zusammensetzungen und Konjugate von HIV-Entry-Inhibitoren |
| ES2821832T3 (es) | 2004-11-12 | 2021-04-27 | Bayer Healthcare Llc | Modificación de FVIII dirigida al sitio |
| US7851565B2 (en) * | 2004-12-21 | 2010-12-14 | Nektar Therapeutics | Stabilized polymeric thiol reagents |
| US8273339B2 (en) * | 2005-04-12 | 2012-09-25 | Nektar Therapeutics | Polymer-based compositions and conjugates of antimicrobial agents |
| JP5021649B2 (ja) * | 2005-08-26 | 2012-09-12 | ノヴォ ノルディスク アクティーゼルスカブ | 高分子システムを変性する方法 |
| WO2007075534A2 (en) | 2005-12-16 | 2007-07-05 | Nektar Therapeutics Al, Corporation | Polymer conjugates of glp-1 |
| US7743730B2 (en) * | 2005-12-21 | 2010-06-29 | Lam Research Corporation | Apparatus for an optimized plasma chamber grounded electrode assembly |
| JP2007209543A (ja) * | 2006-02-09 | 2007-08-23 | Hidetoshi Tsuchida | 表面修飾アルブミンからなる固相膜および酸素吸着膜 |
| CA2642905C (en) * | 2006-02-21 | 2015-04-28 | Nektar Therapeutics Al, Corporation | Segmented degradable polymers and conjugates made therefrom |
| EP2004231A4 (de) | 2006-04-07 | 2013-07-10 | Nektar Therapeutics | Konjugate eines anti-tnf-alpha-antikörpers |
| KR100819064B1 (ko) * | 2006-12-19 | 2008-04-04 | (재)대구경북과학기술연구원 | 생분자 고정화 링커 |
| US20100203066A1 (en) * | 2007-08-20 | 2010-08-12 | Enzon Pharmaceuticals, Inc. | Polymeric linkers containing pyridyl disulfide moieties |
| US7847019B2 (en) * | 2007-10-15 | 2010-12-07 | California Institute Of Technology | Functionalized polymers using protected thiols |
| EP2095829A1 (de) | 2008-02-27 | 2009-09-02 | LEK Pharmaceuticals D.D. | Selenhaltige Modifizierungsmittel und Konjugate |
| WO2009130602A2 (en) * | 2008-04-24 | 2009-10-29 | Celtic Pharma Peg Ltd. | Factor ix conjugates with extended half-lives |
| EP2293818B1 (de) * | 2008-05-16 | 2021-04-28 | Nektar Therapeutics | Konjugate aus butyrylcholinesterase und eines polymers |
| US20110105413A1 (en) * | 2008-05-23 | 2011-05-05 | Enzon Pharmaceuticals, Inc. | Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides |
| EP2326351B1 (de) | 2008-08-19 | 2017-12-27 | Nektar Therapeutics | Konjugate von kurzen interferierenden nukleinsäuren |
| WO2010022320A2 (en) | 2008-08-22 | 2010-02-25 | Baxter International Inc. | Polymeric benzyl carbonate-derivatives |
| WO2010033221A1 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of protegrin peptides |
| EP2340050A2 (de) * | 2008-09-19 | 2011-07-06 | Nektar Therapeutics | Polymerkonjugate von aod-artigen peptiden |
| EP2334334A1 (de) * | 2008-09-19 | 2011-06-22 | Nektar Therapeutics | Polymerkonjugate von nesiritid-peptiden |
| WO2010033227A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of thymosin alpha 1 peptides |
| US20110165112A1 (en) * | 2008-09-19 | 2011-07-07 | Nektar Therapeutics | Polymer conjugates of c-peptides |
| WO2010033240A2 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
| US20110171163A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Polymer conjugates of ziconotide peptides |
| EP2334336A1 (de) * | 2008-09-19 | 2011-06-22 | Nektar Therapeutics | Polymerkonjugate von osteocalcin-peptiden |
| EP2340047A1 (de) * | 2008-09-19 | 2011-07-06 | Nektar Therapeutics | Polymerkonjugate von kiss1-peptiden |
| WO2010033205A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of v681-like peptides |
| WO2010033223A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of opioid growth factor peptides |
| US20110171312A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Modified therapeutic peptides, methods of their preparation and use |
| EP2337585A1 (de) * | 2008-09-19 | 2011-06-29 | Nektar Therapeutics | Polymerkonjugate von glp-2-artigen peptiden |
| WO2010080720A2 (en) | 2009-01-12 | 2010-07-15 | Nektar Therapeutics | Conjugates of a lysosomal enzyme moiety and a water soluble polymer |
| MX388465B (es) | 2010-11-12 | 2025-03-20 | Nektar Therapeutics | Conjugados de un resto de interleucina-2 y un polímero. |
| EP2694528A1 (de) * | 2011-04-05 | 2014-02-12 | Martin-Protean, LLC | Isolierung von cysteinenthaltigen peptiden |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| KR102087854B1 (ko) | 2011-06-10 | 2020-03-12 | 메르사나 테라퓨틱스, 인코포레이티드 | 단백질-중합체-약물 접합체 |
| WO2013020079A2 (en) | 2011-08-04 | 2013-02-07 | Nektar Therapeutics | Conjugates of an il-11 moiety and a polymer |
| CN104870020A (zh) | 2012-10-19 | 2015-08-26 | 康奈尔大学 | 用于关节软骨的仿生型界面润滑剂 |
| WO2015050199A2 (ja) * | 2013-10-04 | 2015-04-09 | 学校法人 東京薬科大学 | 新規化合物、その製造方法及びその用途 |
| EP3054992B1 (de) | 2013-10-11 | 2019-08-14 | Asana BioSciences, LLC | Protein-polymer-wirkstoffkonjugate |
| DK3054991T3 (da) | 2013-10-11 | 2019-05-06 | Mersana Therapeutics Inc | Protein-polymer-lægemiddelkonjugater |
| GB201401133D0 (en) | 2014-01-23 | 2014-03-12 | Renephra Ltd | Fluid extraction device, applicator device and associated methods |
| EP3114138B1 (de) | 2014-03-05 | 2021-11-17 | Pfizer Inc. | Verbesserte muteine von gerinnungsfaktor viii |
| MA39711A (fr) | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
| WO2016074030A1 (en) * | 2014-11-10 | 2016-05-19 | Spinal Developments Pty Ltd, A.T.F. The Spinesr Unit Trust | Rod reduction device |
| US20160151511A1 (en) | 2014-12-02 | 2016-06-02 | Antriabio, Inc. | Proteins and protein conjugates with increased hydrophobicity |
| CA2981501A1 (en) | 2015-06-04 | 2016-12-08 | Antriabio, Inc. | Amine pegylation methods for the preparation of site-specific protein conjugates |
| WO2017062832A1 (en) | 2015-10-08 | 2017-04-13 | Nektar Therapeutics | Combination of an il-2rbeta-selective agonist and a long-acting il-15 agonist |
| JP7109427B2 (ja) | 2016-06-01 | 2022-07-29 | セルヴィエ アイピー ユーケー リミテッド | ポリアルキレンオキシド－アスパラギナーゼの製剤ならびにその製造法および使用法 |
| CN107952064B (zh) * | 2016-10-14 | 2023-10-20 | 江苏豪森药业集团有限公司 | 含有聚乙二醇洛塞那肽的药物制剂及其制备方法 |
| US12344645B2 (en) | 2017-03-29 | 2025-07-01 | Polaris Group | Protein conjugates |
| EP3604386B1 (de) * | 2017-03-30 | 2022-04-06 | NOF Corporation | Abbaubares polyethylenglykolderivat mit disulfid-linker |
| CN111093688B (zh) | 2017-05-15 | 2025-09-16 | 尼克塔治疗公司 | 长效白细胞介素-15受体激动剂以及相关免疫治疗组合物和方法 |
| GB201721503D0 (en) | 2017-12-20 | 2018-01-31 | Univ Essex | Modified globin proteins |
| CA3128035A1 (en) | 2020-08-13 | 2022-02-13 | Bioasis Technologies, Inc. | Combination therapies for delivery across the blood brain barrier |
| AT524137B1 (de) | 2020-08-26 | 2025-08-15 | Pke Holding Ag | Tragbare Vorrichtung zur Steuerung eines Brandfalles |
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| JP3880262B2 (ja) † | 1998-11-02 | 2007-02-14 | 株式会社カネカ | 水不溶化再生コラーゲン繊維の製造方法 |
| US7005123B1 (en) * | 1999-06-17 | 2006-02-28 | Universiteit Gent | Functional poly-α-amino-acid derivatives useful for the modification of biologically active materials and their application |
| AU6368500A (en) † | 1999-07-22 | 2001-02-13 | University Of Medicine And Dentistry Of New Jersey | Materials and processes for controlled release of thioamide moiety-containing therapeutic agents by linking to thiol-containing polymers |
| US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
| KR100346994B1 (ko) † | 2000-01-11 | 2002-07-31 | 한국과학기술연구원 | 술폰산화 폴리에틸렌옥사이드가 결합된 생체적합성 의료용금속 재료 및 이의 제조 방법 |
| TW593427B (en) | 2000-12-18 | 2004-06-21 | Nektar Therapeutics Al Corp | Synthesis of high molecular weight non-peptidic polymer derivatives |
| US7432330B2 (en) * | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| JP4490369B2 (ja) * | 2002-12-31 | 2010-06-23 | ネクター セラピューティクス アラバマ，コーポレイション | マレアミド酸ポリマー誘導体及びこれらの生物学的複合体 |
| ATE485331T1 (de) * | 2003-01-06 | 2010-11-15 | Nektar Therapeutics | Thiolselektive wasserlösliche polymerderivate |
-
2004
- 2004-01-06 AT AT04700409T patent/ATE485331T1/de not_active IP Right Cessation
- 2004-01-06 DE DE602004029646T patent/DE602004029646D1/de not_active Expired - Lifetime
- 2004-01-06 MX MXPA05007348A patent/MXPA05007348A/es active IP Right Grant
- 2004-01-06 EP EP04700409.8A patent/EP1581582B2/de not_active Expired - Lifetime
- 2004-01-06 KR KR1020057012633A patent/KR101177340B1/ko not_active Expired - Lifetime
- 2004-01-06 AU AU2004204136A patent/AU2004204136B2/en not_active Expired
- 2004-01-06 CA CA2509939A patent/CA2509939C/en not_active Expired - Lifetime
- 2004-01-06 JP JP2006500996A patent/JP4490413B2/ja not_active Expired - Lifetime
- 2004-01-06 US US10/753,047 patent/US7910661B2/en active Active
- 2004-01-06 WO PCT/US2004/001190 patent/WO2004063250A1/en not_active Ceased
- 2004-01-06 KR KR1020117031376A patent/KR101207247B1/ko not_active Expired - Lifetime
-
2010
- 2010-10-21 US US12/909,755 patent/US20110034643A1/en not_active Abandoned
-
2012
- 2012-11-19 US US13/681,357 patent/US8722032B2/en not_active Expired - Lifetime
-
2014
- 2014-03-28 US US14/229,547 patent/US9040658B2/en not_active Expired - Lifetime
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2015
- 2015-04-23 US US14/694,160 patent/US9333267B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20140330041A1 (en) | 2014-11-06 |
| KR101177340B1 (ko) | 2012-08-30 |
| AU2004204136A1 (en) | 2004-07-29 |
| WO2004063250A1 (en) | 2004-07-29 |
| EP1581582A1 (de) | 2005-10-05 |
| US20050014903A1 (en) | 2005-01-20 |
| US9333267B2 (en) | 2016-05-10 |
| US7910661B2 (en) | 2011-03-22 |
| EP1581582B1 (de) | 2010-10-20 |
| KR20050090074A (ko) | 2005-09-12 |
| DE602004029646D1 (en) | 2010-12-02 |
| US9040658B2 (en) | 2015-05-26 |
| JP4490413B2 (ja) | 2010-06-23 |
| US8722032B2 (en) | 2014-05-13 |
| US20110034643A1 (en) | 2011-02-10 |
| EP1581582B2 (de) | 2017-06-07 |
| AU2004204136B2 (en) | 2008-10-09 |
| US20130079555A1 (en) | 2013-03-28 |
| US20150224207A1 (en) | 2015-08-13 |
| KR20120007080A (ko) | 2012-01-19 |
| JP2006517600A (ja) | 2006-07-27 |
| CA2509939A1 (en) | 2004-07-29 |
| CA2509939C (en) | 2013-05-21 |
| KR101207247B1 (ko) | 2012-12-03 |
| MXPA05007348A (es) | 2005-10-05 |
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