ATE290564T1 - Funktionsfähige poly-alpha-aminosäurederivate zur modifizierung von biologisch wirksamen stoffen und deren herstellung - Google Patents

Funktionsfähige poly-alpha-aminosäurederivate zur modifizierung von biologisch wirksamen stoffen und deren herstellung

Info

Publication number
ATE290564T1
ATE290564T1 AT00938349T AT00938349T ATE290564T1 AT E290564 T1 ATE290564 T1 AT E290564T1 AT 00938349 T AT00938349 T AT 00938349T AT 00938349 T AT00938349 T AT 00938349T AT E290564 T1 ATE290564 T1 AT E290564T1
Authority
AT
Austria
Prior art keywords
alpha
biologically active
production
amino acid
acid derivatives
Prior art date
Application number
AT00938349T
Other languages
English (en)
Inventor
Etienne Honore Schacht
Veska Toncheva
Original Assignee
Univ Gent
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Gent filed Critical Univ Gent
Application granted granted Critical
Publication of ATE290564T1 publication Critical patent/ATE290564T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/1092—Polysuccinimides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Polyamides (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT00938349T 1999-06-17 2000-06-19 Funktionsfähige poly-alpha-aminosäurederivate zur modifizierung von biologisch wirksamen stoffen und deren herstellung ATE290564T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99870125 1999-06-17
PCT/BE2000/000066 WO2000078791A2 (en) 1999-06-17 2000-06-19 FUNCTIONAL POLY-α-AMINOACID DERIVATIVES USEFUL FOR THE MODIFICATION OF BIOLOGICALLY ACTIVE MATERIALS AND THEIR APPLICATION

Publications (1)

Publication Number Publication Date
ATE290564T1 true ATE290564T1 (de) 2005-03-15

Family

ID=8243853

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00938349T ATE290564T1 (de) 1999-06-17 2000-06-19 Funktionsfähige poly-alpha-aminosäurederivate zur modifizierung von biologisch wirksamen stoffen und deren herstellung

Country Status (9)

Country Link
US (1) US7005123B1 (de)
EP (1) EP1189971B1 (de)
AT (1) ATE290564T1 (de)
AU (1) AU5376500A (de)
CA (1) CA2377267A1 (de)
DE (1) DE60018564T2 (de)
DK (1) DK1189971T3 (de)
ES (1) ES2239602T3 (de)
WO (1) WO2000078791A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19935302A1 (de) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Konjugate und Verfahren zu deren Herstellung sowie deren Verwendung zum Transport von Molekülen über biologische Membranen
WO2001066149A2 (en) 2000-03-03 2001-09-13 Valentis, Inc. Nucleic acid formulations for gene delivery and methods of use
DE10154924A1 (de) * 2001-11-08 2003-05-28 Medinnova Ges Med Innovationen Bioabbaubare Kopolymere
FR2840614B1 (fr) 2002-06-07 2004-08-27 Flamel Tech Sa Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques
MXPA05007348A (es) * 2003-01-06 2005-10-05 Nektar Therapeutics Al Corp Derivados de polimeros solubles en agua tiol-selectivos.
US7833714B1 (en) 2003-04-11 2010-11-16 Affymetrix, Inc. Combinatorial affinity selection
FR2855521B1 (fr) 2003-05-28 2005-08-05 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement h ydrophobe et leurs applications notamment therapeutiques.
FR2858976B1 (fr) * 2003-08-22 2006-02-10 Isochem Sa Procede d'obtention de n-carboxyanhydrides d'alpha-aminoacides a protection urethane
FR2860516B1 (fr) * 2003-10-03 2006-01-13 Flamel Tech Sa Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
EP1923075B1 (de) * 2004-08-13 2015-11-11 Rutgers, The State University Röntgendichte Polymerstents
US20060147940A1 (en) * 2004-12-30 2006-07-06 Affymetrix, Inc. Combinatorial affinity selection
BRPI0619436A2 (pt) 2005-12-05 2011-10-04 Nitto Denko Corp métodos e conjugados de aminoácido-poliglutamato
US20090131589A1 (en) * 2007-10-31 2009-05-21 Carmen Scholz Controlled molecular weight amino acid polymers having functionalizable backbones and end groups and processes for preparing the same
WO2009153209A1 (en) * 2008-06-19 2009-12-23 Henkel Ag & Co. Kgaa Modified polymeric pro-fragrance
US20120052015A1 (en) * 2010-08-26 2012-03-01 Nitto Denko Corporation End-capped polymers
CN102250353B (zh) * 2011-05-23 2012-10-10 黑龙江大学 多组分蒸发结晶共聚改性合成聚天冬氨酸衍生物的方法
CN106478873B (zh) * 2015-08-31 2018-07-20 中国石油化工股份有限公司 一种共聚物及其制备方法与应用
CN106478874B (zh) * 2015-08-31 2018-07-20 中国石油化工股份有限公司 一种共聚物及其制备方法与应用
CN109593195B (zh) * 2018-12-04 2021-04-30 陕西科技大学 一锅法制备功能化多肽的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1049576B (de) * 1955-02-22 1959-01-29 Courtaulds Limited, London Verfahren zur Herstellung von Polyamiden
GB9606975D0 (en) 1996-04-02 1996-06-05 Univ Birmingham Anti-tumor agent
GB9623051D0 (en) * 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems

Also Published As

Publication number Publication date
DE60018564T2 (de) 2006-05-24
ES2239602T3 (es) 2005-10-01
US7005123B1 (en) 2006-02-28
EP1189971B1 (de) 2005-03-09
AU5376500A (en) 2001-01-09
CA2377267A1 (en) 2000-12-28
EP1189971A2 (de) 2002-03-27
DE60018564D1 (de) 2005-04-14
WO2000078791A2 (en) 2000-12-28
WO2000078791A3 (en) 2001-12-13
DK1189971T3 (da) 2005-07-11

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