CN1055921C - 20位改性的维生素ｄ系列衍生物，其制备方法和其药剂 - Google Patents

20位改性的维生素ｄ系列衍生物，其制备方法和其药剂 Download PDF

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Publication number
CN1055921C
CN1055921C CN93107406A CN93107406A CN1055921C CN 1055921 C CN1055921 C CN 1055921C CN 93107406 A CN93107406 A CN 93107406A CN 93107406 A CN93107406 A CN 93107406A CN 1055921 C CN1055921 C CN 1055921C
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CN
China
Prior art keywords
oxa
methyl
ethyl
compound
methylene
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Expired - Fee Related
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CN93107406A
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English (en)
Chinese (zh)
Other versions
CN1089599A (zh
Inventor
A·斯坦迈耶
G·尼夫
G·基尔希
K·施瓦茨
R·西罗夫-艾克迪特
H·威森格
M·哈伯雷
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Bayer Pharma AG
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Schering AG
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Publication of CN1089599A publication Critical patent/CN1089599A/zh
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Publication of CN1055921C publication Critical patent/CN1055921C/zh
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN93107406A 1992-06-24 1993-06-23 20位改性的维生素ｄ系列衍生物，其制备方法和其药剂 Expired - Fee Related CN1055921C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4220757A DE4220757A1 (de) 1992-06-24 1992-06-24 Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
DEP4220757.6 1992-06-24

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB991264738A Division CN1173909C (zh) 1992-06-24 1999-12-23 20位改性的维生素d系列衍生物,其制备方法和其药剂

Publications (2)

Publication Number Publication Date
CN1089599A CN1089599A (zh) 1994-07-20
CN1055921C true CN1055921C (zh) 2000-08-30

Family

ID=6461752

Family Applications (2)

Application Number Title Priority Date Filing Date
CN93107406A Expired - Fee Related CN1055921C (zh) 1992-06-24 1993-06-23 20位改性的维生素ｄ系列衍生物，其制备方法和其药剂
CNB991264738A Expired - Fee Related CN1173909C (zh) 1992-06-24 1999-12-23 20位改性的维生素d系列衍生物,其制备方法和其药剂

Family Applications After (1)

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CNB991264738A Expired - Fee Related CN1173909C (zh) 1992-06-24 1999-12-23 20位改性的维生素d系列衍生物,其制备方法和其药剂

Country Status (24)

Country Link
US (2) US5585368A (enExample)
EP (1) EP0647219B1 (enExample)
JP (1) JPH08501531A (enExample)
KR (1) KR100300274B1 (enExample)
CN (2) CN1055921C (enExample)
AT (1) ATE140918T1 (enExample)
AU (1) AU679685B2 (enExample)
CA (1) CA2138989A1 (enExample)
CZ (1) CZ282151B6 (enExample)
DE (2) DE4220757A1 (enExample)
DK (1) DK0647219T3 (enExample)
ES (1) ES2093440T3 (enExample)
FI (1) FI111720B (enExample)
GR (1) GR3020974T3 (enExample)
HU (1) HUT70563A (enExample)
IL (1) IL106128A0 (enExample)
MX (1) MX9303799A (enExample)
NO (1) NO306614B1 (enExample)
NZ (1) NZ253698A (enExample)
PL (1) PL174024B1 (enExample)
SK (1) SK281244B6 (enExample)
TW (1) TW255883B (enExample)
WO (1) WO1994000428A1 (enExample)
ZA (1) ZA934550B (enExample)

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US5830885A (en) * 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
IL112759A0 (en) * 1994-02-25 1995-05-26 Khepri Pharmaceuticals Inc Novel cysteine protease inhibitors
EP0755922B1 (en) * 1994-04-11 2000-08-16 Chugai Seiyaku Kabushiki Kaisha 22-thiavitamin d3 derivative
DK0717034T3 (da) * 1994-12-14 1999-10-18 Duphar Int Res Vitamin D-forbindelser og fremgangsmåde til fremstilling af disse forbindelser
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
IL118156A (en) * 1995-05-09 2001-08-26 Duphar Int Res Vitamin d compounds, their preparation and pharmaceutical compositions containing them
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
CN1090180C (zh) * 1997-06-25 2002-09-04 帝人株式会社 维生素d3衍生物及其用于炎性呼吸道疾病的治疗剂
AU1022999A (en) * 1997-09-08 1999-03-29 F. Hoffmann-La Roche Ag 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs
DE19744127B4 (de) * 1997-10-01 2006-10-05 Schering Ag Neue Vitamin D-Derivate mit Cyclopropylringen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie ihre Verwendung zur Herstellung von Arzneimitteln
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
AU2001278744A1 (en) * 2000-08-17 2002-02-25 Chugai Seiyaku Kabushiki Kaisha Remedial agent for osteoporosis
US7491711B2 (en) * 2001-09-21 2009-02-17 Roche Palo Alto Llc Methods of treatment using 3-desoxy vitamin D3 analogs
AU2003291810A1 (en) * 2002-11-18 2004-06-15 Teva Pharmaceutical Industries Ltd. A crystallization method for purification of calcipotriene
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
WO2007038250A2 (en) * 2005-09-23 2007-04-05 Bioxell S.P.A. 1,25 - dihydroxy, 20-cyclopropyl, 26-27- deuteroalkyl vitamin d3 compounds and methods of use thereof
MX2009000660A (es) 2006-07-17 2009-04-08 Glaxosmithkline Biolog Sa Vacuna de influenza.
US7888339B2 (en) 2008-07-10 2011-02-15 Wisconsin Alumni Research Foundation 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
CA2981549A1 (en) 2009-01-27 2010-08-05 Berg Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
AU2010282731C1 (en) 2009-08-14 2016-04-21 Berg Llc Vitamin D3 and analogs thereof for treating alopecia
CN103073608B (zh) * 2013-02-26 2014-09-03 昆明理工大学 雄甾-4,6,8（9）,13（14）-四烯-3,11,16-三酮及其应用
CN103073607B (zh) * 2013-02-26 2014-09-03 昆明理工大学 12β-羟基雄甾-4,6,8（9）,13（14）-四烯-3,11,16-三酮及其应用
CA2913543C (en) 2013-05-29 2024-01-09 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
US10548908B2 (en) 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

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US4617297A (en) * 1982-02-12 1986-10-14 Hoffmann-La Roche Inc. Method of treating disease states by the administration of 1α,25,26-trihydroxycholecalciferol
US4594432A (en) * 1983-01-28 1986-06-10 Hoffman-La Roche Inc. Process for the synthesis of 1α,23(S),25-trihydroxycholecalciferol and 1α,23(R),25-trihydroxycholecalciferol
US4719205A (en) * 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
JPS6144860A (ja) * 1984-08-10 1986-03-04 Taisho Pharmaceut Co Ltd １α．２５−ジヒドロキシ−２６．２７−ジメチルビタミンＤ↓３
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ATE45347T1 (de) * 1985-05-30 1989-08-15 Taisho Pharmaceutical Co Ltd Vitamin d3-derivate.
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Also Published As

Publication number Publication date
KR100300274B1 (ko) 2001-11-22
EP0647219B1 (de) 1996-07-31
US5700791A (en) 1997-12-23
DE59303365D1 (de) 1996-09-05
FI111720B (fi) 2003-09-15
US5585368A (en) 1996-12-17
ES2093440T3 (es) 1996-12-16
SK281244B6 (sk) 2001-01-18
ATE140918T1 (de) 1996-08-15
CZ327694A3 (en) 1995-06-14
EP0647219A1 (de) 1995-04-12
NO945034D0 (no) 1994-12-23
JPH08501531A (ja) 1996-02-20
HU9403771D0 (en) 1995-02-28
CN1173909C (zh) 2004-11-03
FI946073A0 (fi) 1994-12-23
CZ282151B6 (cs) 1997-05-14
DE4220757A1 (de) 1994-01-05
NZ253698A (en) 1996-11-26
IL106128A0 (en) 1993-10-20
CN1089599A (zh) 1994-07-20
CA2138989A1 (en) 1994-01-06
NO945034L (no) 1995-02-24
DK0647219T3 (da) 1996-12-09
AU679685B2 (en) 1997-07-10
CN1262267A (zh) 2000-08-09
GR3020974T3 (en) 1996-12-31
KR950702181A (ko) 1995-06-19
FI946073L (fi) 1994-12-23
MX9303799A (es) 1994-07-29
NO306614B1 (no) 1999-11-29
WO1994000428A1 (de) 1994-01-06
AU4500793A (en) 1994-01-24
TW255883B (enExample) 1995-09-01
SK158494A3 (en) 1995-07-11
PL174024B1 (pl) 1998-06-30
HUT70563A (en) 1995-10-30
ZA934550B (en) 1994-01-27

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