KR100300274B1 - 20-위치가변형된비타민d계열의유도체,이들의제조방법,이제조방법을위한중간생성물,이들유도체를함유하는제약제제,및약제제조를위한이들의용도 - Google Patents

20-위치가변형된비타민d계열의유도체,이들의제조방법,이제조방법을위한중간생성물,이들유도체를함유하는제약제제,및약제제조를위한이들의용도 Download PDF

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KR100300274B1
KR100300274B1 KR1019940704723A KR19940704723A KR100300274B1 KR 100300274 B1 KR100300274 B1 KR 100300274B1 KR 1019940704723 A KR1019940704723 A KR 1019940704723A KR 19940704723 A KR19940704723 A KR 19940704723A KR 100300274 B1 KR100300274 B1 KR 100300274B1
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group
oxa
mmol
methylene
secocola
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KR950702181A (ko
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안드레아즈 스타인마이어
귄터 네프
게랄트 키르쉬
카디카 슈바르쯔
티로페케르트
헤르베르트 비싱거
마르틴 하베레이
Original Assignee
에바-마리아 시마-메이어, 얼설라 멜져, 마거, 하르트만
쉐링 악티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019940704723A 1992-06-24 1993-06-24 20-위치가변형된비타민d계열의유도체,이들의제조방법,이제조방법을위한중간생성물,이들유도체를함유하는제약제제,및약제제조를위한이들의용도 Expired - Fee Related KR100300274B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4220757.6 1992-06-24
DE4220757A DE4220757A1 (de) 1992-06-24 1992-06-24 Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
PCT/EP1993/001620 WO1994000428A1 (de) 1992-06-24 1993-06-24 Derivate in der vitamin d-reihe mit modifikationen in der 20 position, verfahren zu ihrer herstellung, zwischenprodukte für dieses verfahren, diese derivate enthaltende pharmazeutische präparate sowie deren verwendung zur herstellung von arzneimitteln

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KR950702181A KR950702181A (ko) 1995-06-19
KR100300274B1 true KR100300274B1 (ko) 2001-11-22

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KR1019940704723A Expired - Fee Related KR100300274B1 (ko) 1992-06-24 1993-06-24 20-위치가변형된비타민d계열의유도체,이들의제조방법,이제조방법을위한중간생성물,이들유도체를함유하는제약제제,및약제제조를위한이들의용도

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US (2) US5585368A (enExample)
EP (1) EP0647219B1 (enExample)
JP (1) JPH08501531A (enExample)
KR (1) KR100300274B1 (enExample)
CN (2) CN1055921C (enExample)
AT (1) ATE140918T1 (enExample)
AU (1) AU679685B2 (enExample)
CA (1) CA2138989A1 (enExample)
CZ (1) CZ282151B6 (enExample)
DE (2) DE4220757A1 (enExample)
DK (1) DK0647219T3 (enExample)
ES (1) ES2093440T3 (enExample)
FI (1) FI111720B (enExample)
GR (1) GR3020974T3 (enExample)
HU (1) HUT70563A (enExample)
IL (1) IL106128A0 (enExample)
MX (1) MX9303799A (enExample)
NO (1) NO306614B1 (enExample)
NZ (1) NZ253698A (enExample)
PL (1) PL174024B1 (enExample)
SK (1) SK281244B6 (enExample)
TW (1) TW255883B (enExample)
WO (1) WO1994000428A1 (enExample)
ZA (1) ZA934550B (enExample)

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US5830885A (en) * 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
AU666563B2 (en) * 1992-08-07 1996-02-15 Wisconsin Alumni Research Foundation Preparation of 19-nor-vitamin D compounds
US5449668A (en) * 1993-06-04 1995-09-12 Duphar International Research B.V. Vitamin D compounds and method of preparing these compounds
IL112759A0 (en) * 1994-02-25 1995-05-26 Khepri Pharmaceuticals Inc Novel cysteine protease inhibitors
WO1995027697A1 (en) * 1994-04-11 1995-10-19 Chugai Seiyaku Kabushiki Kaisha 22-thiavitamin d3 derivative
ATE178596T1 (de) * 1994-12-14 1999-04-15 Duphar Int Res Vitamin-d-derivate und verfahren zur herstellung dieser verbindungen
US6242434B1 (en) 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
IL118156A (en) * 1995-05-09 2001-08-26 Duphar Int Res Vitamin d compounds, their preparation and pharmaceutical compositions containing them
DE19619036A1 (de) 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
SG70010A1 (en) * 1996-05-23 2000-01-25 Hoffmann La Roche Fluorinated vitamin d3 analogs
CN1090180C (zh) * 1997-06-25 2002-09-04 帝人株式会社 维生素d3衍生物及其用于炎性呼吸道疾病的治疗剂
JP4219553B2 (ja) * 1997-09-08 2009-02-04 エフ．ホフマン−ラ ロシュ アーゲー １，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体
DE19744127B4 (de) * 1997-10-01 2006-10-05 Schering Ag Neue Vitamin D-Derivate mit Cyclopropylringen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung sowie ihre Verwendung zur Herstellung von Arzneimitteln
US5972917A (en) * 1998-05-29 1999-10-26 Bone Care Int Inc 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
DE19935771A1 (de) 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
AU2001278744A1 (en) * 2000-08-17 2002-02-25 Chugai Seiyaku Kabushiki Kaisha Remedial agent for osteoporosis
US7491711B2 (en) * 2001-09-21 2009-02-17 Roche Palo Alto Llc Methods of treatment using 3-desoxy vitamin D3 analogs
US7351869B2 (en) * 2002-11-18 2008-04-01 Teva Pharmaceutical Industries Ltd Crystallization method for purification of calcipotriene
US7094775B2 (en) 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
WO2007038250A2 (en) * 2005-09-23 2007-04-05 Bioxell S.P.A. 1,25 - dihydroxy, 20-cyclopropyl, 26-27- deuteroalkyl vitamin d3 compounds and methods of use thereof
EP2043682B1 (en) 2006-07-17 2014-04-02 GlaxoSmithKline Biologicals S.A. Influenza vaccine
US7888339B2 (en) 2008-07-10 2011-02-15 Wisconsin Alumni Research Foundation 2-methylene-20(21)-dehydro-19-nor-vitamin D analogs
SG173119A1 (en) 2009-01-27 2011-08-29 Berg Biosystems Llc Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy
MX366076B (es) 2009-08-14 2019-06-27 Berg Llc Vitamina d3 y analogos de la misma para tratar alopecia.
CN103073608B (zh) * 2013-02-26 2014-09-03 昆明理工大学 雄甾-4,6,8（9）,13（14）-四烯-3,11,16-三酮及其应用
CN103073607B (zh) * 2013-02-26 2014-09-03 昆明理工大学 12β-羟基雄甾-4,6,8（9）,13（14）-四烯-3,11,16-三酮及其应用
SG10201709894RA (en) 2013-05-29 2018-01-30 Berg Llc Preventing or mitigating chemotherapy induced alopecia using vitamin d
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification

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Also Published As

Publication number Publication date
KR950702181A (ko) 1995-06-19
IL106128A0 (en) 1993-10-20
PL174024B1 (pl) 1998-06-30
SK281244B6 (sk) 2001-01-18
HUT70563A (en) 1995-10-30
CZ282151B6 (cs) 1997-05-14
FI111720B (fi) 2003-09-15
NO945034L (no) 1995-02-24
CN1055921C (zh) 2000-08-30
JPH08501531A (ja) 1996-02-20
AU4500793A (en) 1994-01-24
WO1994000428A1 (de) 1994-01-06
ZA934550B (en) 1994-01-27
GR3020974T3 (en) 1996-12-31
NZ253698A (en) 1996-11-26
US5700791A (en) 1997-12-23
CN1173909C (zh) 2004-11-03
EP0647219B1 (de) 1996-07-31
EP0647219A1 (de) 1995-04-12
FI946073A0 (fi) 1994-12-23
AU679685B2 (en) 1997-07-10
DE59303365D1 (de) 1996-09-05
CA2138989A1 (en) 1994-01-06
ATE140918T1 (de) 1996-08-15
CN1262267A (zh) 2000-08-09
SK158494A3 (en) 1995-07-11
US5585368A (en) 1996-12-17
DE4220757A1 (de) 1994-01-05
FI946073L (fi) 1994-12-23
CN1089599A (zh) 1994-07-20
TW255883B (enExample) 1995-09-01
MX9303799A (es) 1994-07-29
NO306614B1 (no) 1999-11-29
HU9403771D0 (en) 1995-02-28
CZ327694A3 (en) 1995-06-14
ES2093440T3 (es) 1996-12-16
DK0647219T3 (da) 1996-12-09
NO945034D0 (no) 1994-12-23

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