CN105051027A - 作为转染期间重排(ret)激酶抑制剂的吡啶衍生物 - Google Patents
作为转染期间重排(ret)激酶抑制剂的吡啶衍生物 Download PDFInfo
- Publication number
- CN105051027A CN105051027A CN201480015907.3A CN201480015907A CN105051027A CN 105051027 A CN105051027 A CN 105051027A CN 201480015907 A CN201480015907 A CN 201480015907A CN 105051027 A CN105051027 A CN 105051027A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- ethoxy
- fluorophenyl
- trifluoromethyl
- acetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCOc1cc(Br)cnc1* Chemical compound CCOc1cc(Br)cnc1* 0.000 description 13
- MDXJETOWOWMSCZ-UHFFFAOYSA-N C=C1C(C2NC2)=CC(c2n[nH]nn2)=CC1C(F)(F)F Chemical compound C=C1C(C2NC2)=CC(c2n[nH]nn2)=CC1C(F)(F)F MDXJETOWOWMSCZ-UHFFFAOYSA-N 0.000 description 1
- KLJLJJHZGGEDSD-ARJAWSKDSA-O CC(C)(C(F)(F)F)/C(/O)=C/C(N)=[NH2+] Chemical compound CC(C)(C(F)(F)F)/C(/O)=C/C(N)=[NH2+] KLJLJJHZGGEDSD-ARJAWSKDSA-O 0.000 description 1
- WRVDTUPCCSPFCR-RLXIPSCYSA-O CC(C)(C(F)(F)F)C(/C=C(/N)\[OH2+])=N Chemical compound CC(C)(C(F)(F)F)C(/C=C(/N)\[OH2+])=N WRVDTUPCCSPFCR-RLXIPSCYSA-O 0.000 description 1
- YHUBZKCLPILRCF-UHFFFAOYSA-N CC(C)(C)OC(C(c(c(C(F)(F)F)c1)ncc1NC)C#N)=O Chemical compound CC(C)(C)OC(C(c(c(C(F)(F)F)c1)ncc1NC)C#N)=O YHUBZKCLPILRCF-UHFFFAOYSA-N 0.000 description 1
- YOEQJXRIVMDKOM-UHFFFAOYSA-N CC(c(c(C(F)(F)F)c1)ncc1N=O)C#N Chemical compound CC(c(c(C(F)(F)F)c1)ncc1N=O)C#N YOEQJXRIVMDKOM-UHFFFAOYSA-N 0.000 description 1
- LTMFTLRZOQJNRP-UHFFFAOYSA-N CC1(C)OS(c2ccc(CC(OC)=O)c(F)c2)OC1(C)C Chemical compound CC1(C)OS(c2ccc(CC(OC)=O)c(F)c2)OC1(C)C LTMFTLRZOQJNRP-UHFFFAOYSA-N 0.000 description 1
- DHKCPXUJXBEYIP-UHFFFAOYSA-N CCCC1=CC(c2ccc(CC(Nc3ccc(CC(C)(C)CO)c(C(F)(F)F)c3)=O)cc2F)=CNC1=O Chemical compound CCCC1=CC(c2ccc(CC(Nc3ccc(CC(C)(C)CO)c(C(F)(F)F)c3)=O)cc2F)=CNC1=O DHKCPXUJXBEYIP-UHFFFAOYSA-N 0.000 description 1
- XEPCZNYKJKQIAG-UHFFFAOYSA-N CCOC(C(c1cc(F)c(CC(Nc2cnc(C(C)(C)CO)c(C(F)(F)F)c2)=O)cc1)=CN1)=CC1=O Chemical compound CCOC(C(c1cc(F)c(CC(Nc2cnc(C(C)(C)CO)c(C(F)(F)F)c2)=O)cc1)=CN1)=CC1=O XEPCZNYKJKQIAG-UHFFFAOYSA-N 0.000 description 1
- ZWTYBYLWIRPFSZ-UHFFFAOYSA-N CCOC(C(c1ccc(CC(Nc(cc2C(F)(F)F)cnc2OCCN(C)C)=O)c(F)c1)=CN1)=CC1=O Chemical compound CCOC(C(c1ccc(CC(Nc(cc2C(F)(F)F)cnc2OCCN(C)C)=O)c(F)c1)=CN1)=CC1=O ZWTYBYLWIRPFSZ-UHFFFAOYSA-N 0.000 description 1
- YDGUKGOCDBDHSY-UHFFFAOYSA-O CCOC1=CC(B2OC(C)(C)C(C)O2)=CNC1[OH2+] Chemical compound CCOC1=CC(B2OC(C)(C)C(C)O2)=CNC1[OH2+] YDGUKGOCDBDHSY-UHFFFAOYSA-O 0.000 description 1
- IAFQHMRLFASZKN-UHFFFAOYSA-N CCOC1=CC(c2cc(F)c(CC(Nc(cc3C(F)(F)F)ccc3OCCO)=O)c(F)c2)=CNC1=O Chemical compound CCOC1=CC(c2cc(F)c(CC(Nc(cc3C(F)(F)F)ccc3OCCO)=O)c(F)c2)=CNC1=O IAFQHMRLFASZKN-UHFFFAOYSA-N 0.000 description 1
- JZVWPDCTWNMSBO-UHFFFAOYSA-N CCOC1=CC(c2ccc(CC(Nc3ccc(CC(CO)(F)F)c(C(F)(F)F)c3)=O)c(F)c2)=CNC1=O Chemical compound CCOC1=CC(c2ccc(CC(Nc3ccc(CC(CO)(F)F)c(C(F)(F)F)c3)=O)c(F)c2)=CNC1=O JZVWPDCTWNMSBO-UHFFFAOYSA-N 0.000 description 1
- LNLPJHXWJXGBEV-UHFFFAOYSA-N CCc(cc1C(F)(F)F)cnc1O Chemical compound CCc(cc1C(F)(F)F)cnc1O LNLPJHXWJXGBEV-UHFFFAOYSA-N 0.000 description 1
- WWTGXYAJVXKEKL-UHFFFAOYSA-N Cc(nc1)c[n]1-c1cc(C(F)(F)F)cc(N)c1 Chemical compound Cc(nc1)c[n]1-c1cc(C(F)(F)F)cc(N)c1 WWTGXYAJVXKEKL-UHFFFAOYSA-N 0.000 description 1
- JHLCLALPGFWTGY-UHFFFAOYSA-N N#CCc(c(C(F)(F)F)c1)ncc1[N+]([O-])=O Chemical compound N#CCc(c(C(F)(F)F)c1)ncc1[N+]([O-])=O JHLCLALPGFWTGY-UHFFFAOYSA-N 0.000 description 1
- LAQFPQSYKMWFAW-UHFFFAOYSA-N N#CCc(c(F)cc(Br)c1)c1F Chemical compound N#CCc(c(F)cc(Br)c1)c1F LAQFPQSYKMWFAW-UHFFFAOYSA-N 0.000 description 1
- RCEMMXVNSKICPW-UHFFFAOYSA-N Nc1c(C[Zn])ccc(C(F)(F)F)c1N Chemical compound Nc1c(C[Zn])ccc(C(F)(F)F)c1N RCEMMXVNSKICPW-UHFFFAOYSA-N 0.000 description 1
- LSRHFWSNUFIKER-UHFFFAOYSA-N OCc(c(F)cc(Br)c1)c1F Chemical compound OCc(c(F)cc(Br)c1)c1F LSRHFWSNUFIKER-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201480015907.3A CN105051027A (zh) | 2013-03-15 | 2014-03-14 | 作为转染期间重排(ret)激酶抑制剂的吡啶衍生物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013072683 | 2013-03-15 | ||
| CN2013090059 | 2013-12-20 | ||
| CN2014072449 | 2014-02-24 | ||
| CN201480015907.3A CN105051027A (zh) | 2013-03-15 | 2014-03-14 | 作为转染期间重排(ret)激酶抑制剂的吡啶衍生物 |
| PCT/IB2014/059817 WO2014141187A1 (en) | 2013-03-15 | 2014-03-14 | Pyridine derivatives as rearranged during transfection (ret) kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105051027A true CN105051027A (zh) | 2015-11-11 |
Family
ID=50390154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480015907.3A Pending CN105051027A (zh) | 2013-03-15 | 2014-03-14 | 作为转染期间重排(ret)激酶抑制剂的吡啶衍生物 |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US9382238B2 (https=) |
| EP (1) | EP2970191B1 (https=) |
| JP (1) | JP2016516026A (https=) |
| CN (1) | CN105051027A (https=) |
| AU (1) | AU2014229233B2 (https=) |
| BR (1) | BR112015023618A2 (https=) |
| CA (1) | CA2905627A1 (https=) |
| CL (1) | CL2015002514A1 (https=) |
| CR (1) | CR20150490A (https=) |
| CY (1) | CY1118730T1 (https=) |
| DK (1) | DK2970191T3 (https=) |
| DO (1) | DOP2015000244A (https=) |
| EA (1) | EA029296B1 (https=) |
| ES (1) | ES2616655T3 (https=) |
| HR (1) | HRP20170363T1 (https=) |
| HU (1) | HUE033423T2 (https=) |
| IL (1) | IL241161A0 (https=) |
| LT (1) | LT2970191T (https=) |
| ME (1) | ME02664B (https=) |
| MX (1) | MX2015012286A (https=) |
| NZ (1) | NZ628388A (https=) |
| PE (1) | PE20151538A1 (https=) |
| PH (1) | PH12015502044A1 (https=) |
| PL (1) | PL2970191T3 (https=) |
| PT (1) | PT2970191T (https=) |
| RS (1) | RS55710B1 (https=) |
| SG (1) | SG11201506695UA (https=) |
| SI (1) | SI2970191T1 (https=) |
| SM (1) | SMT201700152T1 (https=) |
| TW (1) | TW201524958A (https=) |
| UA (1) | UA115264C2 (https=) |
| UY (1) | UY35465A (https=) |
| WO (1) | WO2014141187A1 (https=) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109096264A (zh) * | 2018-08-28 | 2018-12-28 | 山东理工职业学院 | Ret抑制剂及其制备方法、组合物和用途 |
| CN110036007A (zh) * | 2016-09-29 | 2019-07-19 | 第一三共株式会社 | 吡啶化合物 |
| WO2022017524A1 (zh) * | 2020-07-23 | 2022-01-27 | 深圳晶泰科技有限公司 | 吡啶酮类化合物及其制备方法和应用 |
| CN115626880A (zh) * | 2022-11-15 | 2023-01-20 | 常州大学 | 3-硝基-5-氰基三氟甲苯的合成方法 |
| CN115667253A (zh) * | 2020-04-27 | 2023-01-31 | 伊莱利利公司 | 可用于抑制ret激酶的化合物 |
| CN116438179A (zh) * | 2020-11-06 | 2023-07-14 | 伊莱利利公司 | 作为ret激酶抑制剂的吡唑衍生物 |
| CN116925023A (zh) * | 2023-07-18 | 2023-10-24 | 江苏桐孚高新材料有限公司 | 2-全氟烷基-4h-吡喃-4-酮衍生物的改进合成方法 |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ604708A (en) | 2010-05-20 | 2015-05-29 | Array Biopharma Inc | Macrocyclic compounds as trk kinase inhibitors |
| KR20170047396A (ko) * | 2014-09-08 | 2017-05-04 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 2-(4-(4-에톡시-6-옥소-1,6-디히드로피리딘-3-일)-2-플루오로페닐)-n-(5-(1,1,1-트리플루오로-2-메틸프로판-2-일)이속사졸-3-일)아세트아미드의 결정질 형태 |
| EA032030B1 (ru) | 2014-09-10 | 2019-03-29 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Соединения в качестве ингибиторов реаранжированной во время трансфекции (ret) киназы |
| PE20170705A1 (es) | 2014-09-10 | 2017-05-21 | Glaxosmithkline Ip Dev Ltd | Nuevos compuestos como inhibidores de ret (reorganizado durante la transfeccion) |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| BR112018000808A2 (pt) | 2015-07-16 | 2018-09-04 | Array Biopharma Inc | compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| PL3371171T3 (pl) * | 2015-11-02 | 2024-03-25 | Blueprint Medicines Corporation | Inhibitory RET |
| WO2017145050A1 (en) | 2016-02-23 | 2017-08-31 | Glaxosmithkline Intellectual Property Development Limited | Pyridylpyridone derivative useful as a ret kinase inhibitor in the treatment of ibs and cancer |
| WO2017161045A1 (en) * | 2016-03-16 | 2017-09-21 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
| TW201738228A (zh) | 2016-03-17 | 2017-11-01 | 藍圖醫藥公司 | Ｒｅｔ之抑制劑 |
| BR112018073300A2 (pt) | 2016-05-13 | 2019-03-26 | Instituto De Medicina Molecular | métodos para tratamento de doenças associadas com as células ilc3 |
| US10227329B2 (en) | 2016-07-22 | 2019-03-12 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| TWI752098B (zh) | 2016-10-10 | 2022-01-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| US11168090B2 (en) | 2017-01-18 | 2021-11-09 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| JP2020519672A (ja) | 2017-05-15 | 2020-07-02 | ブループリント メディシンズ コーポレイション | ＲＥＴ阻害剤とｍＴＯＲＣ１阻害剤との組合せ及び異常なＲＥＴ活性によって媒介されるがんを処置するためのその使用 |
| US10093648B1 (en) * | 2017-09-22 | 2018-10-09 | Celgene Corporation | Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate, compositions and methods of use thereof |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI812649B (zh) * | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| WO2019143991A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| CN111615514B (zh) | 2018-01-18 | 2022-10-11 | 奥瑞生物药品公司 | 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物 |
| SI3773589T1 (sl) | 2018-04-03 | 2024-03-29 | Blueprint Medicines Corporation | Inhibitor RET za uporabo pri zdravljenju raka, ki ima RET spremembo |
| EP3849986B1 (en) | 2018-09-10 | 2022-06-08 | Array Biopharma, Inc. | Fused heterocyclic compounds as ret kinase inhibitors |
| NZ780966A (en) | 2019-04-18 | 2026-02-27 | Univ Johns Hopkins | Substituted 2-amino-pyrazolyl-[1,2,4]triazolo[1,5a] pyridine derivatives and use thereof |
| CN115210226B (zh) * | 2020-02-20 | 2024-01-09 | 广州白云山医药集团股份有限公司白云山制药总厂 | 喹啉类化合物 |
| JP2023527412A (ja) | 2020-05-29 | 2023-06-28 | ブループリント メディシンズ コーポレイション | プラルセチニブの固体形態 |
| JP2024522938A (ja) | 2021-06-03 | 2024-06-21 | フンダサン デー．アンナ ジ ソーメル チャンパリマウド エー ドクトル カルロス モンテス チャンパリマウド | 脳－脂肪回路を介してｉｌｃ２および肥満度を制御する神経－間葉単位 |
| EP4650002A1 (en) * | 2024-05-15 | 2025-11-19 | Ludwig-Maximilians-Universität | Aniline-based modulators of the nuclear receptor tlx (nr2e1) |
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| AU2002215053A1 (en) * | 2000-11-27 | 2002-06-24 | Pharmacia Italia S.P.A. | Phenylacetamido- pyrazole derivatives and their use as antitumor agents |
| DE10201764A1 (de) | 2002-01-18 | 2003-07-31 | Bayer Cropscience Ag | Substituierte 4-Aminopyridin-Derivate |
| US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| CA2666116A1 (en) * | 2006-10-16 | 2008-04-24 | Novartis Ag | Phenylacetamides useful as protein kinase inhibitors |
| DK2848610T3 (da) * | 2006-11-15 | 2017-11-06 | Ym Biosciences Australia Pty | Hæmmere af kinaseaktivitet |
| JP2013502429A (ja) * | 2009-08-19 | 2013-01-24 | アムビト ビオスシエンセス コルポラチオン | ビアリール化合物及びその使用方法 |
| US9073895B2 (en) | 2010-12-16 | 2015-07-07 | Boehringer Ingelheim International Gmbh | Biarylamide inhibitors of leukotriene production |
| MA38394B1 (fr) | 2013-03-15 | 2018-04-30 | Glaxosmithkline Ip Dev Ltd | Dérivés pyridine utilisés comme inhibiteurs de la kinase réarrangée au cours de la transfection (ret) |
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