DOP2015000244A - Nuevos compuestos como inhibidores de reorganizado durante la transfección (ret) - Google Patents
Nuevos compuestos como inhibidores de reorganizado durante la transfección (ret)Info
- Publication number
- DOP2015000244A DOP2015000244A DO2015000244A DO2015000244A DOP2015000244A DO P2015000244 A DOP2015000244 A DO P2015000244A DO 2015000244 A DO2015000244 A DO 2015000244A DO 2015000244 A DO2015000244 A DO 2015000244A DO P2015000244 A DOP2015000244 A DO P2015000244A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- cancer
- functional
- ret
- thyroid
- disorders
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Abstract
ESTA INVENCIÓN SE REFIERE A NUEVOS COMPUESTOS QUE SON INHIBIDORES DE LA QUINASA REORGANIZADA DURANTE LA TRANSFECCIÓN (RET), A COMPOSICIONES FARMACÉUTICAS QUE LOS CONTIENEN, A LOS PROCEDIMIENTOS PARA SU PREPARACIÓN, Y A SU USO EN TERAPIA, SOLOS O COMBINADOS, PARA LA NORMALIZACIÓN DE LA SENSIBILIDAD, LA MOTILIDAD Y/O LA SECRECIÓN GASTROINTESTINAL Y/O TRASTORNOS O ENFERMEDADES ABDOMINALES Y/O LA FABRICACIÓN DE MEDICAMENTOS ÚTILES PARA EL TRATAMIENTO RELACIONADO CON ENFERMEDADES RELACIONADAS CON LA DISFUNCIÓN DE RET O EN LAS QUE LA MODULACIÓN DE LA ACTIVIDAD DE RET PUEDE TENER UN BENEFICIO TERAPÉUTICO QUE INCLUYE, PERO NO SE LIMITA A, TODAS LAS CLASIFICACIONES DEL SÍNDROME DEL INTESTINO IRRITABLE (SII) INCLUYENDO DIARREA PREDOMINANTE, ESTREÑIMIENTO PREDOMINANTE O UN PATRÓN DE HECES ALTERNANTE, DISTENSIÓN ABDOMINAL FUNCIONAL, ESTREÑIMIENTO FUNCIONAL, DIARREA FUNCIONAL, TRASTORNO INTESTINAL FUNCIONAL NO ESPECIFICADO, SÍNDROME DE DOLOR ABDOMINAL FUNCIONAL, ESTREÑIMIENTO IDIOPÁTICO CRÓNICO, TRASTORNOS ESOFÁGICOS FUNCIONALES, TRASTORNOS GASTRODUODENALES FUNCIONALES, DOLOR ANORRECTAL FUNCIONAL, ENFERMEDAD INFLAMATORIA DEL INTESTINO, ENFERMEDADES PROLIFERATIVAS TALES COMO CÁNCER DE PULMÓN DE CÉLULAS NO PEQUEÑAS, CARCINOMA HEPATOCELULAR, CANCER COLORRECTAL, CÁNCER DE TIROIDES MEDULAR, CÁNCER DE TIROIDES FOLICULAR, CÁNCER DE TIROIDES ANAPLÁSICO, CÁNCER DE TIROIDES PAPILAR, TUMORES CEREBRALES, CÁNCER DE LA CAVIDAD PERITONEAL, TUMORES SÓLIDOS, OTRO CÁNCER DE PULMÓN, CÁNCER DE CABEZA Y CUELLO, GLIOMAS, NEUROBLASTOMAS, SÍNDROME DE VON HIPPEL-LINDAU Y TUMORES DE RIÑÓN, CÁNCER DE MAMA, CÁNCER DE LAS TROMPAS DE FALOPIO, CÁNCER DE OVARIO, CÁNCER DE CÉLULAS TRANSICIONALES, CÁNCER DE PRÓSTATA, CÁNCER DE ESÓFAGO Y DE LA UNIÓN GASTROESOFÁGICA, CÁNCER BILIAR, ADENOCARCINOMA, Y CUALQUIER TUMOR MALIGNO CON UN INCREMENTO DE LA ACTIVIDAD QUINASA RET.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013072683 | 2013-03-15 | ||
| CN2013090059 | 2013-12-20 | ||
| CN2014072449 | 2014-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2015000244A true DOP2015000244A (es) | 2015-12-31 |
Family
ID=50390154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2015000244A DOP2015000244A (es) | 2013-03-15 | 2015-09-15 | Nuevos compuestos como inhibidores de reorganizado durante la transfección (ret) |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US9382238B2 (es) |
| EP (1) | EP2970191B1 (es) |
| JP (1) | JP2016516026A (es) |
| CN (1) | CN105051027A (es) |
| AU (1) | AU2014229233B2 (es) |
| BR (1) | BR112015023618A2 (es) |
| CA (1) | CA2905627A1 (es) |
| CL (1) | CL2015002514A1 (es) |
| CR (1) | CR20150490A (es) |
| CY (1) | CY1118730T1 (es) |
| DK (1) | DK2970191T3 (es) |
| DO (1) | DOP2015000244A (es) |
| EA (1) | EA029296B1 (es) |
| ES (1) | ES2616655T3 (es) |
| HR (1) | HRP20170363T1 (es) |
| HU (1) | HUE033423T2 (es) |
| IL (1) | IL241161A0 (es) |
| LT (1) | LT2970191T (es) |
| ME (1) | ME02664B (es) |
| MX (1) | MX2015012286A (es) |
| NZ (1) | NZ628388A (es) |
| PE (1) | PE20151538A1 (es) |
| PH (1) | PH12015502044A1 (es) |
| PL (1) | PL2970191T3 (es) |
| PT (1) | PT2970191T (es) |
| RS (1) | RS55710B1 (es) |
| SG (1) | SG11201506695UA (es) |
| SI (1) | SI2970191T1 (es) |
| TW (1) | TW201524958A (es) |
| UA (1) | UA115264C2 (es) |
| UY (1) | UY35465A (es) |
| WO (1) | WO2014141187A1 (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3521291A1 (en) | 2010-05-20 | 2019-08-07 | Array Biopharma, Inc. | Macrocyclic compounds as trk kinase inhibitors |
| AU2015313894A1 (en) * | 2014-09-08 | 2017-03-23 | Glaxosmithkline Intellectual Property Development Limited | Crystalline forms of 2-(4-(4-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-n-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide |
| BR112017004900A2 (pt) | 2014-09-10 | 2017-12-12 | Glaxosmithkline Ip Dev Ltd | derivados de piridona como inibidores de quinase rearranjada durante transfecção (ret) |
| EA032030B1 (ru) | 2014-09-10 | 2019-03-29 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Соединения в качестве ингибиторов реаранжированной во время трансфекции (ret) киназы |
| WO2016127074A1 (en) | 2015-02-06 | 2016-08-11 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as ret inhibitors |
| EP3322706B1 (en) | 2015-07-16 | 2020-11-11 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors |
| US10829484B2 (en) | 2015-07-28 | 2020-11-10 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| IL302209B1 (en) | 2015-11-02 | 2024-02-01 | Blueprint Medicines Corp | RET inhibitors |
| WO2017145050A1 (en) | 2016-02-23 | 2017-08-31 | Glaxosmithkline Intellectual Property Development Limited | Pyridylpyridone derivative useful as a ret kinase inhibitor in the treatment of ibs and cancer |
| AU2017232610B2 (en) * | 2016-03-16 | 2021-07-22 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
| US10183928B2 (en) | 2016-03-17 | 2019-01-22 | Blueprint Medicines Corporation | Inhibitors of RET |
| MX2018013885A (es) | 2016-05-13 | 2019-08-16 | Inst De Medicina Molecular Joaeo Lobo Antunes | Métodos de tratamiento de enfermedades asociadas con células linfoides innatas del grupo 3 (cli3). |
| US10227329B2 (en) | 2016-07-22 | 2019-03-12 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| JP2018052878A (ja) * | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
| JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| EP3571203B1 (en) | 2017-01-18 | 2023-06-07 | Array BioPharma Inc. | Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| JP2020519672A (ja) | 2017-05-15 | 2020-07-02 | ブループリント メディシンズ コーポレイション | ＲＥＴ阻害剤とｍＴＯＲＣ１阻害剤との組合せ及び異常なＲＥＴ活性によって媒介されるがんを処置するためのその使用 |
| US10093648B1 (en) * | 2017-09-22 | 2018-10-09 | Celgene Corporation | Crystalline 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione hemihydrate, compositions and methods of use thereof |
| TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| TWI802635B (zh) | 2018-01-18 | 2023-05-21 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡咯并[2,3-d]嘧啶化合物 |
| CN111615514B (zh) | 2018-01-18 | 2022-10-11 | 奥瑞生物药品公司 | 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物 |
| CA3087578C (en) | 2018-01-18 | 2023-08-08 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| SI3773589T1 (sl) | 2018-04-03 | 2024-03-29 | Blueprint Medicines Corporation | Inhibitor RET za uporabo pri zdravljenju raka, ki ima RET spremembo |
| CN109096264B (zh) * | 2018-08-28 | 2019-08-23 | 山东理工职业学院 | Ret抑制剂及其制备方法、组合物和用途 |
| ES2922314T3 (es) | 2018-09-10 | 2022-09-13 | Array Biopharma Inc | Compuestos heterocíclicos condensados como inhibidores de cinasa RET |
| AU2020257301A1 (en) | 2019-04-18 | 2021-11-11 | The Johns Hopkins University | Substituted 2-amino-pyrazolyl-(1,2,4)triazolo(1,5a) pyridine derivatives and use thereof |
| WO2021164742A1 (zh) | 2020-02-20 | 2021-08-26 | 广州白云山医药集团股份有限公司白云山制药总厂 | 喹啉类化合物 |
| TWI777509B (zh) * | 2020-04-27 | 2022-09-11 | 美商美國禮來大藥廠 | 用於抑制ret激酶之化合物 |
| WO2022017524A1 (zh) * | 2020-07-23 | 2022-01-27 | 深圳晶泰科技有限公司 | 吡啶酮类化合物及其制备方法和应用 |
| CN116438179A (zh) | 2020-11-06 | 2023-07-14 | 伊莱利利公司 | 作为ret激酶抑制剂的吡唑衍生物 |
| WO2022254255A1 (en) | 2021-06-03 | 2022-12-08 | Fundacao D. Anna De Sommerchampalimaud E Dr. | Neuro-mesenchyme units control ilc2 and obesity via a brain-adipose circuit |
| CN115626880B (zh) * | 2022-11-15 | 2023-11-14 | 常州大学 | 3-硝基-5-氰基三氟甲苯的合成方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1202733B1 (en) | 1999-08-12 | 2005-10-05 | Pharmacia Italia S.p.A. | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents |
| WO2002048114A1 (en) | 2000-11-27 | 2002-06-20 | Pharmacia Italia S.P.A. | Phenylacetamido- pyrazole derivatives and their use as antitumor agents |
| DE10201764A1 (de) | 2002-01-18 | 2003-07-31 | Bayer Cropscience Ag | Substituierte 4-Aminopyridin-Derivate |
| US7968574B2 (en) | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
| MX2009003985A (es) * | 2006-10-16 | 2009-04-27 | Novartis Ag | Fenil-acetamidas utiles como inhibidores de cinasa de proteina. |
| WO2008058341A1 (en) * | 2006-11-15 | 2008-05-22 | Cytopia Research Pty Ltd | Inhibitors of kinase activity |
| CA2770454A1 (en) * | 2009-08-19 | 2011-02-24 | Ambit Biosciences Corporation | Biaryl compounds and methods of use thereof |
| US9073895B2 (en) | 2010-12-16 | 2015-07-07 | Boehringer Ingelheim International Gmbh | Biarylamide inhibitors of leukotriene production |
| US8937071B2 (en) | 2013-03-15 | 2015-01-20 | Glaxosmithkline Intellectual Property Development Limited | Compounds as rearranged during transfection (RET) inhibitors |
-
2014
- 2014-03-14 MX MX2015012286A patent/MX2015012286A/es unknown
- 2014-03-14 ME MEP-2017-60A patent/ME02664B/me unknown
- 2014-03-14 NZ NZ628388A patent/NZ628388A/en not_active IP Right Cessation
- 2014-03-14 PT PT147135982T patent/PT2970191T/pt unknown
- 2014-03-14 UA UAA201510041A patent/UA115264C2/uk unknown
- 2014-03-14 DK DK14713598.2T patent/DK2970191T3/en active
- 2014-03-14 EP EP14713598.2A patent/EP2970191B1/en active Active
- 2014-03-14 EA EA201591738A patent/EA029296B1/ru not_active IP Right Cessation
- 2014-03-14 HU HUE14713598A patent/HUE033423T2/en unknown
- 2014-03-14 UY UY0001035465A patent/UY35465A/es unknown
- 2014-03-14 SG SG11201506695UA patent/SG11201506695UA/en unknown
- 2014-03-14 PE PE2015001878A patent/PE20151538A1/es not_active Application Discontinuation
- 2014-03-14 CA CA2905627A patent/CA2905627A1/en not_active Abandoned
- 2014-03-14 LT LTEP14713598.2T patent/LT2970191T/lt unknown
- 2014-03-14 AU AU2014229233A patent/AU2014229233B2/en not_active Ceased
- 2014-03-14 ES ES14713598.2T patent/ES2616655T3/es active Active
- 2014-03-14 JP JP2015562529A patent/JP2016516026A/ja active Pending
- 2014-03-14 PL PL14713598T patent/PL2970191T3/pl unknown
- 2014-03-14 RS RS20170177A patent/RS55710B1/sr unknown
- 2014-03-14 WO PCT/IB2014/059817 patent/WO2014141187A1/en active Application Filing
- 2014-03-14 CN CN201480015907.3A patent/CN105051027A/zh active Pending
- 2014-03-14 US US14/775,772 patent/US9382238B2/en not_active Expired - Fee Related
- 2014-03-14 TW TW103109315A patent/TW201524958A/zh unknown
- 2014-03-14 BR BR112015023618A patent/BR112015023618A2/pt not_active IP Right Cessation
- 2014-03-14 SI SI201430170A patent/SI2970191T1/sl unknown
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2015
- 2015-09-03 IL IL241161A patent/IL241161A0/en unknown
- 2015-09-08 CL CL2015002514A patent/CL2015002514A1/es unknown
- 2015-09-10 PH PH12015502044A patent/PH12015502044A1/en unknown
- 2015-09-14 CR CR20150490A patent/CR20150490A/es unknown
- 2015-09-15 DO DO2015000244A patent/DOP2015000244A/es unknown
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2016
- 2016-06-02 US US15/171,229 patent/US9789100B2/en not_active Expired - Fee Related
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2017
- 2017-03-06 HR HRP20170363TT patent/HRP20170363T1/hr unknown
- 2017-03-14 CY CY20171100319T patent/CY1118730T1/el unknown
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