CN105037188B - 用于制备拉非酰胺甲磺酸盐或其r‑对映异构体的方法 - Google Patents
用于制备拉非酰胺甲磺酸盐或其r‑对映异构体的方法 Download PDFInfo
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- CN105037188B CN105037188B CN201510387405.XA CN201510387405A CN105037188B CN 105037188 B CN105037188 B CN 105037188B CN 201510387405 A CN201510387405 A CN 201510387405A CN 105037188 B CN105037188 B CN 105037188B
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C07—ORGANIC CHEMISTRY
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- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
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| EP10161207.5 | 2010-04-27 | ||
| EP10161207 | 2010-04-27 | ||
| CN201180020748.2A CN102858330B (zh) | 2010-04-27 | 2011-04-06 | 用于制备拉非酰胺甲磺酸盐或其r-对映异构体的方法 |
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| CN201180020748.2A Active CN102858330B (zh) | 2010-04-27 | 2011-04-06 | 用于制备拉非酰胺甲磺酸盐或其r-对映异构体的方法 |
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| CA2794389C (en) * | 2010-04-27 | 2016-08-23 | Newron Pharmaceuticals S.P.A. | Process for the production of ralfinamide methanesulfonate salts or their r-enantiomers |
| CN103804341B (zh) * | 2012-11-13 | 2018-04-10 | 中国人民解放军军事医学科学院毒物药物研究所 | 酰胺衍生物及其医药用途 |
| CN104761531B (zh) * | 2014-01-03 | 2017-12-01 | 中国人民解放军军事医学科学院毒物药物研究所 | 镇痛活性化合物及其医药用途 |
| CN104292128A (zh) * | 2014-07-01 | 2015-01-21 | 南京正科制药有限公司 | 一种沙芬酰胺晶型a |
| CN115368310B (zh) | 2021-05-18 | 2025-06-27 | 奥库菲尔医药公司 | 合成甲磺酸酚妥拉明的方法 |
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| CN1738611A (zh) * | 2003-01-16 | 2006-02-22 | 纽朗制药有限公司 | 用作抗偏头痛剂的α－氨基酰胺衍生物 |
| CN101018546A (zh) * | 2004-09-10 | 2007-08-15 | 纽朗制药有限公司 | 作为钠和/或钙通道选择性调节剂的(卤代苄氨基)苄氧基－丙酰胺类 |
| WO2009074478A1 (en) * | 2007-12-11 | 2009-06-18 | Newron Pharmaceuticals S.P.A. | Process for the production of 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides with high purity degree |
| CN101472880A (zh) * | 2006-06-19 | 2009-07-01 | 纽朗制药有限公司 | 生产2-[4-(3-和2-氟苄氧基)苄氨基]丙酰胺类的方法 |
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| IL94466A (en) | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| PT1423168E (pt) | 2001-09-03 | 2006-05-31 | Newron Pharm Spa | Composicao farmaceutica que compreende gabapentina ou um seu analogo e uma x-aminoamida e a sua utilizacao como analgesico |
| EP1596844A2 (en) * | 2003-01-30 | 2005-11-23 | Dynogen Pharmaceuticals Inc. | Use of sodium channel modulators for treating gastrointestinal tract disorders |
| AR044007A1 (es) | 2003-04-11 | 2005-08-24 | Newron Pharmaceuticals Inc | Metodos para el tratamiento de la enfermedad de parkinson |
| US20070276046A1 (en) | 2003-08-25 | 2007-11-29 | Patricia Salvati | Alpha-Aminoamide Derivatives Useful as Anti-Inflammatory Agents |
| EP1557166A1 (en) | 2004-01-21 | 2005-07-27 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders |
| EP1588704A1 (en) | 2004-04-22 | 2005-10-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders |
| EP1870097A1 (en) | 2006-06-15 | 2007-12-26 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of cognitive disorders |
| JP5315674B2 (ja) * | 2007-11-19 | 2013-10-16 | セントラル硝子株式会社 | 非水電池用電解液及びこれを用いた非水電池 |
| NZ586182A (en) | 2007-12-19 | 2012-02-24 | Newron Pharm Spa | Alpha-aminoamide derivatives useful in the treatment of psychiatric disorders |
| WO2009109334A1 (en) | 2008-03-07 | 2009-09-11 | Newron Pharmaceuticals S.P.A. | (s)-(+)-2-[4-fluorbenzyloxy)benzylamino]propanamide for use in the treatment of mixed or combined pain |
| CA2794389C (en) * | 2010-04-27 | 2016-08-23 | Newron Pharmaceuticals S.P.A. | Process for the production of ralfinamide methanesulfonate salts or their r-enantiomers |
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Patent Citations (5)
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|---|---|---|---|---|
| CN1192199A (zh) * | 1995-07-27 | 1998-09-02 | 法玛西雅厄普约翰公司 | 2－(4－取代)－苄基氨基－2－甲基－丙酰胺衍生物 |
| CN1738611A (zh) * | 2003-01-16 | 2006-02-22 | 纽朗制药有限公司 | 用作抗偏头痛剂的α－氨基酰胺衍生物 |
| CN101018546A (zh) * | 2004-09-10 | 2007-08-15 | 纽朗制药有限公司 | 作为钠和/或钙通道选择性调节剂的(卤代苄氨基)苄氧基－丙酰胺类 |
| CN101472880A (zh) * | 2006-06-19 | 2009-07-01 | 纽朗制药有限公司 | 生产2-[4-(3-和2-氟苄氧基)苄氨基]丙酰胺类的方法 |
| WO2009074478A1 (en) * | 2007-12-11 | 2009-06-18 | Newron Pharmaceuticals S.P.A. | Process for the production of 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides with high purity degree |
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