CN104350063A - 疏水性治疗剂的制剂、其制备方法及应用 - Google Patents
疏水性治疗剂的制剂、其制备方法及应用 Download PDFInfo
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- CN104350063A CN104350063A CN201380030423.1A CN201380030423A CN104350063A CN 104350063 A CN104350063 A CN 104350063A CN 201380030423 A CN201380030423 A CN 201380030423A CN 104350063 A CN104350063 A CN 104350063A
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- 229960003250 telithromycin Drugs 0.000 description 1
- 229960002197 temoporfin Drugs 0.000 description 1
- 229960000235 temsirolimus Drugs 0.000 description 1
- 229950006156 teprenone Drugs 0.000 description 1
- 229960002722 terbinafine Drugs 0.000 description 1
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- 229960000580 terconazole Drugs 0.000 description 1
- 229960000351 terfenadine Drugs 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229960000746 testosterone undecanoate Drugs 0.000 description 1
- UDSFVOAUHKGBEK-CNQKSJKFSA-N testosterone undecanoate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCCCCCC)[C@@]1(C)CC2 UDSFVOAUHKGBEK-CNQKSJKFSA-N 0.000 description 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical class [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 229940040944 tetracyclines Drugs 0.000 description 1
- 229960000278 theophylline Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 230000001519 thymoleptic effect Effects 0.000 description 1
- 229960001312 tiaprofenic acid Drugs 0.000 description 1
- 229960004749 tibezonium iodide Drugs 0.000 description 1
- YTSPICCNZMNDQT-UHFFFAOYSA-M tibezonium iodide Chemical compound [I-].C1C(SCC[N+](C)(CC)CC)=NC2=CC=CC=C2N=C1C(C=C1)=CC=C1SC1=CC=CC=C1 YTSPICCNZMNDQT-UHFFFAOYSA-M 0.000 description 1
- 229960005053 tinidazole Drugs 0.000 description 1
- 229960000257 tiotropium bromide Drugs 0.000 description 1
- 229960004631 tixocortol Drugs 0.000 description 1
- YWDBSCORAARPPF-VWUMJDOOSA-N tixocortol Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CS)[C@@H]4[C@@H]3CCC2=C1 YWDBSCORAARPPF-VWUMJDOOSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229960005371 tolbutamide Drugs 0.000 description 1
- 229960003916 tolciclate Drugs 0.000 description 1
- 229960003553 tolterodine tartrate Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 229960004167 toremifene citrate Drugs 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 229960005342 tranilast Drugs 0.000 description 1
- NZHGWWWHIYHZNX-CSKARUKUSA-N tranilast Chemical compound C1=C(OC)C(OC)=CC=C1\C=C\C(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-CSKARUKUSA-N 0.000 description 1
- 229940125725 tranquilizer Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 235000018991 trans-resveratrol Nutrition 0.000 description 1
- 229950010156 tretinoin tocoferil Drugs 0.000 description 1
- 125000005208 trialkylammonium group Chemical group 0.000 description 1
- 229940063839 triamcinolone injection Drugs 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- 229950008546 trimegestone Drugs 0.000 description 1
- JUNDJWOLDSCTFK-MTZCLOFQSA-N trimegestone Chemical compound C1CC2=CC(=O)CCC2=C2[C@@H]1[C@@H]1CC[C@@](C(=O)[C@@H](O)C)(C)[C@@]1(C)CC2 JUNDJWOLDSCTFK-MTZCLOFQSA-N 0.000 description 1
- YCYOWIYHCRGAAH-UHFFFAOYSA-M trimethyl(naphthalen-1-yl)azanium;chloride Chemical compound [Cl-].C1=CC=C2C([N+](C)(C)C)=CC=CC2=C1 YCYOWIYHCRGAAH-UHFFFAOYSA-M 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical compound [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 description 1
- 235000015870 tripotassium citrate Nutrition 0.000 description 1
- YKUJZZHGTWVWHA-UHFFFAOYSA-N triptolide Natural products COC12CC3OC3(C(C)C)C(O)C14OC4CC5C6=C(CCC25C)C(=O)OC6 YKUJZZHGTWVWHA-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 229950010121 ufenamate Drugs 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- 229950008081 unoprostone isopropyl Drugs 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 229940093257 valacyclovir Drugs 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 208000001319 vasomotor rhinitis Diseases 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
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- 229960004528 vincristine Drugs 0.000 description 1
- NMDYYWFGPIMTKO-HBVLKOHWSA-N vinflunine Chemical compound C([C@@](C1=C(C2=CC=CC=C2N1)C1)(C2=C(OC)C=C3N(C)[C@@H]4[C@@]5(C3=C2)CCN2CC=C[C@]([C@@H]52)([C@H]([C@]4(O)C(=O)OC)OC(C)=O)CC)C(=O)OC)[C@H]2C[C@@H](C(C)(F)F)CN1C2 NMDYYWFGPIMTKO-HBVLKOHWSA-N 0.000 description 1
- 229960000922 vinflunine Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
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- 229960005080 warfarin Drugs 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
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- 239000001993 wax Substances 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
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- 229960001643 xibornol Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/009—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by only one oxygen atom doubly bound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Abstract
Description
维A生育醇酯(tocoretinate) | 甲磺酸比托特罗 |
吲哚菁绿,Daiichi | 氟骨三醇 |
棕榈胆磷 | 碘克沙酸 |
奥替尼啶 | 富马酸非索罗定 |
钆磷维塞三钠(gadofosveset trisodium) | 夸西泮 |
普罗布考 | 福沙吡坦二甲葡胺 |
他拉泊芬钠 | 左卡巴司汀 |
四烯甲萘醌 | 环索奈德 |
米铂水合物 | 糠酸莫米松 |
硫胺-cobaltichlorophyllate | 瑞伐拉赞(revaprazan) |
孟鲁司特钠 | 糠酸莫米松,鼻 |
依维莫司 | 糠酸莫米松,DPI,Twisthaler |
依维莫司洗脱支架 | 糠酸莫米松+福莫特罗 |
亚油酸地塞米松 | 糠酸莫米松,Almirall |
雌莫司汀磷酸钠 | 噻托溴铵+富马酸福莫特罗+环索奈德,Cipla |
唑罗莫司 | 糠酸莫米松,植入物,Intersect ENT |
Lipo-地塞米松棕榈酸酯 | 丁氯倍他松 |
替莫泊芬 | 异康唑 |
蒿甲醚+本芴醇 | 咪康唑+过氧化苯甲酰 |
乙酰甘草亭酸铝盐 | 硝酸咪康唑 |
哌泊噻嗪棕榈酸酯 | 咪康唑 |
替米沙坦 | 咪康唑 |
替米沙坦+氢氯噻嗪(HCTZ) | 咪康唑,Barrier |
替米沙坦+氨氯地平,BI | 咪康唑,口腔含化剂, |
(S)-氨氯地平+替米沙坦 | 比拉斯汀 |
西罗莫司 | 地塞米松培酯 |
西罗莫司,纳米晶体 | 阿维a酯 |
西罗莫司,支架,考迪斯-1 | 替贝碘铵(tibenzonium) |
坦罗莫司 | 美雄烷 |
二十二醇 | 依曲韦林 |
氯福克酚 | 合成结合雌激素,B |
碘沙酸葡甲胺 | 硫康唑 |
AGP-103 | 奥美昔芬 |
伊曲康唑 | 布南色林 |
伊曲康唑,Choongwae | 月见草油 |
伊曲康唑,Barrier | 氟曲马唑 |
卤泛群 | γ-亚麻酸 |
依塞罗酯 | SH-U-508 |
十一酸睾酮 | 洛非帕明 |
碘曲西酸葡甲胺 | 曲前列尼尔钠 |
teboroxime | 利美索龙 |
替拉扎特甲磺酸盐 | 曲前列尼尔钠,吸入 |
法扎溴铵 | 地诺孕素+戊酸雌二醇 |
磷丙泊酚钠 | 雌二醇+左炔诺孕酮(贴剂) |
胺碘酮 | 希波酚 |
胺碘酮 | 硫酸普拉酮钠,S-P |
氟维司群 | 二十碳五烯酸乙酯,Amarin |
法呢吲哚美辛 | 苄普地尔 |
亚油甲苄胺 | 联苯苄唑 |
米替福新 | 氯那唑酸钙 |
坎地沙坦西酯 | 阿莫罗芬 |
坎地沙坦西酯+HCTZ | 特比萘芬 |
坎地沙坦西酯+氨氯地平 | 阿莫罗芬,鼻,Kyorin |
阿糖胞苷十八烷基磷酸盐(cytarabine ocfosfate) | 氯那唑酸钙 |
五氟利多 | 全氟己烷 |
棕榈酸帕利哌酮 | 阿普唑仑 |
珠氯噻醇癸酸酯 | 阿普唑仑 |
泼尼松龙法呢酯(prednisolone farnesil) | 阿普唑仑 |
阿托伐他汀钙 | 舍他康唑 |
阿托伐他汀钙+氨氯地平 | 替利霉素 |
阿托伐他汀 | 扎鲁司特 |
阿托伐他汀+非诺贝特(微粉化的),Ethypharm | 双氯芬酸每天一次 |
ASA+阿托伐他汀+雷米普利+美托洛尔ER | 双氯芬酸钾 |
(S)-氨氯地平+阿托伐他汀 | 双氯芬酸钠,Diffucaps |
泼尼莫司汀 | 双氯芬酸每天两次 |
非达米星 | 双氯芬酸 |
特非那定 | 双氯芬酸,应用-1(Applied-1) |
奥利司他 | 双氯芬酸 |
贝沙罗汀 | 双氯芬酸 |
贝沙罗汀,凝胶剂,配体 | 利福昔明 |
碳酸钙+维生素D3 | 利福昔明乳膏剂 |
阿仑膦酸钠+维生素D | 双氯芬酸钠 |
ω-3-酸乙酯 | 双氯芬酸钾 |
帕瑞肽 | 双氯芬酸钠凝胶剂 |
依巴期汀 | 双氯芬酸钾,眼用 |
依巴期汀,口内溶解 | 双氯芬酸钾 |
依诺他滨 | 双氯芬酸钠 |
Malarex | 匹莫齐特 |
吡美莫司 | nabiximols |
福沙那韦钙 | 屈大麻酚 |
克利贝特 | 盐酸决奈达隆 |
托西拉酯 | 司他比锝 |
替普瑞酮 | 阿维a |
地塞米松磷酸钠 | 普拉维林 |
阿达帕林 | 司他斯汀 |
芬替康唑 | 利匹韦林 |
伊沙匹隆 | 米非司酮 |
Epiduo | 塞曲司特 |
Efalex | 阿齐沙坦 |
溴替唑仑 | 米非司酮 |
艾曲泊帕双乙醇胺盐 | 苯磺阿曲库铵 |
醋酸巴多昔芬 | 苯磺顺阿曲库铵 |
布替萘芬 | 依柏康唑 |
Clodermin | 阿司咪唑+伪麻黄碱 |
氯己定 | 碘普胺 |
氯己定 | 奥替溴铵 |
戊酸雌二醇+庚酸炔诺酮 | Piloplex |
盐酸西那卡塞特 | 卟吩姆钠 |
二十碳五烯酸乙酯 | 苯溴马隆 |
氯卓酸钾HCl | 他米巴罗汀 |
非索非那定+伪麻黄碱 | 甲磺酸依普沙坦 |
二甲磺酸阿米三嗪(almitrine bismesilate) | 磺代酚 |
布康唑 | 甲磺酸依普沙坦+HCTZ |
布康唑 | 伊维菌素 |
TBI-PAB | 萘替芬 |
甲羟孕酮,储库制剂 | 炔雌醚 |
醋酸甲羟孕酮LA | 盐酸雷洛昔芬 |
度他雄胺 | 瑞格列奈 |
氟桂利嗪 | 二甲双胍+瑞格列奈 |
度他雄胺+坦洛新 | 硝酸益康唑 |
利拉萘酯 | 贝前列素 |
大麻隆 | 贝前列素钠,SR |
利多氟嗪 | 长春氟宁 |
乙醇胺油酸酯 | 炔雌醇+诺孕曲敏(norelgestromin) |
拉索昔芬 | 盐酸地那维林 |
马拉维若 | 阿瑞吡坦 |
他克莫司 | 氟可丁酯 |
他克莫司,修饰释放 | 单唾液酸神经节苷酯GM-1,Amar |
他克莫司,局部用 | 单唾液酸神经节苷酯GM1 |
他克莫司 | 依贝沙坦 |
苯佐卡因 | 依贝沙坦+HCTZ |
盐酸考尼伐坦 | 苯磺酸氨氯地平+依贝沙坦,Dainippon |
泊沙康唑 | 托伐坦 |
依替唑仑 | 普罗雌烯 |
替拉那韦 | Epavir |
薁磺酸钠 | 乌芬那酯 |
三唑仑 | 阿普林定 |
三唑仑 | 氯苄苷 |
己酸羟孕酮,Hologic | 硫酸阿扎那韦 |
米法莫肽 | 丙谷美辛 |
洛匹那韦+利托那韦 | 己酸羟孕酮 |
利托那韦 | 利福喷汀 |
利托那韦,软凝胶-2 | 索法酮 |
甲氯芬那酸钠 | 莫维a胺 |
阿法骨化醇 | 维拉帕米 |
乙哌仑钠 | 维拉帕米 |
他莫昔芬 | 维拉帕米,OROS |
他莫昔芬 | 维拉帕米 |
枸橼酸托瑞米芬 | 维拉帕米 |
他莫昔芬,口服液,Savient | 维拉帕米SR |
Efamol Marine | 群多普利+维拉帕米 |
特康唑 | 维拉帕米 |
氟伐他汀 | 盐酸维拉帕米 |
氟伐他汀,延长释放 | 缬沙坦 |
氯沙坦+HCTZ | 缬沙坦+HCTZ |
氯沙坦钾 | 氨氯地平+缬沙坦 |
氨氯地平+氯沙坦 | 恩杂鲁胺(enzalutamide) |
(S)-氨氯地平+氯沙坦 | Sm153lexidronam |
二丙酸倍氯米松,3M | 芦比前列酮 |
二丙酸倍氯米松,LA | 帕立骨化醇 |
克霉唑 | 帕立骨化醇,口服 |
二丙酸倍氯米松,Dai | 阿米庚酸 |
倍氯米松+福莫特罗 | 异丙基乌诺前列酮 |
精氨酸血红素 | 洛哌丁胺 |
托特罗定 | 洛哌丁胺 |
托特罗定,延长释放 | 普美孕酮 |
奥昔康唑 | 盐酸舍曲林 |
赋形剂/药物 | 制造商 |
氟替卡松 | Hovione |
甲基纤维素(15cP) | ShinEtsu |
苯扎氯铵(BKC) | Sigma-Aldrich |
聚丙二醇400 | Alfa Aesar |
聚乙二醇400 | Spectrum Chemical |
吐温80 | Spectrum Chemical |
(克) | (%) | |
丙酸氟替卡松 | 2.282 | 0.46 |
吐温80 | 38.337 | 7.66 |
PEG 400 | 115.994 | 23.17 |
PPG 400 | 343.987 | 68.71 |
25℃退火 | |||
时间 | 粒度(nm)1 | 粒度(nm)2 | 粒度(nm)3 |
t0(滴定(tiration)后) | 748.90 | 768.10 | 678.60 |
t1(+98小时) | 596 | 510.8 | 509.2 |
40℃退火 | |||
时间 | 粒度(nm)1 | 粒度(nm)2 | 粒度(nm)3 |
t0(滴定(tiration)后) | 748.90 | 768.10 | 678.60 |
t1(+98小时) | 596.9 | 441.8 | 766.3 |
组分 | 克 | % |
丙酸氟替卡松 | 3.15 | 0.09 |
吐温80 | 53.13 | 1.52 |
聚丙二醇400 | 481.67 | 13.762 |
聚乙二醇400 | 162.05 | 4.63 |
甲基纤维素15cP | 11.2 | 0.32 |
PEG40硬脂酸酯 | 2.8 | 0.08 |
苯扎氯铵 | 0.14 | 0.004 |
柠檬酸盐缓冲液(0.1M),pH 5 | 44.8 | 1.28 |
水 | 2714.06 | 78.32 |
25℃退火 | |||
时间 | 粒度d50,(nm)1 | 粒度d50,(nm)2 | 粒度d50,(nm)3 |
t0(滴定后) | 748.90 | 768.10 | 678.60 |
t1(+98小时) | 596 | 510.8 | 509.2 |
40℃退火 | |||
时间 | 粒度(nm)1 | 粒度(nm)2 | 粒度(nm)3 |
t0(滴定后) | 748.90 | 768.10 | 678.60 |
t1(+98小时) | 296.9 | 441.8 | 766.3 |
成分 | 组成(%) | 预期功能 |
丙酸氟替卡松 | 0.250 | 活性剂 |
苯扎氯铵 | 0.005 | 防腐剂 |
聚山梨酯80 | 0.200 | 包衣分散剂 |
甘油 | 1.000 | 组织湿润剂 |
PEG硬脂酸酯 | 0.200 | 包衣分散剂 |
甲基纤维素4000cP | 0.500 | 聚合的稳定剂 |
氯化钠 | 0.500 | 张度调节剂 |
磷酸氢二钠 | 0.022 | 缓冲剂 |
磷酸二氢钠 | 0.040 | 缓冲剂 |
水 | 97.340 |
成分 | 组成(%) | 预期功能 |
丙酸氟替卡松 | 0.250 | 活性剂 |
苯扎氯铵 | 0.005 | 防腐剂 |
甘油 | 1.000 | 组织湿润剂 |
泰洛沙泊 | 0.200 | 包衣分散剂 |
甲基纤维素4000cP | 0.500 | 聚合的稳定剂 |
氯化钠 | 0.500 | 张度调节剂 |
磷酸氢二钠 | 0.022 | 缓冲剂 |
磷酸二氢钠 | 0.040 | 缓冲剂 |
水 | 97.483 |
Foamec-1 | 聚氨酯 | 聚酯 | 25-3318-U | 25-3318-H | 25-8032PD | 25-8061-PAR | 药棉拭子 |
6.9-22.17 | 1.06 | 0.41 | 13.92 | 18.71 | 14.39 | 1.03 | 0.94 |
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