CN104349779A - Pi-3激酶抑制剂的剂量方案 - Google Patents

Pi-3激酶抑制剂的剂量方案 Download PDF

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Publication number
CN104349779A
CN104349779A CN201380025377.6A CN201380025377A CN104349779A CN 104349779 A CN104349779 A CN 104349779A CN 201380025377 A CN201380025377 A CN 201380025377A CN 104349779 A CN104349779 A CN 104349779A
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Prior art keywords
cancer
substituted
groups
compound
pharmaceutically acceptable
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CN201380025377.6A
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English (en)
Chinese (zh)
Inventor
S·希拉瓦特
C·马萨克斯
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Novartis AG
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Novartis AG
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48626588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN104349779(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN104349779A publication Critical patent/CN104349779A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201380025377.6A 2012-05-16 2013-05-14 Pi-3激酶抑制剂的剂量方案 Pending CN104349779A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261647654P 2012-05-16 2012-05-16
US61/647,654 2012-05-16
PCT/US2013/040877 WO2013173283A1 (en) 2012-05-16 2013-05-14 Dosage regimen for a pi-3 kinase inhibitor

Publications (1)

Publication Number Publication Date
CN104349779A true CN104349779A (zh) 2015-02-11

Family

ID=48626588

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380025377.6A Pending CN104349779A (zh) 2012-05-16 2013-05-14 Pi-3激酶抑制剂的剂量方案

Country Status (19)

Country Link
US (2) US10213432B2 (enExample)
EP (1) EP2849756A1 (enExample)
JP (2) JP6381523B2 (enExample)
KR (1) KR20150009540A (enExample)
CN (1) CN104349779A (enExample)
AU (1) AU2013263043B2 (enExample)
BR (1) BR112014028420A2 (enExample)
CA (1) CA2872526A1 (enExample)
CL (1) CL2014003101A1 (enExample)
HK (1) HK1202435A1 (enExample)
IL (1) IL235567B (enExample)
MX (1) MX360892B (enExample)
NZ (1) NZ700924A (enExample)
PH (1) PH12014502547A1 (enExample)
RU (1) RU2630975C2 (enExample)
SG (2) SG10201608469RA (enExample)
TN (1) TN2014000433A1 (enExample)
WO (1) WO2013173283A1 (enExample)
ZA (1) ZA201407406B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108472289A (zh) * 2015-11-02 2018-08-31 诺华股份有限公司 磷脂酰肌醇3-激酶抑制剂的给药方案

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MX342326B (es) 2011-09-27 2016-09-26 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
PE20151939A1 (es) 2013-03-14 2016-01-08 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante
CA2930359C (en) 2013-12-06 2022-03-01 Novartis Ag Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor
WO2016109426A1 (en) * 2014-12-29 2016-07-07 Verastem, Inc. Oral dosing regimen of a dual mtor and pi3 inhibitor
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WO2018009895A1 (en) * 2016-07-08 2018-01-11 Autotelic Llc Methods for trabedersen dosing by auc

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN108472289A (zh) * 2015-11-02 2018-08-31 诺华股份有限公司 磷脂酰肌醇3-激酶抑制剂的给药方案

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US20150141426A1 (en) 2015-05-21
JP2015517523A (ja) 2015-06-22
IL235567B (en) 2019-08-29
MX2014013904A (es) 2015-01-16
RU2630975C2 (ru) 2017-09-15
HK1202435A1 (en) 2015-10-02
IL235567A0 (en) 2015-01-29
NZ700924A (en) 2016-02-26
CA2872526A1 (en) 2013-11-21
AU2013263043B2 (en) 2016-06-16
ZA201407406B (en) 2015-11-25
AU2013263043A1 (en) 2014-10-30
PH12014502547A1 (en) 2015-01-21
SG10201608469RA (en) 2016-11-29
MX360892B (es) 2018-11-20
EP2849756A1 (en) 2015-03-25
BR112014028420A2 (pt) 2017-09-19
SG11201406550QA (en) 2014-11-27
US20190134052A1 (en) 2019-05-09
WO2013173283A1 (en) 2013-11-21
JP2018108998A (ja) 2018-07-12
JP6381523B2 (ja) 2018-08-29
CL2014003101A1 (es) 2015-02-27
RU2014150860A (ru) 2016-07-10
TN2014000433A1 (en) 2016-03-30
US10213432B2 (en) 2019-02-26
KR20150009540A (ko) 2015-01-26

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Application publication date: 20150211