RU2630975C2 - Режим дозирования pi-3 киназы - Google Patents
Режим дозирования pi-3 киназы Download PDFInfo
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- RU2630975C2 RU2630975C2 RU2014150860A RU2014150860A RU2630975C2 RU 2630975 C2 RU2630975 C2 RU 2630975C2 RU 2014150860 A RU2014150860 A RU 2014150860A RU 2014150860 A RU2014150860 A RU 2014150860A RU 2630975 C2 RU2630975 C2 RU 2630975C2
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- compound
- pharmaceutically acceptable
- acceptable salt
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- cancer
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- CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 229940053867 xeloda Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261647654P | 2012-05-16 | 2012-05-16 | |
| US61/647,654 | 2012-05-16 | ||
| PCT/US2013/040877 WO2013173283A1 (en) | 2012-05-16 | 2013-05-14 | Dosage regimen for a pi-3 kinase inhibitor |
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| Publication Number | Publication Date |
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| RU2014150860A RU2014150860A (ru) | 2016-07-10 |
| RU2630975C2 true RU2630975C2 (ru) | 2017-09-15 |
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| RU2014150860A RU2630975C2 (ru) | 2012-05-16 | 2013-05-14 | Режим дозирования pi-3 киназы |
Country Status (19)
| Country | Link |
|---|---|
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| EP (1) | EP2849756A1 (enExample) |
| JP (2) | JP6381523B2 (enExample) |
| KR (1) | KR20150009540A (enExample) |
| CN (1) | CN104349779A (enExample) |
| AU (1) | AU2013263043B2 (enExample) |
| BR (1) | BR112014028420A2 (enExample) |
| CA (1) | CA2872526A1 (enExample) |
| CL (1) | CL2014003101A1 (enExample) |
| HK (1) | HK1202435A1 (enExample) |
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| MX (1) | MX360892B (enExample) |
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| PH (1) | PH12014502547A1 (enExample) |
| RU (1) | RU2630975C2 (enExample) |
| SG (2) | SG10201608469RA (enExample) |
| TN (1) | TN2014000433A1 (enExample) |
| WO (1) | WO2013173283A1 (enExample) |
| ZA (1) | ZA201407406B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6026544B2 (ja) | 2011-09-27 | 2016-11-16 | ノバルティス アーゲー | 変異体ｉｄｈの阻害剤としての３−ピリミジン−４−イル−オキサゾリジン−２−オン類 |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| US9296733B2 (en) * | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| GEP201706699B (en) | 2013-03-14 | 2017-07-10 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| CA2930359C (en) | 2013-12-06 | 2022-03-01 | Novartis Ag | Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor |
| WO2016109426A1 (en) * | 2014-12-29 | 2016-07-07 | Verastem, Inc. | Oral dosing regimen of a dual mtor and pi3 inhibitor |
| WO2017009751A1 (en) | 2015-07-15 | 2017-01-19 | Pfizer Inc. | Pyrimidine derivatives |
| RU2018119085A (ru) * | 2015-11-02 | 2019-12-04 | Новартис Аг | Схема введения ингибитора фосфатидилинозитол-3-киназы |
| WO2018009895A1 (en) * | 2016-07-08 | 2018-01-11 | Autotelic Llc | Methods for trabedersen dosing by auc |
Citations (2)
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| WO2005037341A2 (en) * | 2003-09-16 | 2005-04-28 | Research Development Foundation | Small particle aerosol liposomes for delivery of anti-cancer drugs |
| WO2007084786A1 (en) * | 2006-01-20 | 2007-07-26 | Novartis Ag | Pyrimidine derivatives used as pi-3 kinase inhibitors |
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-
2013
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- 2013-05-14 CN CN201380025377.6A patent/CN104349779A/zh active Pending
- 2013-05-14 SG SG10201608469RA patent/SG10201608469RA/en unknown
- 2013-05-14 KR KR1020147031775A patent/KR20150009540A/ko not_active Ceased
- 2013-05-14 MX MX2014013904A patent/MX360892B/es active IP Right Grant
- 2013-05-14 HK HK15103031.8A patent/HK1202435A1/xx unknown
- 2013-05-14 RU RU2014150860A patent/RU2630975C2/ru not_active IP Right Cessation
- 2013-05-14 SG SG11201406550QA patent/SG11201406550QA/en unknown
- 2013-05-14 EP EP13729120.9A patent/EP2849756A1/en not_active Withdrawn
- 2013-05-14 NZ NZ700924A patent/NZ700924A/en not_active IP Right Cessation
- 2013-05-14 AU AU2013263043A patent/AU2013263043B2/en not_active Ceased
- 2013-05-14 CA CA2872526A patent/CA2872526A1/en not_active Abandoned
- 2013-05-14 JP JP2015512735A patent/JP6381523B2/ja not_active Expired - Fee Related
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2014
- 2014-10-13 ZA ZA2014/07406A patent/ZA201407406B/en unknown
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2018
- 2018-01-12 JP JP2018003680A patent/JP2018108998A/ja active Pending
- 2018-12-21 US US16/230,737 patent/US20190134052A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005037341A2 (en) * | 2003-09-16 | 2005-04-28 | Research Development Foundation | Small particle aerosol liposomes for delivery of anti-cancer drugs |
| WO2007084786A1 (en) * | 2006-01-20 | 2007-07-26 | Novartis Ag | Pyrimidine derivatives used as pi-3 kinase inhibitors |
Non-Patent Citations (2)
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| CA2872526A1 (en) | 2013-11-21 |
| HK1202435A1 (en) | 2015-10-02 |
| AU2013263043B2 (en) | 2016-06-16 |
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| SG11201406550QA (en) | 2014-11-27 |
| PH12014502547A1 (en) | 2015-01-21 |
| BR112014028420A2 (pt) | 2017-09-19 |
| EP2849756A1 (en) | 2015-03-25 |
| JP6381523B2 (ja) | 2018-08-29 |
| JP2015517523A (ja) | 2015-06-22 |
| TN2014000433A1 (en) | 2016-03-30 |
| CL2014003101A1 (es) | 2015-02-27 |
| US20150141426A1 (en) | 2015-05-21 |
| NZ700924A (en) | 2016-02-26 |
| CN104349779A (zh) | 2015-02-11 |
| KR20150009540A (ko) | 2015-01-26 |
| MX360892B (es) | 2018-11-20 |
| SG10201608469RA (en) | 2016-11-29 |
| JP2018108998A (ja) | 2018-07-12 |
| MX2014013904A (es) | 2015-01-16 |
| US10213432B2 (en) | 2019-02-26 |
| US20190134052A1 (en) | 2019-05-09 |
| ZA201407406B (en) | 2015-11-25 |
| RU2014150860A (ru) | 2016-07-10 |
| IL235567A0 (en) | 2015-01-29 |
| AU2013263043A1 (en) | 2014-10-30 |
| WO2013173283A1 (en) | 2013-11-21 |
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