CN104254325A - 双胍组合物和治疗代谢性病症的方法 - Google Patents
双胍组合物和治疗代谢性病症的方法 Download PDFInfo
- Publication number
- CN104254325A CN104254325A CN201280070968.0A CN201280070968A CN104254325A CN 104254325 A CN104254325 A CN 104254325A CN 201280070968 A CN201280070968 A CN 201280070968A CN 104254325 A CN104254325 A CN 104254325A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- optionally substituted
- composition
- subject
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CN(*)c1nc(*)nc(N(*)*)n1 Chemical compound CN(*)c1nc(*)nc(N(*)*)n1 0.000 description 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Molecular Biology (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910957458.9A CN110693868A (zh) | 2012-01-06 | 2012-07-11 | 双胍组合物和治疗代谢性病症的方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/345135 | 2012-01-06 | ||
| PCT/US2012/020548 WO2012094636A2 (en) | 2011-01-07 | 2012-01-06 | Chemosensory receptor ligand-based therapies |
| USPCT/US2012/020548 | 2012-01-06 | ||
| US13/345,135 US20120177730A1 (en) | 2011-01-07 | 2012-01-06 | Chemosensory Receptor Ligand-Based Therapies |
| US201261649171P | 2012-05-18 | 2012-05-18 | |
| US61/649171 | 2012-05-18 | ||
| PCT/US2012/046335 WO2013103384A1 (en) | 2012-01-06 | 2012-07-11 | Biguanide compositions and methods of treating metabolic disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910957458.9A Division CN110693868A (zh) | 2012-01-06 | 2012-07-11 | 双胍组合物和治疗代谢性病症的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104254325A true CN104254325A (zh) | 2014-12-31 |
Family
ID=48745353
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280070968.0A Pending CN104254325A (zh) | 2012-01-06 | 2012-07-11 | 双胍组合物和治疗代谢性病症的方法 |
| CN201910957458.9A Pending CN110693868A (zh) | 2012-01-06 | 2012-07-11 | 双胍组合物和治疗代谢性病症的方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910957458.9A Pending CN110693868A (zh) | 2012-01-06 | 2012-07-11 | 双胍组合物和治疗代谢性病症的方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10154972B2 (enExample) |
| EP (1) | EP2800561B1 (enExample) |
| JP (4) | JP2015503582A (enExample) |
| KR (4) | KR102035879B1 (enExample) |
| CN (2) | CN104254325A (enExample) |
| AU (2) | AU2012363873B2 (enExample) |
| BR (1) | BR112014016808B1 (enExample) |
| CA (1) | CA2862533C (enExample) |
| EA (1) | EA201491335A1 (enExample) |
| ES (1) | ES2832773T3 (enExample) |
| IL (1) | IL233506B (enExample) |
| MX (2) | MX2014008190A (enExample) |
| SG (2) | SG11201403839SA (enExample) |
| WO (1) | WO2013103384A1 (enExample) |
| ZA (1) | ZA201405046B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112739336A (zh) * | 2018-09-28 | 2021-04-30 | 雀巢产品有限公司 | 增强二甲双胍作用的化合物 |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9480663B2 (en) | 2011-01-07 | 2016-11-01 | Elcelyx Therapeutics, Inc. | Biguanide compositions and methods of treating metabolic disorders |
| US9211263B2 (en) | 2012-01-06 | 2015-12-15 | Elcelyx Therapeutics, Inc. | Compositions and methods of treating metabolic disorders |
| US11759441B2 (en) | 2011-01-07 | 2023-09-19 | Anji Pharmaceuticals Inc. | Biguanide compositions and methods of treating metabolic disorders |
| US11974971B2 (en) | 2011-01-07 | 2024-05-07 | Anji Pharmaceuticals Inc. | Compositions and methods for treating metabolic disorders |
| WO2012094636A2 (en) | 2011-01-07 | 2012-07-12 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
| US8796338B2 (en) | 2011-01-07 | 2014-08-05 | Elcelyx Therapeutics, Inc | Biguanide compositions and methods of treating metabolic disorders |
| US9572784B2 (en) | 2011-01-07 | 2017-02-21 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| CN104349773A (zh) | 2012-01-06 | 2015-02-11 | 埃尔舍利克斯治疗公司 | 用于治疗代谢性病症的组合物和方法 |
| BR112014016808B1 (pt) * | 2012-01-06 | 2022-01-11 | Anji Pharma (Us) Llc | Uso de um composto de biguanida para a fabricação de um medicamento para baixar os níveis de glicose no sangue e para o tratamento de um distúrbio do metabolismo de glicose |
| US20140010783A1 (en) * | 2012-07-06 | 2014-01-09 | Hoffmann-La Roche Inc. | Antiviral compounds |
| KR101994145B1 (ko) * | 2013-01-28 | 2019-07-01 | 한올바이오파마주식회사 | Ν1-고리아민-ν5-치환된 바이구아나이드 유도체를 유효성분으로 함유하는 시차증후군의 예방 또는 치료용 약학 조성물 |
| JP2016510050A (ja) * | 2013-03-05 | 2016-04-04 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗ウイルス性化合物 |
| WO2014135483A1 (en) * | 2013-03-05 | 2014-09-12 | F. Hoffmann-La Roche Ag | Antiviral compounds |
| KR102088001B1 (ko) * | 2013-05-23 | 2020-03-12 | 이뮤노메트테라퓨틱스 인코포레이티드 | N1-고리아민-n5-치환된 바이구아나이드 유도체를 유효성분으로 함유하는 섬유화 예방 또는 치료용 약학 조성물 |
| KR102061390B1 (ko) | 2014-04-17 | 2019-12-31 | 이뮤노메트테라퓨틱스 인코포레이티드 | 구아니딘 화합물 및 그의 용도 |
| CN107205968B (zh) * | 2014-08-14 | 2021-08-20 | 威斯康星州医药大学股份有限公司 | 修饰的线粒体-二甲双胍化合物及其合成和使用方法 |
| CA2978885A1 (en) * | 2015-03-06 | 2016-09-15 | The University Of North Carolina At Chapel Hill | Polymeric metformin and its use as a therapeutic agent and as a delivery vehicle |
| CZ307146B6 (cs) * | 2015-03-31 | 2018-02-07 | Kkcg Se | Trifenylfosfoniové analogy biguanidu, způsob jejich přípravy a jejich použití jako léčiva |
| WO2018058109A1 (en) * | 2016-09-26 | 2018-03-29 | Nusirt Sciences, Inc. | Compositions and methods for treating metabolic disorders |
| WO2018132768A1 (en) * | 2017-01-13 | 2018-07-19 | Sanna Pietro P | Methods and compositions for treating hpa hyperactivity |
| US20210046011A1 (en) | 2019-08-12 | 2021-02-18 | Massachusetts Institute Of Technology | Articles and methods for administration of therapeutic agents |
| KR20220113942A (ko) * | 2019-12-13 | 2022-08-17 | 스미토모 파마 가부시키가이샤 | 제조성 및 용출성이 우수한 소형 정제 |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| WO2023102190A2 (en) * | 2021-12-02 | 2023-06-08 | The Medical College Of Wisconsin, Inc. | Improved compositions and methods for targeting mitochondria in cancer cells |
| CN118141793A (zh) * | 2022-05-17 | 2024-06-07 | 中国医学科学院基础医学研究所 | 二甲双胍及其它含胍化合物溶解夏科-莱登结晶并缓解急性肺损伤炎症中的应用 |
| CN121846068A (zh) | 2023-08-22 | 2026-04-14 | 雅研(天津)生物医药科技中心(有限合伙) | 盐酸二甲双胍肠溶制剂 |
| CN119499203A (zh) | 2023-08-22 | 2025-02-25 | 雅研(天津)生物医药科技中心(有限合伙) | 一种盐酸二甲双胍肠溶片 |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060222709A1 (en) * | 2005-03-18 | 2006-10-05 | Agi Therapeutics Research Ltd. | Metformin methods and formulations for treating chronic constipation |
| CN101978956A (zh) * | 2010-10-13 | 2011-02-23 | 北京京丰制药有限公司 | 盐酸二甲双胍肠溶片及其制备方法 |
Family Cites Families (201)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| JPS58403B2 (ja) | 1975-07-24 | 1983-01-06 | 武田薬品工業株式会社 | L− アスコルビンサンセイザイノ セイゾウホウ |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US4775536A (en) | 1986-02-24 | 1988-10-04 | Bristol-Myers Company | Enteric coated tablet and process for making |
| US5068110A (en) | 1987-09-29 | 1991-11-26 | Warner-Lambert Company | Stabilization of enteric coated dosage form |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| US5135757A (en) | 1988-09-19 | 1992-08-04 | Edward Mendell Co., Inc. | Compressible sustained release solid dosage forms |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5007790A (en) | 1989-04-11 | 1991-04-16 | Depomed Systems, Inc. | Sustained-release oral drug dosage form |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| FR2704146B1 (fr) | 1993-04-19 | 1995-07-13 | Cripdom | Microcapsules d'acide acétylsalicylique à libération contrôlée. |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US5773025A (en) | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
| US5589194A (en) | 1993-09-20 | 1996-12-31 | Minnesota Mining And Manufacturing Company | Method of encapsulation and microcapsules produced thereby |
| GB9412394D0 (en) | 1994-06-21 | 1994-08-10 | Danbiosyst Uk | Colonic drug delivery composition |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| FR2725623A1 (fr) | 1994-10-18 | 1996-04-19 | Flamel Tech Sa | Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os |
| JPH08143476A (ja) | 1994-11-18 | 1996-06-04 | Japan Tobacco Inc | 薬物放出制御膜及び固形製剤 |
| SK141899A3 (en) | 1997-04-15 | 2000-09-12 | Csir Corporate Building | Pharmaceutical compositions having appetite suppressant activity |
| TR199903057T2 (xx) | 1997-06-18 | 2000-04-21 | Smithkline Beecham Plc | Diabetin tiazolidinedion ve metformin ile tedavisi. |
| US5891919A (en) | 1997-09-19 | 1999-04-06 | Burlington Bio-Medical & Scientific Corp. | Denatonium capsaicinate and methods of producing the same |
| EP1052994A2 (en) | 1998-02-02 | 2000-11-22 | Trustees Of Tufts College | Use of dipeptidylpetidase inhibitors to regulate glucose metabolism |
| WO1999047128A1 (en) | 1998-03-19 | 1999-09-23 | Bristol-Myers Squibb Company | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
| US6099859A (en) | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| US6191162B1 (en) | 1998-05-28 | 2001-02-20 | Medical Research Institute | Method of reducing serum glucose levels |
| DE69942453D1 (de) | 1998-05-29 | 2010-07-15 | Jgc Catalysts & Chemicals Ltd | Verfahren zur herstellung photoelektrischer zellen |
| US6099862A (en) | 1998-08-31 | 2000-08-08 | Andrx Corporation | Oral dosage form for the controlled release of a biguanide and sulfonylurea |
| US20040081697A1 (en) | 1998-11-12 | 2004-04-29 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| WO2000028989A1 (en) | 1998-11-12 | 2000-05-25 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| TW514510B (en) | 1999-06-11 | 2002-12-21 | Tanita Seisakusho Kk | Method and apparatus for measuring distribution of body fat |
| ITMI991316A1 (it) | 1999-06-14 | 2000-12-14 | Cip Ninety Two 92 S A | Composizioni farmaceutiche orali a rilascio modificato di mesalazina |
| DE19940944B4 (de) | 1999-08-31 | 2006-10-12 | Grünenthal GmbH | Retardierte, orale, pharmazeutische Darreichungsformen |
| CO5200844A1 (es) | 1999-09-17 | 2002-09-27 | Novartis Ag | Una combinacion que comprende nateglinida y cuando por menos otro compuesto antidiabetico usada para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con dibetes |
| US6530886B1 (en) | 1999-10-08 | 2003-03-11 | Tanita Corporation | Method and apparatus for measuring subcutaneous fat using ultrasonic wave |
| IL132313A0 (en) | 1999-10-11 | 2001-03-19 | Yeda Res & Dev | Leptin assay |
| US6586438B2 (en) | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| MY125516A (en) | 1999-11-16 | 2006-08-30 | Smithkline Beecham Plc | Novel composition based on thiazolidinedione and metformin and use |
| US6676966B1 (en) | 2000-05-09 | 2004-01-13 | Intellipharmaceutics Corp. | Extended release metformin hydrochloride formulations |
| TW515705B (en) | 2000-05-31 | 2003-01-01 | Yamato Scale Co Ltd | Visceral fat meter |
| US6451808B1 (en) | 2000-10-17 | 2002-09-17 | Depomed, Inc. | Inhibition of emetic effect of metformin with 5-HT3 receptor antagonists |
| US6689385B2 (en) | 2000-11-03 | 2004-02-10 | Chronorx Llc | Formulations for the treatment of insulin resistance and type 2 diabetes mellitus |
| US6790459B1 (en) | 2000-11-03 | 2004-09-14 | Andrx Labs, Llc | Methods for treating diabetes via administration of controlled release metformin |
| US20110217394A1 (en) | 2000-12-05 | 2011-09-08 | Brett Justin West | Iridoid Based Formulations |
| US7964216B2 (en) | 2001-01-12 | 2011-06-21 | Sun Pharma Advanced Research Company Limited | Spaced drug delivery system |
| KR100380147B1 (ko) | 2001-01-18 | 2003-04-11 | 주식회사 엘지생명과학 | 류마티스성 자가면역 항체의 검출방법 및 검출키트 |
| US7998947B2 (en) | 2001-03-28 | 2011-08-16 | University Of South Florida | Materials and methods for treatment of cancer and identification of anti-cancer compounds |
| US7883856B2 (en) | 2001-04-05 | 2011-02-08 | Senomyx Inc. | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
| US8030008B2 (en) | 2001-04-05 | 2011-10-04 | Senomyx, Inc. | Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators |
| US20040156900A1 (en) | 2001-04-10 | 2004-08-12 | Shanghvi Dilip Shantilal | Time pulsed release composition |
| JP4848558B2 (ja) * | 2001-05-08 | 2011-12-28 | トーアエイヨー株式会社 | 塩酸メトホルミン含有速放性錠剤 |
| FR2825023B1 (fr) | 2001-05-23 | 2005-04-15 | Flamel Tech Sa | Forme pharmaceutique orale antidiabetique "une prise par jour"comprenant une biguanide et au moins un autre principe actif |
| WO2003004009A1 (en) | 2001-07-02 | 2003-01-16 | Geneva Pharmaceuticals, Inc. | Pharmaceutical composition |
| US20030007420A1 (en) | 2001-07-05 | 2003-01-09 | Koninklijke Philips Electronics N.V. | Dial face of watch graphically represents calendar |
| UA74912C2 (en) | 2001-07-06 | 2006-02-15 | Merck & Co Inc | Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes |
| US6642003B2 (en) | 2001-08-02 | 2003-11-04 | Cedars-Sinai Medical Center | Human glucose-dependent insulin-secreting cell line |
| KR20040044992A (ko) | 2001-09-28 | 2004-05-31 | 썬 파마슈티컬 인더스트리스 리미티드 | 당뇨병 치료용 투여형태 |
| FR2830447B1 (fr) | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques |
| EP1465612A1 (en) | 2001-11-06 | 2004-10-13 | Ranbaxy Laboratories Limited | Controlled release tablets of metformin |
| US6709251B2 (en) | 2001-11-16 | 2004-03-23 | Mgs Enterprises, Inc. | Self-contained frameless rotating mold support |
| ITFI20010230A1 (it) | 2001-11-29 | 2003-05-29 | Menarini Int Operations Lu Sa | Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii |
| US20030113366A1 (en) * | 2001-12-14 | 2003-06-19 | Macgregor Alexander | Reverse-micellar delivery system for controlled transportation and enhanced absorption of agents |
| US7183321B2 (en) | 2001-12-17 | 2007-02-27 | Bristol-Myers Squibb Company | Antidiabetic formulation and method |
| AU2003211131A1 (en) * | 2002-02-14 | 2003-09-04 | Sonus Pharmaceuticals, Inc. | Metformin salts of lipophilic acids |
| US20030171407A1 (en) | 2002-03-07 | 2003-09-11 | Upsher-Smith Laboratories, Inc. | Composition for reducing blood glucose and cholesterol |
| US6830759B2 (en) | 2002-06-28 | 2004-12-14 | Ajinomoto Co., Inc. | Antidiabetic preparation for oral administration |
| US20060019346A1 (en) | 2002-07-29 | 2006-01-26 | Senomyx, Inc. | Identification of a novel bitter taste receptor T2R76 that specifically responds to brucine and prop bitter ligands |
| AU2003261298A1 (en) * | 2002-08-02 | 2004-02-23 | Penwest Pharmaceuticals Company | Sustained release formulations of metformin |
| CN1413582A (zh) * | 2002-11-29 | 2003-04-30 | 贵州圣济堂制药有限公司 | 盐酸二甲双胍肠溶片及其制备方法 |
| EP1581555B1 (en) | 2002-12-18 | 2008-04-30 | Givaudan SA | Chimeric alpha q-gustducin g-proteins |
| DE10308504A1 (de) | 2003-02-26 | 2004-09-09 | Basf Ag | Enzymatische Herstellung von (Meth)acrylsäureestern |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| US20070099884A1 (en) | 2003-06-06 | 2007-05-03 | Erondu Ngozi E | Combination therapy for the treatment of diabetes |
| CN1805738A (zh) | 2003-06-16 | 2006-07-19 | 兰贝克赛实验室有限公司 | 持续释放的二甲双胍片剂 |
| WO2005009351A2 (en) | 2003-07-17 | 2005-02-03 | Santé International, Inc. | Dietary supplement for promoting control of blood-sugar levels and associated pathology in type 2 diabetics |
| WO2005023766A1 (en) | 2003-09-11 | 2005-03-17 | Biocon Limited | Salt of atorvastatin with metformin |
| EA200600598A1 (ru) | 2003-09-19 | 2006-08-25 | Пенвест Фармасьютикалз Ко. | Лекарственные формы замедленного высвобождения |
| RU2006118801A (ru) | 2003-10-31 | 2007-12-10 | Алза Корпорейшн (Us) | Композиции и лекарственные формы для усиления всасывания габапентина и прегабалина |
| CN1901880A (zh) | 2003-10-31 | 2007-01-24 | 阿尔扎公司 | 用于增加二甲双胍吸收的组合物和剂型 |
| TWI350751B (en) | 2003-12-19 | 2011-10-21 | Omega Bio Pharma Ip3 Ltd | Pharmaceutical compositions for treating diabetes |
| WO2005060942A1 (en) | 2003-12-19 | 2005-07-07 | Aurobindo Pharma Ltd | Extended release pharmaceutical composition of metformin |
| EP1591114A1 (en) | 2004-03-12 | 2005-11-02 | Fournier Laboratories Ireland Limited | Use of metformin and orlistat for the treatment or prevention of obesity |
| CN1561980A (zh) * | 2004-03-26 | 2005-01-12 | 贵州圣济堂制药有限公司 | 盐酸二甲双胍肠溶缓释制剂及其制备方法 |
| EP1737442B1 (en) | 2004-04-20 | 2015-01-07 | Deutsches Institut Für Ernährungsforschung - Stiftung Des Öffentlichen Rechts - Vertreten Durch Den Stiftungsvorstand | Agonists of a bitter taste receptor and uses thereof |
| DE102004036437A1 (de) | 2004-07-27 | 2006-03-23 | Röhm GmbH & Co. KG | Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform |
| US20060024335A1 (en) | 2004-07-29 | 2006-02-02 | Roger Stier E | Oral compositions which mask the bitter taste of a bitter-tasting agent |
| AU2005271526B2 (en) | 2004-08-03 | 2011-12-08 | Emisphere Technologies, Inc. | Antidiabetic oral insulin-biguanide combination |
| WO2006053771A2 (en) | 2004-11-18 | 2006-05-26 | Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke Stiftung Des Öffentlichen Rechts | Agonists of bitter taste receptors and uses thereof |
| TW200640497A (en) | 2005-01-21 | 2006-12-01 | Pharmanova Inc | Pharmaceutical formulations and methods of use |
| US20090124702A1 (en) | 2005-01-25 | 2009-05-14 | Pechetti Siva Satya Krishna Babu | Pharmaceutical Compositions of Metformin |
| US20070032420A1 (en) | 2005-02-09 | 2007-02-08 | Entelos, Inc. | Treating diabetes with glucagon-like peptide-1 secretagogues |
| WO2006104401A1 (en) | 2005-03-26 | 2006-10-05 | Protemix Corporation Limited | Copper antagonist compositions |
| KR20080003849A (ko) | 2005-03-31 | 2008-01-08 | 아밀린 파마슈티칼스, 인크. | 비만 및 섭식 장애의 조절, 예방 및 치료를 위한 조성물 및방법 |
| WO2006109175A2 (en) | 2005-04-11 | 2006-10-19 | Aurobindo Pharma Limited | Solid dosage form of an antidiabetic drug |
| JP5056412B2 (ja) | 2005-04-28 | 2012-10-24 | 味の素株式会社 | 新規ラクタム化合物 |
| US20060269617A1 (en) | 2005-05-26 | 2006-11-30 | Suracell, Inc. | Supplement compositions and method of use for enhancement of insulin sensitivity |
| US7797782B2 (en) | 2005-06-21 | 2010-09-21 | Goody Products, Inc. | Handle having a ribbed gel grip |
| JP2009501317A (ja) | 2005-06-22 | 2009-01-15 | セノミクス・インコーポレーテッド | コーヒー中の苦味分子(クロロゲン酸ラクトン)により活性化されるヒトt2r受容体の同定、およびヒト苦味味覚モジュレーターを同定するための関連するアッセイ |
| CN1891229B (zh) * | 2005-07-07 | 2010-05-05 | 北京华安佛医药研究中心有限公司 | 预防或治疗代谢综合征的药物制剂 |
| US7700299B2 (en) | 2005-08-12 | 2010-04-20 | Hoffmann-La Roche Inc. | Method for predicting the response to a treatment |
| BRPI0615410A2 (pt) | 2005-08-30 | 2013-02-13 | Nicholas Piramal India Ltd | composiÇço farmacÊutica de liberaÇço prolongada de metformina e processo para produÇço da mesma |
| FR2891459B1 (fr) | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
| KR100831771B1 (ko) * | 2005-10-27 | 2008-05-27 | 주식회사종근당 | 서방출과 pH 의존성 속방출을 나타내는 약제학적 조성물 |
| US20070104805A1 (en) | 2005-11-01 | 2007-05-10 | Udell Ronald G | Compositions of Hoodia Gordonii and Pinolenic Acid Derivatives |
| GB0526291D0 (en) | 2005-12-23 | 2006-02-01 | Prosidion Ltd | Therapeutic method |
| JP2007215162A (ja) | 2006-01-11 | 2007-08-23 | Canon Inc | 情報処理装置及びその制御方法、プログラム、記憶媒体 |
| TW200808380A (en) | 2006-02-21 | 2008-02-16 | Shinetsu Chemical Co | Enteric-coated preparation for site-specific delivery of drug to site within the small intestine |
| US20070207227A1 (en) | 2006-02-23 | 2007-09-06 | Conopco, Inc., D/B/A Unilever, A Corporation Of New York | Appetite suppressant compositions |
| WO2007116404A2 (en) | 2006-04-10 | 2007-10-18 | Bar-Ilan University | Cucurbitacin glucosides and use thereof in treating cancer |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| CA2551706A1 (en) | 2006-06-27 | 2007-12-27 | Innovative Life Sciences Corporation | Herbal product comprising cinnamon and bitter melon |
| CN100596277C (zh) | 2006-07-10 | 2010-03-31 | 博仲盛景医药技术(北京)有限公司 | 一种促进肠胃蠕动的药物组合物 |
| WO2008019920A1 (en) | 2006-08-17 | 2008-02-21 | Unilever N.V. | Processes for production of hoodia plant extracts containing steroidal glycosides |
| MX2009001866A (es) | 2006-08-24 | 2009-03-02 | Unilever Nv | Proceso para la preparacion de una composicion que comprende glucosidos esteroides. |
| US7811788B2 (en) | 2006-09-05 | 2010-10-12 | Senomyx Inc. | Nucleic acid encoding a haplotype of human T2R receptor hT2R50 |
| US20080107787A1 (en) | 2006-11-02 | 2008-05-08 | The Coca-Cola Company | Anti-Diabetic Composition with High-Potency Sweetener |
| DE602007005402D1 (de) | 2006-11-09 | 2010-04-29 | Orexigen Therapeutics Inc | Mehrschichtige pharmazeutische formulierungen mit einer schnell auflösenden zwischenschicht |
| WO2008058355A2 (en) | 2006-11-16 | 2008-05-22 | Walter Santos Junior | Descriptive report of patent of invention of the medicament 'atorvastatin + metformin' in combined form for cardiovascular diseases |
| BRMU8602999U (pt) | 2006-11-16 | 2008-07-08 | Walter Junior Santos | medicamento "rosuvastatina + metformina" em forma combinada para doenças cardiovasculares |
| CN101190179B (zh) * | 2006-11-20 | 2010-05-12 | 北京利龄恒泰药业有限公司 | 一种治疗糖尿病的肠溶药物组合物及其制备方法 |
| WO2008093984A1 (en) | 2007-01-29 | 2008-08-07 | Hanall Pharmaceutical Company. Ltd | N, n- dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same |
| EP2139464A1 (en) | 2007-03-15 | 2010-01-06 | Nectid, Inc. | Anti-diabetic combinations comprising a slow release biguanide composition and an immediate release dipeptidyl peptidase iv inhibitor composition |
| US20070172525A1 (en) | 2007-03-15 | 2007-07-26 | Ramesh Sesha | Anti-diabetic combinations |
| US20080064701A1 (en) | 2007-04-24 | 2008-03-13 | Ramesh Sesha | Anti-diabetic combinations |
| EP1975612A1 (en) | 2007-03-29 | 2008-10-01 | Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand | Agonists of bitter taste receptors and uses thereof |
| EP1975611A1 (en) | 2007-03-29 | 2008-10-01 | Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand | Agonists of bitter taste receptors and uses thereof |
| AU2008279447A1 (en) * | 2007-07-19 | 2009-01-29 | Metabolex, Inc. | N-azacyclic substituted pyrrole, pyrazole, imidazole, triazole and tetrazole derivatives as agonists of the RUP3 or GPR119 receptor for the treatment of diabetes and metabolic disorders |
| EP2023144A1 (en) | 2007-08-01 | 2009-02-11 | Sanofi-Aventis | Novel AS160-like protein, test systems, methods and uses involving it for the identification of diabetes type 2 therapeutics |
| US20090042813A1 (en) | 2007-08-10 | 2009-02-12 | Sergey Michailovich Melnikov | Hoodia extract oil compositions comprising medium chain triglycerides |
| US8076491B2 (en) | 2007-08-21 | 2011-12-13 | Senomyx, Inc. | Compounds that inhibit (block) bitter taste in composition and use thereof |
| WO2009053980A2 (en) | 2007-10-24 | 2009-04-30 | Arava Hoodia Growers A. C. S. Ltd. | An improved appetite suppressant |
| EP2236149B1 (en) | 2008-01-29 | 2014-06-18 | Nakamori Pharmaceutical Co., Ltd. | Medicinal composition for treating respiratory infectious diseases |
| AU2009220444A1 (en) | 2008-03-04 | 2009-09-11 | Merck Sharp & Dohme Corp. | Pharmaceutical compositions of a combination of metformin and a dipeptidyl peptidase-IV inhibitor |
| CN102065707B (zh) | 2008-05-23 | 2013-10-23 | 奇华顿股份有限公司 | 包含苦味阻断剂的含苦味生物碱的消费品 |
| CN101590007A (zh) * | 2008-05-27 | 2009-12-02 | 北京瑞伊人科技发展有限公司 | 一种盐酸二甲双胍/伏格列波糖降糖口服制剂组合物及其制备 |
| CN101695575A (zh) | 2008-05-29 | 2010-04-21 | 北京奥萨医药研究中心有限公司 | 含有他汀类降脂药物、双胍类降糖药物和烟酸的药物组合物 |
| WO2009149577A1 (en) | 2008-06-13 | 2009-12-17 | Givaudan Sa | Methods of identifying modulators of the bitter taste receptor tas2r44 |
| CN101339178B (zh) | 2008-08-07 | 2013-05-01 | 贵州天安药业股份有限公司 | 盐酸二甲双胍肠溶片的质量控制方法 |
| WO2010022529A1 (en) | 2008-08-29 | 2010-03-04 | Givaudan Sa | Methods to identify modulators |
| TWI469779B (zh) | 2008-08-29 | 2015-01-21 | Suntory Holdings Ltd | Novel epigallocatechin gallate 4, and its vascular endothelial function enhancer |
| WO2010045417A2 (en) | 2008-10-16 | 2010-04-22 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
| WO2010045656A2 (en) | 2008-10-17 | 2010-04-22 | Nectid, Inc. | Novel sglt2 inhibitor dosage forms |
| WO2010060198A1 (en) | 2008-11-26 | 2010-06-03 | West Central Envirotech Inc. | Composition and method for controlling insects |
| JP5485292B2 (ja) | 2008-12-12 | 2014-05-07 | ポクセル・エスアーエス | Ampk活性に関連する疾患を処置するためのテトラヒドロトリアジン化合物 |
| EP2385049A4 (en) | 2009-01-03 | 2012-08-08 | Shizuoka Prefecture Public University Corp | SULFATED C-GLYCOSIDE, METHOD FOR THE ISOLATION THEREOF AND METHOD FOR THE SYNTHESIS THEREOF |
| AR074990A1 (es) * | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| AU2010239311B2 (en) | 2009-04-20 | 2014-05-22 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
| US9901551B2 (en) | 2009-04-20 | 2018-02-27 | Ambra Bioscience Llc | Chemosensory receptor ligand-based therapies |
| US8828953B2 (en) | 2009-04-20 | 2014-09-09 | NaZura BioHealth, Inc. | Chemosensory receptor ligand-based therapies |
| WO2010151503A2 (en) * | 2009-06-25 | 2010-12-29 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
| WO2010151565A2 (en) | 2009-06-26 | 2010-12-29 | Metabolous Pharmaceuticals, Inc. | Combination therapies for the treatment of obesity |
| TW201105336A (en) | 2009-07-01 | 2011-02-16 | Kissei Pharmaceutical | Combined medicine of pyrazole derivative and biguanide drug |
| EP2283830A1 (en) | 2009-07-23 | 2011-02-16 | Actogenix N.V. | Aqueous enteric capsule coating |
| US8709745B2 (en) | 2009-07-28 | 2014-04-29 | Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke | Methods for isolating ligands of the human bitter taste receptor TAS2R49 |
| US20110082407A1 (en) | 2009-10-01 | 2011-04-07 | Aronne Louis J | Combination Therapies for the Treatment of Obesity |
| US20120202849A1 (en) | 2009-10-12 | 2012-08-09 | Anil Pareek | Pharmaceutical compositions for the treatment/prophylaxis of non-alcoholic fatty liver disease |
| US8349818B2 (en) | 2009-10-21 | 2013-01-08 | Wisconsin Alumni Research Foundation | Method of preventing Type 1 diabetes |
| CA2778015C (en) * | 2009-10-26 | 2016-08-02 | Warner Chilcott Company, Llc | Bisphosphonate compounds for treating bone metabolism disorders |
| EP2506933A1 (en) | 2009-12-04 | 2012-10-10 | Colgate-Palmolive Company | Oral compositions containing extracts of garcinia mangostana l. and related methods |
| EP2345646A1 (en) | 2010-01-14 | 2011-07-20 | InterMed Discovery GmbH | Use of tricyclic sesquiterpene lactones in the treatment of obesity and related diseases and non-therapeutic treatable conditions |
| CN101785763B (zh) * | 2010-02-04 | 2011-11-23 | 贵州天安药业股份有限公司 | 一种盐酸二甲双胍肠溶缓释片及其制备方法 |
| US20130273154A1 (en) | 2011-03-02 | 2013-10-17 | Joseph M. Fayad | Oral formulations Mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, Methods of Treatment, Diagnostics and Systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hpperlipidemia, and type 2 diabetes |
| US20140294951A1 (en) * | 2011-10-26 | 2014-10-02 | Joseph M. Fayad | Oral formulations mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, methods of treatment, diagnostics and systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hyperlipidemia, and T2D |
| CN105168174B (zh) | 2010-03-10 | 2019-01-08 | 拉尼医疗有限公司 | 用于利用可吞咽式药剂递送装置递送到肠道内腔中的治疗剂制剂 |
| US8276242B2 (en) | 2010-04-09 | 2012-10-02 | Girard Mylene | Adjustable handle assembly with locking mechanism |
| US8581001B2 (en) * | 2010-04-16 | 2013-11-12 | Codman & Shurtleff | Metformin-cysteine prodrug |
| US20110293753A1 (en) | 2010-05-28 | 2011-12-01 | Louis Bellafiore | Tocotrienol Compositions |
| TWI436768B (zh) | 2010-06-09 | 2014-05-11 | Poxel | 第2型糖尿病之治療 |
| GB201009873D0 (en) | 2010-06-14 | 2010-07-21 | Univ Leuven Kath | Method for hydrogenation of isoalpha-acids (isohumulones) to hexahydro-iso-alpha-acids (hexahydro-isohumulones) by using heterogeneous ruthenium |
| US20140235558A1 (en) | 2010-06-15 | 2014-08-21 | Hanall Biopharma Co., Ltd. | Pharmaceutical composition having activity of anticancer |
| KR101275258B1 (ko) | 2010-06-15 | 2013-06-17 | 한올바이오파마주식회사 | 항암 활성을 나타내는 약제학적 조성물 |
| WO2011159100A2 (ko) | 2010-06-15 | 2011-12-22 | 한올바이오파마주식회사 | 항암 활성을 나타내는 약제학적 조성물 |
| KR20160074015A (ko) | 2010-06-17 | 2016-06-27 | 캘리포니아 인스티튜트 오브 테크놀로지 | 호르몬을 조절하기 위한 방법 및 시스템 및 관련 방법, 작용제 및 조성물 |
| EP2397039A1 (en) | 2010-06-21 | 2011-12-21 | Abbott Laboratories | Compositions for delaying progression of diabetes using Salacia oblonga extract |
| PH12012502524A1 (en) | 2010-06-24 | 2014-02-10 | Boehringer Ingelheim Int | Diabetes therapy |
| MX2013000824A (es) | 2010-07-21 | 2013-10-28 | Nucitec Sa De Cv | Forma de dosificacion diaria unica para la prevencion y tratamiento del sindrome metabolico. |
| WO2012054530A2 (en) | 2010-10-19 | 2012-04-26 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
| EP2629617A4 (en) | 2010-10-19 | 2014-08-27 | Elcelyx Therapeutics Inc | THERAPIES BASED ON CHEMOSOUS RECEPTOR LIGANDS |
| WO2012054527A2 (en) | 2010-10-19 | 2012-04-26 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
| BR112013009635A2 (pt) | 2010-10-19 | 2016-07-12 | Elcelyx Therapeutics Inc | terapias à base de ligante de receptor quimiossensorial |
| EP2629609A4 (en) | 2010-10-19 | 2014-08-27 | Elcelyx Therapeutics Inc | THERAPIES BASED ON CHEMOSOUS RECEPTOR LIGANDS |
| US8796338B2 (en) | 2011-01-07 | 2014-08-05 | Elcelyx Therapeutics, Inc | Biguanide compositions and methods of treating metabolic disorders |
| US9480663B2 (en) | 2011-01-07 | 2016-11-01 | Elcelyx Therapeutics, Inc. | Biguanide compositions and methods of treating metabolic disorders |
| WO2012094636A2 (en) | 2011-01-07 | 2012-07-12 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
| US9211263B2 (en) | 2012-01-06 | 2015-12-15 | Elcelyx Therapeutics, Inc. | Compositions and methods of treating metabolic disorders |
| US9572784B2 (en) | 2011-01-07 | 2017-02-21 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| US11974971B2 (en) | 2011-01-07 | 2024-05-07 | Anji Pharmaceuticals Inc. | Compositions and methods for treating metabolic disorders |
| CN102188429A (zh) * | 2011-05-20 | 2011-09-21 | 吴四清 | 一种治疗糖尿病的药物组合物 |
| CN102357088A (zh) | 2011-10-26 | 2012-02-22 | 河北山姆士药业有限公司 | 盐酸二甲双胍肠溶片 |
| BR112014016808B1 (pt) | 2012-01-06 | 2022-01-11 | Anji Pharma (Us) Llc | Uso de um composto de biguanida para a fabricação de um medicamento para baixar os níveis de glicose no sangue e para o tratamento de um distúrbio do metabolismo de glicose |
| CN104349773A (zh) | 2012-01-06 | 2015-02-11 | 埃尔舍利克斯治疗公司 | 用于治疗代谢性病症的组合物和方法 |
| EP2941245B1 (en) | 2013-01-05 | 2024-06-26 | Anji Pharmaceuticals Inc. | Delayed-release composition comprising biguanide |
-
2012
- 2012-07-11 BR BR112014016808-3A patent/BR112014016808B1/pt active IP Right Grant
- 2012-07-11 EA EA201491335A patent/EA201491335A1/ru unknown
- 2012-07-11 KR KR1020147021875A patent/KR102035879B1/ko active Active
- 2012-07-11 KR KR1020197030360A patent/KR20190120430A/ko not_active Ceased
- 2012-07-11 SG SG11201403839SA patent/SG11201403839SA/en unknown
- 2012-07-11 AU AU2012363873A patent/AU2012363873B2/en active Active
- 2012-07-11 CN CN201280070968.0A patent/CN104254325A/zh active Pending
- 2012-07-11 JP JP2014551231A patent/JP2015503582A/ja not_active Withdrawn
- 2012-07-11 WO PCT/US2012/046335 patent/WO2013103384A1/en not_active Ceased
- 2012-07-11 SG SG10201911743TA patent/SG10201911743TA/en unknown
- 2012-07-11 MX MX2014008190A patent/MX2014008190A/es active IP Right Grant
- 2012-07-11 KR KR1020207034195A patent/KR20200137035A/ko not_active Ceased
- 2012-07-11 CA CA2862533A patent/CA2862533C/en active Active
- 2012-07-11 EP EP12738330.5A patent/EP2800561B1/en active Active
- 2012-07-11 ES ES12738330T patent/ES2832773T3/es active Active
- 2012-07-11 CN CN201910957458.9A patent/CN110693868A/zh active Pending
- 2012-07-11 KR KR1020237020116A patent/KR20230095124A/ko not_active Ceased
-
2014
- 2014-07-02 MX MX2020003112A patent/MX2020003112A/es unknown
- 2014-07-03 IL IL233506A patent/IL233506B/en active IP Right Grant
- 2014-07-10 ZA ZA2014/05046A patent/ZA201405046B/en unknown
-
2016
- 2016-10-31 US US15/339,346 patent/US10154972B2/en active Active
-
2017
- 2017-04-13 JP JP2017079805A patent/JP2017141289A/ja active Pending
-
2018
- 2018-02-22 AU AU2018201308A patent/AU2018201308A1/en not_active Abandoned
- 2018-12-17 US US16/223,002 patent/US11065215B2/en active Active
-
2019
- 2019-09-12 JP JP2019165827A patent/JP7335056B2/ja active Active
-
2021
- 2021-07-21 JP JP2021120385A patent/JP2021169522A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060222709A1 (en) * | 2005-03-18 | 2006-10-05 | Agi Therapeutics Research Ltd. | Metformin methods and formulations for treating chronic constipation |
| CN101978956A (zh) * | 2010-10-13 | 2011-02-23 | 北京京丰制药有限公司 | 盐酸二甲双胍肠溶片及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| AMY LEE, JOHN E. MORLEY: "Metformin decreases food consumption and nduces weight loss in subjects with obesity ith type II non-insulin-dependent diabetes.", 《OBESITY RESEARCH》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112739336A (zh) * | 2018-09-28 | 2021-04-30 | 雀巢产品有限公司 | 增强二甲双胍作用的化合物 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7335056B2 (ja) | ビグアナイド組成物および代謝障害を治療する方法 | |
| US10668031B2 (en) | Biguanide compositions and methods of treating metabolic disorders | |
| US10028923B2 (en) | Biguanide compositions and methods of treating metabolic disorders | |
| US9480663B2 (en) | Biguanide compositions and methods of treating metabolic disorders | |
| US11974971B2 (en) | Compositions and methods for treating metabolic disorders | |
| US11759441B2 (en) | Biguanide compositions and methods of treating metabolic disorders | |
| HK40021363A (en) | Biguanide compositions and methods of treating metabolic disorders | |
| HK1203829B (en) | Biguanide compositions and methods of treating metabolic disorders | |
| EA042749B1 (ru) | Композиции метформина и способы лечения расстройств метаболизма глюкозы |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20141231 |
|
| RJ01 | Rejection of invention patent application after publication |