CN104082740B - 一种具有干预或改善糖尿病的组合物及其制备方法 - Google Patents
一种具有干预或改善糖尿病的组合物及其制备方法 Download PDFInfo
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- 229960004666 glucagon Drugs 0.000 description 1
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- 230000001976 improved effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
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- 201000006370 kidney failure Diseases 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
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- 210000004072 lung Anatomy 0.000 description 1
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- 238000001819 mass spectrum Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
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- 230000017074 necrotic cell death Effects 0.000 description 1
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- 102000039446 nucleic acids Human genes 0.000 description 1
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- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 235000020333 oolong tea Nutrition 0.000 description 1
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- 210000004923 pancreatic tissue Anatomy 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Description
样品 | 0.1mg/ml | 1mg/ml | 5mg/ml | 10mg/ml |
对照组1 | 29.8% | 75.1% | 88.8% | 93.0% |
对照组2 | 11.3% | 26.3% | 31.6% | 33.9% |
HDF-X(实施例3) | 19.2% | 38.3% | 48.7% | 52.1% |
HDF-X(实施例4) | 24.1% | 47.9% | 60.9% | 64.9% |
HDF-X(实施例5) | 32.1% | 63.9% | 81.2% | 86.6% |
样品 | 非模拟胃液 | 模拟胃液 |
对照组2 | 33.9% | 22.4% |
HDF-X(实施例3) | 52.1% | 50.9% |
HDF-X(实施例4) | 64.9% | 63.5% |
HDF-X(实施例5) | 86.6% | 87.0% |
Claims (8)
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CN201410292566.6A CN104082740B (zh) | 2014-06-25 | 2014-06-25 | 一种具有干预或改善糖尿病的组合物及其制备方法 |
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CN201410292566.6A CN104082740B (zh) | 2014-06-25 | 2014-06-25 | 一种具有干预或改善糖尿病的组合物及其制备方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN104431992A (zh) * | 2014-12-25 | 2015-03-25 | 王永产 | 一种灵芝菌丝粉的生产工艺 |
CN104667255A (zh) * | 2015-02-15 | 2015-06-03 | 高长庚 | 一种治疗糖尿病的中药制剂 |
CN106262805A (zh) * | 2016-07-28 | 2017-01-04 | 福建万亿店中店电子商务有限责任公司 | 一种用于防治高血脂的组合物及其制备方法 |
CN106722873A (zh) * | 2016-12-05 | 2017-05-31 | 湖北省农业科学院农产品加工与核农技术研究所 | 猴头菌膨化食品的制备方法 |
CN106982883A (zh) * | 2017-06-05 | 2017-07-28 | 上海越哲食品有限公司 | 一种低糖低脂饼干及其制备方法 |
CN107536061B (zh) * | 2017-07-27 | 2021-01-01 | 贵州源熙生物研发有限公司 | 复合益生菌膳食纤维以及其制备方法 |
CN107898920A (zh) * | 2017-11-22 | 2018-04-13 | 中山市择朋生物科技有限公司 | 一种用于糖尿病的口含制品与制备方法 |
CN107981343A (zh) * | 2017-12-20 | 2018-05-04 | 佳木斯大学附属第医院 | 适宜糖尿病人食用的营养制剂及其制备方法 |
CN108402255A (zh) * | 2018-05-23 | 2018-08-17 | 广西中医药大学 | 一种金花茶叶子降血糖保健茶及其制备方法和应用 |
CN109619545A (zh) * | 2019-01-28 | 2019-04-16 | 江南大学 | 一种采用双向固态发酵生产猴头与大麦共发酵产品的方法 |
CN113521186B (zh) * | 2021-07-24 | 2022-12-23 | 陕西秦岭七药协同创新中心有限公司 | 一种降血糖药物及其制备方法和应用 |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN100998611A (zh) * | 2006-12-28 | 2007-07-18 | 温州大学 | 一种以中药为基质的灰树花发酵制备工艺 |
CN101180984A (zh) * | 2007-12-12 | 2008-05-21 | 山东大学 | 一种食用灵芝菌球奶及其制备方法 |
CN101328487A (zh) * | 2008-07-30 | 2008-12-24 | 江苏大学 | 鸡腿菇液体转化桑叶的发酵液制备方法及其用途 |
CN103404855A (zh) * | 2013-08-05 | 2013-11-27 | 福建农林大学 | 一种灰树花保健口服液及其制备方法 |
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CN100998611A (zh) * | 2006-12-28 | 2007-07-18 | 温州大学 | 一种以中药为基质的灰树花发酵制备工艺 |
CN101180984A (zh) * | 2007-12-12 | 2008-05-21 | 山东大学 | 一种食用灵芝菌球奶及其制备方法 |
CN101328487A (zh) * | 2008-07-30 | 2008-12-24 | 江苏大学 | 鸡腿菇液体转化桑叶的发酵液制备方法及其用途 |
CN103404855A (zh) * | 2013-08-05 | 2013-11-27 | 福建农林大学 | 一种灰树花保健口服液及其制备方法 |
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