CN104039805B - E-选择蛋白拮抗剂化合物、组合物及使用方法 - Google Patents

E-选择蛋白拮抗剂化合物、组合物及使用方法 Download PDF

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Publication number
CN104039805B
CN104039805B CN201280063074.9A CN201280063074A CN104039805B CN 104039805 B CN104039805 B CN 104039805B CN 201280063074 A CN201280063074 A CN 201280063074A CN 104039805 B CN104039805 B CN 104039805B
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compound
selectin
cancer
compounds
alkynyl
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Chinese (zh)
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CN104039805A (zh
Inventor
约翰·L·麦格纳尼
阿朗·K·萨卡
白明吉
弗兰克·E·安德森三世
李艳红
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Crescent Biopharma Inc
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Glycomimetics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
    • C09C1/62—Metallic pigments or fillers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201280063074.9A 2011-12-22 2012-12-21 E-选择蛋白拮抗剂化合物、组合物及使用方法 Expired - Fee Related CN104039805B (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201161579646P 2011-12-22 2011-12-22
US61/579,646 2011-12-22
US201261583547P 2012-01-05 2012-01-05
US61/583,547 2012-01-05
US201261704399P 2012-09-21 2012-09-21
US201261704424P 2012-09-21 2012-09-21
US61/704,424 2012-09-21
US61/704,399 2012-09-21
US201261734924P 2012-12-07 2012-12-07
US61/734,924 2012-12-07
PCT/US2012/071519 WO2013096926A1 (en) 2011-12-22 2012-12-21 E-selectin antagonist compounds, compositions, and methods of use

Publications (2)

Publication Number Publication Date
CN104039805A CN104039805A (zh) 2014-09-10
CN104039805B true CN104039805B (zh) 2016-11-16

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Country Link
US (6) US9109002B2 (enExample)
EP (2) EP3296310A1 (enExample)
JP (5) JP2015500887A (enExample)
KR (1) KR102055958B1 (enExample)
CN (1) CN104039805B (enExample)
AU (1) AU2012358150B2 (enExample)
BR (1) BR112014014547B1 (enExample)
CA (1) CA2858099C (enExample)
CY (1) CY1119794T1 (enExample)
DK (1) DK2794626T6 (enExample)
ES (1) ES2655443T7 (enExample)
HU (1) HUE036253T2 (enExample)
LT (1) LT2794626T (enExample)
PL (1) PL2794626T6 (enExample)
PT (1) PT2794626T (enExample)
SI (1) SI2794626T1 (enExample)
WO (1) WO2013096926A1 (enExample)

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CA2888527A1 (en) * 2012-10-31 2014-05-08 Glycomimetics, Inc. E-selectin antagonists compounds and methods of use
CA2891514C (en) * 2012-12-07 2020-08-25 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
WO2015048616A1 (en) * 2013-09-30 2015-04-02 Glycomimetics, Inc. Methods and compositions for treating and/or preventing mucositis
DE102013112915A1 (de) 2013-11-22 2015-05-28 Universitätsklinikum Hamburg-Eppendorf (UKE) DNA-Aptamere, die E- und P-Selektine spezifisch binden
US20160333043A1 (en) * 2014-01-17 2016-11-17 Glycomimetics, Inc. E-Selectin Antagonists Modified By Macrocycle Formation to the Galactose
PT3227310T (pt) * 2014-12-03 2019-11-06 Glycomimetics Inc Inibidores heterobifuncionais de e-selectinas e recetores de quimiocina cxcr4
WO2016164394A1 (en) * 2015-04-08 2016-10-13 Glycomimetics, Inc. 2-halo-galactose-containing selectin antagonists
US20160331775A1 (en) * 2015-05-14 2016-11-17 The Regents Of The University Of Michigan E-selectin inhibition works in combination with low-molecular weight heparin to decrease venous thrombosis and bleeding risk
US9891811B2 (en) * 2015-06-07 2018-02-13 Apple Inc. Devices and methods for navigating between user interfaces
AU2016349787A1 (en) * 2015-11-03 2018-05-17 Glycomimetics, Inc. Antibodies for targeting cancer stem cells and treating aggressive cancers
WO2017151708A1 (en) * 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
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CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
JP7275131B2 (ja) * 2017-11-30 2023-05-17 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
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WO2019173229A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
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US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
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CN114340736A (zh) 2019-04-24 2022-04-12 糖模拟物有限公司 E-选择蛋白、半乳凝素-3和/或cxcr4趋化因子受体的半乳糖-连接的多聚体糖模拟物抑制剂
US20220220144A1 (en) 2019-04-24 2022-07-14 Glycomimetics, Inc. Multimeric pan-selectin antagonists
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BR112022001847A2 (pt) 2019-07-31 2022-03-29 Glycomimetics Inc Uso de antagonistas multiméricos de e-selectina altamente potentes para tratamento da doença de células falciformes
CA3146048A1 (en) 2019-07-31 2021-02-04 Glycomimetics, Inc. Use of e-selectin antagonists to enhance the survival of reconstituted, bone marrow-depleted hosts
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WO2021195465A1 (en) 2020-03-27 2021-09-30 Magnani John L Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin
US20230165882A1 (en) 2020-05-31 2023-06-01 Glycomimetics, Inc. Compounds and methods for reduction of cancer cell burden and protection of normal hematopoiesis
IL298977A (en) 2020-06-14 2023-02-01 Glycomimetics Inc Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting
CN116113637A (zh) * 2020-09-17 2023-05-12 糖模拟物有限公司 E-选择素靶向剂
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