CN103930133A - 原位可交联的聚合物组合物及其方法 - Google Patents

原位可交联的聚合物组合物及其方法 Download PDF

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Publication number
CN103930133A
CN103930133A CN201280055699.0A CN201280055699A CN103930133A CN 103930133 A CN103930133 A CN 103930133A CN 201280055699 A CN201280055699 A CN 201280055699A CN 103930133 A CN103930133 A CN 103930133A
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China
Prior art keywords
polymer
composition
approximately
wound
biocompatible polymer
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Pending
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CN201280055699.0A
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English (en)
Chinese (zh)
Inventor
J·A·兰多里那
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Sunaris
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Sunaris
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Priority to CN201811325132.6A priority Critical patent/CN109602944A/zh
Publication of CN103930133A publication Critical patent/CN103930133A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Dental Preparations (AREA)
CN201280055699.0A 2011-11-13 2012-11-12 原位可交联的聚合物组合物及其方法 Pending CN103930133A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811325132.6A CN109602944A (zh) 2011-11-13 2012-11-12 原位可交联的聚合物组合物及其方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161559110P 2011-11-13 2011-11-13
US61/559,110 2011-11-13
PCT/US2012/064670 WO2013071235A1 (en) 2011-11-13 2012-11-12 In-situ cross-linkable polymeric compositions and methods thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201811325132.6A Division CN109602944A (zh) 2011-11-13 2012-11-12 原位可交联的聚合物组合物及其方法

Publications (1)

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CN103930133A true CN103930133A (zh) 2014-07-16

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CN201280055699.0A Pending CN103930133A (zh) 2011-11-13 2012-11-12 原位可交联的聚合物组合物及其方法
CN201811325132.6A Pending CN109602944A (zh) 2011-11-13 2012-11-12 原位可交联的聚合物组合物及其方法

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Country Status (16)

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US (4) US20140287061A1 (enExample)
EP (1) EP2776068A4 (enExample)
JP (3) JP2014533181A (enExample)
KR (1) KR20140090670A (enExample)
CN (2) CN103930133A (enExample)
AU (2) AU2012334982A1 (enExample)
BR (1) BR112014011442A8 (enExample)
CA (1) CA2855347C (enExample)
HK (1) HK1201734A1 (enExample)
IL (1) IL232330B (enExample)
IN (1) IN2014CN03524A (enExample)
MX (2) MX366366B (enExample)
RU (2) RU2640084C2 (enExample)
SG (2) SG10201610469QA (enExample)
WO (1) WO2013071235A1 (enExample)
ZA (1) ZA201403166B (enExample)

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CN105030815A (zh) * 2015-08-10 2015-11-11 贵州扬生医用器材有限公司 一种手术冲洗液及其制法
CN105860107A (zh) * 2016-04-26 2016-08-17 中南大学 一种过氧化氢响应及具有电化学活性的壳聚糖水凝胶的制备方法
CN107708750A (zh) * 2015-06-22 2018-02-16 克里斯伦公司 高度有效的止血粘附性聚合物支架
CN108926490A (zh) * 2017-05-25 2018-12-04 南方医科大学南方医院 一种抗凝胃管的制作方法
CN110121350A (zh) * 2016-12-22 2019-08-13 奥姆里克斯生物药品有限公司 包含阴离子交换剂和钙盐的止血组合物
CN111303453A (zh) * 2020-03-09 2020-06-19 中国海洋大学 一种多重敏感型水凝胶聚合物的制备方法和应用

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CA2799818A1 (en) 2010-05-24 2011-12-01 University Of Utah Research Foundation Reinforced adhesive complex coacervates and methods of making and using thereof
EP2637708A2 (en) 2010-11-12 2013-09-18 University of Utah Research Foundation Simple adhesive coacervates and methods of making and using thereof
HK1201734A1 (en) 2011-11-13 2015-09-11 Cresilon, Inc. In-situ cross-linkable polymeric compositions and methods thereof
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AU2015289798B2 (en) 2014-07-14 2019-09-12 University Of Utah Research Foundation In situ solidifying complex coacervates and methods of making and using thereof
JP7493961B2 (ja) * 2015-06-22 2024-06-03 クレシロン， インコーポレイテッド 高度に有用な止血用接着性ポリマー足場
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US11065337B2 (en) 2015-12-14 2021-07-20 University of Pittsburgh—of the Commonwealth System of Higher Education Complex coacervate for controlled release and related methods
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KR102218427B1 (ko) 2017-09-20 2021-02-22 차의과학대학교 산학협력단 단백질 약물을 포함하는 코아세르베이트 조성물 및 이를 포함하는 창상 치료제
CA3088129A1 (en) * 2018-01-26 2019-08-01 Polarityte, Inc. Composite-interfacing biomaterial accelerant substrate
JP7410876B2 (ja) 2018-01-26 2024-01-10 フルイデックス メディカル テクノロジー，リミティッド ライアビリティ カンパニー 血管閉塞のためにその場凝固複合コアセルベートを使用する装置及び方法
RU2675631C1 (ru) * 2018-10-02 2018-12-21 Общество с ограниченной ответственностью "Новые Биомедицинские Решения" Местное гемостатическое средство с повышенной антимикробной активностью
US12605484B2 (en) 2019-04-03 2026-04-21 Dtech - Società A Responsabilità Limitata Two-component system for the therapeutic treatment of skin lesions and production method thereof
CN110157010B (zh) * 2019-05-05 2021-04-02 上海交通大学 一种基于多糖/聚肽的聚电解质复合物水凝胶止血剂
EP3925636A1 (en) 2020-06-17 2021-12-22 Centre Of Experimental Medicine Slovak Academy Of Sciences Institute Of Experimental Pharmacology Composite membranes containing a smart-released cytoprotectant targeting the inflamed tissue and use thereof
JP7818395B2 (ja) * 2021-12-21 2026-02-20 富士フイルム株式会社 止血材組成物
CN115887738B (zh) * 2022-12-16 2024-05-10 湖南师范大学 一种聚丙烯酰胺-壳聚糖/高岭土多孔材料及其制备方法
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