CN103748450A - 双模式微粒表征 - Google Patents

双模式微粒表征 Download PDF

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Publication number
CN103748450A
CN103748450A CN201280040414.6A CN201280040414A CN103748450A CN 103748450 A CN103748450 A CN 103748450A CN 201280040414 A CN201280040414 A CN 201280040414A CN 103748450 A CN103748450 A CN 103748450A
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CN
China
Prior art keywords
sample
light
detector
coherent
detecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280040414.6A
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English (en)
Chinese (zh)
Inventor
E·尼尔·路易斯
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Malvern Panalytical Ltd
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Malvern Instruments Ltd
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Publication date
Application filed by Malvern Instruments Ltd filed Critical Malvern Instruments Ltd
Publication of CN103748450A publication Critical patent/CN103748450A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4709—Backscatter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/80—Indicating pH value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/068—Optics, miscellaneous

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN201280040414.6A 2011-08-19 2012-08-17 双模式微粒表征 Pending CN103748450A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161525669P 2011-08-19 2011-08-19
US61/525,669 2011-08-19
US201161560596P 2011-11-16 2011-11-16
US61/560,596 2011-11-16
US201261669004P 2012-07-06 2012-07-06
US61/669,004 2012-07-06
PCT/GB2012/052019 WO2013027034A1 (en) 2011-08-19 2012-08-17 Dual-mode characterization of particulates

Publications (1)

Publication Number Publication Date
CN103748450A true CN103748450A (zh) 2014-04-23

Family

ID=47046636

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280040414.6A Pending CN103748450A (zh) 2011-08-19 2012-08-17 双模式微粒表征

Country Status (5)

Country Link
US (1) US9816922B2 (enExample)
EP (1) EP2742337B1 (enExample)
JP (1) JP2014524581A (enExample)
CN (1) CN103748450A (enExample)
WO (1) WO2013027034A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104486792A (zh) * 2014-12-19 2015-04-01 宇龙计算机通信科技(深圳)有限公司 Rrm测量方法及测量系统、终端和基站
CN108333024A (zh) * 2018-03-21 2018-07-27 杭州娃哈哈科技有限公司 一种姜黄素纳米混悬剂的稳定性评价方法
CN113029958A (zh) * 2021-04-01 2021-06-25 温州大学 一种用于检测dna变性的动态光散射检测装置

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106030278A (zh) * 2014-03-25 2016-10-12 马尔文仪器有限公司 分散在液相中的蛋白质的拉曼光谱结构调查研究
JP6348349B2 (ja) * 2014-06-20 2018-06-27 大塚電子株式会社 動的光散乱測定装置及び動的光散乱測定方法
EP3088863A1 (en) 2015-05-01 2016-11-02 Malvern Instruments Limited Improvements relating to particle characterisation
US10371641B2 (en) 2016-01-21 2019-08-06 TimeGate Instruments Oy Method and apparatus for measuring inelastic scattering
JP2017150963A (ja) * 2016-02-25 2017-08-31 株式会社島津製作所 凝集体測定方法及び凝集体測定装置
SE1651057A1 (en) * 2016-07-14 2017-12-27 Brännström Gruppen Ab Method and apparatus for determining solids content in a liquid medium
WO2018070324A1 (ja) * 2016-10-13 2018-04-19 国立研究開発法人産業技術総合研究所 ナノ粒子評価方法およびナノ粒子観察装置
US11130686B2 (en) 2017-01-10 2021-09-28 Vermeer Manufacturing Company Systems and methods for dosing slurries to remove suspended solids
CN108663295B (zh) * 2018-08-06 2024-01-23 上海景瑞阳实业有限公司 一种纳米粒子粒径分布测试仪及测试方法
DE102020129179A1 (de) 2020-11-05 2022-05-05 Technische Universität Braunschweig Verfahren, computerprogramm und miniaturisierter optofluidischer chip zum untersuchen von partikeln in einer flüssigen probe
GB2619247A (en) * 2021-03-26 2023-11-29 Hamamatsu Photonics Kk Attenuated total reflectance spectroscopy apparatus, and attenuated total reflectance spectroscopy method
EP4654117A1 (en) * 2024-05-20 2025-11-26 Malvern Panalytical Limited Material characterisation trend analysis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1224174A (zh) * 1998-01-22 1999-07-28 富士通株式会社 光衰减器及分别有光衰减器的系统、光放大器和终端设备
CN101103263A (zh) * 2004-11-17 2008-01-09 霍尼韦尔国际公司 基于拉曼检测的流动血细胞计数器
CN101349631A (zh) * 2007-07-17 2009-01-21 株式会社堀场制作所 粒径分布测定装置

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4586819A (en) * 1982-07-09 1986-05-06 Hitachi, Ltd. Laser Raman microprobe
JPS6053834A (ja) * 1983-09-02 1985-03-27 Hitachi Ltd レ−ザラマンマイクロプロ−ブ
US5506678A (en) * 1992-02-24 1996-04-09 Hewlett Packard Company System for collecting weakly scattered electromagnetic radiation
JP2842064B2 (ja) 1992-07-30 1998-12-24 株式会社デンソー アナログ−ディジタル変換器
AU6559394A (en) * 1993-04-15 1994-11-08 Board Of Regents, The University Of Texas System Raman spectrometer
US6307626B1 (en) * 1997-06-20 2001-10-23 Plasma Tec, Inc. Dispersive atomic vapor raman filter
JP3651755B2 (ja) 1998-11-05 2005-05-25 株式会社東芝 ガス成分濃度計測装置およびガス成分濃度計測方法
JP5088990B2 (ja) 1999-01-26 2012-12-05 Ｈｏｙａ株式会社 内視鏡用の自己蛍光画像化システム
JP3422725B2 (ja) * 1999-05-19 2003-06-30 株式会社堀場製作所 ラマン分光分析と粒度分布測定を同時に行う分析装置
EP1913866A1 (en) 2000-08-21 2008-04-23 The General Hospital Corporation Methods for diagnosing a neurodegenerative condition
JP2005306827A (ja) 2004-04-17 2005-11-04 Isao Shimizu 生体高分子結晶迅速精製・計測の方法および装置
KR100817854B1 (ko) * 2006-09-19 2008-03-31 재단법인서울대학교산학협력재단 라만 산란광 및 광산란의 동시 검출 장치
MX2009004532A (es) 2006-10-27 2009-09-04 Lpath Inc Composiciones y metodos para unir esfingosina-1-fosfato.
FR2933303B1 (fr) 2008-06-30 2010-12-03 Univ Paris Curie Substitut osseux,et procede pour sa preparation.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1224174A (zh) * 1998-01-22 1999-07-28 富士通株式会社 光衰减器及分别有光衰减器的系统、光放大器和终端设备
CN101103263A (zh) * 2004-11-17 2008-01-09 霍尼韦尔国际公司 基于拉曼检测的流动血细胞计数器
CN101349631A (zh) * 2007-07-17 2009-01-21 株式会社堀场制作所 粒径分布测定装置

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BRANCA C. 等: "Swelling processes in aqueous polymer solutions by PCS and Raman scattering", 《JOURNAL OF MOLECULAR STRUCTURE》, vol. 482483, no. 25, 25 May 1999 (1999-05-25) *
彭立新 等: "Elastic and Inelastic Light Scattering from Single", 《ANAL. CHEM.》, vol. 81, no. 10, 15 May 2009 (2009-05-15), pages 4035 - 4042, XP055046278, DOI: doi:10.1021/ac900250x *
艾敏 等: "拉曼镊子在生物单细胞中的应用与进展", 《分析化学(FENXI HUAXUE)评述与进展》, vol. 37, no. 5, 31 May 2009 (2009-05-31), pages 758 - 763 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104486792A (zh) * 2014-12-19 2015-04-01 宇龙计算机通信科技(深圳)有限公司 Rrm测量方法及测量系统、终端和基站
CN104486792B (zh) * 2014-12-19 2018-02-13 宇龙计算机通信科技(深圳)有限公司 Rrm测量方法及测量系统、终端和基站
CN108333024A (zh) * 2018-03-21 2018-07-27 杭州娃哈哈科技有限公司 一种姜黄素纳米混悬剂的稳定性评价方法
CN113029958A (zh) * 2021-04-01 2021-06-25 温州大学 一种用于检测dna变性的动态光散射检测装置

Also Published As

Publication number Publication date
US20150146202A1 (en) 2015-05-28
JP2014524581A (ja) 2014-09-22
EP2742337B1 (en) 2016-05-04
WO2013027034A1 (en) 2013-02-28
US9816922B2 (en) 2017-11-14
EP2742337A1 (en) 2014-06-18

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Application publication date: 20140423