CN103570630B - 氮杂环衍生物及其在药物中的应用 - Google Patents
氮杂环衍生物及其在药物中的应用 Download PDFInfo
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- CN103570630B CN103570630B CN201310303212.2A CN201310303212A CN103570630B CN 103570630 B CN103570630 B CN 103570630B CN 201310303212 A CN201310303212 A CN 201310303212A CN 103570630 B CN103570630 B CN 103570630B
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- 0 *c1c(*)c2c(*)c(*)c(*)nc2c(*)c1* Chemical compound *c1c(*)c2c(*)c(*)c(*)nc2c(*)c1* 0.000 description 7
- PXVKXLKCLZVYLZ-UHFFFAOYSA-N Bc(c(F)c1)ccc1N Chemical compound Bc(c(F)c1)ccc1N PXVKXLKCLZVYLZ-UHFFFAOYSA-N 0.000 description 1
- HNFVHZIYZCOFEJ-UHFFFAOYSA-N Bc(ccc([N+]([O-])=O)c1)c1F Chemical compound Bc(ccc([N+]([O-])=O)c1)c1F HNFVHZIYZCOFEJ-UHFFFAOYSA-N 0.000 description 1
- WMBIRFVHTXRWAQ-LURJTMIESA-N CC(C)[C@@H]1CSNC1 Chemical compound CC(C)[C@@H]1CSNC1 WMBIRFVHTXRWAQ-LURJTMIESA-N 0.000 description 1
- IFRXNMWZPLUKCV-UHFFFAOYSA-O CC([NH2+]C(COC1=CNCCC1)N1c(cc2)cc(F)c2NCCO)=CC1=O Chemical compound CC([NH2+]C(COC1=CNCCC1)N1c(cc2)cc(F)c2NCCO)=CC1=O IFRXNMWZPLUKCV-UHFFFAOYSA-O 0.000 description 1
- YJZQSLJTTZHRID-UONOGXRCSA-N CCNCCC[C@H](C)CC[C@@H](C)C(C)C Chemical compound CCNCCC[C@H](C)CC[C@@H](C)C(C)C YJZQSLJTTZHRID-UONOGXRCSA-N 0.000 description 1
- BTLJESFVQZHVKO-UHFFFAOYSA-N c1ccc2N=[I]C=Cc2c1 Chemical compound c1ccc2N=[I]C=Cc2c1 BTLJESFVQZHVKO-UHFFFAOYSA-N 0.000 description 1
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
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| CA2635581C (en) | 2005-12-28 | 2017-02-28 | Vertex Pharmaceuticals Incorporated | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| US9902712B2 (en) | 2013-12-19 | 2018-02-27 | Sunshine Lake Pharma Co., Ltd. | Nitrogenous heterocyclic derivatives and their application in drugs |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| RU2749213C2 (ru) | 2014-10-07 | 2021-06-07 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе |
| CN106397408B (zh) * | 2015-07-30 | 2019-04-02 | 四川大学 | 5-甲基-2(1h)吡啶酮衍生物及其制备方法和用途 |
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN106083817B (zh) * | 2016-06-14 | 2019-01-18 | 四川大学 | 吡非尼酮衍生物及其制备方法 |
| CN106045971B (zh) * | 2016-06-16 | 2018-12-21 | 杨若一 | 吡非尼酮衍生物及其制备方法 |
| CN107663177B (zh) * | 2016-07-27 | 2022-07-08 | 广东东阳光药业有限公司 | 2,6-二甲基嘧啶酮衍生物的盐及其用途 |
| WO2018019244A1 (zh) * | 2016-07-27 | 2018-02-01 | 广东东阳光药业有限公司 | 2,6-二甲基嘧啶酮衍生物的盐及其用途 |
| EP3652158B1 (en) * | 2017-07-14 | 2024-05-29 | Sunshine Lake Pharma Co., Ltd. | Method for preparing pyrimidone compound |
| CN112770757B (zh) * | 2018-10-19 | 2024-01-16 | 广东东阳光药业股份有限公司 | 一种治疗纤维化疾病的药物组合或药物组合物 |
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| MX2021008661A (es) | 2019-01-18 | 2021-08-19 | Astrazeneca Ab | Inhibidores de la pcsk9 y metodos de uso de los mismos. |
| CN109734618B (zh) * | 2019-02-27 | 2021-08-17 | 宜春学院 | 一种苯氧乙酰胺类化合物的制备方法和苯氧乙酰胺类化合物 |
| CN109942497A (zh) * | 2019-05-06 | 2019-06-28 | 南京工业大学 | 一种多取代嘧啶酮化合物及其制备方法 |
| WO2021198191A1 (en) | 2020-03-30 | 2021-10-07 | Enyo Pharma | Quinazolinone derivatives and uses thereof for treating a cancer |
| IL307258A (en) | 2021-04-05 | 2023-11-01 | Halia Therapeutics Inc | NEK7 inhibitors |
| US20250177382A1 (en) | 2021-04-22 | 2025-06-05 | Halia Therapeutics, Inc. | Nek7 inhibitors |
| WO2023056935A1 (zh) | 2021-10-09 | 2023-04-13 | 广东东阳光药业有限公司 | 抗纤维化组合物 |
| KR102762725B1 (ko) * | 2022-03-24 | 2025-02-06 | 주식회사 케이에스비튜젠 | 레보드로프로피진을 유효성분으로 포함하는 근육질환의 예방, 치료 또는 개선용 조성물 |
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| EP2875001A4 (en) | 2016-06-01 |
| CA2872110A1 (en) | 2014-01-23 |
| EP2875001A1 (en) | 2015-05-27 |
| RU2701156C9 (ru) | 2019-12-18 |
| AU2013292950B2 (en) | 2015-09-10 |
| WO2014012360A1 (en) | 2014-01-23 |
| KR20150036223A (ko) | 2015-04-07 |
| BR112014030284A2 (pt) | 2017-06-27 |
| EP2875001B1 (en) | 2019-01-09 |
| RU2015105262A (ru) | 2016-09-10 |
| KR102057877B1 (ko) | 2019-12-20 |
| AU2013292950A1 (en) | 2014-11-13 |
| HK1207065A1 (en) | 2016-01-22 |
| MX2015000830A (es) | 2015-10-26 |
| RU2701156C2 (ru) | 2019-09-25 |
| CA2872110C (en) | 2019-08-06 |
| CN103570630A (zh) | 2014-02-12 |
| BR112014030284B1 (pt) | 2021-11-30 |
| US20150087639A1 (en) | 2015-03-26 |
| JP6186434B2 (ja) | 2017-08-23 |
| US9434695B2 (en) | 2016-09-06 |
| AU2013292950C1 (en) | 2016-01-21 |
| JP2015526411A (ja) | 2015-09-10 |
| ES2716008T3 (es) | 2019-06-07 |
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