JP6186434B2 - 窒素複素環誘導体及びその医薬品への応用 - Google Patents
窒素複素環誘導体及びその医薬品への応用 Download PDFInfo
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- JP6186434B2 JP6186434B2 JP2015521942A JP2015521942A JP6186434B2 JP 6186434 B2 JP6186434 B2 JP 6186434B2 JP 2015521942 A JP2015521942 A JP 2015521942A JP 2015521942 A JP2015521942 A JP 2015521942A JP 6186434 B2 JP6186434 B2 JP 6186434B2
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- alkoxy
- aliphatic
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- 0 C*C(N(C)C)=* Chemical compound C*C(N(C)C)=* 0.000 description 13
- IERWMZNDJGYCIA-UHFFFAOYSA-N CCCCCN1CCOCC1 Chemical compound CCCCCN1CCOCC1 IERWMZNDJGYCIA-UHFFFAOYSA-N 0.000 description 2
- QMJGKISBOFRECR-UHFFFAOYSA-N Bc([s]1)ncc1Br Chemical compound Bc([s]1)ncc1Br QMJGKISBOFRECR-UHFFFAOYSA-N 0.000 description 1
- JDLLELNGNQSRNF-UHFFFAOYSA-N Bc1ncc[s]1 Chemical compound Bc1ncc[s]1 JDLLELNGNQSRNF-UHFFFAOYSA-N 0.000 description 1
- HIRJXXVUTMFDLD-UHFFFAOYSA-N CC(C)(Cc(cc1F)ccc1Cl)NC Chemical compound CC(C)(Cc(cc1F)ccc1Cl)NC HIRJXXVUTMFDLD-UHFFFAOYSA-N 0.000 description 1
- LSYYUTLVQGUXFO-UHFFFAOYSA-N CC(N=C(C)N1c(cc2)cc(F)c2N(C)CCN2CCOCC2)=CC1=O Chemical compound CC(N=C(C)N1c(cc2)cc(F)c2N(C)CCN2CCOCC2)=CC1=O LSYYUTLVQGUXFO-UHFFFAOYSA-N 0.000 description 1
- XYICQGOLRWHBBX-UHFFFAOYSA-N CC(N=C(C)N1c(cc2)cc(F)c2NCCCCN2CCOCC2)=CC1=O Chemical compound CC(N=C(C)N1c(cc2)cc(F)c2NCCCCN2CCOCC2)=CC1=O XYICQGOLRWHBBX-UHFFFAOYSA-N 0.000 description 1
- CNYKEVSQRFJQRK-UHFFFAOYSA-N CC(N=C(C)N1c(ccc(NCCN2CCOCC2)c2)c2Cl)=CC1=O Chemical compound CC(N=C(C)N1c(ccc(NCCN2CCOCC2)c2)c2Cl)=CC1=O CNYKEVSQRFJQRK-UHFFFAOYSA-N 0.000 description 1
- TWQLMSSZCLAHJE-UHFFFAOYSA-N CC(N=C(COc1cc(C#N)ccc1)N1c(cc2)cc(Cl)c2N2CCOCC2)=CC1=O Chemical compound CC(N=C(COc1cc(C#N)ccc1)N1c(cc2)cc(Cl)c2N2CCOCC2)=CC1=O TWQLMSSZCLAHJE-UHFFFAOYSA-N 0.000 description 1
- GBOMEIMCQWMHGB-UHFFFAOYSA-N CCCCC1OCCC1 Chemical compound CCCCC1OCCC1 GBOMEIMCQWMHGB-UHFFFAOYSA-N 0.000 description 1
- QLEIDMAURCRVCX-UHFFFAOYSA-N CCCN1CCNCC1 Chemical compound CCCN1CCNCC1 QLEIDMAURCRVCX-UHFFFAOYSA-N 0.000 description 1
- RWIVICVCHVMHMU-UHFFFAOYSA-N NCCN1CCOCC1 Chemical compound NCCN1CCOCC1 RWIVICVCHVMHMU-UHFFFAOYSA-N 0.000 description 1
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
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| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| US9902712B2 (en) | 2013-12-19 | 2018-02-27 | Sunshine Lake Pharma Co., Ltd. | Nitrogenous heterocyclic derivatives and their application in drugs |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| RU2749213C2 (ru) | 2014-10-07 | 2021-06-07 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе |
| CN106397408B (zh) * | 2015-07-30 | 2019-04-02 | 四川大学 | 5-甲基-2(1h)吡啶酮衍生物及其制备方法和用途 |
| FR3046793B1 (fr) * | 2016-01-14 | 2018-01-05 | Les Laboratoires Servier | Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN106083817B (zh) * | 2016-06-14 | 2019-01-18 | 四川大学 | 吡非尼酮衍生物及其制备方法 |
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| CN109734618B (zh) * | 2019-02-27 | 2021-08-17 | 宜春学院 | 一种苯氧乙酰胺类化合物的制备方法和苯氧乙酰胺类化合物 |
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- 2013-07-18 EP EP13819193.7A patent/EP2875001B1/en active Active
- 2013-07-18 AU AU2013292950A patent/AU2013292950C1/en active Active
- 2013-07-18 KR KR1020157002193A patent/KR102057877B1/ko active Active
- 2013-07-18 ES ES13819193T patent/ES2716008T3/es active Active
- 2013-07-18 CN CN201310303212.2A patent/CN103570630B/zh active Active
- 2013-07-18 CA CA2872110A patent/CA2872110C/en active Active
- 2013-07-18 RU RU2015105262A patent/RU2701156C9/ru active
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|---|---|
| EP2875001A4 (en) | 2016-06-01 |
| CA2872110A1 (en) | 2014-01-23 |
| EP2875001A1 (en) | 2015-05-27 |
| RU2701156C9 (ru) | 2019-12-18 |
| AU2013292950B2 (en) | 2015-09-10 |
| WO2014012360A1 (en) | 2014-01-23 |
| KR20150036223A (ko) | 2015-04-07 |
| BR112014030284A2 (pt) | 2017-06-27 |
| EP2875001B1 (en) | 2019-01-09 |
| RU2015105262A (ru) | 2016-09-10 |
| KR102057877B1 (ko) | 2019-12-20 |
| AU2013292950A1 (en) | 2014-11-13 |
| CN103570630B (zh) | 2016-04-20 |
| HK1207065A1 (en) | 2016-01-22 |
| MX2015000830A (es) | 2015-10-26 |
| RU2701156C2 (ru) | 2019-09-25 |
| CA2872110C (en) | 2019-08-06 |
| CN103570630A (zh) | 2014-02-12 |
| BR112014030284B1 (pt) | 2021-11-30 |
| US20150087639A1 (en) | 2015-03-26 |
| US9434695B2 (en) | 2016-09-06 |
| AU2013292950C1 (en) | 2016-01-21 |
| JP2015526411A (ja) | 2015-09-10 |
| ES2716008T3 (es) | 2019-06-07 |
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