CN103432079A - 含有寡核苷酸的微球体及其在制备用于治疗1型糖尿病的药物中的应用 - Google Patents

含有寡核苷酸的微球体及其在制备用于治疗1型糖尿病的药物中的应用 Download PDF

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Publication number
CN103432079A
CN103432079A CN2012105929369A CN201210592936A CN103432079A CN 103432079 A CN103432079 A CN 103432079A CN 2012105929369 A CN2012105929369 A CN 2012105929369A CN 201210592936 A CN201210592936 A CN 201210592936A CN 103432079 A CN103432079 A CN 103432079A
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Prior art keywords
microspheres
oligonucleotides
cells
medicament
oligonucleotide
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Pending
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CN2012105929369A
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Chinese (zh)
Inventor
特伦斯·L·斯克特
黛博拉·拉弗里尼埃
尼克·吉安努卡基斯
韦雷德·比什克－利布
拉里·R·布朗
珍妮弗·梅琴
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Baxter Healthcare SA
Baxter International Inc
University of Pittsburgh
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Baxter Healthcare SA
Baxter International Inc
University of Pittsburgh
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Publication of CN103432079A publication Critical patent/CN103432079A/zh
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K9/1629—Organic macromolecular compounds
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CN2012105929369A 2004-05-12 2005-05-12 含有寡核苷酸的微球体及其在制备用于治疗1型糖尿病的药物中的应用 Pending CN103432079A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US57027304P 2004-05-12 2004-05-12
US60/570,273 2004-05-12
US62548304P 2004-11-05 2004-11-05
US60/625,483 2004-11-05

Related Parent Applications (1)

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CN 200580015308 Division CN1980641A (zh) 2004-05-12 2005-05-12 含有寡核苷酸的微球体及其在制备用于治疗1型糖尿病的药物中的应用

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CN103432079A true CN103432079A (zh) 2013-12-11

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CN2012105929369A Pending CN103432079A (zh) 2004-05-12 2005-05-12 含有寡核苷酸的微球体及其在制备用于治疗1型糖尿病的药物中的应用

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US (2) US7884085B2 (enExample)
EP (1) EP1758558B1 (enExample)
JP (2) JP2007537288A (enExample)
CN (1) CN103432079A (enExample)
AU (1) AU2005244851B2 (enExample)
CA (1) CA2566199C (enExample)
DK (1) DK1758558T3 (enExample)
ES (1) ES2442115T3 (enExample)
MX (1) MXPA06012989A (enExample)
PT (1) PT1758558E (enExample)
WO (1) WO2005112885A2 (enExample)

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CA2566199C (en) 2013-10-22
US20060024240A1 (en) 2006-02-02
US9115357B2 (en) 2015-08-25
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US7884085B2 (en) 2011-02-08
EP1758558A2 (en) 2007-03-07
PT1758558E (pt) 2013-12-05
WO2005112885A3 (en) 2006-02-09
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