JP5457414B2 - オリゴヌクレオチド含有マイクロスフェア、1型糖尿病を処置する医薬の製造のための、その使用 - Google Patents
オリゴヌクレオチド含有マイクロスフェア、1型糖尿病を処置する医薬の製造のための、その使用 Download PDFInfo
- Publication number
- JP5457414B2 JP5457414B2 JP2011199945A JP2011199945A JP5457414B2 JP 5457414 B2 JP5457414 B2 JP 5457414B2 JP 2011199945 A JP2011199945 A JP 2011199945A JP 2011199945 A JP2011199945 A JP 2011199945A JP 5457414 B2 JP5457414 B2 JP 5457414B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- microspheres
- oligonucleotide
- microns
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
2004年5月12日に出願された、仮特許出願シリアル番号60/570,273、および2004年11月5日に出願された、仮特許出願シリアル番号60/625,483。
(発明の分野)
本発明は、一般的に、特に、非肥満性糖尿病(NOD)マウスモデルにおいて、樹状細胞寛容を誘導するためのAS−オリゴヌクレオチドのマイクロスフェア送達に関する。より詳しくは、本発明は、完全に水性の条件を使用して製造されるマイクロスフェア(マイクロスフェアは、アンチセンス(AS)オリゴヌクレオチドをとりこむ)による薬物送達技術に関する。これらのマイクロスフェアは、インビボおよびインサイチュでのNODマウスにおける自己免疫性糖尿病状態を予防する、アンチセンスアプローチのために使用される。
微粒子、マイクロスフェアおよびマイクロカプセルは、1mm未満の直径、より好ましくは100ミクロン未満の直径を有する、固体または半固体の粒子であり、これらは、種々の材料(合成ポリマー、タンパク質および多糖類が挙げられる)から形成され得る。マイクロスフェアは、多くの異なる用途(主に、分離、診断および薬物送達)において使用されてきた。
本発明にしたがって、樹状細胞に送達されるべきDNAは、マイクロスフェアとして送達される。このような送達アプローチは、マイクロスフェア中の核酸へのヌクレアーゼの接近を防止すると考えられる。AS−オリゴヌクレオチドのマイクロスフェア送達は、特に、NODマウスモデルにおいて、樹状細胞の寛容を誘導するために実行される。マイクロスフェアは、マイクロスフェアがアンチセンス(AS)オリゴヌクレオチドを取り込む、水性条件を使用して製造される。これらのマイクロスフェアは、遺伝子発現を阻害し、そしてインビボおよびインサイチュでのNODマウスにおける自己免疫性糖尿病状態を予防するために使用される。
例えば、本願発明は以下の項目を提供する。
(項目1)
1型糖尿病の処置のためのオリゴヌクレオチドを含むマイクロスフェアであって、該オリゴヌクレオチドは、該マイクロスフェアの全重量に基づいて、該マイクロスフェアの約30重量%と約100重量%との間を構成し、該マイクロスフェアは、約50ミクロンを超えない平均粒子サイズを有する、マイクロスフェア。
(項目2)
前記オリゴヌクレオチドが、CD40、CD80およびCD86一次転写産物ならびにその組み合わせからなる群から選択される一次転写産物に結合するように標的化される、項目1に記載のマイクロスフェア。
(項目3)
前記オリゴヌクレオチドは、配列番号1、配列番号2または配列番号3およびその組み合わせからなる群から選択される、項目2に記載のマイクロスフェア。
(項目4)
1型糖尿病を有する個体へ、マイクロスフェアの形態で核酸を送達するためのプロセスであって、該マイクロスフェアの送達のための投与経路は、静脈内、筋内、皮下、局所、皮内、腹腔内、経口、肺、眼、経鼻または直腸からなる群から選択される、プロセス。
(項目5)
項目1に記載のマイクロスフェアを皮下注射する工程を包含する、自己免疫性の破壊から非肥満性糖尿病マウスの膵臓β細胞を防御するためのプロセス。
(項目6)
項目2に記載のマイクロスフェアを皮下注射する工程を包含する、自己免疫性の破壊から非肥満性糖尿病マウスの膵臓β細胞を防御するためのプロセス。
(項目7)
項目1に記載のマイクロスフェアを皮下注射する工程を包含する、自己免疫性の破壊から個体の膵臓β細胞を防御するためのプロセス。
(項目8)
項目2に記載のマイクロスフェアを皮下注射する工程を包含する、自己免疫性の破壊から個体の膵臓β細胞を防御するためのプロセス。
(項目9)
項目1に記載のマイクロスフェアを皮下注射する工程を包含する、自己免疫性の破壊からヒトの膵臓β細胞を防御するためのプロセス。
(項目10)
項目2に記載のマイクロスフェアを皮下注射する工程を包含する、自己免疫性の破壊からヒトの膵臓β細胞を防御するためのプロセス。
(項目11)
項目1に記載のマイクロスフェアを皮下注射する工程を包含する、自己免疫性の破壊および1型糖尿病の発症から個体の膵臓β細胞を防御するためのプロセス。
(項目12)
項目2に記載のマイクロスフェアを皮下注射する工程を包含する、自己免疫性の破壊および1型糖尿病の発症から個体の膵臓β細胞を防御するためのプロセス。
必要とされるように、本発明の詳細な実施形態が、本明細書で開示される;しかしながら開示される実施形態は、本発明の例示であるにすぎず、本発明は種々の形態に具体化され得ることが理解されるべきである。したがって、本明細書で開示される特定の詳細は、限定として解釈されるべきではなく、特許請求のための単なる根拠として、そして実質的に任意の適切な様式で本発明を種々に使用するように当業者へ教示するための代表的な根拠として解釈されるべきである。
CD40、CD80およびCD86一次転写産物に標的化される、3つのAS−オリゴヌクレオチドを、University of Pittsburgh(Pittsburgh、PA)にあるDNA合成設備により合成した。AS−オリゴヌクレオチドの配列は、以下である:
Prussia、PAによるポリ−L−リジン・HBr 50,000まで)。ポリ−L−リジン・HBrを、1:1の体積比で、このオリゴヌクレオチド溶液に添加した。この混合物を、穏やかにボルテックスした。pH=5.5でのlM 酢酸ナトリウム(Spectrum、Gardena、CA)中に、12.5%のPVP(ポリビニルピロリドン、40,000ダルトン、Spectrum Chemicals、Gardena、CA)と12.5%のPEG(ポリエチレングリコール、3,350ダルトン、Spectrum Chemicals、Gardena、CA)とを含む25%ポリマー溶液を作製した。このポリマー溶液を以下:750μ1のAS−オリゴヌクレオチド、0.75mlのポリ−L−リジン・HBr、3.0mlのPEG/PVPのように2:1の体積比で添加し、そして4.50mlの全容積にした。
CD40、CD80およびCD86一次転写産物に標的化される、AS−オリゴヌクレオチドは、実施例1のAS−オリゴヌクレオチド配列であった。このオリゴヌクレオチド混合物の水溶液を、3つのオリゴヌクレオチド溶液(各々は、1つの型のオリゴヌクレオチドを含んだ)のアリコートを組み合わせることにより調製し、3つの型のオリゴヌクレオチドの10[mg/ml]溶液を生成した。オリゴヌクレオチド混合物の溶液を調製した。diH2O中で5[mg/ml]のポリ−L−オルニチン・HBrを調製した(Sigmaによるポリ−L−オルニチン・HBr 11,900(vis))。ポリ−L−オルニチン・HBrを、このオリゴヌクレオチド溶液に添加した。この混合物を、穏やかにボルテックスした。pH=5.5での0.1M 酢酸ナトリウム(Spectrum Chemicals、Gardena、CA)中に、12.5%のPVP(40,000ダルトン、Spectrum Chemicals、Gardena、CA)と12.5%のPEG(3,350ダルトン、Spectrum Chemicals、Gardena、CA)とを含む25%ポリマー溶液を作製した。このポリマー溶液を添加した。実施例1に記載されるように、インキュベーションとリンスが続いた。1.5mlのAS−オリゴヌクレオチド、1.5mlのポリ−L−オルニチン・HBr、3.0mlのPEG/PVP、そして全容積、6.0mlを調製した。
インビボ研究を、1型真性糖尿病のNODマウスモデルを使用して実行した。1型糖尿病は、図1に示されるように、膵臓のインシュリン産生β細胞の自己免疫性の破壊により発現する。AS−オリゴヌクレオチドを、β細胞の自己免疫性の破壊を妨害する試みにおいて、3つの適用により使用した。この目標は、T細胞の活性化に必要とされる樹状細胞(dendritric cell)表面タンパク質をコードするCD40、CD80およびCD86一次転写産物を標的化することにより、樹状細胞の機能を妨害することである。低レベルのCD40、CD80およびCD86を有する樹状細胞は、インビボにおいて、抑制性の免疫細胞ネットワークを促進することが公知である。これらのカスケードは、インビボにおいて、β細胞に対するT細胞の反応低下をもたらし得る。
Claims (14)
- マイクロスフェアを含む組成物であって、該マイクロスフェアが、CD40一次転写産物を標的化する第1のアンチセンスオリゴヌクレオチド、CD80一次転写産物を標的化する第2のアンチセンスオリゴヌクレオチド、および、CD86一次転写産物を標的化する第3のアンチセンスオリゴヌクレオチドを含み、該第1、第2および第3のオリゴヌクレオチドの各々が、それぞれ、CD40、CD80、および、CD86のインビボ発現を減少させるかまたは抑制し、該マイクロスフェアは投与されると、樹状細胞が取り込むことができるものであり、かつ、1型糖尿病を治療する、組成物。
- 前記オリゴヌクレオチドが、前記マイクロスフェアの全重量に基づいて、該マイクロスフェアの30重量%以上を構成する、請求項1に記載の組成物。
- 前記マイクロスフェアは、ポリカチオンをさらに含む、請求項1または請求項2に記載の組成物。
- 前記マイクロスフェアは、アンチセンスオリゴヌクレオチドおよび前記ポリカチオンからなる、請求項3に記載の組成物。
- 前記組成物は、インビボでの送達に適した注射用組成物である、請求項1〜4のいずれか1項に記載の組成物。
- 前記組成物は、皮下投与に適しているものである、請求項1〜5のいずれか1項に記載の組成物。
- 前記マイクロスフェアは、50ミクロン未満の平均粒子サイズを有する、請求項1〜6のいずれか1項に記載の組成物。
- 前記マイクロスフェアは、0.2ミクロン〜8ミクロンの粒子サイズを有する、請求項1〜7のいずれか1項に記載の組成物。
- 前記マイクロスフェアは、0.5ミクロン〜4ミクロンの粒子サイズを有する、請求項1〜8のいずれか1項に記載の組成物。
- 前記マイクロスフェアは、2ミクロンの平均粒子サイズを有する、請求項1〜9のいずれか1項に記載の組成物。
- 前記マイクロスフェアは、2.5ミクロンの平均粒子サイズを有する、請求項1〜9のいずれか1項に記載の組成物。
- 1型糖尿病を有する個体の処置のための、請求項1〜11のいずれか1項に記載の組成物であって、該組成物の送達のための投与経路は、静脈内、筋肉内、皮下、局所、皮内、腹腔内、経口、肺、眼、経鼻または直腸からなる群から選択される、組成物。
- 自己免疫性の破壊から個体の膵臓β細胞を防御するための、請求項1〜11のいずれか1項に記載の組成物であって、該組成物は、皮下注射されることを特徴とする、組成物。
- 前記個体がヒトである、請求項13に記載の組成物。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57027304P | 2004-05-12 | 2004-05-12 | |
US60/570,273 | 2004-05-12 | ||
US62548304P | 2004-11-05 | 2004-11-05 | |
US60/625,483 | 2004-11-05 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007513370A Division JP2007537288A (ja) | 2004-05-12 | 2005-05-12 | オリゴヌクレオチド含有マイクロスフェア、1型糖尿病を処置する医薬の製造のための、その使用 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2011256204A JP2011256204A (ja) | 2011-12-22 |
JP2011256204A5 JP2011256204A5 (ja) | 2013-10-03 |
JP5457414B2 true JP5457414B2 (ja) | 2014-04-02 |
Family
ID=35134160
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007513370A Pending JP2007537288A (ja) | 2004-05-12 | 2005-05-12 | オリゴヌクレオチド含有マイクロスフェア、1型糖尿病を処置する医薬の製造のための、その使用 |
JP2011199945A Expired - Fee Related JP5457414B2 (ja) | 2004-05-12 | 2011-09-13 | オリゴヌクレオチド含有マイクロスフェア、1型糖尿病を処置する医薬の製造のための、その使用 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007513370A Pending JP2007537288A (ja) | 2004-05-12 | 2005-05-12 | オリゴヌクレオチド含有マイクロスフェア、1型糖尿病を処置する医薬の製造のための、その使用 |
Country Status (11)
Country | Link |
---|---|
US (2) | US7884085B2 (ja) |
EP (1) | EP1758558B1 (ja) |
JP (2) | JP2007537288A (ja) |
CN (1) | CN103432079A (ja) |
AU (1) | AU2005244851B2 (ja) |
CA (1) | CA2566199C (ja) |
DK (1) | DK1758558T3 (ja) |
ES (1) | ES2442115T3 (ja) |
MX (1) | MXPA06012989A (ja) |
PT (1) | PT1758558E (ja) |
WO (1) | WO2005112885A2 (ja) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080026068A1 (en) * | 2001-08-16 | 2008-01-31 | Baxter Healthcare S.A. | Pulmonary delivery of spherical insulin microparticles |
US7884085B2 (en) * | 2004-05-12 | 2011-02-08 | Baxter International Inc. | Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes |
US8728525B2 (en) * | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
DK1765294T3 (da) * | 2004-05-12 | 2008-11-10 | Baxter Int | Nukleinsyremikrokugler samt deres fremstilling og afgivelse |
WO2007001448A2 (en) | 2004-11-04 | 2007-01-04 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
MX2007013356A (es) * | 2005-04-27 | 2008-03-26 | Baxter Int | Microparticulas modificadas en la superficie y metodos de formacion y uso de las mismas. |
WO2007070682A2 (en) | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | System for screening particles |
CA2648099C (en) | 2006-03-31 | 2012-05-29 | The Brigham And Women's Hospital, Inc | System for targeted delivery of therapeutic agents |
EP2019691B1 (en) | 2006-05-15 | 2020-08-12 | Massachusetts Institute of Technology | Polymers for functional particles |
US20070281031A1 (en) * | 2006-06-01 | 2007-12-06 | Guohan Yang | Microparticles and methods for production thereof |
WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
AU2013213750B2 (en) * | 2006-08-04 | 2013-09-26 | Baxter Healthcare S.A. | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
JP5118139B2 (ja) | 2006-08-04 | 2013-01-16 | バクスター・インターナショナル・インコーポレイテッド | 新規発症自己免疫性糖尿病を予防および/または逆転させるためのマイクロスフィアに基づく組成物 |
EP2068845A2 (en) * | 2006-10-06 | 2009-06-17 | Baxter International Inc. | Microencapsules containing surface-modified microparticles and methods of forming and using the same |
US9217129B2 (en) | 2007-02-09 | 2015-12-22 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
EP2144600A4 (en) | 2007-04-04 | 2011-03-16 | Massachusetts Inst Technology | POLY (AMINIC ACID) TARGET MOLECULES |
BRPI0817664A2 (pt) | 2007-10-12 | 2015-03-24 | Massachusetts Inst Technology | Nanopartículas, método para preparar nanopartículas e método para tratar terapeuticamente ou profilaticamente um indivíduo |
AU2009237577B2 (en) * | 2008-04-18 | 2014-06-05 | Baxter Healthcare Sa | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
US8367427B2 (en) * | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323615B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
US20100047292A1 (en) * | 2008-08-20 | 2010-02-25 | Baxter International Inc. | Methods of processing microparticles and compositions produced thereby |
US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
AU2014348184B2 (en) | 2013-11-18 | 2020-08-27 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Microsphere-based delivery and ex vivo manipulation of dendritic cells for autoimmune therapies |
WO2018024849A1 (en) * | 2016-08-03 | 2018-02-08 | Aalborg Universitet | ANTISENSE OLIGONUCLEOTIDES (ASOs) DESIGNED TO INHIBIT IMMUNE CHECKPOINT PROTEINS |
Family Cites Families (139)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US373337A (en) * | 1887-11-15 | Shaft-hanger | ||
DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
JPS523342B2 (ja) | 1972-01-26 | 1977-01-27 | ||
US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4818542A (en) | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
US4584894A (en) | 1984-02-29 | 1986-04-29 | Borg-Warner Corporation | Transmission anti-clash and anti-rattle brake |
US5417986A (en) | 1984-03-16 | 1995-05-23 | The United States Of America As Represented By The Secretary Of The Army | Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
ATE61935T1 (de) | 1985-02-07 | 1991-04-15 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von mikrokapseln. |
JP2551756B2 (ja) | 1985-05-07 | 1996-11-06 | 武田薬品工業株式会社 | ポリオキシカルボン酸エステルおよびその製造法 |
US5102872A (en) | 1985-09-20 | 1992-04-07 | Cetus Corporation | Controlled-release formulations of interleukin-2 |
GB8601100D0 (en) | 1986-01-17 | 1986-02-19 | Cosmas Damian Ltd | Drug delivery system |
EP0248531A3 (en) | 1986-05-02 | 1988-09-28 | Southern Research Institute | Encapsulated nucleic acids |
ES2053549T3 (es) | 1986-08-11 | 1994-08-01 | Innovata Biomed Ltd | Un proceso para la preparacion de una formulacion farmaceutica apropiada para inhalacion. |
US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
US4861627A (en) | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
US4848542A (en) * | 1988-04-18 | 1989-07-18 | Richard Burnette | Package for retaining and mounting a mirror |
US5422120A (en) | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
GB8903593D0 (en) | 1989-02-16 | 1989-04-05 | Pafra Ltd | Storage of materials |
USRE39497E1 (en) * | 1989-02-16 | 2007-02-27 | Nektar Therapeutics | Storage of materials |
AU5741590A (en) | 1989-05-04 | 1990-11-29 | Southern Research Institute | Improved encapsulation process and products therefrom |
MY107937A (en) | 1990-02-13 | 1996-06-29 | Takeda Chemical Industries Ltd | Prolonged release microcapsules. |
DE69133136T2 (de) | 1990-05-16 | 2003-06-18 | Southern Research Institute, Birmingham | Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstums |
JPH0436233A (ja) * | 1990-05-29 | 1992-02-06 | Biomaterial Universe Kk | 生理活性物質含有生体内分解吸収性の徐放性製剤 |
GB9016885D0 (en) | 1990-08-01 | 1990-09-12 | Scras | Sustained release pharmaceutical compositions |
US5149543A (en) | 1990-10-05 | 1992-09-22 | Massachusetts Institute Of Technology | Ionically cross-linked polymeric microcapsules |
IT1243390B (it) * | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
WO1992014449A1 (en) | 1991-02-20 | 1992-09-03 | Nova Pharmaceutical Corporation | Controlled release microparticulate delivery system for proteins |
US5330768A (en) | 1991-07-05 | 1994-07-19 | Massachusetts Institute Of Technology | Controlled drug delivery using polymer/pluronic blends |
US6063910A (en) | 1991-11-14 | 2000-05-16 | The Trustees Of Princeton University | Preparation of protein microparticles by supercritical fluid precipitation |
US5525519A (en) | 1992-01-07 | 1996-06-11 | Middlesex Sciences, Inc. | Method for isolating biomolecules from a biological sample with linear polymers |
US5173454A (en) | 1992-01-09 | 1992-12-22 | Corning Incorporated | Nanocrystalline materials |
US5912015A (en) | 1992-03-12 | 1999-06-15 | Alkermes Controlled Therapeutics, Inc. | Modulated release from biocompatible polymers |
DE4211169C1 (ja) | 1992-03-31 | 1993-06-03 | Klaus Kretzschmar | |
JP2651320B2 (ja) | 1992-07-16 | 1997-09-10 | 田辺製薬株式会社 | 徐放性マイクロスフェア製剤の製造方法 |
JP3277342B2 (ja) | 1992-09-02 | 2002-04-22 | 武田薬品工業株式会社 | 徐放性マイクロカプセルの製造法 |
EP0595030A3 (en) | 1992-10-01 | 1995-06-07 | Tanabe Seiyaku Co | Composition of microspheres with several delayed release nuclei and its preparation process. |
DE69329295T2 (de) | 1992-12-02 | 2001-03-15 | Alkermes Controlled Therapeutics, Inc. | Wachstumhormon enthaltende mikrosphaeren mit kontrollierter freisetzung |
WO1994018947A1 (en) * | 1993-02-16 | 1994-09-01 | Sharifa Karali | High purity protamine-dna complex and use of same |
US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US5578709A (en) | 1993-03-09 | 1996-11-26 | Middlesex Sciences, Inc. | Macromolecular microparticles and methods of production |
US5994314A (en) | 1993-04-07 | 1999-11-30 | Inhale Therapeutic Systems, Inc. | Compositions and methods for nucleic acid delivery to the lung |
TW360548B (en) | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
DE69432867T2 (de) | 1993-11-18 | 2004-04-22 | Sirtex Medical Ltd., Burswood | Zubereitung mit gesteuerter freisetzung |
AU684324B2 (en) | 1993-11-19 | 1997-12-11 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
US5650173A (en) | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
US5858973A (en) | 1994-02-23 | 1999-01-12 | The General Hospital Corporation | Transcription factor and uses therefor |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
MX9701394A (es) | 1994-08-04 | 1998-03-31 | Quadrant Holdings Cambridge | Sistemas de administracion de solidos para la liberacion controlada de moleculas incorporadas en losmismos y metodos para hacer los mismos. |
US5542920A (en) | 1994-09-12 | 1996-08-06 | Delab | Needle-less parenteral introduction device |
US6387399B1 (en) | 1994-12-02 | 2002-05-14 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Microencapsulated bioactive agents and method of making |
US5877021A (en) * | 1995-07-07 | 1999-03-02 | Ribozyme Pharmaceuticals, Inc. | B7-1 targeted ribozymes |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US6265389B1 (en) | 1995-08-31 | 2001-07-24 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of oligonucleotides |
SE505146C2 (sv) | 1995-10-19 | 1997-06-30 | Biogram Ab | Partiklar för fördröjd frisättning |
US5665428A (en) * | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
US6270795B1 (en) | 1995-11-09 | 2001-08-07 | Microbiological Research Authority | Method of making microencapsulated DNA for vaccination and gene therapy |
CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
US5958769A (en) * | 1996-01-18 | 1999-09-28 | Fred Hutchinson Cancer Research Center | Compositions and methods for mediating cell cycle progression |
GB9607035D0 (en) | 1996-04-03 | 1996-06-05 | Andaris Ltd | Spray-dried microparticles as therapeutic vehicles |
GB9610992D0 (en) | 1996-05-24 | 1996-07-31 | Glaxo Group Ltd | Concentrated antibody preparation |
EP0920339A2 (en) | 1996-07-09 | 1999-06-09 | The Johns Hopkins University | Gene delivery system |
US6395302B1 (en) | 1996-11-19 | 2002-05-28 | Octoplus B.V. | Method for the preparation of microspheres which contain colloidal systems |
US6077833A (en) | 1996-12-31 | 2000-06-20 | Isis Pharmaceuticals, Inc. | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US6319906B1 (en) | 1996-12-31 | 2001-11-20 | Isis Pharmaceuticals | Oligonucleotide compositions and methods for the modulation of the expression of B7 protein |
US20020182258A1 (en) * | 1997-01-22 | 2002-12-05 | Zycos Inc., A Delaware Corporation | Microparticles for delivery of nucleic acid |
US5945126A (en) | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
JP2002514215A (ja) | 1997-04-17 | 2002-05-14 | アムジエン・インコーポレーテツド | 治療薬の徐放送達のための生分解性微粒子 |
TR200001021T2 (tr) | 1997-07-18 | 2000-09-21 | Infimed Inc. | Aktif maddelerin kontrollü salınması için biyo aşındırılabilir makromerler. |
DE69812968T2 (de) * | 1997-08-18 | 2004-02-12 | Exxonmobil Chemical Patents Inc., Baytown | Verfahren zur alkylierung eines aromaten mit einem verdünnten, propylen- und ethylen-enthaltenden gasstrom |
US6042792A (en) * | 1997-09-18 | 2000-03-28 | International Flavors & Fragrances Inc. | Apparatus for preparing a solid phase microparticulate composition |
US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
SE512663C2 (sv) | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
ATE281844T1 (de) * | 1998-01-16 | 2004-11-15 | Univ Johns Hopkins | Orale verabreichung von nukleinsäure-impstoffen durch partikelkomplexe |
US20040186071A1 (en) | 1998-04-13 | 2004-09-23 | Bennett C. Frank | Antisense modulation of CD40 expression |
US6395253B2 (en) * | 1998-04-23 | 2002-05-28 | The Regents Of The University Of Michigan | Microspheres containing condensed polyanionic bioactive agents and methods for their production |
US6197584B1 (en) | 1998-05-01 | 2001-03-06 | Isis Pharmaceuticals, Inc. | Antisense modulation of CD40 expression |
EP1104309B8 (en) | 1998-08-14 | 2006-07-05 | Valentis Inc. | Co-lyophilized complex comprising a nucleic acid vector and a formulating agent |
US6270802B1 (en) | 1998-10-28 | 2001-08-07 | Oakwood Laboratories L.L.C. | Method and apparatus for formulating microspheres and microcapsules |
US6194006B1 (en) | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
ATE241965T1 (de) * | 1999-01-13 | 2003-06-15 | Univ Johns Hopkins Med | Genetische immunisierung mit gleichzeitiger verabreichung von nukleinsäuren und zytokinen |
GB9904627D0 (en) * | 1999-03-02 | 1999-04-21 | Danbiosyst Uk | Polymer compositions for polynucleotide delivery |
US6630169B1 (en) | 1999-03-31 | 2003-10-07 | Nektar Therapeutics | Particulate delivery systems and methods of use |
WO2000062759A1 (en) | 1999-04-16 | 2000-10-26 | Novo Nordisk A/S | Dry, mouldable drug formulation |
EP1046651A1 (en) * | 1999-04-19 | 2000-10-25 | Koninklijke Universiteit Nijmegen | Composition and method for modulating dendritic cell-T interaction |
KR20080052690A (ko) | 1999-04-30 | 2008-06-11 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 돌연변이체 인간 cd80, 이를 포함하는 조성물, 및 이를제조하고 이용하는 방법 |
CA2373016A1 (en) | 1999-05-04 | 2000-11-09 | Genethor Gmbh | Method for diminishing specific immune reactions |
DE69910987T2 (de) | 1999-06-14 | 2004-05-19 | Baxter International Inc., Deerfield | Mikrosphären mit verzögerter Wirkstoffabgabe |
EP1194128A2 (en) | 1999-06-23 | 2002-04-10 | Sedum Laboratories | Ionically formulated biomolecule microcarriers |
US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
US7129222B2 (en) | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
FR2809309B1 (fr) | 2000-05-23 | 2004-06-11 | Mainelab | Microspheres a liberation prolongee pour administration injectable |
DE60127954T2 (de) | 2000-05-26 | 2008-01-17 | Symphogen A/S | Rekombinante oder gereinigte polyklonale antikörper zur behandlung den allergien |
US6849259B2 (en) | 2000-06-16 | 2005-02-01 | Symphogen A/S | Polyclonal antibody composition for treating allergy |
KR100392501B1 (ko) | 2000-06-28 | 2003-07-22 | 동국제약 주식회사 | 다중 에멀젼법에 의한 서방출성 미립구의 제조방법 |
US6471995B1 (en) | 2000-09-27 | 2002-10-29 | Alkermes Controlled Therapeutics, Inc. Ii | Apparatus and method for preparing microparticles using liquid-liquid extraction |
SI1324776T2 (en) | 2000-10-12 | 2018-06-29 | Genentech, Inc. | Concentrated protein formulations with reduced viscosity |
SE518007C2 (sv) * | 2000-11-16 | 2002-08-13 | Bioglan Ab | Förfarande för framställning av mikropartiklar |
CA2433353C (en) | 2000-12-28 | 2017-03-21 | Altus Biologics, Inc. | Crystals of whole antibodies and fragments thereof and methods for making and using them |
EP1801123A3 (en) | 2000-12-28 | 2007-11-21 | Altus Pharmaceuticals Inc. | Crystals of whole antibodies and fragments thereof and methods for making and using them |
US6896905B2 (en) | 2001-02-15 | 2005-05-24 | Rohm And Haas Company | Porous particles, their aqueous dispersions, and method of preparation |
GB0113179D0 (en) | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
NZ530700A (en) | 2001-06-21 | 2009-02-28 | Altus Pharmaceuticals Inc | Spherical protein particles and methods of making and using them |
US20080026068A1 (en) * | 2001-08-16 | 2008-01-31 | Baxter Healthcare S.A. | Pulmonary delivery of spherical insulin microparticles |
WO2003015750A1 (en) | 2001-08-16 | 2003-02-27 | Baxter International, Inc. | Propellant-based microparticle formulations |
GB0207440D0 (en) * | 2002-03-28 | 2002-05-08 | Ppl Therapeutics Scotland Ltd | Tolerogenic antigen-presenting cells |
WO2005123131A2 (en) | 2004-06-14 | 2005-12-29 | Medimmune Vaccines, Inc. | High pressure spray-dry of bioactive materials |
WO2003099228A2 (en) | 2002-05-28 | 2003-12-04 | Mirus Corporation | Compositions and processes for inhibiting gene expression using polynucleotides |
US6900998B2 (en) | 2002-05-31 | 2005-05-31 | Midwest Research Institute | Variable-speed wind power system with improved energy capture via multilevel conversion |
CN1671741A (zh) | 2002-06-21 | 2005-09-21 | 拜奥根Idec公司 | 浓缩抗体的缓冲剂制剂及其使用方法 |
US20040014698A1 (en) | 2002-07-18 | 2004-01-22 | Gonzalo Hortelano | Oral administration of therapeutic agent coupled to transporting agent |
CA2497723A1 (en) | 2002-09-11 | 2004-03-25 | Tanabe Seiyaku Co., Ltd. | Method for preparation of microspheres and apparatus therefor |
US20060002862A1 (en) | 2002-12-17 | 2006-01-05 | Medimmune Vaccines, Inc. | High pressure spray-dry of bioactive materials |
KR20100107083A (ko) | 2002-12-17 | 2010-10-04 | 메디뮨 엘엘씨 | 생물활성 물질의 고압 분무 건조 |
AU2003291527A1 (en) | 2002-12-31 | 2004-07-29 | Nektar Therapeutics | Antibody-containing particles and compositions |
AU2004229335C1 (en) | 2003-04-04 | 2010-06-17 | Genentech, Inc. | High concentration antibody and protein formulations |
US20050158303A1 (en) | 2003-04-04 | 2005-07-21 | Genentech, Inc. | Methods of treating IgE-mediated disorders comprising the administration of high concentration anti-IgE antibody formulations |
ES2216707B1 (es) | 2003-04-08 | 2005-12-16 | Josep Maria Aran Perramon | Secuencia oligoribonucleotidica homologa a una region del cdna que codifica para el receptor cd40 humano y oligoribonucleotidos duplex, vectores, composiciones farmaceuticas y usos correspondientes. |
ES2315664T3 (es) | 2003-06-30 | 2009-04-01 | Domantis Limited | Anticuerpos de dominio unico (dab) pegilados. |
US7066023B2 (en) | 2003-07-14 | 2006-06-27 | Environmental Security Corporation | Distributed sensor array for fluid contaminant monitoring |
US20050142205A1 (en) * | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for encapsulating small spherical particles prepared by controlled phase separation |
KR101137785B1 (ko) * | 2003-07-18 | 2012-04-25 | 백스터 인터내셔널 인코포레이티드 | 제어된 상 분리에 의해 제조된 작은 구형 입자의 제조방법, 이용 방법 및 조성물 |
DE10355904A1 (de) | 2003-11-29 | 2005-06-30 | Merck Patent Gmbh | Feste Formen von anti-EGFR-Antikörpern |
US20050234002A1 (en) | 2004-01-23 | 2005-10-20 | Mourich Dan V | Antisense oligomers and methods for inducing immune tolerance and immunosuppression |
CA2555791A1 (en) | 2004-02-12 | 2005-08-25 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Highly concentrated liquid formulations of anti-egfr antibodies |
US7884085B2 (en) * | 2004-05-12 | 2011-02-08 | Baxter International Inc. | Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes |
DK1765294T3 (da) * | 2004-05-12 | 2008-11-10 | Baxter Int | Nukleinsyremikrokugler samt deres fremstilling og afgivelse |
US20060051347A1 (en) | 2004-09-09 | 2006-03-09 | Winter Charles M | Process for concentration of antibodies and therapeutic products thereof |
WO2006072527A1 (de) | 2005-01-05 | 2006-07-13 | Siemens Aktiengesellschaft | Head-up-display für ein kraftfahrzeug |
JP4595112B2 (ja) | 2005-02-14 | 2010-12-08 | 独立行政法人産業技術総合研究所 | タンパク質の高効率分離または濃縮方法 |
EP1871803B1 (en) | 2005-04-18 | 2013-02-20 | Yeda Research And Development Company Limited | Stabilized anti-hepatitis b (hbv) antibody formulations |
RU2303833C2 (ru) | 2005-07-26 | 2007-07-27 | Самсунг Электро-Меканикс Ко., Лтд. | Осветительное устройство |
AU2006330858A1 (en) | 2005-12-21 | 2007-07-05 | Wyeth | Protein formulations with reduced viscosity and uses thereof |
JP5118139B2 (ja) * | 2006-08-04 | 2013-01-16 | バクスター・インターナショナル・インコーポレイテッド | 新規発症自己免疫性糖尿病を予防および/または逆転させるためのマイクロスフィアに基づく組成物 |
US8002046B2 (en) * | 2008-10-10 | 2011-08-23 | Neeb Daniel A | Apparatus for reducing the incidence of tampering with automatic fire sprinkler assemblies |
-
2005
- 2005-05-12 US US11/127,360 patent/US7884085B2/en active Active
- 2005-05-12 MX MXPA06012989A patent/MXPA06012989A/es active IP Right Grant
- 2005-05-12 CN CN2012105929369A patent/CN103432079A/zh active Pending
- 2005-05-12 JP JP2007513370A patent/JP2007537288A/ja active Pending
- 2005-05-12 WO PCT/US2005/016689 patent/WO2005112885A2/en active Application Filing
- 2005-05-12 DK DK05749674.7T patent/DK1758558T3/da active
- 2005-05-12 PT PT57496747T patent/PT1758558E/pt unknown
- 2005-05-12 CA CA2566199A patent/CA2566199C/en active Active
- 2005-05-12 ES ES05749674.7T patent/ES2442115T3/es active Active
- 2005-05-12 AU AU2005244851A patent/AU2005244851B2/en not_active Ceased
- 2005-05-12 EP EP05749674.7A patent/EP1758558B1/en active Active
-
2010
- 2010-06-24 US US12/822,774 patent/US9115357B2/en not_active Expired - Fee Related
-
2011
- 2011-09-13 JP JP2011199945A patent/JP5457414B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2005244851A1 (en) | 2005-12-01 |
EP1758558A2 (en) | 2007-03-07 |
JP2007537288A (ja) | 2007-12-20 |
US9115357B2 (en) | 2015-08-25 |
WO2005112885A2 (en) | 2005-12-01 |
PT1758558E (pt) | 2013-12-05 |
CA2566199C (en) | 2013-10-22 |
MXPA06012989A (es) | 2007-06-12 |
CN103432079A (zh) | 2013-12-11 |
JP2011256204A (ja) | 2011-12-22 |
AU2005244851B2 (en) | 2010-08-26 |
US20100260855A1 (en) | 2010-10-14 |
US7884085B2 (en) | 2011-02-08 |
EP1758558B1 (en) | 2013-10-16 |
CA2566199A1 (en) | 2005-12-01 |
US20060024240A1 (en) | 2006-02-02 |
DK1758558T3 (da) | 2014-01-20 |
WO2005112885A3 (en) | 2006-02-09 |
ES2442115T3 (es) | 2014-02-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5457414B2 (ja) | オリゴヌクレオチド含有マイクロスフェア、1型糖尿病を処置する医薬の製造のための、その使用 | |
EP2072040B1 (en) | Therapeutic use of nucleic acid micropheres | |
US6555525B2 (en) | Microencapsulation and sustained release of oligonucleotides | |
JP2011256204A5 (ja) | ||
KR20070116653A (ko) | 핵산 분자와 콜라겐의 복합체 미세 입자 제제 | |
JP5620946B2 (ja) | 新規発症自己免疫性糖尿病を予防および/または逆転させるためのマイクロスフィアに基づく組成物 | |
JP4602298B2 (ja) | 医薬製剤 | |
CA2476437A1 (en) | Chemosensitizing with liposomes containing oligonucleotides | |
CN1980641A (zh) | 含有寡核苷酸的微球体及其在制备用于治疗1型糖尿病的药物中的应用 | |
KR102677871B1 (ko) | 텔로머라제 활성화제와 나노 리포좀 입자를 포함하는 약물 전달용 조성물 및 이를 포함하는 탈모 예방, 개선 또는 치료용 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110913 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120828 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121220 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130607 |
|
A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20130821 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130911 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20131112 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20131213 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140109 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5457414 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
LAPS | Cancellation because of no payment of annual fees |