CN103249404A - 生物基质支架 - Google Patents

生物基质支架 Download PDF

Info

Publication number
CN103249404A
CN103249404A CN2011800426899A CN201180042689A CN103249404A CN 103249404 A CN103249404 A CN 103249404A CN 2011800426899 A CN2011800426899 A CN 2011800426899A CN 201180042689 A CN201180042689 A CN 201180042689A CN 103249404 A CN103249404 A CN 103249404A
Authority
CN
China
Prior art keywords
cell
culture
bio
matrix support
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800426899A
Other languages
English (en)
Chinese (zh)
Inventor
Y·王
L·C·M·里德
M·亚莫基
C-B·崔
A·Z·王
M·E·维尔纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Priority to CN201610286180.3A priority Critical patent/CN106362211A/zh
Publication of CN103249404A publication Critical patent/CN103249404A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/28—Materials or treatment for tissue regeneration for liver reconstruction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/14—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20051—Methods of production or purification of viral material
    • C12N2710/20052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10123—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10151—Methods of production or purification of viral material
    • C12N2730/10152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24223—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24251—Methods of production or purification of viral material
    • C12N2770/24252—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Prostheses (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN2011800426899A 2010-07-02 2011-07-01 生物基质支架 Pending CN103249404A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610286180.3A CN106362211A (zh) 2010-07-02 2011-07-01 生物基质支架

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36093910P 2010-07-02 2010-07-02
US61/360,939 2010-07-02
PCT/US2011/042805 WO2012003450A2 (en) 2010-07-02 2011-07-01 Biomatrix scaffolds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610286180.3A Division CN106362211A (zh) 2010-07-02 2011-07-01 生物基质支架

Publications (1)

Publication Number Publication Date
CN103249404A true CN103249404A (zh) 2013-08-14

Family

ID=45402468

Family Applications (4)

Application Number Title Priority Date Filing Date
CN2011800426899A Pending CN103249404A (zh) 2010-07-02 2011-07-01 生物基质支架
CN201510751844.4A Pending CN105713868A (zh) 2010-07-02 2011-07-01 用于工业规模分散的生物基质支架
CN201610286180.3A Pending CN106362211A (zh) 2010-07-02 2011-07-01 生物基质支架
CN201180042690.1A Expired - Fee Related CN103491898B (zh) 2010-07-02 2011-07-01 用于工业规模分散的生物基质支架

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN201510751844.4A Pending CN105713868A (zh) 2010-07-02 2011-07-01 用于工业规模分散的生物基质支架
CN201610286180.3A Pending CN106362211A (zh) 2010-07-02 2011-07-01 生物基质支架
CN201180042690.1A Expired - Fee Related CN103491898B (zh) 2010-07-02 2011-07-01 用于工业规模分散的生物基质支架

Country Status (11)

Country Link
US (7) US8802081B2 (enExample)
EP (6) EP3581171B1 (enExample)
JP (7) JP2013539960A (enExample)
CN (4) CN103249404A (enExample)
DK (2) DK2588027T3 (enExample)
ES (6) ES2624742T3 (enExample)
HU (2) HUE032730T2 (enExample)
LT (2) LT2588027T (enExample)
PL (2) PL2588027T3 (enExample)
PT (2) PT2588027T (enExample)
WO (2) WO2012003463A1 (enExample)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104928241A (zh) * 2015-03-27 2015-09-23 北京康爱瑞浩生物科技股份有限公司 一种增强型nk细胞的活化方法及细胞制备方法
CN105833353A (zh) * 2016-05-09 2016-08-10 拜欧迪赛尔(北京)生物科技有限公司 一种生物工程脱细胞真皮基质的制备及用途
CN106362212A (zh) * 2016-10-21 2017-02-01 华中科技大学同济医学院附属协和医院 一种用于去除组织细胞的亲脂性去细胞溶液、试剂盒和方法
CN108431209A (zh) * 2015-06-12 2018-08-21 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
CN108753687A (zh) * 2018-06-22 2018-11-06 北京达博威迎医药技术有限公司 微肝组织培养模型、其构建方法及其应用
CN108753686A (zh) * 2018-06-22 2018-11-06 北京达博威迎医药技术有限公司 组织工程肝脏模型、其构建方法及其应用
CN109415690A (zh) * 2016-05-11 2019-03-01 北卡罗来纳大学教堂山分校 用于生物工程组织的组合物和方法
CN109843328A (zh) * 2016-07-12 2019-06-04 北卡罗来纳大学教堂山分校 用于癌症诊断和建模的生物基质支架
CN110257335A (zh) * 2019-04-10 2019-09-20 首都医科大学附属北京天坛医院 单层或多层的3d脑胶质瘤细胞培养模型及其构建方法和应用
CN111032090A (zh) * 2017-06-12 2020-04-17 北卡罗来纳大学教堂山分校 用于细胞植入的补片植入物组合物
CN111050697A (zh) * 2017-07-31 2020-04-21 亚历山大·多坎托·扎戈 促进快速支柱覆盖和血管内皮覆盖的装置和方法
CN111712270A (zh) * 2017-10-13 2020-09-25 创伤护理咨询创伤学研究有限责任公司 弹性蛋白的减少实现软骨植入物的再细胞化
CN111760072A (zh) * 2020-08-24 2020-10-13 鲁峰 脂肪来源的真皮内填充物及其制备和应用
CN112243384A (zh) * 2018-05-14 2021-01-19 鲁斯特生物股份有限公司 与源自高渗细胞溶液的细胞外物质有关的方法和组合物
WO2021135564A1 (zh) * 2019-12-30 2021-07-08 广东泓志生物科技有限公司 大网膜脱细胞基质材料的制备方法及软骨组织的构建方法
CN114748208A (zh) * 2022-04-15 2022-07-15 柔脉医疗(深圳)有限公司 一种可原位检测多种化学、生物成分的组织工程支架
CN115948331A (zh) * 2022-10-17 2023-04-11 中国人民解放军西部战区总医院 一种从小鼠胆囊中分离获取间充质干细胞的方法

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2588027T (lt) * 2010-07-02 2017-06-12 The University Of North Carolina At Chapel Hill Pramoniniu mastu disperguoti biomatricos karkasai
NL2009145C2 (en) * 2012-07-06 2014-01-07 Xeltis B V Implant.
CN103536967B (zh) * 2012-07-10 2016-04-13 上海微创医疗器械(集团)有限公司 一种制备细胞外基质支架材料的脱细胞方法
US9533013B2 (en) * 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
SG10201906304TA (en) * 2013-03-15 2019-08-27 Miromatrix Medical Inc Use of perfusion decellularized liver for islet cell recellularization
WO2014143990A1 (en) * 2013-03-15 2014-09-18 NuTech Medical, Inc. Preparations derived from placental materials of making and using same
KR102129562B1 (ko) * 2013-04-08 2020-07-03 유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 결장절제없이 염증성 장 질환을 치료하는 방법 및 조성물
WO2015017500A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
CN103432627B (zh) * 2013-08-26 2015-03-25 北京瑞健高科生物科技有限公司 一种制备动物脱细胞组织基质材料的方法及其制备的组织基质材料
EP3739041A1 (en) 2014-03-27 2020-11-18 The Salk Institute for Biological Studies Compositions and methods for treating type 1 and type 2 diabetes and related disorders
GB201409858D0 (en) * 2014-06-03 2014-07-16 Ucl Business Plc Human liver scaffolds
CN104288837B (zh) * 2014-09-11 2016-04-13 杨淑珍 一种脱细胞真皮基质及其制备方法和用途
US10920199B2 (en) 2015-02-27 2021-02-16 Salk Institute For Biological Studies Reprogramming progenitor compositions and methods of use therefore
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US12551509B2 (en) 2015-11-18 2026-02-17 Lucina Patent Holdco, Llc Acellular regenerative products and methods of their manufacture
CN106884002B (zh) * 2015-12-15 2021-03-19 上海市针灸经络研究所 一种稳定的结肠上皮细胞培养方法
EP3936610A1 (en) 2016-05-25 2022-01-12 Salk Institute for Biological Studies Compositions and methods for organoid generation and disease modeling
GB2555787A (en) * 2016-11-07 2018-05-16 Landberg Goran Diagnostic methods
CN116243006B (zh) * 2016-11-30 2026-08-07 布鲁克·道尔顿有限及两合公司 制备活的微生物样品和微生物用于随后的质谱测量和评估
WO2018144469A1 (en) * 2017-01-31 2018-08-09 University Of Vermont And State Agricultural College Avian based lung assist device
WO2019129646A1 (en) * 2017-12-29 2019-07-04 F. Hoffmann-La Roche Ag Tissue sample preparation system
WO2019241499A1 (en) 2018-06-13 2019-12-19 Miromatrix Medical Inc. Fistula filler and deployment system
MX2021004140A (es) 2018-10-12 2021-08-05 Salk Inst For Biological Studi Celulas, isletas y organoides que evaden la deteccion inmunitaria y la autoinmunidad, metodos de produccion y usos de los mismos.
CN109735490A (zh) * 2019-03-06 2019-05-10 福建省海西细胞生物工程有限公司 一种脂肪干细胞提取方法
EP3969086B1 (en) 2019-05-16 2025-11-05 ResMed Pty Ltd Two-way communication in a medical device
KR102360023B1 (ko) * 2019-09-04 2022-02-09 한국생명공학연구원 증식 가능한 간 오가노이드
CN110559485B (zh) * 2019-09-25 2021-02-02 北京大清生物技术股份有限公司 一种生物组织基质材料及其制备方法与应用
DE102019130568A1 (de) 2019-11-13 2021-05-20 Aesculap Ag Chirurgischer Fräser mit verbesserter Spanabfuhr
JP7623017B2 (ja) * 2020-02-14 2025-01-28 セルアートジェン インコーポレイテッド 臓器オルガノイドの培養及び移植のための脱細胞臓器組織由来の支持体及びその製造方法
GB202102232D0 (en) * 2021-02-17 2021-03-31 Cambridge Entpr Ltd Methods of Expanding Cholangiocytes
WO2026023535A1 (ja) * 2024-07-22 2026-01-29 東洋濾紙株式会社 細胞培養体の製造方法、細胞培養部材の製造方法、細胞培養体、および細胞培養部材

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866414A (en) * 1995-02-10 1999-02-02 Badylak; Stephen F. Submucosa gel as a growth substrate for cells
US6149891A (en) * 1995-05-31 2000-11-21 Israel Humanitarian Foundation Ltd. X-ray contrast medium and method for protecting against harmful effects thereof
US6296810B1 (en) * 1993-02-01 2001-10-02 Praelux Incorporated Apparatus for DNA sequencing
US20020115208A1 (en) * 2000-08-16 2002-08-22 Shannon Mitchell Decellularized tissue engineered constructs and tissues
US20030014126A1 (en) * 2001-06-28 2003-01-16 Patel Umesh H. Graft prosthesis devices containing renal capsule collagen
US20070190649A1 (en) * 2006-01-18 2007-08-16 Hemacell Perfusion Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19569C (de) ANNA ERBER in Brieg Neuerungen an der unter Nr. 17581 patentirten Handlaterne
US20020177551A1 (en) * 2000-05-31 2002-11-28 Terman David S. Compositions and methods for treatment of neoplastic disease
EP2338983B1 (en) 2001-02-14 2015-10-07 Anthrogenesis Corporation Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells
US20040187877A1 (en) * 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
US7727550B2 (en) * 2003-02-21 2010-06-01 The Uab Research Foundation Biologically active native biomatrix composition
CA2530490A1 (en) 2003-06-25 2005-01-13 Stephen F. Badylak Conditioned matrix compositions for tissue restoration
ES2569780T3 (es) 2003-06-27 2016-05-12 DePuy Synthes Products, Inc. Células posparto derivadas de tejido placentario y métodos de preparación y uso de las mismas
ZA200800144B (en) * 2005-06-10 2010-02-24 Celgene Corp Human placental collagen compositions, processes for their preparation, methods of their use and kits comprising the compositions
US20090060961A1 (en) 2005-08-10 2009-03-05 Toray Industries Inc. Spongelike Structure and Powder, As Well As Process for Producing the Same
US8241908B2 (en) * 2006-05-16 2012-08-14 Becton, Dickinson And Company Extracellular matrix coated surface for culturing cells
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
AU2009298560B2 (en) 2008-09-30 2014-05-01 The Regents Of The University Of California Compositions and methods for tissue repair with extracellular matrices
EP2393914B1 (en) * 2009-02-04 2017-01-04 Yale University Tissue engineering of lung
WO2010099463A2 (en) * 2009-02-27 2010-09-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Joint bioscaffolds
EP2588592B1 (en) * 2010-06-30 2017-09-06 Miromatrix Medical Inc. Use of perfusion decellularized organs for matched recellularization
LT2588027T (lt) * 2010-07-02 2017-06-12 The University Of North Carolina At Chapel Hill Pramoniniu mastu disperguoti biomatricos karkasai

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6296810B1 (en) * 1993-02-01 2001-10-02 Praelux Incorporated Apparatus for DNA sequencing
US5866414A (en) * 1995-02-10 1999-02-02 Badylak; Stephen F. Submucosa gel as a growth substrate for cells
US6149891A (en) * 1995-05-31 2000-11-21 Israel Humanitarian Foundation Ltd. X-ray contrast medium and method for protecting against harmful effects thereof
US20020115208A1 (en) * 2000-08-16 2002-08-22 Shannon Mitchell Decellularized tissue engineered constructs and tissues
US20030014126A1 (en) * 2001-06-28 2003-01-16 Patel Umesh H. Graft prosthesis devices containing renal capsule collagen
US20070190649A1 (en) * 2006-01-18 2007-08-16 Hemacell Perfusion Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ROBERT E.BURGESON ET AL: "fetal membrane collagens:identification of two new collagen alpha chains", 《PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES》 *
ROSS ET AL: "Embryonic Stem Cells Proliferate and Differentiate when Seeded into Kidney Scaffolds", 《J AM SOC NEPHROL》 *

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104928241A (zh) * 2015-03-27 2015-09-23 北京康爱瑞浩生物科技股份有限公司 一种增强型nk细胞的活化方法及细胞制备方法
CN104928241B (zh) * 2015-03-27 2018-04-13 北京康爱瑞浩生物科技股份有限公司 一种增强型nk细胞的活化方法及细胞制备方法
CN108431209A (zh) * 2015-06-12 2018-08-21 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
US11795436B2 (en) 2015-06-12 2023-10-24 Agency For Science, Technology And Research Derivation of hepatic stem cells and mature liver cell types and uses thereof
CN108431209B (zh) * 2015-06-12 2023-02-10 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
CN105833353B (zh) * 2016-05-09 2018-04-20 拜欧迪赛尔(北京)生物科技有限公司 一种生物工程脱细胞真皮基质的制备及用途
CN105833353A (zh) * 2016-05-09 2016-08-10 拜欧迪赛尔(北京)生物科技有限公司 一种生物工程脱细胞真皮基质的制备及用途
CN109415690A (zh) * 2016-05-11 2019-03-01 北卡罗来纳大学教堂山分校 用于生物工程组织的组合物和方法
CN109843328A (zh) * 2016-07-12 2019-06-04 北卡罗来纳大学教堂山分校 用于癌症诊断和建模的生物基质支架
CN106362212A (zh) * 2016-10-21 2017-02-01 华中科技大学同济医学院附属协和医院 一种用于去除组织细胞的亲脂性去细胞溶液、试剂盒和方法
CN111032090A (zh) * 2017-06-12 2020-04-17 北卡罗来纳大学教堂山分校 用于细胞植入的补片植入物组合物
CN111050697A (zh) * 2017-07-31 2020-04-21 亚历山大·多坎托·扎戈 促进快速支柱覆盖和血管内皮覆盖的装置和方法
CN111712270A (zh) * 2017-10-13 2020-09-25 创伤护理咨询创伤学研究有限责任公司 弹性蛋白的减少实现软骨植入物的再细胞化
CN112243384A (zh) * 2018-05-14 2021-01-19 鲁斯特生物股份有限公司 与源自高渗细胞溶液的细胞外物质有关的方法和组合物
CN108753687A (zh) * 2018-06-22 2018-11-06 北京达博威迎医药技术有限公司 微肝组织培养模型、其构建方法及其应用
CN108753687B (zh) * 2018-06-22 2021-04-16 中国人民解放军军事科学院军事医学研究院 微肝组织培养模型、其构建方法及其应用
CN108753686B (zh) * 2018-06-22 2021-06-22 中国人民解放军军事科学院军事医学研究院 组织工程肝脏模型、其构建方法及其应用
CN108753686A (zh) * 2018-06-22 2018-11-06 北京达博威迎医药技术有限公司 组织工程肝脏模型、其构建方法及其应用
CN110257335B (zh) * 2019-04-10 2020-09-29 首都医科大学附属北京天坛医院 单层或多层的3d脑胶质瘤细胞培养模型及其构建方法和应用
CN110257335A (zh) * 2019-04-10 2019-09-20 首都医科大学附属北京天坛医院 单层或多层的3d脑胶质瘤细胞培养模型及其构建方法和应用
WO2021135564A1 (zh) * 2019-12-30 2021-07-08 广东泓志生物科技有限公司 大网膜脱细胞基质材料的制备方法及软骨组织的构建方法
CN111760072A (zh) * 2020-08-24 2020-10-13 鲁峰 脂肪来源的真皮内填充物及其制备和应用
CN111760072B (zh) * 2020-08-24 2022-09-23 鲁峰 脂肪来源的真皮内填充物及其制备和应用
CN114748208A (zh) * 2022-04-15 2022-07-15 柔脉医疗(深圳)有限公司 一种可原位检测多种化学、生物成分的组织工程支架
CN114748208B (zh) * 2022-04-15 2024-01-12 柔脉医疗(深圳)有限公司 一种可原位检测多种化学、生物成分的组织工程支架
CN115948331A (zh) * 2022-10-17 2023-04-11 中国人民解放军西部战区总医院 一种从小鼠胆囊中分离获取间充质干细胞的方法

Also Published As

Publication number Publication date
HK1243928A1 (en) 2018-07-27
WO2012003450A3 (en) 2012-04-05
JP2017079757A (ja) 2017-05-18
JP2019017392A (ja) 2019-02-07
US20190024043A1 (en) 2019-01-24
US9102913B2 (en) 2015-08-11
EP2588027B1 (en) 2017-03-08
ES2791312T3 (es) 2020-11-03
US20160024463A1 (en) 2016-01-28
EP3603622A1 (en) 2020-02-05
EP2588083A4 (en) 2013-11-13
CN106362211A (zh) 2017-02-01
PL2588027T3 (pl) 2017-09-29
EP2588027A1 (en) 2013-05-08
DK2588027T3 (en) 2017-06-19
CN105713868A (zh) 2016-06-29
EP2588083B1 (en) 2017-03-08
ES2946590T3 (es) 2023-07-21
JP2013539960A (ja) 2013-10-31
EP2588027A4 (en) 2013-12-11
PL2588083T3 (pl) 2017-08-31
EP3581171A1 (en) 2019-12-18
EP3192862A1 (en) 2017-07-19
HUE032727T2 (en) 2017-10-30
US10640747B2 (en) 2020-05-05
US20130137176A1 (en) 2013-05-30
US10246678B2 (en) 2019-04-02
CN103491898A (zh) 2014-01-01
JP6527272B2 (ja) 2019-06-05
HUE032730T2 (en) 2017-10-30
PT2588083T (pt) 2017-06-26
EP3581171B1 (en) 2022-03-09
JP2019017393A (ja) 2019-02-07
WO2012003463A1 (en) 2012-01-05
PT2588027T (pt) 2017-06-23
EP3216444A1 (en) 2017-09-13
JP6308781B2 (ja) 2018-04-11
ES2626145T3 (es) 2017-07-24
LT2588027T (lt) 2017-06-12
US8802081B2 (en) 2014-08-12
ES2624742T3 (es) 2017-07-17
US20200002667A1 (en) 2020-01-02
JP6612722B2 (ja) 2019-11-27
HK1193018A1 (zh) 2014-09-12
JP2017055764A (ja) 2017-03-23
LT2588083T (lt) 2017-06-12
EP2588083A2 (en) 2013-05-08
JP2013535961A (ja) 2013-09-19
US20150110753A1 (en) 2015-04-23
CN103491898B (zh) 2015-11-25
US9944896B2 (en) 2018-04-17
EP2588027B8 (en) 2017-07-26
EP3603622B1 (en) 2023-03-08
EP3216444B1 (en) 2020-03-11
US20130195811A1 (en) 2013-08-01
US20170015974A1 (en) 2017-01-19
ES2879246T3 (es) 2021-11-22
DK2588083T3 (en) 2017-06-19
WO2012003450A2 (en) 2012-01-05
EP3192862B1 (en) 2021-04-07
JP2018143249A (ja) 2018-09-20
ES2916580T3 (es) 2022-07-01

Similar Documents

Publication Publication Date Title
CN103491898B (zh) 用于工业规模分散的生物基质支架
HK1233552A1 (en) Biomatrix scaffolds
HK1188143A (en) Biomatrix scaffolds
HK1180235A (en) Biomatrix scaffolds
HK1180235B (en) Biomatrix scaffolds
HK1243928B (en) Biomatrix scaffolds for industrial scale dispersal
HK40023076A (en) Biomatrix scaffolds for industrial scale dispersal
HK40023076B (en) Biomatrix scaffolds for industrial scale dispersal

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1188143

Country of ref document: HK

RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20130814

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1188143

Country of ref document: HK