CN103055031B - Pure Chinese medicinal composition for treating lime disease of bees and preparation method of pure Chinese medicinal composition - Google Patents
Pure Chinese medicinal composition for treating lime disease of bees and preparation method of pure Chinese medicinal composition Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicinal composition for treating the lime disease of bees. The pure Chinese medicinal composition is prepared by mixing the following components in part by weight: 25 to 35 parts of tuckahoe, 15 to 35 parts of lightyellow sophora root, 25 to 45 parts of tobacco, 15 to 35 parts of lonicera japonica, 15 to 35 parts of dandelion, 15 to 35 parts of szechuan lovage rhizome, 15 to 35 parts of licorice root, 15 to 35 parts of plantain herb, 15 to 35 parts of folium isatidis and 25 to 35 parts of rhubarb. The invention has the advantages that the pure Chinese medicinal composition is rational in formula, easy to prepare, free of medicament residues, medicament resistance and toxic or side effects, can treat both symptoms and root causes, is sterilized through fumigation and has remarkable curative effects, and clinical results prove that the pure Chinese medicinal composition has a special effect of treating the lime disease of the bees.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of ascospherosis of bee and preparation method thereof, belong to animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment ascospherosis of bee and preparation method thereof.
Background technology
Ascospherosis of bee has another name called calcium carbonate disease, is a kind of fungal infectious disease that is caused bee larvae death by Ascosphaera apis parasitism, and the multiple the spring or early summer of being born in particularly easily occurs under overcast and rainy moist environmental condition.Ascosphaera apis is a kind of fungus, only attacks bee larvae.Die of illness larva and contaminated feedstuff, Nidus Vespae etc. is the primary disease source of infection.Mainly propagate by sporangiospore and ascospore.Bee larvae eats the feedstuff of pollution, and spore is sprouted at enteral, grows mycelia penetrable intestinal wall, and a large amount of mycelia make enterorrhexis after larva and dead, and form Sporangium at dead polypide table.After larva death, be just pale asphyxia, rear grey or black.After larva corpse is withered, become open-textured Chalk shape thing, body surface is covered with white hypha.
This disease spreads all over more than 100 countries of five continents, is widely distributed.At present, treat this disease the most frequently used be various antifungal drugs, though receive certain effect, because its toxic and side effects by force, easily produces the problem such as drug resistance and drug residue, clinical practice is very limited or bans use of.
Therefore researching and developing a kind of specific medicament for the treatment of ascospherosis of bee is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, the pure Chinese medicine composition of effectively treating ascospherosis of bee and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of ascospherosis of bee, by following component by weight mixed preparing form: Poria 25-35 part, Radix Sophorae Flavescentis 15-35 part, Nicotiana tabacum L. 25-45 part, Flos Lonicerae 15-35 part, Herba Taraxaci 15-35 part, Rhizoma Chuanxiong 15-35 part, Radix Glycyrrhizae 15-35 part, Herba Plantaginis 15-35 part, Folium Isatidis 15-35 part, Radix Et Rhizoma Rhei 25-35 part.
Described various component optimum ratio amount is: 30 parts, Poria, 25 parts of Radix Sophorae Flavescentiss, 35 parts, Nicotiana tabacum L., 25 parts of Flos Loniceraes, 25 parts of Herba Taraxacis, 25 parts of Rhizoma Chuanxiongs, 25 parts, Radix Glycyrrhizae, 25 parts of Herba Plantaginiss, 25 parts of Folium Isatidiss, 30 parts of Radix Et Rhizoma Rhei.
Treat a preparation method for the pure Chinese medicine composition of ascospherosis of bee, carry out as follows:
(1) the various compositions in prescription are pulverized respectively to rear mistake 100 mesh sieves;
(2) take by weight Poria 25-35 part, Radix Sophorae Flavescentis 15-35 part, Nicotiana tabacum L. 25-45 part, Flos Lonicerae 15-35 part, Herba Taraxaci 15-35 part, mix 5-10 minute to even;
(3) take by weight Rhizoma Chuanxiong 15-35 part, Radix Glycyrrhizae 15-35 part, Herba Plantaginis 15-35 part, Folium Isatidis 15-35 part, Radix Et Rhizoma Rhei 25-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Poria: sweet, light, flat, return lung, the heart, spleen, kidney channel, there is the function of promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming; Cure mainly that edema oliguria, insufficiency of the spleen lack of appetite, loose stool are had loose bowels, malaise etc.
Radix Sophorae Flavescentis: bitter, cold, return liver, the heart, stomach, large intestine, urinary bladder channel, have that heat clearing and damp drying, parasite killing go to amass, the function of diuretic; Cure mainly damp-heat dysentery etc.
Nicotiana tabacum L.: pungent, warm, return liver, lung meridian, there is the function of subduing swelling and detoxicating, parasite killing; Cure mainly furuncle swelling toxin, tinea capitis, tinea alba, tinea alba etc.
Flos Lonicerae: sweet, cold, return lung, the heart, stomach warp, there is the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Herba Taraxaci: bitter, sweet, cold, return liver, stomach warp, there is the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome; Cure mainly sore, lung abscess, pharyngalgia, jaundice due to damp-heat, pyretic stranguria etc.
Rhizoma Chuanxiong: pungent, warm, return gallbladder, liver, pericardium channel, there is the function of blood-activating and qi-promoting, wind-expelling pain-stopping; Cure mainly traumatic injury, stagnation of QI-blood, puerperal blood stasis, rheumatic arthralgia etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Herba Plantaginis: sweet, be slightly cold, return liver, kidney, lung, small intestine meridian, there is clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria, the function of improving eyesight; Cure mainly pyretic stranguria hematuria, have loose bowels, conjunctival congestion and swelling pain, edema etc.
Folium Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.
Radix Et Rhizoma Rhei: bitter, cold, return large intestine, spleen, stomach, liver, pericardium channel, there is the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain, enteritis etc.
All taste Chinese medicine, according to the theoretical compatible combination of Chinese veterinarian, for pathogenic microorganism and the clinical symptoms of ascospherosis of bee, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and cost is low, draws materials wide, drug residue free, has no drug resistance, has no side effect, sootiness sterilization, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this Ten Herbs, and makes them form pure Chinese medicine according to optimum ratio, and clinical practice proves that treatment ascospherosis of bee is had to specially good effect.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of ascospherosis of bee and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are pulverized respectively to rear mistake 100 mesh sieves;
(2) take by weight 250 parts, Poria, 150 parts of Radix Sophorae Flavescentiss, 250 parts, Nicotiana tabacum L., 150 parts of Flos Loniceraes, 150 parts of Herba Taraxacis, mix 5-10 minute to even;
(3) take by weight 150 parts of Rhizoma Chuanxiongs, 150 parts, Radix Glycyrrhizae, 150 parts of Herba Plantaginiss, 150 parts of Folium Isatidiss, 250 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of ascospherosis of bee and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are pulverized respectively to rear mistake 100 mesh sieves;
(2) take by weight 300 parts, Poria, 250 parts of Radix Sophorae Flavescentiss, 350 parts, Nicotiana tabacum L., 250 parts of Flos Loniceraes, 250 parts of Herba Taraxacis, mix 5-10 minute to even;
(3) take by weight 250 parts of Rhizoma Chuanxiongs, 250 parts, Radix Glycyrrhizae, 250 parts of Herba Plantaginiss, 250 parts of Folium Isatidiss, 300 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of ascospherosis of bee and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are pulverized respectively to rear mistake 100 mesh sieves;
(2) take by weight 350 parts, Poria, 350 parts of Radix Sophorae Flavescentiss, 450 parts, Nicotiana tabacum L., 350 parts of Flos Loniceraes, 350 parts of Herba Taraxacis, mix 5-10 minute to even;
(3) take by weight 350 parts of Rhizoma Chuanxiongs, 350 parts, Radix Glycyrrhizae, 350 parts of Herba Plantaginiss, 350 parts of Folium Isatidiss, 350 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
It is the ill Apis of ascospherosis of bee that clinical experiment animal is selected Laboratory Diagnosed.The isolation of ill honeybee is raised separately, be divided at random 3 groups, every group of 3 casees totally 15 spleen honeybees, 3 groups of feeding environments are identical, and experimental period is carried out 5 days altogether; Blank group is left intact, and medicine matched group uses treatment by institute's control drug by its description; Present composition group is sub-packed in product of the present invention (the prepared compositions of the embodiment of the present invention 1) in little paper bag, 5 grams every bag or 10 grams, after lighting one jiao of paper bag, blow out naked light, putting into beehive does not have a side of honeybee spleen, airtight smoking controlled 20 minutes to 30 minutes, every 3-5 days smoked controlling once, carry out 2-3 time continuously.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result (testing the 6th day) when following table is experiment end.
Table is the applicable cases contrast of the present invention and other medicines treatment ascospherosis of bee:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 21 | 54 | 25 |
| II | Griseofulvin spray group | 10 | 80 | 10 |
| III | Present composition group | 6 | 88 | 6 |
This clinical effectiveness statistical analysis, present composition treatment group and griseofulvin spray group significant difference (P < 0.05) compared with aspect cure rate.
Safety testing:
Choose 1 case 5 spleen of healthy Apis, according to 5 times of continuous fume smokings of the made compositions recommended dose of the embodiment of the present invention 1 60 minutes, during medication, healthy Apis is without any bad or Deviant Behavior performance, and difference is not remarkable compared with blank group (being not administration of health group).
The above-mentioned detailed description that pure Chinese medicine composition to this treatment ascospherosis of bee and preparation method thereof carries out with reference to embodiment; illustrative instead of determinate; can list several embodiment according to institute's limited range; therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a pure Chinese medicine composition for ascospherosis of bee, it is characterized in that being mixed by weight by following component: Poria 25-35 part, Radix Sophorae Flavescentis 15-35 part, Nicotiana tabacum L. 25-45 part, Flos Lonicerae 15-35 part, Herba Taraxaci 15-35 part, Rhizoma Chuanxiong 15-35 part, Radix Glycyrrhizae 15-35 part, Herba Plantaginis 15-35 part, Folium Isatidis 15-35 part, Radix Et Rhizoma Rhei 25-35 part.
2. the pure Chinese medicine composition for the treatment of ascospherosis of bee according to claim 1, is characterized in that being mixed by weight by following component: 30 parts, Poria, 25 parts of Radix Sophorae Flavescentiss, 35 parts, Nicotiana tabacum L., 25 parts of Flos Loniceraes, 25 parts of Herba Taraxacis, 25 parts of Rhizoma Chuanxiongs, 25 parts, Radix Glycyrrhizae, 25 parts of Herba Plantaginiss, 25 parts of Folium Isatidiss, 30 parts of Radix Et Rhizoma Rhei.
3. a preparation method for the pure Chinese medicine composition for the treatment of ascospherosis of bee according to claim 1, is characterized in that carrying out as follows:
(1) the various compositions in prescription are pulverized respectively to rear mistake 100 mesh sieves;
(2) take by weight Poria 25-35 part, Radix Sophorae Flavescentis 15-35 part, Nicotiana tabacum L. 25-45 part, Flos Lonicerae 15-35 part, Herba Taraxaci 15-35 part, mix 5-10 minute to even;
(3) take by weight Rhizoma Chuanxiong 15-35 part, Radix Glycyrrhizae 15-35 part, Herba Plantaginis 15-35 part, Folium Isatidis 15-35 part, Radix Et Rhizoma Rhei 25-35 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103735628B (en) * | 2014-01-24 | 2016-05-11 | 刘兴华 | A kind of medicine for the treatment of ascospherosis of bee and preparation method thereof |
| RU2552672C1 (en) * | 2014-02-04 | 2015-06-10 | Рашит Габдулхаевич Фархутдинов | Composition for stimulation of development of bee families, prevention and treatment of ascospherosis |
| CN106214819A (en) * | 2016-08-30 | 2016-12-14 | 澧县玖久养蜂专业合作社 | The medicine for the treatment of ascospherosis of bee |
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| CN1541679A (en) * | 2003-11-07 | 2004-11-03 | 王希颜 | Chinese traditional medicine preparation for preventing and treating bee diseases |
| CN1325107C (en) * | 2004-06-17 | 2007-07-11 | 叶达华 | Composition for treating bee disease and medicinal fodder |
| CN102273495A (en) * | 2010-06-11 | 2011-12-14 | 滕纯森 | Baofengjian |
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| KR101230975B1 (en) * | 2010-10-19 | 2013-02-07 | 김권회 | Composition for prevention and treatment of foulbrood in honey bee |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1541679A (en) * | 2003-11-07 | 2004-11-03 | 王希颜 | Chinese traditional medicine preparation for preventing and treating bee diseases |
| CN1325107C (en) * | 2004-06-17 | 2007-07-11 | 叶达华 | Composition for treating bee disease and medicinal fodder |
| CN102273495A (en) * | 2010-06-11 | 2011-12-14 | 滕纯森 | Baofengjian |
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