CN106334076A - Compound Chinese herbal preparation for preventing and controlling avian infectious laryngotracheitis and application thereof - Google Patents
Compound Chinese herbal preparation for preventing and controlling avian infectious laryngotracheitis and application thereof Download PDFInfo
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Abstract
The invention provides a compound Chinese herbal preparation for preventing and controlling avian infectious laryngotracheitis and application thereof, and belongs to the technical field of traditional Chinese medicine. According to the technical scheme, the compound Chinese herbal preparation for preventing and controlling avian infectious laryngotracheitis is prepared from, by weight, 10-25 parts of liquorice root, 20-35 parts of blackberry lily, 25-40 parts of radix isatidis, 25-40 parts of radix sophorae subprostratae, 20-40 parts of platycodon grandiflorum, 20-30 parts of the bulb of fritillary, 20-40 parts of fructus forsythia, 15-30 parts of radix astragali, 10-30 parts of radix scutellariae, 10-30 parts of mint, 10-20 parts of pig bile powder and 20-35 parts of gypsum. The compound Chinese herbal preparation has the advantages of being remarkable in effect of preventing and controlling avian infectious laryngotracheitis and greatly enhancing the comprehensive constitution performance of organism, chemicals such as antibacterial and antiviral drugs are not added, drug residue in livestock and poultry products, the food safety of the human is greatly improved, and the compound Chinese herbal preparation is environmentally friendly; the compound Chinese herbal preparation is simple in production process, low in cost and good in economic benefit and has wide application prospects.
Description
Technical field
The invention belongs to technical field of Chinese medicines is and in particular to a kind of compound recipe medium-height grass for preventing and treating infectious laryngotracheitis of chicken
Medicine preparation and its application.
Background technology
Infectious laryngotracheitis of chicken (avian infectious laryngo.tracheitis.ilt) is current China collection
Reduction poultry in affect one of larger disease, it is prevented and treated, mainly with vaccine prevention and be aided with antibiotic preventing and treating secondary infection.
Though being the Main Means of prevention and control primary disease using vaccine prevention. vaccination and lead to this disease outburst report be also to see not repeatly
Fresh, therefore risk is also larger, is also the one of chicken farm to worry greatly.
In the treatment of infectious laryngotracheitis of chicken, using antiviral drugs such as ribavirin, amantadine and Moroxydines
When, action target spot is single, and while obtaining certain curative effect, its many drawback more manifests, and is such as also easy to produce drug resistance drug resistance and makes
Product drug residue, livestock product safe and sanitary is not up to standard, jeopardizes human food's safety, under the speed of growth of chicken group and laying rate
Fall, causes serious economic loss etc., and due to its drug misadventure, to highlight above-mentioned Therapeutic Method disabled.Therefore, for poultry
The research of class medicine, is badly in need of the medicine of the wide preventing and treating infectious laryngotracheitis of chicken imitating safety, environmental protection of exploitation.With Chinese veterinarian
It is increasingly deep that theory is studied, and Chinese herbal medicine is increasingly becoming the focus of research preventing and treating avian infectious laryngotracheitis viruses disease, however,
The extremely various complexity of the important composition component of preventing and treating infectious laryngotracheitis of chicken, preparation technology are comparatively laborious, therefore suddenly at present
The major-minor assistant of the more scientific traditional Chinese medical science need to be studied makes compatibility theory, optimum organization composition formula, so that drug effect is excellent, preparation is easier to make
Make, in order to popularize.
Content of the invention
In order to solve current infectious laryngotracheitis of chicken drug component compatibility, science, the complicated loaded down with trivial details technology of preparation method are not asked
Topic, the present invention provides a kind of Chinese medicine formula for preventing and treating infectious laryngotracheitis of chicken, by major-minor in traditional Chinese veterinary medicine
Assistant makes under the guidance of compatibility theory, and science selects to have reinforcing body resistance, the work(such as pyretic toxicity, expulsion pathogenic factor, relieving cough and resolving phlegm in removing summer-heat body
The Chinese medicinal components of effect carry out compatibility it is achieved that simplifying component, strengthening therapeutic effect, and can improve the daily gain of chicken, enhancing body
Immunity, can greatly improve the economic benefit of raiser.
The technical solution used in the present invention is: a kind of Chinese medicine formula for preventing and treating infectious laryngotracheitis of chicken,
The raw material of described Chinese medicine formula includes the component of following ratio of weight and number: Radix Glycyrrhizae 10-25, Rhizoma Belamcandae 20-35, Radix Isatidis
25-40, Radix Sophorae Tonkinensiss 25-40, Radix Platycodoniss 20-40, Bulbus Fritillariae Uninbracteatae 20-30, Fructus Forsythiae 20-40, Radix Astragali 15-30, Radix Scutellariae 10-30, Herba Menthae 10-
30th, Fel Sus domestica powder 10-20 and Gypsum Fibrosum 20-35.
Preferably, the raw material of described Chinese medicine formula includes the component of following ratio of weight and number: Radix Glycyrrhizae 17-23, penetrates
Dry 25-35, Radix Isatidis 25-35, Radix Sophorae Tonkinensiss 25-35, Radix Platycodoniss 25-35, Bulbus Fritillariae Uninbracteatae 20-30, Fructus Forsythiae 25-35, Radix Astragali 15-25, Radix Scutellariae
10-30, Herba Menthae 10-30, Fel Sus domestica powder 10-20 and Gypsum Fibrosum 20-35.
It is furthermore preferred that the raw material of described Chinese medicine formula includes the component of following ratio of weight and number: Radix Glycyrrhizae 20, Rhizoma Belamcandae
30th, Radix Isatidis 30, Radix Sophorae Tonkinensiss 30, Radix Platycodoniss 30, Bulbus Fritillariae Uninbracteatae 25, Fructus Forsythiae 30, the Radix Astragali 20, Radix Scutellariae 20, Herba Menthae 20, Fel Sus domestica powder 15 and
Gypsum Fibrosum 25.
Preferably, described Chinese medicine formula is powder, and preparation method comprises the following steps: 1. former for weighing in proportion
Material;2. raw material pulverizing is made superfine powder mix homogeneously.
It is furthermore preferred that described superfine powder particle diameter≤75 μm.
It is furthermore preferred that described superfine powder particle diameter is 40 μm, 10 μm or 1 μm.
Preferably, described Chinese medicine formula usage amount is to account for 0.5 ~ 1.5wt.% of basic feedstuff.
The present invention also provides any of the above-described described Chinese medicine formula to be used for preventing and treating chicken infectivity throat trachea in preparation
Application in scorching preparation.
The present invention also provides any of the above-described described Chinese medicine formula to be used for preventing and treating poultry laryngotracheitis in preparation
Application in preparation.
In technique scheme, for preventing and treating the Chinese medicine formula of infectious laryngotracheitis of chicken, its raw material composition bag
Include Radix Glycyrrhizae, Rhizoma Belamcandae, Radix Isatidis, Radix Sophorae Tonkinensiss, Radix Platycodoniss, Bulbus Fritillariae Uninbracteatae, Fructus Forsythiae, the Radix Astragali, Radix Scutellariae, Herba Menthae, Fel Sus domestica powder and Gypsum Fibrosum, according in
The pathogeny of pharmacopeia, theory of Chinese medical science, document report and infectious laryngotracheitis of chicken and face the experience of examining, infectious laryngotracheitis of chicken
Belong to traditional Chinese veterinary medicine damp-heat disease scope, characteristic of disease belongs to heat, in lung, impairment of dispersing and descending function of the lung, inability of body fluid to function forms phlegm retention for sick position, cough, gas
Breathe heavily, the cardinal symptom such as rale and dyspnea.We's tool depressed lung-energy dispersing, the effect of relieving the exterior syndrome by diaphoresis, cure mainly to attack on ailment said due to cold or exposure pyretic toxicity and prolong
Afterwards, pharyngalgia sore throat, the card of the strongly fragrant lung of wind heat.Radix Platycodoniss, Bulbus Fritillariae Uninbracteatae and Radix Sophorae Tonkinensiss treatment swelling and sore throat, relieving cough and resolving phlegm is to take stopgap measures;Radix Isatidis,
Fructus Forsythiae, Rhizoma Belamcandae, Radix Scutellariae and Fel Sus domestica powder can in removing summer-heat body pyretic toxicity, expulsion pathogenic factor to effect a permanent cure;Herba Menthae is pungent and cold medicine for relieving the exterior syndrome;Gypsum Fibrosum
Cold in nature, there is powerful clearing away heat-fire effect, heating maincenter can be suppressed to play refrigeration function, and sweat gland secretion can be suppressed, meanwhile,
Gypsum Fibrosum acts on a part of calcium through gastric acid is made blood calcium concentration increase by absorption, it is possible to decrease vascular permeability, plays antiinflammatory, hemostasis is made
With;The Radix Astragali contains substantial amounts of astragalus polysaccharidess, is immunologic active material, has QI invigorating tonifying YANG, the effect of pick out positive eliminating evil, to body
Cellular immunization and humoral immunization have important regulation improvement result, can induce body produce interferon, the activated lymphocyte factor, by force
Change body's immunity;Radix Glycyrrhizae has invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, heat-clearing and toxic substances removing, the work(of coordinating the actions of various ingredients in a prescription.Our monarch drug reuses yellow
A kind of reed mentioned in ancient books, Fructus Forsythiae, Radix Platycodoniss, Radix Isatidis, Bulbus Fritillariae Uninbracteatae, wherein Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication;Radix Platycodoniss lung qi dispersing sore-throat relieving, eliminating the phlegm evacuation of pus;Fructus Forsythiae
Heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, Radix Isatidis clearing away heat and cooling blood, Bulbus Fritillariae Uninbracteatae energy resolving sputum lung qi dispersing;Several tastes altogether be monarch drug, can dissolve phlegm retention be jammed,
The card of inhibited pulmonary QI.Expectorant heat attacks lung by pathogenic heat, and caused by liver-fire raises up, therefore minister is with Rhizoma Belamcandae, Pulvis Fellis Suiss, Gypsum Fibrosum, can discongest irritability, clear
Lung cough-relieving, eliminating the phlegm are antipyretic;Attack on pyretic toxicity, the swollen pharyngalgia of chin or cheek, Gu Zuo with Herba Menthae, Radix Sophorae Tonkinensiss, with Radix Glycyrrhizae, Radix Astragali coordinating the actions of various ingredients in a prescription, with disease
Plus-minus, can heat clearing and damp drying, lung qi dispersing sore-throat relieving.Said components are all expectorant under moistening and cleaning throat, Qinghuo Jiedu, expectorant under pathogenic fire reducing, relieving sore throat and diminishing swelling, just in
Sick institute, above-mentioned Chinese medicinal components scientific compatibility, synergism are started with lung, spleen and kidney tripartite cooperation, are had antibacterial and disappear
Inflammation, antiviral, antianaphylaxis function, moreover it is possible to excite the immunologic function of chicken itself, improve immunity of organisms, thus strengthening disease-resistant energy
Power, all medicines and with amounting to heat-clearing and toxic substances removing, relieving cough and asthma, improve laryngeal edema, remove the effect of respiratory tract infarct symptoms, many experiments
Show, the Chinese herbal and crude drugs preparationses treatment infectious laryngotracheitis of chicken effect highly significant of this research, and can reduce in livestock products
Drug residue, green safety.
The invention has the beneficial effects as follows: the Chinese herbal compound preparation treatment infectious laryngotracheitis of chicken that (1) present invention provides
Effect highly significant, and improve the immunologic function of body itself, greatly strengthen body synthesis body constitution performance, reduce chicken again
The probability of subinfection disease, protects poultry from the infringement of noxious substance, virus etc.;(2) this Chinese herbal compound preparation without
The chemical drugss such as antimicrobial drug and antiviral chemical medicine, drug residue free in livestock product, substantially increase human food's safety, to poultry
Animal husbandry, food safety are all significant, green, environmental protection;(3), in further improved technical scheme, ultrafine powder is big
Big raising Chinese herbal medicine utilization rate, reduces usage amount, reduces side effect, reduce and waste;(4) this Chinese herbal compound preparation dispensing and life
Production. art is simple, cost is relatively low, good in economic efficiency it is adaptable to industrialized production and promoting on a large scale, have a extensive future.
Specific embodiment
The present invention provides a kind of Chinese medicine formula for preventing and treating infectious laryngotracheitis of chicken and its application, below leads to
Cross specific embodiment and experimental technique illustrates the composition of this Chinese medicine formula and its is applied to prevent and treat chicken infectivity throat trachea
Scorching effect, to be better understood from the present invention, wherein involved raw material, if no special instructions, all commercially obtain,
Involved experimental technique, operational approach, are conventional meanses if no special instructions.
Chinese medicine formula for preventing and treating infectious laryngotracheitis of chicken forms compatibility example ginseng and is shown in Table 1.
Table 1, Chinese medicine formula composition compatibility example (ratio of weight and number)
The above-mentioned Chinese medicine formula for preventing and treating infectious laryngotracheitis of chicken, can make various dosage forms after weighing in proportion,
Preferred powder type in the present embodiment, the preparation method of described Chinese medicine formula powder comprises the following steps: 1. claims in proportion
Take raw material;2. by raw material pulverizing, and mix homogeneously makes superfine powder, obtains final product powder, for ensureing curative effect, the superfine powder particle diameter of pulverizing
≤ 75 μm, after micronizing, specific surface area increases Chinese herbal medicine, and particle diameter reaches micron order, this utilization rate to raising Chinese crude drug,
Medicament curative effect enhancement;Further, micronizing not only breaks up the intercellular layer between cell, and cell is smashed, and makes Chinese medicine
Material cell wall breaking, also further improves the utilization rate of Chinese crude drug, medicament curative effect enhancement.
During practical application, crushing material can be become 40 μm, 10 μm by Study on Supermicro-pulverization of Traditional Chinese Drugs, even up to less than 1 μm ultra-fine
Powder, cell-wall breaking ratio >=95%.Process above-mentioned raw materials using Chinese medicine ultra-fine powder technology, make compound Chinese herb powder, prescription is not
Become, indication is constant, instructions of taking is constant, but technique improves, pharmacologically active greatly improves, clinical efficacy also greatly improves, right
In actual industry application, have reduce usage amount, reduce gastrointestinal side effect advantage, become green cultivation mixed feeding or mixed drink to
The preferred manner of medicine.In following clinical trials, it is to use dosage form with above-mentioned ultrafine powder, concrete test is as follows.
Test the clinical trial to artificial challenge's infectious laryngotracheitis of chicken for the 1 compound Chinese herb ultrafine powder
1.1 experimental animal packets and process
By the healthy commercial generation sea blue ash chicken 600 of 60 ages in days, it is randomly divided into six groups, every group 100, wherein ,-organize as people
Work infects the chicken of infectious laryngotracheitis of chicken, and the group is not infected group, i.e. healthy group.The fed feedstuff of~group be
Add compound Chinese herb ultrafine powder shown in the various dose embodiment of the present invention 4 respectively, spice amount is respectively in normal feedstuff
Account for 0.5%, 1.0% and the 1.5% of normal feedstuff mass percent;Organize and (in normal feedstuff, add moroxydine for drug control group
Treatment group, dosage presses the 0.75g/kg body weight recommended);Organize as positive controls (infecting not administration group);Organize as sky
White matched group (not infecting the healthy control group not being administered), concrete packet and process are shown in Table 2, each group chicken locellus isolated rearing,
After the test strong venom of chicken inoculation iltv 24 h, in addition to blank control group and positive controls, remaining each group chicken is respectively pressed above-mentioned
Design Treatment is administered treatment.Each group chicken feed and the drinking-water same day necessary net groove, successive administration 7d, stop observation post administration 10d.
The packet of table 2 test chicken and process
1.2 test results and analysis
Each group mortality rate, effective percentage, cure rate, body weight increase rate are shown in Table 3.
The efficacy result to artificial challenge's infectious laryngotracheitis of chicken for the table 3 compound Chinese herb superfine powder
* refer to spontaneous recovery rate
Above-mentioned result of the test carries out statistical analysiss, and result shows: (1) effective percentage: compound Chinese herb ultrafine powder is high, medium and low
Dosage group and drug control group higher by 35% than positive controls respectively, 35%, 25%, 30%, difference is all extremely notable (p < 0.01);Multiple
The high, medium and low dosage group of square Chinese herbal medicine ultra-fine powder is compared with drug control group respectively, and difference is neither notable (p > 0.05).(2) control
More rate: the high, medium and low dosage group of compound Chinese herb ultrafine powder and moroxydine group higher by 45% than positive controls respectively, 47%,
35%th, 33%, difference is all extremely notable (p < 0.01);Compound Chinese herb superfine powder is high, middle dose group respectively with drug control group ratio
Relatively, difference is all notable (p < 0.05), differs 12% and 14% respectively, compound Chinese herb ultrafine powder low dose group compares high dose
Group and middle dose group respectively low 10% and 12%, difference is all notable (p < 0.05).(3) rate of body weight gain: compound Chinese herb ultrafine powder
, respectively high 21.19% and 24.33% than positive controls, difference is all extremely notable (p < 0.01), compares drug control for height, middle dose group
Group difference high 6.06% and 9.2%.Compound Chinese herb superfine powder low dose group and medicine matched group are higher than positive controls respectively
13.21% and 15.13%, difference is all notable (p < 0.05);Compound Chinese herb superfine powder middle dose group is respectively than low dose group and medicine
Thing matched group high 11.12% and 9.20%, difference is all notable (p < 0.05).
This result illustrates, adds, in 1.0wt.% ratio, the compound Chinese herb superfine powder that the present invention provides in normal feedstuff
Powder energy effectively treatment artificial challenge's infectious laryngotracheitis of chicken, its effective percentage, cure rate and body weight increase rate respectively 95%,
92% and 81.35%, treatment is superior to drug control group, and the compound Chinese herb superfine powder biological safety that the present invention provides
High.
Test the clinical trial to natural infection infectious laryngotracheitis of chicken for the 2 compound Chinese herb superfine powder
Statistics participates in the chicken group totally 3562 of test, and chicken number natural infection infectious laryngotracheitis of chicken is detected is 1471
Only, feed in normal feedstuff in the Chinese herbal medicine ultra-fine powder powder that the ratio of daily 1.0wt.% adds proportioning shown in embodiment 6,
Continuous feeding treatment 7d, then observe 10d, statistical result is shown in Table 4.
The efficacy result to natural infection infectious laryngotracheitis of chicken for the table 4 compound Chinese herb superfine powder
The result of table 4 shows, this chicken group's ilt sickness rate is up to 41.3%, using in compound Chinese herb superfine powder therapeutic process, sends out
Now normal chicken no infection conditions generation again, the sick fowl spirit having infected infectious laryngotracheitiss gradually takes a turn for the better, dyspneic
Symptom mitigation, appetite is remarkably reinforced, and feces also switch to normally.(when observing the 10th day), all illness at the end of experimental period
Chicken almost all is cured, and cure rate reaches 95.9%, and laying rate has rebound significantly.For early stage sickness rate up to 41.3%, morbidity
The chicken group that the situation is tense, chicken death only 44 in whole therapeutic process, diseased chicken mortality rate only 3.0%, with regard to natural infection diseased chicken
For, sickness rate is so high, but final mortality rate is very low, illustrates compound Chinese herb ultrafine powder to chicken infectivity throat trachea
Inflammation has good therapeutic effect, and meanwhile, in therapeutic process, normal chicken does not continue to infect, and infectious laryngotracheitis feelings do not expand
Greatly, illustrate that this compound Chinese herb ultrafine powder is good to the preventive effect of infectious laryngotracheitiss.
Visible in sum, provided by the present invention for preventing and treating the Chinese medicine formula component of infectious laryngotracheitis of chicken
Simply, compatibility more optimizes science, preparation method simply, good to the prevention effect of infectious laryngotracheitis of chicken, improves simultaneously
Immunity of organisms, improves daily gain and the laying rate of chicken, can greatly improve the economic benefit of raiser, this Chinese herbal and crude drugs preparations can
It is more broadly useful for preparing preparation, the preventing and treating poultry laryngotracheitis preparation of preventing and treating infectious laryngotracheitis of chicken, be suitable to extensive
Popularization and application.
Claims (9)
1. a kind of Chinese medicine formula for preventing and treating infectious laryngotracheitis of chicken is it is characterised in that described compound Chinese herb
The raw material of preparation includes the component of following ratio of weight and number: Radix Glycyrrhizae 10-25, Rhizoma Belamcandae 20-35, Radix Isatidis 25-40, Radix Sophorae Tonkinensiss 25-
40th, Radix Platycodoniss 20-40, Bulbus Fritillariae Uninbracteatae 20-30, Fructus Forsythiae 20-40, Radix Astragali 15-30, Radix Scutellariae 10-30, Herba Menthae 10-30, Fel Sus domestica powder 10-20
With Gypsum Fibrosum 20-35.
2. Chinese medicine formula according to claim 1 is it is characterised in that the raw material bag of described Chinese medicine formula
Include the component of following ratio of weight and number: Radix Glycyrrhizae 17-23, Rhizoma Belamcandae 25-35, Radix Isatidis 25-35, Radix Sophorae Tonkinensiss 25-35, Radix Platycodoniss 25-35,
Bulbus Fritillariae Uninbracteatae 20-30, Fructus Forsythiae 25-35, Radix Astragali 15-25, Radix Scutellariae 10-30, Herba Menthae 10-30, Fel Sus domestica powder 10-20 and Gypsum Fibrosum 20-35.
3. Chinese medicine formula according to claim 1 is it is characterised in that the raw material bag of described Chinese medicine formula
Include the component of following ratio of weight and number: Radix Glycyrrhizae 20, Rhizoma Belamcandae 30, Radix Isatidis 30, Radix Sophorae Tonkinensiss 30, Radix Platycodoniss 30, Bulbus Fritillariae Uninbracteatae 25, Fructus Forsythiae 30,
The Radix Astragali 20, Radix Scutellariae 20, Herba Menthae 20, Fel Sus domestica powder 15 and Gypsum Fibrosum 25.
4. according to the arbitrary described Chinese medicine formula of claim 1-3 it is characterised in that described Chinese medicine formula is
Powder, preparation method comprises the following steps: 1. for weighing raw material in proportion;2. raw material pulverizing is made superfine powder and mix all
Even.
5. Chinese medicine formula according to claim 4 is it is characterised in that described superfine powder particle diameter≤75 μm.
6. Chinese medicine formula according to claim 4 is it is characterised in that described superfine powder particle diameter is 40 μm, 10 μm
Or 1 μm.
7. according to the arbitrary described Chinese medicine formula of claim 1-3 it is characterised in that described Chinese medicine formula makes
Consumption is the 0.5 ~ 1.5wt.% accounting for basic feedstuff.
8. the arbitrary described Chinese medicine formula of claim 1-3 is used for preventing and treating the preparation of infectious laryngotracheitis of chicken in preparation
In application.
9. the arbitrary described Chinese medicine formula of claim 1-3 is used for preventing and treating in poultry laryngotracheitis preparation in preparation
Application.
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Cited By (1)
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CN108261478A (en) * | 2017-12-11 | 2018-07-10 | 刘凡领 | A kind of preparation method for treating poultry infectious laryngotracheitis medicament |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101773569A (en) * | 2010-03-04 | 2010-07-14 | 河北工程大学 | Oral Chinese medicine liquid for treating chicken infectious laryngotracheitis |
CN102357158A (en) * | 2011-10-24 | 2012-02-22 | 中国农业科学院兰州畜牧与兽药研究所 | Medicament for preventing and curing avian infectious laryngotracheitis and preparation method thereof |
CN104173453A (en) * | 2013-08-30 | 2014-12-03 | 郑州后羿制药有限公司 | Traditional Chinese medicinal composition used for preventing and treating infectious laryngotracheitis of chicken, and preparation method thereof |
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2016
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101773569A (en) * | 2010-03-04 | 2010-07-14 | 河北工程大学 | Oral Chinese medicine liquid for treating chicken infectious laryngotracheitis |
CN102357158A (en) * | 2011-10-24 | 2012-02-22 | 中国农业科学院兰州畜牧与兽药研究所 | Medicament for preventing and curing avian infectious laryngotracheitis and preparation method thereof |
CN104173453A (en) * | 2013-08-30 | 2014-12-03 | 郑州后羿制药有限公司 | Traditional Chinese medicinal composition used for preventing and treating infectious laryngotracheitis of chicken, and preparation method thereof |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN108261478A (en) * | 2017-12-11 | 2018-07-10 | 刘凡领 | A kind of preparation method for treating poultry infectious laryngotracheitis medicament |
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