CN1733074A

CN1733074A - Externally applied medicine for treating dermatosis

Info

Publication number: CN1733074A
Application number: CNA2005100912681A
Authority: CN
Inventors: 芦虎
Original assignee: Individual
Current assignee: Individual
Priority date: 2005-08-19
Filing date: 2005-08-19
Publication date: 2006-02-15
Anticipated expiration: 2025-08-19
Also published as: CN100342868C

Abstract

The invention discloses an externally applied medicine for treating dermatosis, which is prepared from Chinese medicinal herbs including honeysuckle flower, baikal skullcap root, Chinese angelica root, root of red rooted saliva, siberian cocklebur fruit, achyranthes and cyathula root, Chinese ephedra, Schizonepeta tenuifolia, cassia twig, pearl powder through cleaning, heating, drying, disintegrating, grease making and sterilizing.

Description

The dermopathic external used medicine of a kind of treatment

The dermopathic external used medicine of a kind of treatment of the present invention relates to pharmaceutical field, it specifically is raw material with the Chinese herbal medicine, through big gun process, dry, pulverize, external preparation for skin powder, unguentum that Technologies such as system cream, sterilization are made, the invention still further relates to the preparation method of this powder unguentum.

The skin and the mucosal infections disease that are caused by the source of disease microorganism are human threats greatly, and mucocutaneous be one of the area of liability of multiple pathogen, the skin pruritus that causes thus, eczema, beriberi, Yin Xiao disease, vaginitis, tinea corporis and cruris are common clinical, and relapse rate is high, and often bring out multiple secondary infection disease, bring unmentionable pain to people.Greatly developing along with the industrialization industry in recent years, mucocutaneous infections sharply rises, its reason may be in a large amount of listings of chemical substance, and air pollution is relevant to multiple factors such as the infringement of human body and patient's itself body constitution, nutritional status, dysfunction of nervous regulation, metabolism disorders.Though mucocutaneous disease is safe from harm to life for the moment, can bring in various degree the misery or affect and imitate rule with work orthobiosis of feeling embarrassed to mention to the patient.The dermopathic external used medicine powder of a kind of treatment of the present invention unguentum, part by skin or mucosa is coated with to touch administration or light and sucks smoked the treatment, the combination of inner and outside, suction reaches whole body meridian and relaxes logical, smear direct inhibition or deactivation antibacterial and fungus colony, thereby improve self resistance against diseases effectively, prevent the breeding of source of disease microorganism, propagate, reach the purpose of antibacterial anti-inflammatory, killing parasites for relieving itching, removing heat from blood dehumidifying and disease-prevention health and correction immune imbalance.

The object of the present invention is to provide and a kind ofly have putrefaction-removing granulation-promoting, detoxicating, killing bacteria, removing heat from blood dehumidifying and directly act on the part and suck the smoked logical whole body passages through which vital energy circulates for the treatment of, relax, correct the external used medicine of immune imbalance.Main component is Flos Lonicerae, Radix Scutellariae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Fructus Xanthii, Radix Achyranthis Bidentatae, Herba Ephedrae, Herba Schizonepetae, Ramulus Cinnamomi, Margarita powder etc. ten flavor herbal raw materials, processs method and modern science technology is made powder, unguentum through special big gun.The direct administration of skin reaches local putrefaction-removing granulation-promoting, detoxicating, killing bacteria, suck smoked the treatment, obviously the human body immunity improving function enters intravital drug smell and can quicken interior environment metabolism, promote the regeneration and restoration of skin surface necrosis, make various source of disease infected by microbes disease quickly-healings.

Another object of the present invention provides a kind of preparation method for the treatment of dermopathic external used medicine.It is characterized in that earlier Flos Lonicerae, Radix Scutellariae, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Fructus Xanthii, Radix Achyranthis Bidentatae, Herba Ephedrae, Herba Schizonepetae, the Ramulus Cinnamomi nine that will clean flavor be single putting the iron pan internal heating one by one and being stirred to into black wood charcoal, flame-out, spray 10% filtrate that decocts with water with the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Fructus Psoraleae three flavors, stir, cool, drying, it is standby to be crushed to 120 mesh sieve fine powders; Weigh the proportioning weight and the Margarita powder mix homogeneously of every herbal medicine, packing gets powder; Other gets powder and vaseline and is mixed with into 30% ointment, ointment, packing, G ₆₀Radiation sterilizing gets product.

The characteristics of a kind of external use medicine for treating dermatosis thing of the present invention are partial smearing or light and suck the smoked nose administration for the treatment of, the logical whole body passages through which vital energy circulates that can relax, inside and outside take into account, easy to use, lasting medicine, side effect is little, can see good result in a short time, better to the therapeutic effect of chronic dermatosis.

Medicine of the present invention shows through antibacterial tests and skin irritation test, carry out the repeatedly skin irritation test of staphylococcus aureus and White Rabbit single-use skin irritant test, Cavia porcellus according to Ministry of Public Health " disinfection technology standard " (version in 2002) method, the result shows strong, the no skin irritation of a kind of treatment dermatosis external powder cream antibacterial antiplaque agent power that provides by the related standards scoring.Result of the test sees Table 1, table 2 and table 3.

Table 1 Lu Hu dermatosis externally used paste is to staphylococcus aureus bacteriostatic test result

Print inhibition zone diameter (mm) bacterial concentration negative control is antibacterial

Test sequence number 1234 meansigma methodss (cfu/ml) ring diameters (mm)

1 13.0 14.0 15.0 16.0 14.5 180 * 10 ⁴Do not have

2 14.0 14.0 15.0 15.0 14.5 165 * 10 ⁴Do not have

3 13.0 15.0 16.0 14.0 14.5 175 * 10 ⁴Do not have

Meansigma methods 14.5 173 * 10 ⁴Do not have

Conclusion, product of the present invention as can be seen from Table 1 has antibacterial action preferably to three tests of staphylococcus aureus.

Table 2 Lu Hu dermatosis externally used paste is to irritant reaction of White Rabbit skin

1h 24h 48h

The contrast of the same product control sample of numbering animality complicated variant control sample

(kg) the total red water of the total red water of the total red water of the total red water of the total red water of red water is total

Speckle is swollen to divide that speckle is swollen to divide that speckle is swollen to divide that speckle is swollen to divide that speckle is swollen to divide that speckle is swollen to be divided

1 male 2.2 000 000 000 000 000 000

2 male 2.2 000 000 000 000 000 000

3 male 2.6 000 000 000 000 000 000

Integral mean value 000000

Conclusion, product of the present invention as can be seen from Table 2 belongs to nonirritant to the White Rabbit skin irritation.

Table 3 Lu Hu dermatosis externally used paste is tested the guinea pig skin allergy

The group number of animals is induced the erythematous response intensity edema response strength sensitization rate when observing that excites

(h) 0123401234 (%) between (only) dosage dosage

Tried the former cream 24h 16,/16 0000 16,/16 00000 of 16 former cream

Thing group 48h 16,/16 0000 16,/16 00000

Negative to 16/former cream 24h 16,/16 0000 16,/16 00000

According to group 48h 16,/16 0000 16,/16 00000

Positive in 16 8% 2% 24h 6,/16 6,/16 4,/16 00 16,/16 0000 62.5

According to group 48h 6,/16 6,/16 4,/16 00 16,/16 0000 62.5

Conclusion, product of the present invention as can be seen from Table 3 to the sensitization of skin intensity of experimental animal Cavia porcellus for not seeing skin allergic reaction.

Medicine of the present invention is treated follow-up observation to 210 routine patients, and wherein sicken age was at 1 month to 5 years, and administration time 10 to 90 days, the unguentum of a packing specification are 20 grams, smear 2 times on the one according to the size of skin affected part area; One in powder is packaged as 10 grams, lights smoked the treatment for 1 time on the one, prohibits sexual life during the medication, avoids maror.Cure 82 examples, account for 39.1%, produce effects 103 examples account for 49.0%; Effective 17 examples account for 8.1%; Invalid 8 examples account for 3.8%, and total effective rate reaches 96.2%.Therefore, invent the external of a kind of dermatosis powder unguentum and smear and suck smoked the treatment, the combination of inner and outside, improve healthy energy, consolidate the training source, curative effect is lasting, effect is obvious, be difficult for recurrence, chronic skin patient and medical market service are had great significance, put on market generation considerable economic and social benefit.

Claims

1, the dermopathic external used medicine of a kind of treatment is characterized in that it is the topical agent of being made by following herbal raw material proportioning:

Flos Lonicerae 12 gram Radix Scutellariaes 10 gram Radix Angelicae Sinensis 10 gram Radix Salviae Miltiorrhizaes 10 grams

Fructus Xanthii 10 gram Radix Achyranthis Bidentataes 20 gram Herba Ephedraes 20 gram Herba Schizonepetae 10 grams

Ramulus Cinnamomi 10 gram Margarita powder 8 grams.

2, the dermopathic external used medicine of a kind of treatment according to claim 1 is characterized in that said dosage form is external preparation for skin powder or ointment.

3, a kind of preparation method for preparing the treatment external use medicine for treating dermatosis thing of aforesaid right requirement 1 or 2, it is characterized in that earlier Flos Lonicerae 12 grams, Radix Scutellariae 10 grams, Radix Angelicae Sinensis 10 grams, Radix Salviae Miltiorrhizae 10 grams, Fructus Xanthii 10 grams, Radix Achyranthis Bidentatae 20 grams, Herba Ephedrae 20 grams, Herba Schizonepetae 10 grams, Ramulus Cinnamomi 10 grams nine that will clean flavor be single putting the iron pan internal heating one by one and being stirred to into black wood charcoal, flame-out, spray 10% filtrate that decocts with water with the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, each 10 gram of Fructus Psoraleae, stir, cool, drying, it is standby to be crushed to 120 mesh sieve fine powders; Weigh the proportioning weight and the Margarita powder 8 gram mix homogeneously of every herbal medicine, packing promptly gets powder; Also desirable powder and vaseline are mixed with into 30% ointment, ointment; Packing, G ₆₀Radiation sterilizing gets product.