CN111097040A

CN111097040A - Antiviral lung-heat clearing peptide

Info

Publication number: CN111097040A
Application number: CN202010101795.0A
Authority: CN
Inventors: 苟春虎
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-02-19
Filing date: 2020-02-19
Publication date: 2020-05-05

Abstract

The antiviral lung-heat clearing peptide is characterized in that raw hedysarum polybotrys extract, large flower extract, echinacea extract, cassia twig extract, giant knotweed rhizome extract, tetrahydrocurcumin, ginkgo extract, lactoferrin peptide and auxiliary materials are used as raw materials. The product has effects in enhancing immunity, clearing lung-heat, removing toxic substances, preventing infection of coronavirus and influenza virus, preventing and treating viral pneumonia and myocarditis, resisting pathogen, killing bacteria, relieving inflammation, nourishing lung, protecting lung, preventing fever, relieving cough, eliminating phlegm, and enhancing immunity. Experiments prove that the product can inhibit the replication of coronavirus and avian influenza virus and prevent and treat viral pneumonia in vitro cell culture, can inhibit the coronavirus and avian influenza virus in mouse experiments, and has good inhibitory effect on deoxyribonucleic acid of the viruses.

Description

Antiviral lung-heat clearing peptide

The technical field is as follows: the present invention belongs to a special medical food combining Chinese traditional medicine and western medicine, particularly to a special medical food which is processed by natural pollution-free high-quality plant extracts and other raw materials by the modern most advanced ultrasonic extraction technology.

Secondly, background art: the product has effects in enhancing immunity, resisting virus and various influenza virus infections, preventing and treating viral pneumonia and myocarditis, resisting pathogen, killing bacteria, relieving inflammation, nourishing and protecting lung, clearing lung-heat, removing toxic substances, and preventing and clearing away heat. The product is a hard capsule prepared from natural medicinal and edible plants and biological products serving as raw materials, and has the advantages of high purity, strong biological activity, good absorption and utilization, no toxic or side effect, convenient taking and obvious effect.

Thirdly, the invention content: the life is loved, and the coronavirus infection is scientifically prevented and treated. The national Weijian Commission soon reminds people in China, and the coronavirus pandemic is particularly important to be prevented. Coronavirus possesses a surprising infectivity, and a viral droplet inhaled directly into the air is infected. The severe epidemic of sars in 2003 has made people aware of the fear of viral infections. Viral disease infection has become a pandemic disease that human society must address. Therefore, the product is innovated and researched, has important and profound social significance and economic benefit, and can also benefit mankind.

Fourthly, raw material formula: 50-100 kg of raw radix hedysari extract, 40-90 kg of rhodiola crenulata extract, 30-80 kg of echinacea extract, 20-70 kg of cassia twig extract, 10-60 kg of polygonum cuspidatum extract, 15-65 kg of tetrahydrocurcumin, 25-45 kg of ginkgo extract, 5-50 kg of lactoferrin peptide and auxiliary materials as raw materials.

Fifthly, the technical scheme is as follows:

radix Hedysari extract (Radix Hedysari extract) is prepared from Radix Hedysari, which is dried root of multiple-sequence Radix Hedysari of Leguminosae. It is warm in nature, sweet in flavor and enters lung and spleen meridians. Has effects in strengthening body resistance, consolidating constitution, invigorating lung, invigorating yang, consolidating superficial resistance, arresting sweating, clearing away heat and toxic materials, preventing and treating toxic pneumonia, promoting granulation, inducing diuresis, relieving swelling, healing sore, and promoting granulation. It is suitable for pneumonia caused by various viruses such as lung qi debilitation, lung deficiency short breath, viral pneumonia, coronavirus and avian influenza. Modern medical research shows that the traditional Chinese medicine has a plurality of functions of enhancing immune function, resisting pathogens, resisting viruses, preventing warm, resisting inflammation, preventing and treating pneumonia and myocarditis caused by viruses, preventing and treating respiratory virus infection and the like.

The chemical components of radix hedysari comprise radix hedysari glycoside, isoacyl radix hedysari glycoside, isohedysari glycoside, kaempferol, quercetin, radix hedysari polysaccharide, stearic acid, ferulic acid, β -sitosterol, choline, various trace elements and the like.

The pharmacological action is as follows: 1. the in vivo test shows that the radix hedysari extract has the functions of reducing death, prolonging survival period, protecting mice from myocarditis or lightening myocarditis pathological changes for the coronavirus infected mice. Including coronavirus, HIV, etc. Meanwhile, the radix hedysari extract can also inhibit cytopathic effect after virus infection, and has growth inhibition effect on replicating viruses.

2. And (3) resisting pathogens: radix hedysari has obvious inhibition effect on diplococcus pneumoniae, staphylococcus aureus, bacillus anthracis, corynebacterium diphtheriae, staphylococcus albus, streptococcus hemolyticus and the like in vitro.

3. Anti-inflammatory: the radix hedysari extract has good prevention and treatment effects on pneumonia caused by coronavirus, including pneumonia caused by various viruses such as influenza virus, avian influenza and the like. Animal experiments prove that the radix hedysari extract can obviously inhibit the process of pneumonia infected by the viruses when being injected into rats.

4. Enhancing the immune function: the latest clinical research proves that the radix hedysari extract, the polysaccharide and other components can obviously improve the nonspecific immune function. Has the functions of promoting and enhancing humoral and cellular immunity, obviously activating interferon environment, inducing self, promoting the generation of interferon, promoting the activity volatilization and the like.

5. Preventing and treating viral myocarditis: clinical application proves that the radix hedysari extract has good effect on treating myocarditis. Myocarditis is commonly caused by exogenous infection, upper respiratory tract infection, and 1-5 weeks after infection with viruses such as coronavirus. The latest research shows that the effective components of radix hedysari have the functions of resisting virus and regulating immunity, have the activation effect on interferon, and have the effects of improving the growth of endothelial cells and enhancing the myocardial contraction. Viral serological diagnosis of myocarditis is related to coronavirus, and radix Hedysari extract has protective effect on myocarditis infected by coronavirus and other viruses, and can improve cardiac function of patients, and has good effect of preventing and treating myocarditis.

In addition, radix Hedysari extract also has effect of resisting pulmonary hypertension.

The Rhodiola crenulata extract (Rhodiola Rosea) is a whole herb of Rhodiola crenulata of Crassulaceae, and is cold in nature, sweet in taste, astringent and capable of entering spleen and lung channels. Has effects in strengthening body resistance, consolidating constitution, invigorating qi, nourishing blood, clearing away heat, relieving fever, clearing away lung heat, relieving cough, promoting blood circulation, and dispelling blood stasis. Can be used for treating pneumonia, fever, coronary heart disease, viral myocarditis, pulmonary edema, chronic pulmonary obstruction, anoxia, and fatigue.

The chemical components of rhodiola root contain salidroside, flavonoid, cinnamyl alcohol, β -sitosterol, gallic acid, carrot, 19 amino acids, fatty acid, various mineral substances and trace elements.

The pharmacological action is as follows: 1. and (3) antivirus: the rhodiola rosea extract can effectively prevent coronaviruses, subtype influenza viruses and the like from being adsorbed on host cells, and has extremely strong inhibition effect on the replication process of the viruses in the host cells. The cultured coronavirus attacks of the rhodiola crenulata contain tyrosol which has a good anti-attack effect. The mechanism is that rhodiola rosea tyrosol and virus compete for certain receptor sites on cell membranes simultaneously, thereby blocking the adsorption and penetration processes of the virus.

2. Anti-inflammatory: animal experiments show that the rhodiola rosea decoction has obvious inhibition effect on various pneumonia of rats caused by virus after being infused, can inhibit virus inflammation exudation, and can prevent leukocytosis caused by subcutaneous injection.

3. Enhancing the immune function: animal experiments prove that the rhodiola rosea extract can promote the phagocytic function of a reticuloendothelial system of a mouse and increase a specific antibody of the serum of the mouse. The rhodiola rosea saponin can also promote T, B lymphoreaction stimulated by lymphoblastoid, has a promoting effect on the immunologic function of the spleen of a rat, can enhance the enhancement reaction of splenic T cells on the phaseolin A, promotes the induction of interleukin-2, and improves the activity of spleen natural killer cells. Has good immunity enhancing effect.

4. Prevention and treatment of viral-induced myocarditis: research shows that the rhodiola rosea polysaccharide can obviously inhibit the release of myocardial enzyme caused by virus infection of in vitro cultured myocardial cells and obviously reduce the proliferation amount of the virus in the myocardial cells, and research results of a mouse model of Coxsackie B6 virus induced by influenza show that the rhodiola rosea polysaccharide has obvious promotion effect on the improvement of myocardial function of a sick mouse, enhances the antiviral ability of the mouse and has certain prevention and treatment effect on viral-infected myocarditis. In addition, radix Rhodiolae has antitoxin, antifatigue, and anoxia resisting effects.

(III), Echinacea purpurea extract (Echinacea extract), also known as Echinacea purpurea, an perennial herb Echinacea purpurea of Echinacea, is a wild flower of Compositae, belonging to perennial herb Echinacea purpurea. Antibacterial, antifungal, antiinflammatory, antiviral, free radical scavenging, and antitumor effects. The composition is clinically applied to treating cold, bronchial asthma, acute virus infection, upper respiratory tract infection, cancer and immune diseases.

Chemical components: echinacea purpurea mainly contains sugar, caffeic acid derivatives, polyacetylene and isobutyric acid amine. Volatile oil, flavone, alkaloid, phytosterol raw sugar, unsaturated ketone, vitamin A, vitamin C, vitamin E, mineral potassium, calcium, iodine, sulfur, magnesium, iron, zinc and the like.

The pharmacological action is as follows: 1. and (3) antibiosis: in vitro tests of Echinacea purpurea prove that the Echinacea purpurea has inhibitory activity on staphylococcus aureus and streptococcus pyogenes; the multi-block components have strong inhibitory activity on pseudomonas aeruginosa and escherichia coli; the Echinacea purpurea extract has effect in inhibiting Mycobacterium tuberculosis, and can inhibit the growth of epidermal fresh bacteria.

The echinacea purpurea extract has different degrees of inhibition effects on clinically separated staphylococcus aureus, group B streptococcus, klebsiella, influenza bacillus and epidermic coccus. Has strong inhibiting effect on staphylococcus aureus, group B streptococcus and staphylococcus epidermidis.

Animal experiments show that the echinacea purpurea can reduce the animal mortality rate caused by staphylococcus aureus infection, and the echinacea purpurea has a certain protection effect on staphylococcus aureus infected animals. Echinacea extract was found to stop streptococcal infections in rats. The echinacea purpurea can effectively inhibit infection diffusion in bodies of experimental animals, the effect is related to an action mechanism for inhibiting hyaluronidase, the hyaluronic acid protects cells from microbial invasion, tissues are not easy to be infected and reproduced by microbes, and the hyaluronidase plays a role in decomposing the hyaluronic acid.

2. Antifungal activity: echinacea purpurea polysaccharide has antifungal effect. The echinacea polysaccharide is used for treating the immunodeficient mouse model, so that the candida albicans infection in the kidney of the mouse can be obviously reduced, and the candida infection with lethal dose can be obviously protected. The test shows that the echinacea purpurea can enhance the capability of immune cells of mice to inhibit candida albicans. Monocytes of healthy humans have increased phagocytic capacity against Candida albicans after treatment with Echinacea purpurea extract.

3. And (3) antivirus: the echinacea purpurea extract has obvious inhibition effect on influenza virus, herpes virus and poliomyelitis virus; the Echinacea purpurea extract has inhibitory activity against influenza Virus A2, and also inhibits replication of encephalomyocarditis Virus (EMC-Virus) and filterable stomatitis Virus (VSV). Echinacea purpurea polysaccharide is the main antiviral component, and has 80% inhibition effect on herpes simplex virus replication.

It is reported that: the results of the internal anti-virus tests of the echinacea purpurea carried out by researchers of domestic medical colleges show that the echinacea purpurea has obvious inhibition effect on influenza virus and has certain effect on the Asahi group viruses COXB3 and COXB5, the respiratory syncytial virus RSV and the herpes virus HSV-2. For the mouse pneumonia caused by the influenza virus, the echinacea purpurea is administrated by gastric gavage continuously for 5 days, the lung inflammation can be obviously reduced, the lung index is obviously reduced compared with that of a control group, and the echinacea purpurea has an obvious inhibiting effect on the mouse pneumonia caused by the influenza virus.

4. Resisting infection: in vivo and in vitro pharmacological experimental studies, echinacea and the components contained in the echinacea seem to have only mild antibacterial activity. Surprisingly, however, a variety of echinacea containing products have shown clinically robust broad spectrum anti-infective effects. Obviously, the anti-infection effect of echinacea purpurea is not a simple effect of killing and inhibiting pathogen, but a deeper mechanism.

The research of foreign medical experts finds that the powerful anti-infection function of echinacea purpurea not only directly inhibits pathogens, but also improves the autoimmunity of human body to exert the effect by stimulating the immune system of the organism. The main action mechanism treatment of the echinacea purpurea for effectively resisting infection is as follows: (1) and stimulating macrophage activity. (2) Increasing phagocytic activity of the cells. (3) Stimulation of T-cell proliferation. (4) And promoting the production of interferon cytokines.

5. Anti-inflammatory action: inflammatory response is the normal defense and relief response of body tissues to various infections and non-infectious injuries, and is the main pathological change of many diseases.

Pharmacological experiments and clinical researches show that echinacea has extremely strong anti-inflammatory activity, and the anti-inflammatory activity of echinacea is derived from the activity of inhibiting hyaluronidase, stimulating adrenal cortex, inhibiting inflammatory factor cyclooxygenase, 5-lipoxygenase and arachidonic acid.

6. Enhancing the immune function: a series of pharmacological and clinical researches show that the echinacea purpurea has wide anti-infection capacity because the echinacea purpurea can obviously improve the immunity of human bodies. Therefore, the composition has high effect on treating various infectious diseases. Echinacea is now a famous immunoregulatory herbal medicine in western countries. Because the echinacea purpurea is most effective in treating cold, influenza and various infectious diseases of the whole body, the echinacea purpurea has the function of promoting the immune system of the human body. As a result of tens of intensive and thorough research, echinacea purpurea has the effect of regulating the human immune system, mainly by means of systemic macrophages and other effector cells, improving the alertness and vitality of the human monitoring system, especially the mucosal immune system, and fighting invading pathogens. It has also been reported that echinacea can promote phagocytic function and promote activity of monocytes, macrophages and NK cells. Has effects of preventing influenza and shortening common cold period.

7. Antioxidation: more and more experiments have confirmed that many common diseases are associated with antioxidant substances in humans, such as: respiratory tract infection, periodontal disease, rheumatoid arthritis, cardiovascular disease, cancer, and dermatoses. The use of antioxidant can inactivate oxygen free radicals and treat related diseases.

The polyphenol components such as echinacoside, chicoric acid, caffeic acid, etc. in Echinacea purpurea have free radical scavenging effect, can protect skin protoprotein III from damage of free radical degradation, and can be used for preventing and treating light skin injury.

8. The medicine has special effects of treating cold: echinacea purpurea has the widest treatment application and the best curative effect, and the most studied is the treatment of upper respiratory fluid infection, including cold, influenza, tonsillitis, bronchitis and cough; the curative effect for treating cold and flu is particularly remarkable.

Echinacea purpurea relies on multiple mechanisms of action to exert anti-cold and anti-influenza effects. Echinacea purpurea plays a role in activating immune system, inducing interferon, preventing virus replication, protecting cell membrane, blocking virus invasion to mucosal endothelial cells, resisting inflammation, resisting allergic reaction and other biological effects, and can resist cold and influenza virus invasion together, so that the treatment effect is very obvious, and the early use effect is excellent. The echinacea purpurea has different cold resisting mode from traditional Chinese medicine, can simultaneously play the roles of resisting virus and improving immunity, has the double effects of relieving exterior syndrome and supplementing agent, and can treat both principal and secondary aspects of diseases. Therefore, the echinacea purpurea can be used at any stage of cold, and has better effect particularly at the initial stage of cold, and when you feel the first symptom of cold, the echinacea purpurea preparation can be taken immediately to stop the cold quickly or relieve the symptom, shorten the course of disease and enhance the disease resistance of patients.

In addition, the echinacea purpurea can also effectively relieve symptoms, shorten the course of disease, treat both symptoms and root causes, and prevent cold and influenza.

9. Treating sphagitis: the sphagitis belongs to the effective treatment field of echinacea purpurea. A plurality of random double-blind placebo control experiments prove that echinacea has the relieving effect on various sphagitis and has better effect on viral infection. The inhibition of treatment with the purple cone is good. Treatment with Echinacea can inhibit infection and various symptoms and accelerate recovery. For some serious infections, echinacea purpurea is selected as an auxiliary therapeutic agent of antibiotics, and has the effects of shortening the course of disease and relieving symptoms, and clinical research results carried out so far are all full of keken echinacea to have good curative effects on treating sphagitis infection.

10. The medicine is safe and effective for treating the upper respiratory tract infection of children: the echinacea purpurea is safe and effective in treating the upper respiratory tract infection of children including cold, and in the clinical test of treating 209 children with cold of 3-5 years old, the echinacea purpurea can obviously reduce the number of days of fever of the children when being ill, compared with a control group, and other control clinical tests also prove that the echinacea purpurea is effective in the cold and the flu of the children.

As a result of comparative study on 1280 children suffering from bronchitis by echinacea, the german medical scientist found that treatment with echinacea can significantly shorten the course of disease and accelerate disease healing compared with other treatments, and even is better than single use of antibiotics, because bronchitis is mostly caused by viral infection, the single use of antibiotics has poor curative effect, and echinacea can play double roles of promoting immunologic function and resisting virus. Research shows that the patients with 'pulmonary dry cough' or obstructive tracheitis are improved most obviously, and the combined treatment effect of antibiotics and echinacea is better.

(IV) ramulus Cinnamomi extract (astor Bean), ramulus Cinnamomi is the twig of Cinnamomum cassia Presl of Lauraceae. Warm in nature, pungent and sweet in flavor. It enters bladder, heart and lung meridians. Has the effects of clearing away heat and toxic materials, dispelling cold, relieving exterior syndrome, warming channels, activating yang, etc. Can be used for relieving exterior syndrome due to sweating, common cold, fever, and phlegm retention in chest and spleen. Modern medical research shows that the cassia twig extract has the functions of clearing away heat and toxic material, resisting virus, resisting bacteria and diminishing inflammation, enhancing immunity, relieving fever, eliminating phlegm and stopping cough, protecting cardiac muscle, tranquilizing and relieving pain and the like.

The chemical components of ramulus Cinnamomi include cinnamyl alcohol, coumarin, β -sitosterol, protocatechuic acid, and glucose.

The pharmacological action is as follows: 1. and (3) resisting pathogens: the ethanol extract has certain inhibitory effect on Staphylococcus aureus, Diplococcus pneumoniae, Escherichia coli, Bacillus proteus, Bacillus dysenteriae and Bacillus typhi.

2. And (3) antivirus: clinical research proves that the cassia twig decoction has an inhibiting effect on 6-1 strains of Asia and A influenza viruses and coronavirus, and the cassia twig alcohol extract on embryos has a remarkable inhibiting effect on pneumonia viruses and influenza viruses by using human embryo pronephrosis single-layer epithelial tissue culture. In addition, the cassia twig extract is also used for treating cold and fever clinically.

3. And (3) clearing heat and cooling: the cassia twig decoction is injected into abdominal cavity at 125mg/kg and 250mg/kg and is infused into stomach at 500mg/kg, and has the function of cooling fever of mice and rabbits caused by normal body temperature, typhoid fever and paratyphoid fever of the mice. It also has antipyretic effect on fever caused by influenza.

4. Anti-inflammatory: the ramulus Cinnamomi volatile oil is discharged from respiratory tract, and has effects of eliminating inflammation, relieving inflammation of respiratory tract, and increasing leukocyte by using cinnamyl alcohol.

5. Improving immunity: the cassia twig extract shows the effect of inhibiting complement activity on heterophily antibody reaction and has good function of enhancing immunity.

And (V) extract of rhizoma Polygoni Cuspidati (Japanese Polygonaceae) which is root and stem of Polygonum cuspidatum of Polygonaceae. It is cold in nature, bitter in taste, entering liver, gallbladder and lung meridians. Has effects in clearing away heat and toxic materials, removing dampness, eliminating jaundice, dispelling blood stasis, relieving pain, relieving cough, eliminating phlegm, and removing toxic materials. Is suitable for treating epidemic febrile disease, cough due to lung heat, arthralgia and myalgia, venomous snake bite, etc. Modern researches have considered that giant knotweed has the effects of resisting bacteria and coronavirus, preventing heat and clearing heat, protecting heart and the like.

Chemical components: contains nutrient components such as emodin, lappaconitine, chrysophanol, resveratrol glucose, resveratrol, etc.

The pharmacological action is as follows: 1. and (3) resisting pathogens: the latest clinical research shows that the giant knotweed extract has good bacteriostatic action. Has different degrees of inhibiting effects on staphylococcus aureus, streptococcus pneumoniae, diplococcus hepaticus, staphylococcus pneumoniae white staphylococcus, paratyphoid bacillus and the like. The antibacterial mechanism is to inhibit the synthesis of nucleic acid and protein of bacterial cells and the sugar metabolism of the bacterial cells.

2. And (3) antivirus: the giant knotweed extract has good inhibition effect on 7 viruses such as coronavirus herpes simplex virus, influenza virus, Asian influenza A Jing strain 68-1 virus and the like. Meanwhile, the giant knotweed rhizome emodin has obvious antiviral effect on mice infected by the herpes simplex virus, the influenza virus and the coronavirus.

3. And (3) clearing heat: when the giant knotweed rhizome decoction is infused into the rabbits with fever caused by pneumococcus infection, the body temperature of the rabbits with pathological fever is reduced, and the content of PGE in the third ventricular flow is obviously reduced. One of the cooling mechanisms is by affecting the level of the central loop nucleotide.

(hexa) tetrahydrocurcumin (clrymins) curcumin is a polyphenolic compound present in turmeric. Recent medical research shows that curcumin has wide pharmacological activity.

The pharmacological action is as follows: 1. antifungal action: in the latest clinical research, curcumin has obvious inhibiting and killing effects on pneumococcus, helicobacter pylori, streptococcus pneumoniae, typhoid bacillus, staphylococcus aureus and other germs. An animal experiment shows that the effective rate of curcumin for inhibiting mouse pneumococcus is 98.1%, and the curcumin has better effect on mice infected with the curcumin and drunk by decoction.

2. Enhancing the immune function: animal experiments show that curcumin can promote rat lymphocyte mitosis, increase the number of splenic lymphocytes of a mouse, stimulate a reticuloendothelial cell system and has a good immune promotion effect.

3. And (3) antivirus: recent research shows that curcumin is a broad-spectrum antiviral agent, is an inhibitor for preventing coronavirus, influenza virus and avian influenza virus from infecting cells, and can also prevent the coronavirus, the influenza virus and the avian influenza virus from replicating in the cells. Coronavirus, influenza virus and avian influenza virus are viruses which cause fever acutely and cause serious harm to human life. Studies have demonstrated that curcumin interferes with and prevents the response of cells to infection. Curcumin can inhibit the replication of the viruses in-vitro cell cultures, can effectively inhibit coronavirus, influenza virus and avian influenza virus in mouse experiments, and has good inhibitory effect on deoxyribonucleic acid of the viruses.

4. Anti-inflammatory: animal experiments prove that curcumin has extremely strong anti-inflammatory effect on acute, subacute and chronic inflammation of mice and rats. The latest research considers that curcumin has obvious anti-inflammatory effect on various inflammations caused by various viruses, and particularly has better effect on acute and subacute pneumonia.

(VII) Ginkgo biloba extract (Semen Ginkgo) is dry mature seed of Ginkgo biloba of Ginkgoaceae. Neutral in nature, sweet in flavor, bitter and astringent, entering lung meridian. Has effects in astringing lung, relieving asthma, promoting blood circulation, relieving cough, eliminating phlegm, and relieving pain. The ginkgo biloba extract is used for treating lung deficiency cough and asthma, bronchial asthma, viral pneumonia and other symptoms, and has the functions of enhancing immunity, resisting bacteria, resisting virus, resisting viral pneumonia, reducing cholesterol, eliminating free radicals, enhancing coronary blood flow and the like according to modern medical research.

Chemical components: ginkgo mainly contains active ingredients such as flavonoid compounds, bilobalide, ginkgolide, terpene lactone compounds, various trace elements and the like.

The pharmacological action is as follows: 1. enhancing the immune function: animal experiments prove that the ginkgo biloba extract can promote the proliferation reaction of splenic T lymphocytes and B lymphocytes of tumor-bearing mice respectively induced by concanavalin and LPS no matter the ginkgo biloba extract is cultured in vitro or administered in vivo, and the ginkgo biloba extract has obvious regulating effect on low cellular immunity and humoral immunity of the tumor-bearing mice.

2. And (3) antibiosis: the ginkgo biloba extract has strong antibacterial effect on human tubercle bacillus, pneumococcus, staphylococcus aureus and the like in vitro tests.

3. And (3) antivirus: research shows that the ginkgo extract has a good inhibitory effect on viruses, and the ginkgo can enhance the antiviral reaction of organisms. The experimental results show that the mortality rate related to the viral pneumonia of the mice treated by the ginkgetin is obviously reduced compared with the control group. Meanwhile, the lung injury of mice treated with ginkgetin is far less than that of the control group during virus infection. The action mechanism is to protect the lung tissue by enhancing the immune response of the organism. Therefore, the ginkgo biloba extract can play an antiviral role.

4. Preventing and treating acute lung injury: through establishing an acute lung injury animal model experiment, the influence of the ginkgo extract on the morphology and the biology of lung tissues is observed, and the heart rate, respiration, frequency, blood gas analysis and related cytokine expression dynamic change results are simultaneously researched, so that the ginkgo extract can inhibit the increase of the content of TNF-a in plasma, relieve the infiltration of interstitial lung inflammatory cells, activate the activity of anti-inflammatory factors in the lung, relieve the edema degree of the lung tissues and play an effective role in protecting the acute lung injury. Therefore, the ginkgo biloba extract has obvious protective effect on acute lung injury.

(VIII) lactoferricin lfcin which is a small peptide containing 25-28 amino acids generated after the degradation of lactoferrin in the milk of a cow in the digestive tract of an animal by acid pepsin. Lactoferricin, a glycoprotein that binds iron, is considered as a prototype protein to be a very important inhibitory mechanism against bacterial infections, is rapidly effective after exposure to pathogenic bacteria, and is a good antibiotic substitute. Has antibacterial, anti-pathogen, antiviral, and immunity enhancing effects.

Biological activity function: 1. and (3) resisting pathogen invasion: lactoferricin is the major active component of the mucosal defence system, which prevents attachment of microorganisms to the respiratory epithelium and has antibody activity against viral bacteria and general antigens. Clinical researches prove that the content of the lactoferrin peptide in the respiratory secretion directly influences the resistance effect of the respiratory mucosa to pathogens, and the effects are in positive correlation. Therefore, the lactoferrin peptide anti-biological antibody has the bactericidal, bacteriolytic, phagocytosis-promoting and agglutination effects which are 200 times higher than those of other protein peptides, plays an extremely important role in early defense of organisms, and plays a role in killing pathogens and targeting cells.

2. And (3) antivirus: recent studies have shown that lactoferricin plays an extremely important role in antiviral, specific antibodies. Clinical studies have shown that the application of lactoferricin can block the spread of coronavirus and influenza virus in upper respiratory tract cells and lower respiratory tract infection, thereby preventing these viral infections and preventing viral patients from spreading the virus. In addition, it has been reported that lactoferricin can be used as an effective agent for the emergency prevention and treatment of viruses, and it can neutralize the entry of viruses into the viral region and thus prevent the viruses from adsorbing and invading cells. Animal experiments show that the lactoferrin peptide can be used for emergency prevention of mouse influenza, and the specific immunity protection rate of highly pathogenic coronavirus and avian influenza virus reaches 81%. Thus, it was demonstrated that lactoferricin has a significant antiviral effect.

3. Enhancing the immune function: clinical studies have shown that oral administration of lactoferricin results in the release of neutrophils, when lactoferricin is present on the surface of various immunocytes, such as lymphocytes, due to the activity of Natural Killer (NK) cells in spleen cells. Under the condition of general infection, the yield of the neutrophils induced by the lactoferricin is 6 times of that of the neutrophils in normal times, the release amount is increased by 20 times, and the effects of remarkably promoting the phagocytosis of the neutrophils and phagocytes, promoting the activity of natural killer cells and promoting the proliferation and regulation of the lymphocytes neutrophils in vivo or in vitro are proved.

In conclusion, the product has the effects of enhancing the immune function, clearing away the lung-heat and detoxifying, preventing various virus infections such as coronavirus, influenza virus and the like, preventing and treating viral pneumonia and myocarditis, resisting pathogens, sterilizing and diminishing inflammation, nourishing and protecting the lung, preventing warm and clearing away heat, relieving cough and reducing sputum, enhancing the immune function and the like. Experiments prove that the product can inhibit the replication of coronavirus and avian influenza virus and prevent and treat viral pneumonia in vitro cell culture, can inhibit the coronavirus and avian influenza virus in mouse experiments, and has good inhibitory effect on deoxyribonucleic acid of the viruses.

Sixth, the embodiment:

example (b): taking 50-100 kg of raw hedysarum polybotrys, 40-90 kg of rhodiola crenulata, 30-80 kg of echinacea, 20-70 kg of cassia twig, 10-60 kg of giant knotweed rhizome, 15-65 kg of tetrahydrocurcumin, 25-45 kg of ginkgo, 25-45 kg of lactoferrin peptide and auxiliary materials as raw materials, respectively crushing the raw materials into 50 meshes, respectively taking 70% ethanol as an extraction solvent, respectively, carrying out suction filtration and 2-time ultrasonic extraction on filter residues by using a vacuum pump after ultrasonic treatment is finished, combining filtrates obtained in two times, concentrating by using a rotary evaporator, feeding concentrated solution into an evaporator for vacuum drying to obtain various raw material extracts, then mixing the raw material extracts with the residual curcumin and the lactoferrin peptide in the formula, uniformly stirring, feeding into a filling machine, filling the raw materials into capsules, and (5) inspecting and packaging to obtain a finished product.

Claims

1. The preparation process of the antiviral lung-heat clearing peptide is characterized by comprising the following steps: respectively crushing the raw materials into 50 meshes, respectively taking 70% ethanol as an extraction solvent, carrying out suction filtration by using a vacuum pump after ultrasonic treatment at 40 ℃ for 40min, carrying out ultrasonic extraction on filter residues for 2 times after ultrasonic treatment is finished, combining filtrates obtained in two times, concentrating by using a rotary evaporator, sending the concentrated solution into an evaporator for vacuum drying to obtain various raw material extracts, mixing the raw material extracts with the residual curcumin and lactoferrin peptide in the formula, uniformly stirring, sending into a filling machine, filling the raw materials into capsules, inspecting, and packaging to obtain finished products.