CN103656267B - A kind of Chinese medicine composition that is used for the treatment of pig blue-ear disease and its preparation method and application - Google Patents
A kind of Chinese medicine composition that is used for the treatment of pig blue-ear disease and its preparation method and application Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition that is used for the treatment of pig blue-ear disease, belong to field of traditional Chinese veterinary. It is characterized in that with Radix Isatidis, climbing groundsel, rhizome of cyrtomium, Chinese violet, gypsum, the wind-weed, lophatherum gracile, Chinese mahonia, the radix paeoniae rubrathe according to certain proportion proportioning, refining through extracting, add pharmaceutical adjunct and make according to a conventional method corresponding preparation. It is evident in efficacy that the present invention adopts this Chinese medicine composition to have the treatment of highly pathogenic PRRS, treats both principal and secondary aspect of disease, and cure rate is high, has no side effect, and is difficult for recurrence, and without poisoning, cost is low, and meat is without advantages such as the sorrows of commodity inspection.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and its preparation method and application, particularly a kind of pig blue-ear disease of being used for the treatment ofChinese medicine composition and its preparation method and application, belongs to the field of Chinese medicines.
Background technology
Pig breeding claims again blue otopathy with respiratory system syndrome (PRRS), is by pig breeding and respiratory system syndrome virus(PRRSV) one of principal disease of the current harm pig industry causing, main manifestations is sow breeding difficulty and different daysThe respiratory symptom of pig. Reproductive and respiratory syndrome virus is persistent infection in swinery, can destroy each age in days pig function of immune system, makesSwinery, to other pathogen susceptibles, has a strong impact on the immune effect of other vaccines, the production performance of the swinery reducing greatly.PRRSV can pass placenta by blood circulation is infected tire pig, thereby causes that sow heavy in pig miscarriage waits breeding barrierHinder.
In recent years, there is new epidemic characteristic in China in this disease, and virus morphs, and pathogenicity strengthens, in some areasOccur that large-scale outbreak is popular. Clinical with high heat, skin cyanosis, eye conjunctivitis, Respiratory symptoms, nervous symptoms andDeath is main, shows as rapid onset, serious symptom, pathology obvious, and the death rate is high, has brought huge to China's pig industryEconomic loss
Mycillin, Amoxicillin, cephalosporins medicine, FQNS etc. all lack compellent curative effect; Some pigsExcept adding heavy dose of sulfonamides beyond the region of objective existence, also coordinate 5 kinds～6 kinds other antibiotic in feed, result has causedEven more serious death; And conventional antipyretic can not effectively bring down a fever as analgin, aminopyrine etc., even body temperatureDrop to normally, the feed intake of pig can not be recovered, and after 2h～3h, body temperature also can rebound; Use separately some disease-resistantPoison has also increased the weight of death as the excessive use of amantadine, Ribavirin; Or use herbal medicine preparation Radix Isatidis orHerba Andrographitis etc. also difficulty very cache must expect result for the treatment of. Even if take the malicious therapy of attacking of corresponding vaccine, can not ensure treatmentEffect, and danger close, may bring larger loss.
Qingwen baidu powder prescription by gypsum, glutinous rehmannia, cornu bubali, the coptis, cape jasmine, balloonflower root, the root of large-flowered skullcap, the wind-weed, the radix paeoniae rubrathe,The 14 taste compositions such as radix scrophulariae, the capsule of weeping forsythia, Radix Glycyrrhizae, moutan bark, lophatherum gracile, function purging intense heat and detonicating, cool blood, cures mainly heat poison and sends outSpot, unconsciousness due to high fever. Its prescription pulverizes and sieves rear being directly used as medicine and makes powder for adopting, not through extracting processing, its biologyUtilization rate is low, effect is the slowest; And in we, apply that cornu bubali, the coptis etc. are valuable, the high medicinal material of valency, cause cost higher;Moreover eliminating pestilence and relieving toxicity powder preparation is too cold and cool, conventional meeting causes impairment of yin, for the prophylactic of most of the time, in principleQingwen baidu powder is not also at its row.
Summary of the invention
It is a kind of more effective that the first object of the present invention is to provide, and side effect is little, free of contamination, has synergyChinese medicine; The second object of the present invention is to provide the preparation method of this Chinese medicine and the application in treatment pig blue-ear disease disease thereof.
The object of the invention the first object is achieved in that
Be used for the treatment of a Chinese medicine composition for pig blue-ear disease, the bulk drug of this medicine by Radix Isatidis, climbing groundsel, rhizome of cyrtomium,Chinese violet, gypsum, the wind-weed, lophatherum gracile, Chinese mahonia, radix paeoniae rubrathe composition, its consumption has in following ranges preferablyCurative effect: Radix Isatidis 10～30 weight portions, climbing groundsel 10～30 weight portions, rhizome of cyrtomium 10～30 weight portions, Chinese violet 10～30 weight portions, gypsum 125～175 weight portions, the wind-weed 10～30 weight portions, lophatherum gracile 10～30 weight portions, ten large meritsLabor 10～30 weight portions, the radix paeoniae rubrathe 10～30 weight portions.
Preferred bulk drug weight proportion is: Radix Isatidis 20 weight portions, climbing groundsel 20 weight portions, rhizome of cyrtomium 20 weight portions,Chinese violet 20 weight portions, gypsum 150 weight portions, the wind-weed 20 weight portions, lophatherum gracile 20 weight portions, Chinese mahonia 20Weight portion, the radix paeoniae rubrathe 20 weight portions.
In this patent prescription, Radix Isatidis is containing indigo, indigo red, Anthraquinones, cupreol, clionasterol and multipleThe compositions such as amino acid, also contain antibacterial substance and the kinetin of resisting gram-positive and negative bacteria, have heat-clearing, antibacterial,Antiviral, removing toxic substances, improve effect of immunity; Climbing groundsel is containing flavoxanthin, chrysanthemaxanthin, senecionine, climbing groundsel phenanthreneSpirit alkali and hydrogen ester, vanillic acid, salicylic acid, pyromucyl acid, in addition containing volatile oil, glycosides displayed, the compositions such as tannin, toolThere is clearing heat and detoxicating, antipruritic effect; Rhizome of cyrtomium containing filicic acid, flavaspidic acid, albaspidin, iso-amylene gland glucoside, diploptene,The compositions such as diplopterol, have expelling parasite, antiviral, antibacterial effect; Chinese violet is containing glucoside, flavonoids, wax, cerinic acidAnd the composition such as unsaturated acids (Ceroticacid), have clearing heat and detoxicating, effect of cool blood detumescence; Gypsum is natural twoWater gypsum (CaSO4·2H2O), there is clearing heat and detoxicating effect; The wind-weed is containing total saponin approximately 6%, wherein have 1-timosaponin A-1-I, A-II, A-III, A-IV, the compositions such as B-I and B-II, the effect that there is clearing heat-fire, promotes the production of body fluid and moisturize; Lophatherum gracileThe compositions such as Arundoin, Cylindrin, taraxerol, freidelin, have sweetly lightly ooze profit, cold in naturely fall clearly, the kind heart of leadingWith the descending and effect of inducing diuresis for treating strangurtia of the fire of small intestine; Chinese mahonia is containing jamaicin, palmatine, jateorrhizine, magnolineDeng composition, there is effect of clearing heat and detoxicating, detumescence, antidiarrheal; The radix paeoniae rubrathe is containing containing Paeoniflorin, oxypaeoniflorin, benzoyl Chinese herbaceous peonyThe compositions such as medicine glycosides, galloylpaeoniflorin, have effect of the row stasis of blood, pain relieving, cool blood, detumescence. Comprehensive above flavour of a drug,This product is very grave mainly for the heat poison of warm disease, that is gas divides, the card of excessive heat in the blood system.
The second object of the present invention is to provide preparation method and the application thereof of above-mentioned Chinese medicine. Those skilled in the art can facilitateDrug ingedient of the present invention is coordinated suitable auxiliary material by ground, is prepared into various external preparations. The preparation technology of medicine of the present invention pressesFollowing step is carried out:
Get gypsum, add 4～8 times of water gagings, decoct 20～40 minutes, then add Radix Isatidis, climbing groundsel, rhizome of cyrtomium, pale reddish brownChinese violet, the wind-weed, lophatherum gracile, Chinese mahonia, the radix paeoniae rubrathe, add 8～12 times of water gagings and decoct 2～4 times, add to decoct 0.5～at every turn1.5 hours, filter, merging filtrate, the concentrate that while being concentrated into 60 DEG C, relative density is 1.00～1.20, adds medicinalAuxiliary material, mixes, and makes corresponding preparations.
Further preferred preparation technology is:
Get gypsum, add 6 times of water gagings, decoct 30 minutes, then add Radix Isatidis, climbing groundsel, rhizome of cyrtomium, Chinese violet, knowMother, lophatherum gracile, Chinese mahonia, the radix paeoniae rubrathe, add 10 times of water gagings and decoct 3 times, adds at every turn and decoct 1.0 hours, filters, and closesAnd filtrate, the concentrate that while being concentrated into 60 DEG C, relative density is 1.10～1.15, adds pharmaceutic adjuvant, mixes systemBecome corresponding preparations.
In above preparation technology, can be prepared into granule or oral liquid, but the invention is not restricted to above-mentioned formulation. Moulding workSkill can separately add the assistant formation pharmaceutic adjuvants such as dextrin, aspartame, Icing Sugar.
More than composition, according to weight portion as proportioning, can increase or reduce according to corresponding ratio in the time producing, as greatlyLarge-scale production can with kilogram or taking ton as unit, small-scale production also can be in grams, weight can increase or subtractFew, but raw medicinal herbs weight proportion constant rate between each composition.
Chinese medicine composition of the present invention can be applied in the medicine for the treatment of pig blue-ear disease disease. The present invention is pure Chinese medicinal preparation,Be the good special product for the treatment of pig blue-ear disease effect, there is good preventive and therapeutic action, be worth developing.
Beneficial effect
For the further therapeutic action of checking Chinese medicine composition of the present invention, inventor has carried out suffering from the clinical testing of blue otopathy pigInvestigate:
1, material
1.1 animals: 60 of the sick pigs of pig blue-ear disease.
1.2 test samples: with embodiment 1; Positive control drug: qingwen baidu powder (prescription by gypsum, glutinous rehmannia, cornu bubali,14 tastes such as the coptis, cape jasmine, balloonflower root, the root of large-flowered skullcap, the wind-weed, the radix paeoniae rubrathe, radix scrophulariae, the capsule of weeping forsythia, Radix Glycyrrhizae, moutan bark, lophatherum gracileComposition).
2, method and result
2.1 experimental techniques: will be diagnosed as the sick pig of pig blue-ear disease, focus on isolation house, choose at random size and the patient's condition basic60 of consistent sick pigs, are divided into 3 groups, and 20 every group, the 1st group is this patent prescription group, the 2nd group of positive medicine group,The 3rd group is not administration group. Medication is 1 dose of every pig every day, point feeds for 2 times, and administration time is 5 days.
2.2 observational techniques: Continuous Observation 20 days from certainly offeing medicine, respectively observe in every morning, afternoon 1 time, do in timeGood observed and recorded.
The control of 2.3 feeding environments: duration of test keep colony house dry, clean, ventilate, feed, drinking-water and feeding and managementCarry out according to a conventional method, be consistent as far as possible.
2.4 criterion: (1) cures: sick temperature of pig body, body colour, ight soil, spirit, appetite recover normal, and do not recur; (2) effective: sick temperature of pig body, body colour, spirit, appetite are progressively recovered normally, dry and hard excrement degree progressively improve orSick pig is fully recovered gradually, in the observation period, recurs again; (3) invalid: after medication, sick pig symptom is not alleviated, and even addsHeavy dead. For statistical facility, in not administration group, live pig is also united according to above-mentioned standard depending on its remission situationMeter is sorted out.
2.5 experimental results: experimental result sees the following form.
The result for the treatment of experimental result table of table to the sick pig of pig blue-ear disease
Above experimental result shows, this patent group and qingwen baidu powder group are all remarkable to testing the efficient and cure rate of disease pigHigher than not administration group, illustrate that this patent group and qingwen baidu powder group all have good result for the treatment of to the sick pig of pig blue-ear disease; ThisPatent group is all better than qingwen baidu powder group to the efficient and cure rate of testing disease pig, illustrates that this patent writes out a prescription to pig blue-ear diseaseResult for the treatment of be better than qingwen baidu powder.
Detailed description of the invention
Enumerate embodiment below, further illustrate the present invention, each embodiment only, for the present invention is described, does not limit thisBright:
Embodiment 1
Radix Isatidis 200g climbing groundsel 200g rhizome of cyrtomium 200g Chinese violet 200g
Gypsum 1500g wind-weed 200g lophatherum gracile 200g Chinese mahonia 200g
Radix paeoniae rubrathe 200g
Get gypsum, add 6 times of water gagings, decoct 30 minutes, then add Radix Isatidis, climbing groundsel, rhizome of cyrtomium, Chinese violet, knowMother, lophatherum gracile, Chinese mahonia, the radix paeoniae rubrathe, add 10 times of water gagings and decoct 3 times, adds at every turn and decoct 1.0 hours, filters, and closesAnd filtrate, the concentrate that while being concentrated into 60 DEG C, relative density is 1.10～1.15, adds Tween 80 20ml, adds water to1000ml, mixes, and makes oral liquid.
Embodiment 2
Radix Isatidis 300g climbing groundsel 200g rhizome of cyrtomium 200g Chinese violet 300g
Gypsum 1500g wind-weed 200g lophatherum gracile 300g Chinese mahonia 300g
Radix paeoniae rubrathe 200g
Get gypsum, add 8 times of water gagings, decoct 30 minutes, then add Radix Isatidis, climbing groundsel, rhizome of cyrtomium, Chinese violet, knowMother, lophatherum gracile, Chinese mahonia, the radix paeoniae rubrathe, add 12 times of water gagings and decoct 2 times, adds at every turn and decoct 1.5 hours, filters, and closesAnd filtrate, the concentrate that while being concentrated into 60 DEG C, relative density is 1.10～1.15, adds dextrin, mixes, and granulation,Dry, whole grain, granulation agent 1000g.
Embodiment 3
Radix Isatidis 300g climbing groundsel 200g rhizome of cyrtomium 100g Chinese violet 200g
Gypsum 1500g wind-weed 300g lophatherum gracile 200g Chinese mahonia 300g
Radix paeoniae rubrathe 300g
Get gypsum, add 4 times of water gagings, decoct 30 minutes, then add Radix Isatidis, climbing groundsel, rhizome of cyrtomium, Chinese violet, knowMother, lophatherum gracile, Chinese mahonia, the radix paeoniae rubrathe, add 8 times of water gagings and decoct 3 times, adds at every turn and decoct 1.0 hours, filters, and closesAnd filtrate, the concentrate that while being concentrated into 60 DEG C, relative density is 1.10～1.15, adds Tween 80 10ml, propane diols 10ml,Add water to 1000ml, mix, make oral liquid.
Embodiment 4
Radix Isatidis 300g climbing groundsel 100g rhizome of cyrtomium 100g Chinese violet 300g
Gypsum 1500g wind-weed 100g lophatherum gracile 300g Chinese mahonia 300g
Radix paeoniae rubrathe 300g
Get gypsum, add 6 times of water gagings, decoct 30 minutes, then add Radix Isatidis, climbing groundsel, rhizome of cyrtomium, Chinese violet, knowMother, lophatherum gracile, Chinese mahonia, the radix paeoniae rubrathe, add 10 times of water gagings and decoct 3 times, adds at every turn and decoct 1 hour, filters, and mergesFiltrate, the concentrate that while being concentrated into 60 DEG C, relative density is 1.10～1.15, adds dextrin, mixes, granulation, dryDry, whole grain, granulation agent 1000g.
Claims (3)
1. a Chinese medicine composition that is used for the treatment of pig blue-ear disease, is characterized in that, its formula is following composition:
Radix Isatidis 10～30 weight portions;
Climbing groundsel 10～30 weight portions;
Rhizome of cyrtomium 10～30 weight portions;
Chinese violet 10～30 weight portions;
Gypsum 125～175 weight portions;
The wind-weed 10～30 weight portions;
Lophatherum gracile 10～30 weight portions;
Chinese mahonia 10～30 weight portions;
The radix paeoniae rubrathe 10～30 weight portions.
2. Chinese medicine composition according to claim 1, is characterized in that, its formula is following composition:
Radix Isatidis 20 weight portions;
Climbing groundsel 20 weight portions;
Rhizome of cyrtomium 20 weight portions;
Chinese violet 20 weight portions;
Gypsum 150 weight portions;
The wind-weed 20 weight portions;
Lophatherum gracile 20 weight portions;
Chinese mahonia 20 weight portions;
The radix paeoniae rubrathe 20 weight portions.
3. the application of the Chinese medicine composition described in claim 1 or 2 in the medicine of preparation treatment pig blue-ear disease.
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| 高致病性猪蓝耳病的临床诊断与防治;邱立新，等;《中国畜牧兽医》;20081231(第01期);114-115 * |
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