CN100346816C - Chinese medicine composition for preventing and treating influenza - Google Patents
Chinese medicine composition for preventing and treating influenza Download PDFInfo
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- CN100346816C CN100346816C CNB2004100097573A CN200410009757A CN100346816C CN 100346816 C CN100346816 C CN 100346816C CN B2004100097573 A CNB2004100097573 A CN B2004100097573A CN 200410009757 A CN200410009757 A CN 200410009757A CN 100346816 C CN100346816 C CN 100346816C
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Abstract
The present invention discloses a Chinese medicine composition. The present invention is mainly prepared from the following crude drugs of the portion by weight: 1 to 50 portions of cornu antelopis slivers, 1 to 50 portions of coastal glehnia roots, 1 to 50 portions of wild chrysanthemum flowers, 1 to 50 portions of chuanxiong rhizomes, 1 to 50 portions of herba agastachis, 1 to 50 portions of cogongrass rhizomes, 1 to 50 portions of magnolia flowers, 1 to 50 portions of white reed rhizomes, 1 to 50 portions of folium isatidis and 1 to 50 portions of raw licorice roots. The present invention can be in the form of capsules, tablets, pills, oral liquid, etc. The present invention has the effects on clearing heat, detoxicating, inducing sweat, relieving exterior syndrome, cooling blood and purging the pathogenic fire, and can be used for preventing and treating influenza as well as common colds and other viral colds.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, is a kind of grippal pharmaceutical composition that is used for preventing and treating specifically.
Background technology
Influenza is the acute respiratory infectious disease that is caused by influenza virus, and pathogen is first, second, the third three type influenza viruss, and this disease is by droplet transmission.Infectiousness is strong, has " variation " characteristic, constantly produces new hypotype, and the susceptible person is numerous, and Chang Rongyi causes that fulminant is popular or worldwide to be very popular.
Primary disease about 1-2 incubation period days.Onset is unexpected mostly, and General Symptoms is heavier and respiratory symptom is lighter.Beginning can show as fear of cold, heating, and body temperature can be up to 39-40 ℃, and the patient feels headache, systemic pain, weakness simultaneously, and normal sense eye is done, dry pharynx, slight pharyngalgia.Part patient can have sneeze, watery nasal discharge, nasal obstruction.Sometimes visible gastrointestinal symptom adds nausea,vomiting,diarrhea etc.Heating generally reached the peak with above-mentioned this shape in 1-2 days, 3-4 day interior-heat moves back, and symptom disappears thereupon.Weak with the cough sustainable 1-2 week.
Primary disease does not still have specific drug and can control, the inoculation influenza vaccines are main method (especially to the high-risk group) of flu-prevention and complication thereof, use the specificity anti-influenza virus medicament also very important to control and flu-prevention, the medicine that has gone on the market has: amantadine, rimantadine, zanamivir, ribavirin and Oseltamivir etc., or give the symptomatic treatment hyperpyrexia, headache, the heavier person of systemic pain, take the circumstances into consideration to give APC or antondin etc., the play person of coughing can be coughed must disappear, cough mixture etc., to Secondary cases bacterial infection person, can take the circumstances into consideration to give antibiotic therapy and sulphonamides is oral.
Chinese traditional treatment, it is oral to give Chinese patent medicine, as: YINQIAO JIEDU PIAN, capsule for cold, Radix Isatidis etc.
By the retrieval to prior art, not finding is having the Chinese medicine composition similar and/or identical with the present invention.The inventor sums up by animal experiment and clinical observation, thereby has finished the present invention.
Summary of the invention
The purpose of this invention is to provide a kind of grippal Chinese medicine composition that is used for preventing and treating.
The invention provides a kind of grippal Chinese medicine composition that is used for preventing and treating, it is made up of active ingredient and/or pharmaceutically acceptable carrier, mainly is the medicament of being made by following raw materials by weight proportions: Cornu Saigae Tataricae 1-50 part, Radix Glehniae 1-50 part, Flos Chrysanthemi Indici 1-50 part, Rhizoma Chuanxiong 1-50 part, Herba Pogostemonis 1-50 part, Rhizoma Imperatae 1-50 part, Flos Magnoliae 1-50 part, white Rhizoma Phragmitis 1-50 part, Folium Isatidis 1-50 part, Radix Glycyrrhizae 1-50 part.
Wherein preferred, Cornu Saigae Tataricae 1-13 part, Radix Glehniae 5-23 part, Flos Chrysanthemi Indici 1-17 part, Rhizoma Chuanxiong 1-9 part, Herba Pogostemonis 1-11 part, white Rhizoma Phragmitis 1-14 part, Flos Magnoliae 1-12 part, Rhizoma Imperatae 17-34 part, Folium Isatidis 2-25 part, Radix Glycyrrhizae 1-8 part.
Wherein said Herba Pogostemonis can substitute with Herba Schizonepetae, and wherein said Flos Magnoliae can substitute with Flos Sophorae Immaturus (processed), and wherein said Folium Isatidis can substitute with Herba Bidentis Bipinnatae.
Chinese medicine composition of the present invention can be made peroral dosage form commonly used clinically together with its active ingredient and acceptable accessories, as: dosage forms such as capsule, tablet, pill, oral liquid.
The present invention has the effect of heat-clearing and toxic substances removing, relieving the exterior syndrome by diaphoresis, removing heat from blood pathogenic fire purging by animal experiment and clinical observation, can be used for prevention and treatment influenza, and common cold and other viral influenza are also had certain curative effect.
Specific embodiment
Embodiment 1: the preparation of capsule of the present invention
Take by weighing following materials of weight proportions medicine: Cornu Saigae Tataricae 50g, Radix Glehniae 50g, Flos Chrysanthemi Indici 15g, Rhizoma Chuanxiong 50g, Herba Pogostemonis 1g, Rhizoma Imperatae 10g, Flos Magnoliae 1g, white Rhizoma Phragmitis 1g, Folium Isatidis 50g, Radix Glycyrrhizae 50g, carry out preliminary working with Cornu Saigae Tataricae, Radix Glehniae, Flos Chrysanthemi Indici, Rhizoma Chuanxiong, Herba Pogostemonis, white Rhizoma Phragmitis, Flos Magnoliae, Rhizoma Imperatae, Folium Isatidis, Radix Glycyrrhizae; The medicine that then processing is cooked drops into multi-function extractor, the water that adds 4-8 times of drug weight, heat and decoct boiling back 25 minutes to 3 hours after-filtration of slow fire for the first time, the water that adds for the second time 4-8 times of drug weight, back 25 minutes to 3 hours after-filtration seethe with excitement, the water that adds 3-5 times of drug weight for the third time, back 25 minutes to 3 hours after-filtration seethe with excitement, after three times three filtered medicine liquid being dropped into vacuum concentrator concentrates, after concentrating, extract to drop in the jacketed pan and carry out water evaporates, put into the heated drying case again, the temperature in the drying baker is controlled between the 40-70 degree, takes out after 5-8 hour, planar, again through pulverizing, sieve, add adjuvant (starch, PVP etc.) make granule, above-mentioned granule pack in the hungry area softgel shell capsule.
Embodiment 2: the preparation of tablet of the present invention
Take by weighing following materials of weight proportions medicine: 1 part of Cornu Saigae Tataricae 15g, Radix Glehniae 35g, 35 parts of g of Flos Chrysanthemi Indici, Rhizoma Chuanxiong 10g, Herba Schizonepetae 35g, Rhizoma Imperatae 15g, Flos Magnoliae 50g, white Rhizoma Phragmitis 15g, Folium Isatidis 45g, Radix Glycyrrhizae, carry out preliminary working with Cornu Saigae Tataricae, Radix Glehniae, Flos Chrysanthemi Indici, Rhizoma Chuanxiong, Herba Schizonepetae, white Rhizoma Phragmitis, Flos Magnoliae, Rhizoma Imperatae, Folium Isatidis, Radix Glycyrrhizae; The medicine that then processing is cooked drops into multi-function extractor, the water that adds 4-8 times of drug weight, heat and decoct boiling back 25 minutes to 3 hours after-filtration of slow fire for the first time, the water that adds for the second time 4-8 times of drug weight, back 25 minutes to 3 hours after-filtration seethe with excitement, the water that adds 3-5 times of drug weight for the third time, back 25 minutes to 3 hours after-filtration seethe with excitement, after three times three filtered medicine liquid being dropped into vacuum concentrator concentrates, after concentrating, extract to drop in the jacketed pan and carry out water evaporates, put into the heated drying case again, the temperature in the drying baker is controlled between the 40-70 degree, takes out after 5-8 hour, planar, again through pulverizing, sieve, add adjuvant (starch, PVP etc.) making granule, is slabbing after the tablet machine compression.
Embodiment 3: the preparation of pill of the present invention
Take by weighing following materials of weight proportions medicine: Cornu Saigae Tataricae 1g, Radix Glehniae 1g, Flos Chrysanthemi Indici 45g, Rhizoma Chuanxiong 10g, Herba Pogostemonis 50g, Rhizoma Imperatae 50g, 50 parts of g of Flos Sophorae Immaturus (processed), white Rhizoma Phragmitis 50g, Folium Isatidis 45g, Radix Glycyrrhizae 1g, carry out preliminary working with Cornu Saigae Tataricae, Radix Glehniae, Flos Chrysanthemi Indici, Rhizoma Chuanxiong, Herba Pogostemonis, white Rhizoma Phragmitis, Flos Sophorae Immaturus (processed), Rhizoma Imperatae, Folium Isatidis, Radix Glycyrrhizae; The medicine that then processing cooked is pulverized, is sieved, and sterilizes again, put in right amount at last the Mel of perfecting mix the back pill.
Embodiment 4: the preparation of oral liquid of the present invention
Take by weighing following materials of weight proportions medicine: Cornu Saigae Tataricae 1g, Radix Glehniae 10g, Flos Chrysanthemi Indici 50g, Rhizoma Chuanxiong 15g, Herba Pogostemonis 45g, Rhizoma Imperatae 10g, Flos Magnoliae 50g, white Rhizoma Phragmitis 35g, Herba Bidentis Bipinnatae 50g, Radix Glycyrrhizae 50g, Cornu Saigae Tataricae, Radix Glehniae, Flos Chrysanthemi Indici, Rhizoma Chuanxiong, Herba Pogostemonis, white Rhizoma Phragmitis, Flos Magnoliae, Rhizoma Imperatae, Herba Bidentis Bipinnatae, Radix Glycyrrhizae are boiled decocting three times, filter, merging filtrate, concentrate, add sweeting agent Mel and diluent water and make oral liquid.
Embodiment 5: the preparation of capsule of the present invention
According to embodiment 1 described method, difference is to select for use following materials of weight proportions medicine: Cornu Saigae Tataricae 1g, Radix Glehniae 23g, Flos Chrysanthemi Indici 1g, Rhizoma Chuanxiong 4g, Herba Pogostemonis 11g, Rhizoma Imperatae 1g, Flos Magnoliae 12g, white Rhizoma Phragmitis 17g, Folium Isatidis 1g, Radix Glycyrrhizae 8g.
Embodiment 6: the preparation of tablet of the present invention
According to embodiment 2 described methods, difference is to select for use following materials of weight proportions medicine: Cornu Saigae Tataricae 13g, Radix Glehniae 5g, Flos Chrysanthemi Indici 17g, Rhizoma Chuanxiong 1g, Herba Pogostemonis 1g, Rhizoma Imperatae 14g, Flos Magnoliae 1g, white Rhizoma Phragmitis 23g, Folium Isatidis 25g, Radix Glycyrrhizae 1g.
Embodiment 7: the preparation of pill of the present invention
According to embodiment 3 described methods, difference is to select for use following materials of weight proportions medicine: Cornu Saigae Tataricae 12g, Radix Glehniae 13g, Flos Chrysanthemi Indici 6g, Rhizoma Chuanxiong 9g, Herba Pogostemonis 9g, Rhizoma Imperatae 6g, Flos Magnoliae 7g, white Rhizoma Phragmitis 25g, Folium Isatidis 13g, Radix Glycyrrhizae 7g.
Embodiment 8: the preparation of oral liquid of the present invention
According to embodiment 4 described methods, difference is to select for use following materials of weight proportions medicine: Cornu Saigae Tataricae 10g, Radix Glehniae 9g, Flos Chrysanthemi Indici 12g, Rhizoma Chuanxiong 4g, Herba Pogostemonis 3g, Rhizoma Imperatae 9g, Flos Magnoliae 8g, white Rhizoma Phragmitis 34g, Folium Isatidis 25g, Radix Glycyrrhizae 8g.
Below set forth the effect of this Chinese medicine composition by test.
Experimental example 1:
1, case is selected
1.1 the standard of including in
1) meets Western medicine diagnose standard (according to the requirement of " new Chinese medicine clinical research guideline " (2002 editions))
The popular contact history of flu is arranged
Based on local symptom, General Symptoms can have or be not obvious
Local symptom: sneeze, nasal obstruction, watery nasal discharge, cough sometimes, pharyngalgia, hoarseness, shed tears
General Symptoms: fever with aversion to cold, general malaise, headache and dizziness, extremity aching pain in waist and back.
Hemogram: how normal numeration of leukocyte is or on the low side
2) meet the tcm syndrome diagnostic criteria
Wind-cold syndrome (or wind-heat syndrome)
Primary symptom: aversion to cold is heavy, and heating is light, and is lossless, headache, the podomere ache, it is low voice speaking have a stuffy nose, the time snivel, floating pulse or tightly floating
Inferior disease: itching throat, cough, it is white that expectorant is told thin color, mouthful not thirsty or thirsty desire for hot drinks, thin white fur of tongue and moistening
3) fell ill back 48 hours in
4) 18～45 one full year of life of age
5) signature Informed Consent Form
1.2 exclusion standard
1). gestation or women breast-feeding their children
2). the psychotic
3). merge to have the inclination, liver, renal function and the serious primary disease person of hemopoietic system
4). used other treatment medicine person
5). allergic constitution or to multiple drug allergy person
1.3 the case physical data is included in this test in
Case 236 examples are included in this test altogether in, male's 127 examples wherein, women's 109 examples; Minimum 9 one full year of life at age, maximum 73 one full year of life.
2, observation index
2.1 health giving quality observation index
1) related symptoms: the variation of symptom such as aversion to cold, heating, nasal obstruction, watery nasal discharge, cough, headache, pharyngalgia, general malaise, thirsty, urine, observe its variation every day.
2) temperature taking: inpatient, per 4 hour records 1 time, and attached body temperature label; The outpatient writes down body temperature by the experimenter, every day 4 times.
3) picture of the tongue before and after the treatment, the variation of pulse condition
4) the blood leukocytes sum adds classification
5) can do relevant inspections such as viral isolation identification and serum virus test according to the state of an illness
2.2 safety observation index
Blood routine examination
Routine urianlysis
Hepatic and renal function is checked (ALT in the blood, AST, Cre, BUN level)
3, test method
1) grouping: 236 cases are divided into 2 groups, each 118 people of treatment group and matched group at random
2) medication:
Treatment group: take oral liquid of the present invention, every day 3 times, each 25g
Matched group: take virazole, every day 3 times, each 2
3) course of treatment: 3 days
4, efficacy determination
1) curative effect of disease criterion
Clinical recovery: treat 3 days normal with interior temperature recovery, cold symptoms all disappears
Produce effects: treat 3 days normal with interior body temperature, most of transference cure of flu
Effectively: treat and reduced than before with interior body temperature in 3 days, the cardinal symptom of flu partly disappears
Invalid: treat and do not fall with interior body temperature or raise in 3 days, the cardinal symptom of flu does not have improvement
2) therapeutic effect of syndrome criterion
Clinical recovery: clinical symptoms, sign disappear or basic the disappearance, and the syndrome integration reduces 〉=95%
Produce effects: clinical symptoms, sign are obviously improved, and the syndrome integration reduces 〉=70%
Effectively: clinical symptoms, sign all take a favorable turn, and the syndrome integration reduces 〉=30%
Invalid: clinical symptoms, sign do not have obvious improvement, even increase the weight of, the syndrome integration reduces less than 30%
3) body temperature onset time criterion
Different observation time point body temperature change: begin from taking medicine to be onset time to 0.5 ℃ of required time of body temperature decline
The analgesic time: begin to drop to 37 ℃ of required times from taking medicine and be the analgesic time to body temperature
Cure time: begin to recover the normal required time to the syndrome sign from taking medicine
5, clinical test results
Among the 236 routine testers, have 203 examples to finish test, 33 examples lose to be visited (wherein matched group 19 examples, 14 examples are organized in treatment).
5.1 clinical trial result: see Table 1
Table 1,203 routine experimenter's acute disease therapeutic evaluation results
As seen from the above table, learn by statistics and handle, significant difference does not appear in treatment group data and matched group.
5.2 safety testing result:
Two groups of experimenters are tested routine blood test, routine urinalysis, the hepatic and renal function index of front and back and carry out statistical analysis, reach two groups of data before and after the test between two groups and significant difference all do not occur.
6, conclusion
1) the present invention is oral a good safety, has no side effect
Through clinical observation, take the present invention after, can effectively treat influenza in three days
Claims (6)
1, a kind ofly is used for prevention and treats grippal Chinese medicine composition, it is made up of active ingredient and pharmaceutically acceptable carrier, it is characterized in that: made by following raw materials by weight proportions: Cornu Saigae Tataricae 1-50 part, Radix Glehniae 1-50 part, Flos Chrysanthemi Indici 1-50 part, Rhizoma Chuanxiong 1-50 part, Herba Pogostemonis 1-50 part, Rhizoma Imperatae 1-50 part, Flos Magnoliae 1-50 part, white Rhizoma Phragmitis 1-50 part, Folium Isatidis 1-50 part, Radix Glycyrrhizae 1-50 part.
2, Chinese medicine composition according to claim 1 is characterized in that: made by following raw materials by weight proportions: Cornu Saigae Tataricae 1-13 part, Radix Glehniae 5-23 part, Flos Chrysanthemi Indici 1-17 part, Rhizoma Chuanxiong 1-9 part, Herba Pogostemonis 1-11 part, white Rhizoma Phragmitis 1-14 part, Flos Magnoliae 1-12 part, Rhizoma Imperatae 17-34 part, Folium Isatidis 2-25 part, Radix Glycyrrhizae 1-8 part.
3, Chinese medicine composition according to claim 1 and 2, wherein said Herba Pogostemonis can substitute with Herba Schizonepetae.
4, Chinese medicine composition according to claim 1 and 2, wherein said Flos Magnoliae can substitute with Flos Sophorae Immaturus (processed).
5, Chinese medicine composition according to claim 1 and 2, wherein said Folium Isatidis can substitute with Herba Bidentis Bipinnatae.
6, Chinese medicine composition according to claim 1 and 2, it can be capsule, tablet, pill, oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100097573A CN100346816C (en) | 2004-11-08 | 2004-11-08 | Chinese medicine composition for preventing and treating influenza |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100097573A CN100346816C (en) | 2004-11-08 | 2004-11-08 | Chinese medicine composition for preventing and treating influenza |
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| Publication Number | Publication Date |
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| CN1772207A CN1772207A (en) | 2006-05-17 |
| CN100346816C true CN100346816C (en) | 2007-11-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2004100097573A Expired - Fee Related CN100346816C (en) | 2004-11-08 | 2004-11-08 | Chinese medicine composition for preventing and treating influenza |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102698048B (en) * | 2012-05-31 | 2013-09-18 | 蒋保珍 | Traditional Chinese medicine composition for treating wind heat bovine influenza |
| CN106309676A (en) * | 2015-06-15 | 2017-01-11 | 郑浩生 | Method for preventing and treating sheep common cold |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129578A (en) * | 1995-12-04 | 1996-08-28 | 周凌煜 | Formulation of Ganmaosuyusan for curing common cold |
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
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- 2004-11-08 CN CNB2004100097573A patent/CN100346816C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129578A (en) * | 1995-12-04 | 1996-08-28 | 周凌煜 | Formulation of Ganmaosuyusan for curing common cold |
| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
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| CN1772207A (en) | 2006-05-17 |
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