CN1631389A - Medicine for treating acute and chronic pharyngitis and its preparing process - Google Patents

Abstract

The invention provides a medicine for treating acute and chronic pharyngitis and its preparing process, wherein the medicine is prepare from sweet wormwood, Bupleurum root, great burdock achene, Clematis chinensis, root of large-flowered skullcap and licorice by a predetermined of weight ratio proportion.

Description

A kind of medicine for the treatment of acute, chronic pharyngitis and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of acute, chronic pharyngitis and preparation method thereof, be specifically a kind of be the treatment acute pharyngitis made of raw material and pure Chinese medicinal preparation of chronic pharyngitis and preparation method thereof with the natural Chinese medicinal herb.

Background technology

Pharyngitis belongs to the traditional Chinese medical science " sore throat " category, is clinical commonly encountered diseases, frequently-occurring disease.Pharyngitis is divided into two kinds of acute pharyngitis and chronic pharyngitiss.

Acute pharyngitis is main because of virus, courses of infection, or the stimulation causing of multiple physical chemical factor pharyngeal mucous membrane, submucous tissue, adenoid acute congestion swelling, inflammatory reaction such as pain.

Chronic pharyngitis is because the outbreak repeatedly of acute pharyngitis; Oral cavity, nasal cavity illness or stimulated by physics, chemical factor and the chronic expectorant disease of multiple general etc. causes pharyngeal mucosa, submucous tissue, lymphoid tissue diffuse inflammation.

The traditional Chinese medical science is included acute and chronic pharyngitis in the sore throat category, think pathogeny be affection due to external wind and heat, on steam throat; Affection by exopathogenic cold-wind, strongly fragrant lung heat-transformation, on stop up throat; Lifes in eating and drinking without temperance, tobacco and wine are excessive, damp and hot, accumulated heat in the lung and stomach, stifling throat or impairment caused by overstrain excessively, zang-fu disharmony, hyperactivity of deficient fire, smoke and burn due to the throat.Acute pharyngitis belongs to acute pharyngitis due to wind-heat more, and chronic pharyngitis belongs to sore-throat due to yin deficiency more.Acute pharyngitis shows effect repeatedly, does not prolongedly heal, and causes YIN-deficiency of the lung and kidney, body fluid deficiency liquid few, then can develop into chronic pharyngitis.Obstinate can cause the state of an illness to increase the weight of, and influences the healthy of people.

At present, the medicament of commercially available treatment pharyngitis is a lot of, and pill is arranged, and tablet also has liquid spray.Raw material is very not identical, and compatibility is more inconsistent, and manufacture method is how complicated, and the medicine of its preparation has side effect, and behind the medicine life-time service that has, various virus and bacterias can produce drug resistance, so curative effect is not ideal enough, and cure rate is not high.Some Chinese patent medicine also exists cures the symptoms, not the disease, only control acute, do not control deficiencies such as chronic, all can not reach the purpose of radical cure as existing " winter Ganoderma ", " LIUSHEN WAN ", " larynx disease ball ", especially for inflammation such as acute pharyngitis, tonsillitis, a little less than the existing Chinese medicine preparation antibacterial action, curative effect is slow, makes patient's painful time lengthening.Therefore, people still at the Chinese medicine preparation of constantly studying more remarkable treatment effect, satisfy clinical demand.

Summary of the invention

The objective of the invention is to overcome the weak point of above-mentioned existing medicine, a kind of medicine for the treatment of acute, chronic pharyngitis and preparation method thereof is provided, effects such as this medicine has the collateral dredging of inducing sweat, the sore-throat relieving that dispels the wind, heat-clearing and toxic substances removing, be particularly useful for treating diseases caused by exogenous pathogenic factor from the beginning of, fever with aversion to wind, acute pharyngitis and tonsillitis.That medicine of the present invention has is analgesic, analgesia, antiphlogistic pharmacological action, can treat acute pharyngitis, can treat chronic pharyngitis again.

An aspect of of the present present invention provides a kind of medicine acute, chronic pharyngitis for the treatment of, and it is by being prepared from by following Chinese medicinal raw materials in portion by weight:

Herba Artemisiae Annuae 100-250,

Radix Bupleuri 100-300,

Fructus Arctii 100-300,

Radix Clematidis 100-300,

Radix Scutellariae 150-350,

Radix Glycyrrhizae 0-200.

The preferred a kind of medicine acute, chronic pharyngitis for the treatment of of the present invention, it is by forming by following weight portion proportioning feedstock production:

Herba Artemisiae Annuae 150-200,

Radix Bupleuri 150-250,

Fructus Arctii 150-250,

Radix Clematidis 150-250,

Radix Scutellariae 200-300,

Radix Glycyrrhizae 50-150.

The most preferred a kind of medicine acute, chronic pharyngitis for the treatment of of the present invention, it is by forming by following weight portion proportioning feedstock production:

Herba Artemisiae Annuae 170,

Radix Bupleuri 200,

Fructus Arctii 200,

Radix Clematidis 200,

Radix Scutellariae 250,

Radix Glycyrrhizae 100.

A kind of medicine acute, chronic pharyngitis for the treatment of of the present invention, it can make various dosage forms according to a conventional method, comprises oral liquid, capsule, tablet, soft capsule, granule, buccal tablet, powder, spray, injection, pill or drop pill etc.

In various dosage forms, preferred a kind of oral liquid of making by following method, this preparation method is:

1. the Herba Artemisiae Annuae and the Radix Bupleuri that take by weighing recipe quantity shred, and soak 0.5-2 hour, add thermal distillation and collect volatile oil, and device is preserved in addition;

2. aqueous solution after the distillation and medicinal residues and other four Chinese medicine material add water to 8-9 and doubly measure decoction 2 times, and 1.5-2.5 hour for the first time, 0.5-1.5 hour for the second time, collecting decoction filtered, and filtrate is concentrated into relative density and is about 1.08;

3. add ethanol and make and contain the alcohol amount and reach 70%, fully stir, left standstill 24 hours, filter, reclaim ethanol to there not being the alcohol flavor, add an amount of dilution of water after, regulate PH3.0, placed 48 hours down, filter for 5 ℃;

4. add Oleum menthae, volatile oil, simple syrup and sorbitol successively, stir, add water to ormal weight, regulate PH6.0, kept at room temperature overnight filters, and embedding becomes 10ml, sterilization, promptly.

Concrete instructions of taking and consumption: oral, every day three times, each 10-20ml.Acute pharyngitis is a course of treatment for three days on end, and chronic pharyngitis was a course of treatment in continuous 7 days.

In various dosage forms, also preferred a kind of capsule of making by following method, this preparation method is:

1. the Herba Artemisiae Annuae and the Radix Bupleuri that take by weighing recipe quantity shred, and soak 0.5-2 hour, add thermal distillation and collect volatile oil, and device is preserved in addition;

2. aqueous solution after the distillation and medicinal residues and other four Chinese medicine material add water to 8-9 and doubly measure decoction 2 times, and 1.5-2.5 hour for the first time, 0.5-1.5 hour for the second time, collecting decoction filtered, and filtrate is concentrated into relative density and is about 1.08;

3. add ethanol and make and contain the alcohol amount and reach 70%, fully stir, left standstill 24 hours, filter, reclaim ethanol to there not being the alcohol flavor, filtrate concentrates, and is spray dried to fine powder;

4. fine powder adds appropriate amount of starch, microcrystalline cellulose, and mix homogeneously divides in the capsule shells of packing into, finished product.

In various dosage forms, also preferred a kind of granule of making by following method, this preparation method is:

1. the Herba Artemisiae Annuae and the Radix Bupleuri that take by weighing recipe quantity shred, and soak 0.5-2 hour, add thermal distillation and collect volatile oil, and device is preserved in addition;

2. aqueous solution after the distillation and medicinal residues and other four Chinese medicine material add water to 8-9 and doubly measure decoction 2 times, and 1.5-2.5 hour for the first time, 0.5-1.5 hour for the second time, collecting decoction filtered, and filtrate is concentrated into relative density and is about 1.08;

3. add ethanol and make and contain the alcohol amount and reach 70%, fully stir, left standstill 24 hours, filter, reclaim ethanol to not having alcohol flavor, filtrate concentrated extract;

4. add sucrose, dextrin and ethanol and make granule in right amount in extractum, drying adds volatile oil, makes granule.

Concrete instructions of taking and consumption: oral, every day three times, each 10g.Acute pharyngitis is a course of treatment for three days on end, and chronic pharyngitis was a course of treatment in continuous 7 days.

The Chinese medicine of respectively distinguishing the flavor of in the medicine of the present invention is crude drug.Radix Scutellariae in the side mainly contains flavone compound, also is the effective ingredient of Radix Scutellariae, contains a small amount of sterol and aminoacid in addition.Radix Scutellariae has wider antimicrobial spectrum, and analgesic, blood pressure lowering, diuretic actions are arranged.

Herba Artemisiae Annuae is the dry aerial parts of Compositae (Compositae) plant Artemisia annua Artemisia annua L..All produce all parts of the country, and it contains multiple sesquiterpene lactones: arteannuin (Qinghaosu, Artemisinin, Arteannuin) is the malaria main active, and arteannuin I, II, III, IV, V etc., and other terpenoids: artelinic acid, artemisilactone, artemisinol etc.Herba Artemisiae Annuae has the effect of heat-clearing and toxic substances removing, relieving the exterior syndrome with drugs of pungent in flavor and cool in nature.

Radix Bupleuri is Umbelliferae (Umbelliferae) plant Radix Bupleuri Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum scorznerifolium Willd. or the dry root that belongs to several plants together.The Radix Bupleuri root contains volatile oil, Saponin, flavone, plant sterol, coumarin, fatty acid etc.That Radix Bupleuri has is analgesic, calm, analgesia and antiphlogistic effect.

Fructus Arctii is the dry mature fruit of Compositae (Compositae) plant Fructus Arctii Arctium lappa L..Fructus Arctii contains arctigenin (arctiin), and other contains sterol, vitamin B etc.Fructus Arctii has the effect of dispelling wind and heat pathogens, lung qi dispersing rash, subduing swelling and detoxicating.

But Radix Clematidis is dry root and the rhizome of Ranunculaceae plant Radix Clematidis Clematis chinensis Osbeck, Clematis hexapetala Clematis hexapetala Pall. or northeast clematis Clematis manshurica Rupr..Root contains multiple triterpenoid saponin, is oleanolic acid or hederagenin derivant.Radix Clematidis has the effect of wind-damp dispelling, the meridian dredging.

Radix Glycyrrhizae is the dry root and rhizome of pulse family Leguminosae liquorice root Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. G.inflata Bat. or Glycyrrhiza glabra L. G.glabra L..Root of Radix Glycyrrhizae and rhizome contain the triterpenoid saponin glycyrrhizic acid.Radix Glycyrrhizae has antitussive, lung moistening, antidotal effect.

Multiple medicines in the drug prescription of the present invention is shared, and is promptly thin clearly, separates and invites, and removing obstruction for relieving pain amounts to relieving sore-throat by clearing away heat again, and the effect of bringing down a fever is extremely remarkable for acute, the chronic pharyngitis of treatment, tonsillitis effect.It is of the present invention that a kind of to treat medicine acute, chronic pharyngitis be to be prepared from by Chinese herbal medicine, its prescription science, rationally, and concertedness is good, curative effect highly significant, shortcoming such as overcome that existing prescription flavour of a drug are many, complex process, curative effect are not remarkable.

The specific embodiment

Below adopt embodiment to specify a kind of medicine for the treatment of acute, chronic pharyngitis of the present invention and preparation method thereof.

Embodiment 1

A kind ofly treat medicine acute, chronic pharyngitis, it is prepared from by following Chinese medicine raw materials by weight proportion:

Herba Artemisiae Annuae 100g,

Radix Bupleuri 100g,

Fructus Arctii 100g,

Radix Clematidis 100g,

Radix Scutellariae 150g.

Its preparation method is:

1. the Herba Artemisiae Annuae and the Radix Bupleuri that take by weighing recipe quantity shred, and soak 1 hour, add thermal distillation and collect volatile oil, and device is preserved in addition;

2. aqueous solution after the distillation and medicinal residues and other four Chinese medicine material add water to 8 times of amount decoctions 2 times, and 2 hours for the first time, 1 hour for the second time, collecting decoction filtered, and filtrate is concentrated into relative density and is about 1.08;

3. add ethanol and make and contain the alcohol amount and reach 70%, fully stir, left standstill 24 hours, filter, reclaim ethanol to not having alcohol flavor, filtrate concentrated extract;

4. get extractum 1 weight portion, sucrose 2 weight portions, dextrin 2.5 weight portions and ethanol and make granule in right amount, drying adds volatile oil, makes granule.

Embodiment 2

A kind ofly treat medicine acute, chronic pharyngitis, it is prepared from by following Chinese medicine raw materials by weight proportion:

Herba Artemisiae Annuae 250g,

Radix Bupleuri 300g,

Fructus Arctii 300g,

Radix Clematidis 300g,

Radix Scutellariae 350g,

Radix Glycyrrhizae 200g.

Its preparation method is with embodiment 1.

Embodiment 3

A kind ofly treat medicine acute, chronic pharyngitis, it is prepared from by following Chinese medicine raw materials by weight proportion:

Herba Artemisiae Annuae 170g,

Radix Bupleuri 200g,

Fructus Arctii 200g,

Radix Clematidis 200g,

Radix Scutellariae 250g,

Radix Glycyrrhizae 100g.

Its preparation method is with embodiment 1.

Below further specify a kind of drug action for the treatment of the medicine of acute, chronic pharyngitis of the present invention by pharmacodynamics test:

1 experiment material

1.1 animal: Kunming mouse and Wistar are that rat provides by Zhongshan University's animal center.

1.2 medicine: the granule of the embodiment of the invention 3 preparations; Penicillin, Guangzhou right overhead pharmaceutical factory, lot number

021201; Aspirin, Xuzhou En Hua pharmaceutcal corporation, Ltd.

1.3 being Qionghai City, Hainan Province Potiria pectinifera (Mukller et Tro Sehel) agar factory, produces the culture medium ordinary nutrient agar.Trypsinization soya peptone agar is Britain OXOID product.

2 methods and result

2.1 antibacterium effect

Cause that acute pharyngitis and tonsillitic common pathogen staphylococcus aureus, B family streptococcus, Diplococcus pneumoniae, staphylococcus epidermidis and Cray bacillus are test strain 2.1.1 external this experiment of bacteriostasis is adopted, amount to 6 kind of 110 strain clinical isolates.Agar dilution is adopted in test.The agar that be added in by the reagent thing to have melted followed make doubling dilution in the base, pour into the plating medium that becomes to contain different liquor strengths.With the method for reduced turbidity, each bacterial strain is diluted to 1/2 of No. 1 standard pipe in Maxwell, dibbling is on the plating medium of variable concentrations respectively for the bacterium liquid that dilution is good, and every 10 μ l cultivated 24 hours for 37 ℃.Be provided with the contrast of blank and penicillin positive drug simultaneously.Write down the growing state of each strain on different pharmaceutical concentration culture medium, the least concentration that this medicine suppresses bacteria growing is minimal inhibitory concentration, and the bacteriostatic level of the granule of minimal inhibitory concentration (MIC) the expression embodiment of the invention 3 preparations is adopted in this experiment.

Result of the test shows (seeing Table 1), the granule of the embodiment of the invention 3 preparation all has in various degree vitro inhibition effect to the growth of all experimental bacteria, wherein the growth to staphylococcus aureus and staphylococcus epidermidis has stronger restraint, its minimal inhibitory concentration is respectively 43.44 ± 39.24mg/ml and 36.25 ± 24.64mg/ml, to the streptococcic minimal inhibitory concentration of B family is 76.25 ± 27.48mg/ml, to the bacteriostasis of D family streptococcus, klebsiella spp and Diplococcus pneumoniae a little less than.

The external bacteriostasis of the granule of table 1 embodiment of the invention 3 preparations

Experimental strain	Bacterial strain number (strain)	The antibacterial contrast	Penicillin contrast (100U/ml)	Minimal inhibitory concentration (MIC) (mg/ml)	MIC scope (mg/ml)
						Staphylococcus aureus	??20	??+	??-	??43.44±39.24	??6.25～100
B family streptococcus	??20	??+	??-	??76.25±27.48	??25～100
						D family streptococcus	??20	??+	??-	??151.25±64.11	??25～200
Diplococcus pneumoniae	??20	??+	??-	??161.25±101.46	??25～400
						Staphylococcus epidermidis	??20	??+	??-	??36.25±24.64	??12.5～100
Klebsiella spp	??10	??+	??-	??145.00±59.86	??50～200

Annotate: "+" bacterial growth "-" antibacterial does not grow

2.1.2 vivo bacteria corrosion action

The healthy male mice of body weight 16～18g is divided into 5 groups at random by body weight: blank group, three various dose groups of granule of the embodiment of the invention 3 preparation (8.5,17 and 34g/kg) and positive drug matched group (penicillin).Infect preceding 48 hours beginning gastric infusions, successive administration five days, blank treated animal are irritated stomach and medicinal liquid every day with the volume distilled water.Penicillin is intramuscular injection, infects to begin administration, successive administration three days back half an hour.Depletion Staphylococcus aureus culture is inoculated among the 2mlTSB, cultivated 7 hours for 37 ℃, get among 7 hours culture 0.1ml transferred species 10mlTSB, continue to cultivate 17 o'clock, above-mentioned 7～17 hours cultures are done 7 times of dilutions with the gastric Mucin suspension, with this bacterium liquid with every Mus 0.5ml.The infection back is observed and morbidity of record animal and death condition every day, observes a week continuously, adds up the mortality rate of each treated animal and carries out X2 mensuration.

Experimental result shows (seeing Table 2,3), and after the mice that infects above-mentioned two kinds of antibacterials was taken the granule of the embodiment of the invention 3 preparations, its mortality rate was starkly lower than control group mice.When the granule of the embodiment of the invention 3 preparation with 17 and 34g/kg dosage irritate when feeding mice; mice to the abdominal cavity infection staphylococcus aureus has significant protective effect; its protective rate is respectively 45.45% and 54.55%; with 8.5 and the dosage of 17g/kg irritate and feed abdominal cavity infection B family streptococcus mice and also show significant protective effect, its protective rate is 81.82%.

The granule of table 2 embodiment of the invention 3 preparations is to staphylococcus aureus

The dead protective effect of infecting mouse

Group dosage number of animals dead animal is counted per cent death loss (g/kg) (only) (only) (%)
	Control group-11 11 100 penicillin group 250,000 U 11 0 0** embodiment 3 granule groups 8.5 11 9 81.82 17.0 11 6 54.55* 34.0 11 5 45.45*

Compare * P＜0.05 * * P＜0.001 with matched group

Table 3 embodiment of the invention 3 granules are to the dead protective effect of B family coccus infecting mouse

Group dosage number of animals dead animal is counted per cent death loss (g/kg) (only) (only) (%)
	Control group-11 8 72.73 penicillin group 250,000 5U 11 0 0** embodiment 3 granule groups 8.5 11 2 18.18* 17.0 11 2 18.18*

Compare * P＜0.05 * * P＜0.01 with matched group

2.2 antiinflammatory action

2.2.1 to the exquisite rat paw edema influence of egg

By after the body weight grouping, animal was taken medicine three days continuously to body weight 130～140g male rat, and the girth that injected the right sole of the foot of rat with 10% Ovum Gallus domesticus album 0.1ml in 1 hour after time administration was surveyed once totally 4 times every 1 hour later on.Calculate the administration group of each time point and the difference of matched group, carry out the t check.As known from Table 4, the granule of the embodiment of the invention 3 preparations all can obviously suppress the caused rat paw edema of Ovum Gallus domesticus album in the dosage range that is tried, and effect can continue until more than 3 hours.

Table 4 embodiment 3 granules are to the influence of Ovum Gallus domesticus album pedal swelling

The group dosage number of animals normal foot sole of the foot causes swelling difference (the cm) ± s 0.5h 1h 2h 3h of the scorching back different time and the normal foot sole of the foot

Control group 9 3.02 ± 0.09 1.33 ± 0.21 1.12 ± 0.14 0.88 ± 0.91 0.57 ± 0.14 aspirin group 0.2 9 3.03 ± 0.07 1.33 ± 0.25 0.88 ± 0.21*, 0.61 ± 0.20**, 0.40 ± 0.12* embodiment, 3 granule groups 6.5 9 2.99 ± 0.06 1.08 ± 0.30*, 0.77 ± 0.21***, 0.66 ± 0.21*, 0.43 ± 0.09*, 13.0 10 3.00 ± 0.09 1.04 ± 0.19*, 0.75 ± 0.21***, 0.62 ± 0.21*, 0.43 ± 0.14*, 26.0 10 3.03 ± 0.07 0.93 ± 0.22***, 0.69 ± 0.18***, 0.55 ± 0.19**, 0.35 ± 0.17*

Compare * P＜0.05 * * P＜0.01 * * * P＜0.001 with matched group

Table 5 embodiment 3 granule groups are to the influence of rat fresh yeast artificial fever

The group dosage number of animals normal foot sole of the foot causes swelling difference (the cm) ± s 0.5h 1h 2h 3h of the scorching back different time and the normal foot sole of the foot
	Control group 10 37.3 ± 0.4 1.8 ± 0.5 2.3 ± 0.4 2.1 ± 0.4 1.9 ± 0.4 aspirin group 0.2 10 31.73 ± 0.4 0.4 ± 0.7***, 0.1 ± 0.25***, 0.03 ± 0.6***, 0.02 ± 0.3*** embodiment, 3 granule group 6.5 10 37.1 ± 0.5 1.2 ± 0.7 1.3 ± 0.7*, 1.3 ± 0.9*, 1.1 ± 0.7*, 13.0 10 37.4 ± 0.8 1.1 ± 0.9 1.2 ± 0.9*, 1.1 ± 0.8***, 0.8 ± 0.6***, 26.0 10 37.4 ± 0.5 0.7 ± 0.8***, 1.0 ± 0.7***, 0.8 ± 0.9***, 0.8 ± 0.8**

Compare * P＜0.05 * * P＜0.01 * * * P＜0.001 with matched group

2.3 refrigeration function

Male rat to body weight 130～140g carries out the anus temperature measurement, select the anus temperature 36.3C～38.3 ℃ person as the body temperature eligible.After the body weight grouping, successive administration three days was pressed the dosage of 2ml/100g body weight the same day of last administration, and it is subcutaneous to be injected in rat nape portion with 1.5% fresh yeast suspension respectively.The 4th hour beginning gastric infusion began to survey the anus temperature in 1 hour behind the medicine behind the injection yeast mixture, measured once every 1 hour later on, surveyed the anus temperature and basic anus using warming therapy difference is the index of body temperature variation with different time.Experimental result shows (seeing Table 5), and three dosage of granule of embodiment 3 preparations all have tangible antipyretic effect to the rat of fresh yeast artificial fever, and its effect can be kept about 4 hours.

3 discuss

Pharmacological evaluation has proved that medicine of the present invention has stronger antibacterial action external to golden yellow Fructus Vitis viniferae ball, and in vivo to having significant protective effect by staphylococcus aureus and the B family microbial animal dead of hammer.According to former report; the animal dead protection test; owing to cause that the bacterial infection amount of animal dead is bigger; the animal morbidity is also more anxious, and the Chinese medicine ingredients complexity, after the drug metabolism; in blood, have antibacterial activity ten thousand/ concentration be not enough to kill pathogenic organisms; so,, seldom can watch for animals and avoid the death that causes by bacterial infection through the animal gastric infusion at external Chinese medicine with antibacterial action.And medicine of the present invention has antimicrobial ability in the body to the existing external direct bacteriostasis of pathogenic bacterium.The separation of clinical bacteria at present shows that pharyngitis and tonsillitis are mainly caused by staphylococcus aureus and B family streptococcus, so clinical drug of the present invention treatment pharyngitis and tonsillitis have curative effect preferably, are new drugs with development prospect.

Claims (7)

1. the medicine of acute, the chronic pharyngitis of a treatment, it is by being prepared from by following Chinese medicinal raw materials in portion by weight:

Herba Artemisiae Annuae 100-250,

Radix Bupleuri 100-300,

Fructus Arctii 100-300,

Radix Clematidis 100-300,

Radix Scutellariae 150-350,

Radix Glycyrrhizae 0-200.

2. treat medicine acute, chronic pharyngitis according to claim 1 a kind of, it is by forming by following weight portion proportioning feedstock production:

Herba Artemisiae Annuae 150-200,

Radix Bupleuri 150-250,

Fructus Arctii 150-250,

Radix Clematidis 150-250,

Radix Scutellariae 200-300,

Radix Glycyrrhizae 50-150.

3. treat medicine acute, chronic pharyngitis according to claim 2 a kind of, it is by forming by following weight portion proportioning feedstock production:

Herba Artemisiae Annuae 170,

Radix Bupleuri 200,

Fructus Arctii 200,

Radix Clematidis 200,

Radix Scutellariae 250,

Radix Glycyrrhizae 100.

4. treat medicine acute, chronic pharyngitis according to claim 1-3 a kind of, it can be oral liquid, capsule, tablet, soft capsule, granule, buccal tablet, powder, spray, injection, pill or drops.

5. claim 1 a kind of treats the preparation method of the medicine of acute, chronic pharyngitis, and it may further comprise the steps:

A. the Herba Artemisiae Annuae and the Radix Bupleuri that take by weighing recipe quantity shred, and soak 0.5-2 hour, add thermal distillation and collect volatile oil, and device is preserved in addition;

B. aqueous solution after the distillation and medicinal residues and other four Chinese medicine material add water to 8-9 and doubly measure decoction 2 times, and 1.5-2.5 hour for the first time, 0.5-1.5 hour for the second time, collecting decoction filtered, and filtrate concentrates;

C. add ethanol, fully stir, leave standstill, filter, reclaim ethanol to there not being the alcohol flavor, add an amount of dilution of water after, regulate PH, placed 48 hours down, filter for 5 ℃;

D. add Oleum menthae, volatile oil, simple syrup and sorbitol successively, stir, add water to ormal weight, regulate PH6.0, kept at room temperature overnight filters, embedding, and sterilization is promptly.

6. claim 1 a kind of treats the preparation method of the medicine of acute, chronic pharyngitis, and it may further comprise the steps:

A. the Herba Artemisiae Annuae and the Radix Bupleuri that take by weighing recipe quantity shred, and soak 0.5-2 hour, add thermal distillation and collect volatile oil, and device is preserved in addition;

B. aqueous solution after the distillation and medicinal residues and other four Chinese medicine material add water to 8-9 and doubly measure decoction 2 times, and 1.5-2.5 hour for the first time, 0.5-1.5 hour for the second time, collecting decoction filtered, and filtrate concentrates;

C. add ethanol, fully stir, leave standstill, filter, reclaim ethanol to there not being the alcohol flavor, filtrate concentrates, and is spray dried to fine powder;

D. add appropriate amount of starch, microcrystalline cellulose to fine powder, mix homogeneously divides in the capsule shells of packing into, finished product.

7. claim 1 a kind of treats the preparation method of the medicine of acute, chronic pharyngitis, and it may further comprise the steps:

A. the Herba Artemisiae Annuae and the Radix Bupleuri that take by weighing recipe quantity shred, and soak 0.5-2 hour, add thermal distillation and collect volatile oil, and device is preserved in addition;

B. aqueous solution after the distillation and medicinal residues and other four Chinese medicine material add water to 8-9 and doubly measure decoction 2 times, and 1.5-2.5 hour for the first time, 0.5-1.5 hour for the second time, collecting decoction filtered, and filtrate concentrates;

C. add ethanol, fully stir, leave standstill, filter, reclaim ethanol to not having alcohol flavor, filtrate concentrated extract;

D. add sucrose, dextrin and ethanol and make granule in right amount in extractum, drying adds volatile oil, makes granule.