CN1231250C - Chinese medicine preparation for treating acute and chronic pharyngitis, preparing method thereof - Google Patents
Chinese medicine preparation for treating acute and chronic pharyngitis, preparing method thereof Download PDFInfo
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- CN1231250C CN1231250C CN 03119521 CN03119521A CN1231250C CN 1231250 C CN1231250 C CN 1231250C CN 03119521 CN03119521 CN 03119521 CN 03119521 A CN03119521 A CN 03119521A CN 1231250 C CN1231250 C CN 1231250C
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Abstract
The present invention relates to a traditional Chinese medicine preparation for treating acute pharyngitis and chronic pharyngitis and a preparing method thereof. The traditional Chinese medicine preparation is formed by preparing native achyranthes, roughhaired holly root and radix glycyrrhiza according to certain weight proportioning. The traditional Chinese medicine has the functions of clearing heat, detoxicating, relieving the throat to restore voice, promoting salivation, eliminating vexation, dispersing accumulation and dissolving stagnation. In particular, the present invention is suitable for treating swelling and pain in the throat caused by exuberant lung and stomach. The traditional Chinese preparation of the present invention has the functions of relieving fever and relieving pain, and has the pharmacological action on the prevention of inflammation. The present invention both can be used for treating acute pharyngitis and can also be used for treating chronic pharyngitis.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of acute and chronic pharyngitis and preparation method thereof, be specifically a kind of be the treatment acute pharyngitis made of raw material and pure Chinese medicinal preparation of chronic pharyngitis and preparation method thereof with the natural Chinese medicinal herb.
Background technology
Pharyngitis belongs to the traditional Chinese medical science " sore throat " category, is clinical commonly encountered diseases, frequently-occurring disease.Pharyngitis is divided into two kinds of acute pharyngitis and chronic pharyngitiss.
Acute pharyngitis is main because of virus, courses of infection, or the stimulation causing of multiple physical chemical factor pharyngeal mucous membrane, submucous tissue, adenoid acute congestion swelling, inflammatory reaction such as pain.
Chronic pharyngitis is because the outbreak repeatedly of acute pharyngitis; Oral cavity, nasal cavity illness or stimulated by physics, chemical factor and the chronic expectorant disease of multiple general etc. causes pharyngeal mucosa, submucous tissue, lymphoid tissue diffuse inflammation.
The traditional Chinese medical science is included acute and chronic pharyngitis in the sore throat category, think pathogeny be affection due to external wind and heat, on steam throat; Affection by exopathogenic cold-wind, strongly fragrant lung heat-transformation, on stop up throat; Lifes in eating and drinking without temperance, tobacco and wine are excessive, damp and hot, accumulated heat in the lung and stomach, stifling throat or impairment caused by overstrain excessively, zang-fu disharmony, hyperactivity of deficient fire, smoke and burn due to the throat.Acute pharyngitis belongs to acute pharyngitis due to wind-heat more, and chronic pharyngitis belongs to sore-throat due to yin deficiency more.Acute pharyngitis shows effect repeatedly, does not prolongedly heal, and causes YIN-deficiency of the lung and kidney, body fluid deficiency liquid few, then can develop into chronic pharyngitis.Obstinate can cause the state of an illness to increase the weight of, and influences the healthy of people.
At present, the medicament of commercially available treatment pharyngitis is a lot of, and pill is arranged, and tablet also has liquid spray.Raw material is very not identical, and compatibility is more inconsistent, and manufacture method is how complicated, and the medicine of its preparation has side effect, and behind the medicine life-time service that has, various virus and bacterias can produce drug resistance, so curative effect is not ideal enough, and cure rate is not high.Some Chinese patent medicine also exists cures the symptoms, not the disease, only control acute, do not control deficiencies such as chronic.All can not reach the purpose of radical cure as existing " winter Ganoderma ", " LIUSHEN WAN ", " larynx disease ball ".
Summary of the invention
The objective of the invention is to overcome the weak point of above-mentioned existing medicine, a kind of Chinese medicine preparation for the treatment of acute, chronic pharyngitis and preparation method thereof is provided, the effect that this Chinese medicine preparation has heat-clearing and toxic substances removing, relieving sore throat to recover voice, the relieving restlessness of promoting the production of body fluid, removing food stagnancyization stagnate is particularly useful for treating the laryngopharynx swelling and pain due to the exuberant lung-stomach heat.That Chinese medicine preparation of the present invention has is analgesic, analgesia, antiphlogistic pharmacological action, can treat acute pharyngitis, can treat chronic pharyngitis again.
An aspect of of the present present invention provides a kind of Chinese medicine preparation acute, chronic pharyngitis for the treatment of, and it is prepared from by following weight portion proportioning by Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae:
Radix Achyranthis 45-60,
Radix Ilicis Asprellae 70-85,
Radix Glycyrrhizae 8-12.
The preferred a kind of Chinese medicine preparation acute, chronic pharyngitis for the treatment of of the present invention, it is prepared from by following weight portion proportioning by Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae:
Radix Achyranthis 50-55,
Radix Ilicis Asprellae 75-80,
Radix Glycyrrhizae 8-12.
The most preferred a kind of Chinese medicine preparation acute, chronic pharyngitis for the treatment of of the present invention, it is prepared from by following weight portion proportioning by Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae:
Radix Achyranthis 53,
Radix Ilicis Asprellae 77,
Radix Glycyrrhizae 10.
A kind of Chinese medicine preparation acute, chronic pharyngitis for the treatment of of the present invention, it can make various dosage forms according to a conventional method, comprises oral liquid, capsule, tablet, soft capsule, granule, buccal tablet, powder, spray, pill or drop pill etc.
In various dosage forms, preferred a kind of oral liquid of making by following method, this preparation method is:
A. Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae are added 3-6 times of water gaging and decoct twice, 2-2.5 hour for the first time, 1.5-2 hour for the second time;
B. filter, merging filtrate, and concentrate, added the 50-60% soak with ethanol 10-15 hour, filter, reclaim ethanol, add water to aequum, and add a certain amount of antiseptic;
C. be distributed into finished product.
Concrete instructions of taking and consumption: oral, every day three times, each 10-20ml.Acute pharyngitis is a course of treatment for three days on end, and chronic pharyngitis was a course of treatment in continuous 7 days.
In various dosage forms, also preferred a kind of capsule of making by following method, this preparation method is:
A. Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae are mixed after crude drug is handled, add 3-6 times of water gaging and boil, extract 2 times, 2-2.5 hour for the first time, 1.5-2 hour for the second time;
B. filter, merge secondary filtrate, concentrate;
C. added the 50-60% soak with ethanol 10-15 hour, and filtered, reclaim ethanol, filtrate concentrates, and is spray dried to fine powder;
D. fine powder adds appropriate amount of starch, microcrystalline cellulose, and mix homogeneously divides in the capsule shells of packing into, finished product.
The Chinese medicine of respectively distinguishing the flavor of in the Chinese medicine preparation of the present invention is crude drug.Radix Achyranthis puckery in the side is little sweet, warm in nature, nontoxic.It is born in the other spacious ground of hill village wing, or artificial culture.One or biennial herb.Stem is sturdy upright, and multi-branched is square slightly, and what are by hair, Senior Two, three chis, and the base portion band is wooden, saves swollen wood like Radix Achyranthis Bidentatae, and leaf is to life, ellipse, long two, three cun, short bristle is arranged, green entirely, the tip point, the base portion wedge shape has petiole.The Xia Qiu locusta of earing, close by fine hair, to spend for a short time, green is turned one's coat after opening and is close to floral axis, and two pieces of the sharp bracts of firm reality are arranged, and easily sews attached medicated clothing.
It is of the present invention that a kind of to treat Chinese medicine preparation acute, chronic pharyngitis be to be prepared from by three kinds of Chinese herbal medicine, its prescription science, rationally, and concertedness is good, curative effect highly significant, shortcoming such as overcome that existing prescription flavour of a drug are many, complex process, curative effect are not remarkable.
The specific embodiment
Below adopt embodiment to specify a kind of Chinese medicine preparation for the treatment of acute, chronic pharyngitis of the present invention and preparation method thereof.
Embodiment 1
A kind ofly treat oral liquid acute, chronic pharyngitis, it is prepared from by following weight by Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae:
Radix Achyranthis 815 grams,
Radix Ilicis Asprellae 1175 grams,
Radix Glycyrrhizae 153 grams.
The preparation technology of above-mentioned oral liquid is as follows:
A. Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae are added 5 times of water gagings and decoct twice, 2 hours for the first time, 2 hours for the second time;
B. filter, merging filtrate, and concentrate, added the 50-60% soak with ethanol 10-15 hour, filter, reclaim ethanol, add water to 1000ml; Add 0.5 gram nipalgin;
C. be distributed into 100ml.
Embodiment 2
A kind ofly treat medicament capsule acute, chronic pharyngitis, it is prepared from by following weight by Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae:
Radix Achyranthis 2650 grams,
Radix Ilicis Asprellae 3900 grams,
Radix Glycyrrhizae 500 grams.
Above-mentioned capsular preparation technology is as follows:
A. Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae are mixed after crude drug is handled, add 4 times of water gagings and boil, extract 2 times, 2 hours for the first time, 2 hours for the second time;
B. filter, merge secondary filtrate, concentrate;
C. added the 50-60% soak with ethanol 12 hours, and filtered, reclaim ethanol, filtrate concentrates, and is spray dried to fine powder;
D. fine powder adds appropriate amount of starch, microcrystalline cellulose, and mix homogeneously divides 1000 capsules of packing into, and packing promptly.
Below further specify a kind of drug action for the treatment of the Chinese medicine preparation of acute, chronic pharyngitis of the present invention by pharmacodynamics test:
1 experiment material
1.1 medicine and reagent Chinese medicine preparation of the present invention (trade name: sore-throat relieving side) is provided by Guangdong Gaosheng medicine Development Co., Ltd, brown powder, and every g is equivalent to crude drug in whole 4.8g.Herba Pileae Scriptae Tabellae, pharmaceutical factory's product in the river.Aspirin, Xuzhou En Hua pharmaceutcal corporation, Ltd.High-activity yeast, The Mc-DougallsKitchen, Englangd.Other is commercially available analytical reagent.
1.2 animal NIH mice (quality certification number: 01A018), body weight 17～21g; The SD rat (quality certification number: 01A017), body weight 180～220g.Provide by Guangdong Medical Lab Animal Center.
1.3 instrument GJ-8402 type hot plate dolorimeter, the white stone scientific instrument in Zhejiang factory.7550 type spectrophotometers, Shanghai Analytical Instrument Co., Ltd of Hewlett-Packard.Japan's Ao Mulong numeral shows thermometer.
2 methods and result
2.1 male SD rat is got in the influence to the fresh yeast artificial fever, body weight 180～220g, and the per anum temperature measurement is selected the anus temperature 50 of 36.6 ℃～38.3 ℃ persons, is divided into 5 groups at random, 10 every group; Normal saline group, the basic, normal, high dosage group in sore-throat relieving side (2.5,5,10g/kg), aspirin (0.2g/kg) group.Sore-throat relieving side's successive administration 3 days to the 3rd day, is pressed the dosage of 2ml/100g body weight, and it is subcutaneous to be injected in rat nape portion with 1.5% fresh yeast suspension.The 5th hour beginning gastric infusion behind the injection yeast, 1 hour begins to survey the anus temperature after the administration, measures 1 time every 1 hour later on.It is 22 ℃ room that rat places room temperature all the time.
The results are shown in Table 1, there is tangible antipyretic effect (P0.001) sore-throat relieving side to the rat of fresh yeast artificial fever, and its effect can be kept 4 hours at least.
2.2 18～22g male mice is got in pain caused influence to hot plate method, each 1 is placed on 55 ± 0.5 ℃ the metal hot plate, and mice is from being placed on the hot plate to the pain threshold of metapedes required time (s) as this Mus occurring licking.Allly lick the metapedes time less than 5 seconds or give it up greater than 30 seconds or leaper.Qualified mice is divided into 5 groups at random, every group 10, repeat to survey its normal pain threshold, pressed table 2 dosage successive administration 3 days, every day 1 time, negative control group gives normal saline 0.4ml/ only, after the last administration, measured pain threshold in 60,120,180,240 minutes respectively, if pain threshold 60 seconds with calculating in 60 seconds, is observed in order to avoid scald the influence of animal vola next time.Animal places 20 ℃ room all the time.
The results are shown in Table 2.The middle and high dosage in sore-throat relieving side all has significant inhibitory effect to hot plate method induced mice pain, high dose group (10g/kg) had significant analgesic activity (P 0.01) in 60～240 minutes after administration, middle dosage group (5g/kg) also had significant analgesic activity (P 0.01) in 60～180 minutes after administration.
2.3 50 of body weight 18～22g mices are got in the influence that the mouse peritoneal capillary permeability increases, be divided into 5 groups at random, every group 10, gastric infusion is 4 days continuously, after the last administration 1 hour, tail vein injection concentration is the blue solution 0.1ml/ of the ivens of 1g/100ml, and lumbar injection 0.6% acetum 0.2ml/ simultaneously, put to death mice after 20 minutes, cut off the abdominal cavity, with 3ml distilled water flushing abdominal cavity for several times, draw the about 3～4ml of abdominal cavity eluate, 1000r/ minute centrifugal 5 minutes, measure the trap value at the 590nm place.
The results are shown in Table 3, three dosage of sore-throat relieving side are to H
+Due to the mouse peritoneal capillary permeability increase the obvious suppression effect all arranged, suppress inflammatory exudation, compare with the normal saline group, utmost point significant difference (P0.01) is arranged.
3 discuss
The effect that sore-throat relieving side has is significantly analgesic, analgesia, anti-inflammatory are oozed out.For rat fresh yeast artificial fever, the highest 0.8 ℃ of the body temperature that reduces in sore-throat relieving side.Pain caused for hot plate method, sore-throat relieving can obviously improve the threshold of pain, the highest threshold of pain 43.8% of improving.Sore-throat relieving side also can suppress the raising of the mouse peritoneal capillary permeability due to the acetic acid, and suppression ratio can reach 34.8%.The clinical efficacy that acute and chronic pharyngitis is treated by effect experiment result and sore-throat relieving side matches.
Table 1, sharp because of the side to the influence of fresh yeast artificial fever (x ± s, n=10)
| Group | Dosage (%) | Rat temperature (℃) | |||||
| -5 | 0 | 1 | 2 | 3 | 4h | ||
| Normal saline | 20ml/kg | 37.4±0.2 | 39.3±0.2 | 39.7±0.4 | 40.1±0.2 | 40.0±0.3 | 39.9±0.3 |
| Sore-throat relieving side | 2.5 | 37.8±0.2 | 39.3±0.4 | 39.5±0.4 | 39.7±0.3** | 39.8±0.2 | 39.9±0.2 |
| 5 | 375±0.2 | 39.2±0.2 | 39.3±0.3* | 39.3±0.3*** | 39.6±0.3** | 39.6±0.2** | |
| 10 | 37.5±0.1 | 39.2±0.2 | 39.0±0.7** | 39.3±0.5*** | 39.4±0.3*** | 39.4±0.3*** | |
| Herba Pileae Scriptae Tabellae | 0.2 | 37.4±0.2 | 39.0±0.2 | 37.6±0.2*** | 37.5±0.3** | 38.0±0.5*** | 38.2±0.5*** |
Compare * P 0.05, * * P 0.01, * * * P 0.001 with the normal saline group
The influence pain caused to the mice hot plate method of table 2 sore-throat relieving side (x ± s, n=10)
| Group | Dosage (%) | Rat temperature (℃) | ||||
| 0 | 60 | 120 | 180 | 240 | ||
| Normal saline | 20ml/kg | 14.1±3.8 | 14.5±4.3 | 13.8±3.8 | 13.8±3.2 | 13.3±3.0 |
| Sore-throat relieving side | 2.5 | 13.7±3.9 | 15.6±3.7 | 15.1±3.6 | 16.9±3.3* | 14.4±4.4 |
| 5 | 14.0±2.6 | 18.4±2.7* | 17.4±2.7* | 18.3±3.7** | 15.3±3.5 | |
| 10 | 13.6±3.7 | 19.6±4.6** | 19.6±5.5** | 19.8±5.1** | 18.12±3.7** | |
| Herba Pileae Scriptae Tabellae | 2 | 13.8±2.4 | 18.4±4.0* | 18.7±4.2** | 18.6±4.0** | 17.1±3.0** |
Compare * P 0.05, * * P 0.01 with the normal saline group
Table 3 sore-throat relieving side to the influence of mouse peritoneal capillary permeability (x ± s, n=10)
| Group | Dosage | OD590 | Suppression ratio (%) |
| Normal saline | 20ml/kg | 0.310±0.072 | |
| Sore-throat relieving side | 2 | 0.232±0.088* | 25.16 |
| 4 | 0.216±0.094** | 30.32 | |
| 8 | 0.202±0.081** | 34.84 | |
| Herba Pileae Scriptae Tabellae | 2 | 0.215±0.086** | 30.64 |
Compare * P 0.05, * * P 0.01 with the normal saline group
Claims (6)
1. the Chinese medicine preparation of acute, the chronic pharyngitis of a treatment, it is prepared from by following weight portion proportioning by Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae:
Radix Achyranthis 45-60,
Radix Ilicis Asprellae 70-85,
Radix Glycyrrhizae 8-12.
2. treat Chinese medicine preparation acute, chronic pharyngitis according to claim 1 a kind of, it is prepared from by following weight portion proportioning by Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae:
Radix Achyranthis 50-55,
Radix Ilicis Asprellae 75-80,
Radix Glycyrrhizae 8-12.
3. treat Chinese medicine preparation acute, chronic pharyngitis according to claim 1 a kind of, it is prepared from by following weight portion proportioning by Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae:
Radix Achyranthis 53,
Radix Ilicis Asprellae 77,
Radix Glycyrrhizae 10.
4. treat Chinese medicine preparation acute, chronic pharyngitis according to claim 1-3 a kind of, it can be oral liquid, capsule, tablet, soft capsule, granule, buccal tablet, powder, spray, pill or drops.
5. claim 1 a kind of treats the preparation method of the Chinese medicine preparation of acute, chronic pharyngitis, and it is made up of following steps:
A. Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae are added 3-6 times of water gaging and decoct twice, 2-2.5 hour for the first time, 1.5-2 hour for the second time;
B. filter, merging filtrate, and concentrate; Add the 50-60% soak with ethanol 10-15 hour, and filtered, reclaim ethanol, add water to aequum;
C. be distributed into the finished product oral liquid.
6. claim 1 a kind of treats the preparation method of the Chinese medicine preparation of acute, chronic pharyngitis, and it is made up of following steps:
A. Radix Achyranthis, Radix Ilicis Asprellae and Radix Glycyrrhizae are mixed after crude drug is handled, add 3-6 times of water gaging and boil, extract 2 times, 2-2.5 hour for the first time, 1.5-2 hour for the second time;
B. filter, merge secondary filtrate, concentrate;
C. added the 50-60% soak with ethanol 10-15 hour, and filtered, reclaim ethanol, filtrate concentrates, and is spray dried to fine powder;
D. fine powder adds appropriate amount of starch, microcrystalline cellulose, and mix homogeneously divides in the capsule of packing into, finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03119521 CN1231250C (en) | 2003-03-10 | 2003-03-10 | Chinese medicine preparation for treating acute and chronic pharyngitis, preparing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 03119521 CN1231250C (en) | 2003-03-10 | 2003-03-10 | Chinese medicine preparation for treating acute and chronic pharyngitis, preparing method thereof |
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| Publication Number | Publication Date |
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| CN1530128A CN1530128A (en) | 2004-09-22 |
| CN1231250C true CN1231250C (en) | 2005-12-14 |
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| CN 03119521 Expired - Lifetime CN1231250C (en) | 2003-03-10 | 2003-03-10 | Chinese medicine preparation for treating acute and chronic pharyngitis, preparing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103518912B (en) * | 2013-10-22 | 2015-03-04 | 吉首大学 | Traditional Chinese medicinal health-protection tea for treating chronic pharyngitis and preparation method of traditional Chinese medicinal health-protection tea |
| CN103535485A (en) * | 2013-10-24 | 2014-01-29 | 哈尔滨浩拓生物科技开发有限公司 | Formula and production method of chrysanthemum heart-fire-clearing tea |
| CN104000962A (en) * | 2014-06-18 | 2014-08-27 | 徐艳 | Lozenge for curing acute pharyngitis and preparation method and application thereof |
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