CN103055221B - Pure Chinese medicinal composition for treating acarine disease and preparation method thereof - Google Patents

Abstract

The invention relates to a Pure Chinese medicinal composition for treating acarine disease. The composition is characterized by being prepared by mixing and extracting the following components in part by weight: 25 to 35 parts of cyrtomium rhizome, 25 to 45 parts of Chinese mugwort leaf, 25 to 45 parts of tobacco leaf, 25 to 35 parts of sessile stemona root, 25 to 35 parts of Chinese atractylodes, 15 to 35 parts of phellodendron and 15 to 35 parts of rangooncreeper fruit. The Pure Chinese medicinal composition is reasonable in formula, is easy to prepare, does not have any toxic or side effect, treats both symptoms and root causes, is fumigated, has a very obvious curative effect and is clinically proven to have a special effect of treating acarine disease, and medicine residue and medicine resistance are avoided.

Description

Pure Chinese medicine composition for the treatment of acarine disease and preparation method thereof

Technical field

The present invention relates to pure Chinese medicine composition for the treatment of acarine disease and preparation method thereof, belong to animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment acarine disease and preparation method thereof.

Background technology

The general designation of several parasitic disease of the honeybee that acarine disease is caused by varoa mite and Mites, OIE is classified as category-B epidemic disease.Chalcid fly acaricide is a kind of epizootic disease of the Apis that caused by Mites, is typical lair entozoa, main harm honeybee children and Pupa Apis; Mites all can be seen throughout the year at south China, visible young demodicid mite extremely in lair, the blackening of rotting, pupa can not be sprouted wings, or young honeybee dysplasia, wing after sprouting wings is incomplete, disorderly climbs in front of the door or on place at nest; The lighter causes a large amount of disabled honeybees, weakens group's gesture, reduces the output of Mel, Lac regis apis, and severe one makes larva and the Pupa Apis death, rotten on all sub-spleens, until full group's destruction.Varoa mite disease is a kind of epizootic disease of the Apis that caused by Varroa jacobsoni, and the main harm honeybee that grows up, also endangers bee larvae, and be the peak period of its development annual autumn; The Apis dysplasia of parasitic varoa mite, has bad physiques, and collection power declines, the lost of life; The larva of parasitic varoa mite, some death, have in death in pupa time, luckily sprout wings into honeybee, be often also wing foot is incomplete, can not circle in the air after going out room; Therefore, the bee colony that is subject to varoa mite infringement usually extremely honeybee, dead pupa everywhere, young honeybee around is climbed, group gesture fails rapidly.Large and small honeybee demodicid mite is very large to bee colony harm, causes heavy losses to beekeeping, even causes that full group is dead.

This disease spreads all over more than 100 countries of five continents, is widely distributed.At present, treat this disease the most frequently used be various anti-parasite medicines, though receive certain effect, because its toxic and side effects by force, easily produces the problem such as drug resistance and drug residue, clinical practice is very limited or bans use of.

Therefore researching and developing a kind of specific medicament for the treatment of acarine disease is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, the pure Chinese medicine composition of effectively treating acarine disease and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of acarine disease, by following component, mixed extraction is formulated by weight: Rhizoma Osmundae 25-35 part, Folium Artemisiae Argyi 25-45 part, Nicotiana tabacum L. 25-45 part, Radix Stemonae 25-35 part, Rhizoma Atractylodis 25-35 part, Cortex Phellodendri 15-35 part, Fructus Quisqualis 15-35 part.

Described various component optimum ratio amount is: 30 parts of Rhizoma Osmundae, 35 parts of Folium Artemisiae Argyis, 35 parts, Nicotiana tabacum L., 30 parts of the Radixs Stemonae, 30 parts of Rhizoma Atractylodis, 25 parts of Cortex Phellodendris, 25 parts of Fructus Quisqualis.

Treat a preparation method for the pure Chinese medicine composition of acarine disease, carry out as follows:

(1) the various compositions in prescription are pulverized respectively to rear mistake 100 mesh sieves;

(2) take by weight Rhizoma Osmundae 25-35 part, Folium Artemisiae Argyi 25-45 part, Nicotiana tabacum L. 25-45 part, Radix Stemonae 25-35 part, mix 5-10 minute to even;

(3) take by weight Rhizoma Atractylodis 25-35 part, Cortex Phellodendri 15-35 part, Fructus Quisqualis 15-35 part, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Rhizoma Osmundae: bitter, cold, return liver, stomach warp, there is the function of heat-clearing and toxic substances removing, cooling blood for hemostasis, anthelmintic; Cure mainly epidemic disease flu, maculae caused by violent heat pathogen, sore swollen toxin, abdominal pain due to worm stagnation etc.

Folium Artemisiae Argyi: acrid, bitter, warm, return liver,kidney,spleen warp, there is the function of dispersing cold for relieving pain, warming the meridian for stopping bleeding; Cure mainly anemofrigid-damp arthralgia, tripe abdomen cold type of pain etc.

Nicotiana tabacum L.: pungent, warm, return liver, lung meridian, there is the function of subduing swelling and detoxicating, parasite killing; Cure mainly furuncle swelling toxin, tinea capitis, tinea alba, tinea alba etc.

The Radix Stemonae: sweet, bitter, return lung meridian, there is the function of nourishing the lung to arrest cough, parasite killing; Cure mainly cough, enterobiasis, ascariasis, scabies, body louse etc.

Rhizoma Atractylodis: acrid, bitter, warm, return spleen, stomach, Liver Channel, there is the function of drying damp and strengthening spleen, expelling wind and cold, improving eyesight; Cure mainly have loose bowels, edema, anemofrigid-damp arthralgia, anemofrigid cold, nyctalopia etc.

Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.

Fructus Quisqualis: sweet, warm, return stomach, spleen channel, there is the function of killing insect and eliminating accumulation; Cure mainly ascariasis, abdominal pain due to worm stagnation, enterobiasis etc.

All taste Chinese medicine, according to the theoretical compatible combination of Chinese veterinarian, for pathogenic microorganism and the clinical symptoms of acarine disease, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and cost is low, draws materials wide, drug residue free, has no drug resistance, has no side effect, sootiness sterilization, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this seven tastes Chinese medicine, and makes them form pure Chinese medicine according to optimum ratio, and clinical practice proves that treatment acarine disease is had to specially good effect.

Detailed description of the invention

Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:

Embodiment 1

A kind of pure Chinese medicine composition for the treatment of acarine disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are pulverized respectively to rear mistake 100 mesh sieves;

(2) take by weight 250 parts of Rhizoma Osmundae, 250 parts of Folium Artemisiae Argyis, 250 parts, Nicotiana tabacum L., 250 parts of the Radixs Stemonae, mix 5-10 minute to even;

(3) take by weight 250 parts of Rhizoma Atractylodis, 150 parts of Cortex Phellodendris, 150 parts of Fructus Quisqualis, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of pure Chinese medicine composition for the treatment of acarine disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are pulverized respectively to rear mistake 100 mesh sieves;

(2) take by weight 300 parts of Rhizoma Osmundae, 350 parts of Folium Artemisiae Argyis, 350 parts, Nicotiana tabacum L., 300 parts of the Radixs Stemonae, mix 5-10 minute to even;

(3) take by weight 300 parts of Rhizoma Atractylodis, 250 parts of Cortex Phellodendris, 250 parts of Fructus Quisqualis, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of pure Chinese medicine composition for the treatment of acarine disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are pulverized respectively to rear mistake 100 mesh sieves;

(2) take by weight 350 parts of Rhizoma Osmundae, 450 parts of Folium Artemisiae Argyis, 450 parts, Nicotiana tabacum L., 350 parts of the Radixs Stemonae, mix 5-10 minute to even;

(3) take by weight 350 parts of Rhizoma Atractylodis, 350 parts of Cortex Phellodendris, 350 parts of Fructus Quisqualis, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

It is the ill Apis of acarine disease that clinical experiment animal is selected Laboratory Diagnosed.The isolation of ill honeybee is raised separately, be divided at random 3 groups, every group of 3 casees totally 15 spleen honeybees, 3 groups of feeding environments are identical, and experimental period is carried out 5 days altogether; Blank group is left intact, and medicine matched group uses treatment by institute's control drug by its description; Present composition group is sub-packed in product of the present invention (the prepared compositions of the embodiment of the present invention 1) in little paper bag, 5 grams every bag or 10 grams, after lighting one jiao of paper bag, blow out naked light, putting into beehive does not have a side of honeybee spleen, airtight smoking controlled 20 minutes to 30 minutes, every 3-5 days smoked controlling once, carry out 2-3 time continuously.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result (testing the 6th day) when following table is experiment end.

Table is the applicable cases contrast of the present invention and other medicines treatment acarine disease:

Numbering	Group	Mortality rate %	Cure rate %	When end, there is symptom rate %
					I	Blank group	31	37	32
II	Chlorfenethol fumigant group	11	75	14
					III	Present composition group	7	84	9

This clinical effectiveness statistical analysis, present composition treatment group and chlorfenethol fumigant group extremely significantly (P < 0.01) of difference compared with aspect cure rate.

Safety testing:

Choose 1 case 5 spleen of healthy Apis, according to 5 times of continuous fume smokings of the made compositions recommended dose of the embodiment of the present invention 1 60 minutes, during medication, healthy Apis is without any bad or Deviant Behavior performance, and difference is not remarkable compared with blank group (being not administration of health group).

The above-mentioned detailed description that pure Chinese medicine composition to this treatment acarine disease and preparation method thereof carries out with reference to embodiment; illustrative instead of determinate; can list several embodiment according to institute's limited range; therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a pure Chinese medicine composition for acarine disease, it is characterized in that being mixed by weight by following component: Rhizoma Osmundae 25-35 part, Folium Artemisiae Argyi 25-45 part, Nicotiana tabacum L. 25-45 part, Radix Stemonae 25-35 part, Rhizoma Atractylodis 25-35 part, Cortex Phellodendri 15-35 part, Fructus Quisqualis 15-35 part.

2. the pure Chinese medicine composition for the treatment of acarine disease according to claim 1, is characterized in that being mixed by weight by following component: 30 parts of Rhizoma Osmundae, 35 parts of Folium Artemisiae Argyis, 35 parts, Nicotiana tabacum L., 30 parts of the Radixs Stemonae, 30 parts of Rhizoma Atractylodis, 25 parts of Cortex Phellodendris, 25 parts of Fructus Quisqualis.

3. a preparation method for the pure Chinese medicine composition for the treatment of acarine disease according to claim 1, is characterized in that carrying out as follows:

(1) the various compositions in prescription are pulverized respectively to rear mistake 100 mesh sieves;

(2) take by weight Rhizoma Osmundae 25-35 part, Folium Artemisiae Argyi 25-45 part, Nicotiana tabacum L. 25-45 part, Radix Stemonae 25-35 part, mix 5-10 minute to even;

(3) take by weight Rhizoma Atractylodis 25-35 part, Cortex Phellodendri 15-35 part, Fructus Quisqualis 15-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.