CN103055221A - Pure Chinese medicinal composition for treating acarine disease and preparation method thereof - Google Patents

Abstract

The invention relates to a Pure Chinese medicinal composition for treating acarine disease. The composition is characterized by being prepared by mixing and extracting the following components in part by weight: 25 to 35 parts of cyrtomium rhizome, 25 to 45 parts of Chinese mugwort leaf, 25 to 45 parts of tobacco leaf, 25 to 35 parts of sessile stemona root, 25 to 35 parts of Chinese atractylodes, 15 to 35 parts of phellodendron and 15 to 35 parts of rangooncreeper fruit. The Pure Chinese medicinal composition is reasonable in formula, is easy to prepare, does not have any toxic or side effect, treats both symptoms and root causes, is fumigated, has a very obvious curative effect and is clinically proven to have a special effect of treating acarine disease, and medicine residue and medicine resistance are avoided.

Description

Pure Chinese medicine composition for the treatment of acarine disease and preparation method thereof

Technical field

The present invention relates to pure Chinese medicine composition for the treatment of acarine disease and preparation method thereof, belong to the animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to the treatment acarine disease and preparation method thereof.

Background technology

The general designation of several parasitic disease of the honeybee that acarine disease is caused by varoa mite and Mites, OIE classifies it as category-B epidemic disease.The chalcid fly acaricide is a kind of epizootic disease of the Apis that caused by Mites, is typical lair entozoa, main harm honeybee children and Pupa Apis; Mites all can be seen throughout the year at south China, visible young demodicid mite extremely in lair, the blackening of rotting, pupa can not be sprouted wings, or young honeybee dysplasia, wing after sprouting wings are incomplete, disorderly climbs in front of the door or on the place at nest; The lighter causes a large amount of disabled honeybees, weakens group's gesture, reduces the output of Mel, Lac regis apis, and severe one makes larva and the Pupa Apis on all sub-spleens dead, rotten, until full group's destruction.The varoa mite disease is a kind of epizootic disease of the Apis that caused by Varroa jacobsoni, and the main harm honeybee that grows up also endangers bee larvae, and be the peak period of its development annual autumn; The Apis dysplasia of parasitic varoa mite is had bad physiques, and collection power descends, the lost of life; The larva of parasitic varoa mite, some death, what have is dead in pupa time, luckily sprouts wings into honeybee, also often is the wing foot is incomplete, can not circle in the air after going out the room; Therefore, the bee colony that is subjected to varoa mite infringement usually extremely honeybee, dead pupa everywhere, young honeybee around is climbed, group gesture fails rapidly.Large and small honeybee demodicid mite is very large to bee colony harm, produces for bee-keeping and causes heavy losses, even cause that full group is dead.

This disease spreads all over more than 100 countries of five continents, is widely distributed.At present, treat this disease the most frequently used be various anti-parasite medicines, though receive certain effect, because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, clinical practice is very limited or bans use of.

Therefore researching and developing a kind of specific medicament for the treatment of acarine disease is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, effectively treat the pure Chinese medicine composition and preparation method thereof of acarine disease.

Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of acarine disease, mixed extraction is formulated by weight by following component: Rhizoma Osmundae 25-35 part, Folium Artemisiae Argyi 25-45 part, Nicotiana tabacum L. 25-45 part, Radix Stemonae 25-35 part, Rhizoma Atractylodis 25-35 part, Cortex Phellodendri 15-35 part, Fructus Quisqualis 15-35 part.

Described various component optimum ratio amount is: 30 parts of Rhizoma Osmundae, 35 parts of Folium Artemisiae Argyis, 35 parts on Nicotiana tabacum L., 30 parts of the Radixs Stemonae, 30 parts of Rhizoma Atractylodis, 25 parts of Cortex Phellodendris, 25 parts of Fructus Quisqualis.

A kind of preparation method for the treatment of the pure Chinese medicine composition of acarine disease, carry out as follows:

(1) the various compositions in the prescription is pulverized respectively rear mistake 100 mesh sieves;

(2) take by weighing by weight Rhizoma Osmundae 25-35 part, Folium Artemisiae Argyi 25-45 part, Nicotiana tabacum L. 25-45 part, Radix Stemonae 25-35 part, mix 5-10 minute to even;

(3) take by weighing by weight Rhizoma Atractylodis 25-35 part, Cortex Phellodendri 15-35 part, Fructus Quisqualis 15-35 part, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Rhizoma Osmundae: bitter, cold, return liver, stomach warp, have the function of heat-clearing and toxic substances removing, cooling blood for hemostasis, anthelmintic; Cure mainly epidemic disease flu, maculae caused by violent heat pathogen, sore swollen toxin, abdominal pain due to worm stagnation etc.

Folium Artemisiae Argyi: hot, bitter, warm, return the liver,kidney,spleen warp, have the function of dispersing cold for relieving pain, warming the meridian for stopping bleeding; Cure mainly anemofrigid-damp arthralgia, tripe abdomen cold type of pain etc.

Nicotiana tabacum L.: hot, warm, return liver, lung meridian, have the function of subduing swelling and detoxicating, parasite killing; Cure mainly furuncle swelling toxin, tinea capitis, tinea alba, tinea alba etc.

The Radix Stemonae: sweet, bitter, return lung meridian, have the function of nourishing the lung to arrest cough, parasite killing; Cure mainly cough, enterobiasis, ascariasis, scabies, body louse etc.

Rhizoma Atractylodis: hot, bitter, warm, return spleen, stomach, Liver Channel, the function that have drying damp and strengthening spleen, expelling wind and cold, makes eye bright; Cure mainly have loose bowels, edema, anemofrigid-damp arthralgia, anemofrigid cold, nyctalopia etc.

Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, have the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.

Fructus Quisqualis: sweet, warm, return stomach, spleen channel, have the function of killing insect and eliminating accumulation; Cure mainly ascariasis, abdominal pain due to worm stagnation, enterobiasis etc.

Above all flavor Chinese medicine for pathogenic microorganism and the clinical symptoms of acarine disease, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease according to the theoretical compatible combination of Chinese veterinarian.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and cost is low, draws materials wide, drug residue free, has no drug resistance, has no side effect, sootiness sterilization, curative effect highly significant.The present invention optimizes this seven flavors Chinese medicine, and makes them form pure Chinese medicine according to optimum ratio according to Chinese veterinarian's traditional theory, and clinical practice proves that the treatment acarine disease is had specially good effect.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

A kind of pure Chinese medicine composition for the treatment of acarine disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is pulverized respectively rear mistake 100 mesh sieves;

(2) take by weighing by weight 250 parts of Rhizoma Osmundae, 250 parts of Folium Artemisiae Argyis, 250 parts on Nicotiana tabacum L., 250 parts of the Radixs Stemonae, mix 5-10 minute to even;

(3) take by weighing by weight 250 parts of Rhizoma Atractylodis, 150 parts of Cortex Phellodendris, 150 parts of Fructus Quisqualis, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of pure Chinese medicine composition for the treatment of acarine disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is pulverized respectively rear mistake 100 mesh sieves;

(2) take by weighing by weight 300 parts of Rhizoma Osmundae, 350 parts of Folium Artemisiae Argyis, 350 parts on Nicotiana tabacum L., 300 parts of the Radixs Stemonae, mix 5-10 minute to even;

(3) take by weighing by weight 300 parts of Rhizoma Atractylodis, 250 parts of Cortex Phellodendris, 250 parts of Fructus Quisqualis, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of pure Chinese medicine composition for the treatment of acarine disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is pulverized respectively rear mistake 100 mesh sieves;

(2) take by weighing by weight 350 parts of Rhizoma Osmundae, 450 parts of Folium Artemisiae Argyis, 450 parts on Nicotiana tabacum L., 350 parts of the Radixs Stemonae, mix 5-10 minute to even;

(3) take by weighing by weight 350 parts of Rhizoma Atractylodis, 350 parts of Cortex Phellodendris, 350 parts of Fructus Quisqualis, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

It is the ill Apis of acarine disease that the clinical experiment animal is selected Laboratory Diagnosed.The isolation of ill honeybee is raised separately, be divided at random 3 groups, every group of 3 casees totally 15 spleen honeybees, 3 groups of feeding environments are identical, and experimental period was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with institute's control drug by its description; Present composition group is sub-packed in product of the present invention (embodiment of the invention 1 prepared compositions) in the little paper bag, restrain for every bag 5 or 10 grams, blow out naked light after lighting one jiao of paper bag, putting into beehive does not have a side of honeybee spleen, airtight smoking controlled 20 minutes to 30 minutes, every 3-5 days smoked controlling are once carried out 2-3 time continuously.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 6th day) when following table is the experiment end.

Table is the applicable cases contrast of the present invention and other medicines treatment acarine disease:

Numbering	Group	Mortality rate %	Cure rate %	Symptom rate % is arranged during end
					I	The blank group	31	37	32
II	Chlorfenethol fumigant group	11	75	14
					III	Present composition group	7	84	9

This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with chlorfenethol fumigant group aspect the cure rate.

Safety testing:

Choose 1 case 5 spleen of healthy Apis, according to 5 times of continuous fume smokings of the embodiment of the invention 1 made compositions recommended dose 60 minutes, during the medication, healthy Apis is without any the performance of bad or Deviant Behavior, and to compare difference not remarkable with blank group (being not administration of health group).

Above-mentioned detailed description of pure Chinese medicine composition of this treatment acarine disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (3)

1. pure Chinese medicine composition for the treatment of acarine disease, it is characterized in that by following component by weight mixed extraction form: Rhizoma Osmundae 25-35 part, Folium Artemisiae Argyi 25-45 part, Nicotiana tabacum L. 25-45 part, Radix Stemonae 25-35 part, Rhizoma Atractylodis 25-35 part, Cortex Phellodendri 15-35 part, Fructus Quisqualis 15-35 part.

2. the pure Chinese medicine composition for the treatment of acarine disease according to claim 1, it is characterized in that by following component by weight mixed extraction form: 30 parts of Rhizoma Osmundae, 35 parts of Folium Artemisiae Argyis, 35 parts on Nicotiana tabacum L., 30 parts of the Radixs Stemonae, 30 parts of Rhizoma Atractylodis, 25 parts of Cortex Phellodendris, 25 parts of Fructus Quisqualis.

3. the preparation method of the pure Chinese medicine composition of a treatment acarine disease according to claim 1 and 2 is characterized in that carrying out as follows:

(1) the various compositions in the prescription is pulverized respectively rear mistake 100 mesh sieves;

(2) take by weighing by weight Rhizoma Osmundae 25-35 part, Folium Artemisiae Argyi 25-45 part, Nicotiana tabacum L. 25-45 part, Radix Stemonae 25-35 part, mix 5-10 minute to even;

(3) take by weighing by weight Rhizoma Atractylodis 25-35 part, Cortex Phellodendri 15-35 part, Fructus Quisqualis 15-35 part, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.