CN103263613B - Piglet eczematous dermatitis treatment traditional Chinese medicine and preparation method thereof - Google Patents
Piglet eczematous dermatitis treatment traditional Chinese medicine and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese veterinary medicines, and relates to a piglet eczematous dermatitis treatment traditional Chinese medicine and a preparation method thereof. Active components of the piglet eczematous dermatitis treatment traditional Chinese medicine comprise safflower, glabrous greenbrier rhizome, rheum, longleaf garden burnet root, amur corktree bark, divaricate saposhnikovia, common cnidium fruit and gypsum. The piglet eczematous dermatitis treatment traditional Chinese medicine can be made into powder or an oral liquid, and can be blended with a piglet feed or drinking water to be used, wherein a piglet eczematous dermatitis cure rate achieves 93.7%.
Description
Technical field
The present invention relates to field of medicaments for animals, be specifically related to a kind of Chinese medicine for the treatment of eczematous dermitis of young pigs and preparation method thereof.
Background technology
Eczematous dermitis of young pigs is the multiple commonly encountered diseases of a kind of piglet, a kind of inflammation mostly causing at skin surface tissue because of causes such as pig house are dark moist, and sanitary condition is poor.The piglet mortality rate that eczematoid dermatitis causes is not high, but can obviously affect the normal growth growth of piglets.At present, treatment eczematous dermitis of young pigs general method that adopts injection, oral antibiotic or dermal drug to embrocate on veterinary clinic.In recent years, about the research for the treatment of eczematous dermitis of young pigs, there are reports, as:
Chinese patent CN1219413, discloses a kind of Chinese medicine preparation for the treatment of eczematous dermitis of young pigs, and its formula is (percentage by weight): Flos Lonicerae 35-45, Radix Isatidis 35-45, Herba Taraxaci 5-15, cyrtomium fortunei 5-15.
Chinese patent CN102210749A, discloses a kind of Chinese medicine preparation for the treatment of eczematous dermitis of young pigs, and its effective ingredient comprises Flos Lonicerae, geranium, the Fructus Kochiae, Fructus Cnidii.
A kind of diagnoses and treatment of eczematous dermitis of young pigs introduced in Hao Men town, Men Yuan county veterinary station Qin Zhong literary composition, is specially: first clean affected part with 0.1% potassium permanganate, then 10% sodium salicylate injection is spread on to wound surface equably, every day 2 times.(Qinghai animal and veterinary magazine, the 28th the 4th phase of volume in 1998,14 pages)
But above compatibility of drugs is simple, though effective fast, can not systematic treating, probably cure the symptoms, not the disease.In addition the method that, adopts medicinal liquid skin appearance to apply is also relatively difficult to carry out treatment in medium-and-large-sized plant.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine for the treatment of eczematous dermitis of young pigs and preparation method thereof.
The Chinese medicine preparation for the treatment of eczematous dermitis of young pigs of the present invention is to be prepared from by the raw material that comprises following weight portion:
Flos Carthami 20～45 Rhizoma Smilacis Glabrae 20～45 Radix Et Rhizoma Rhei 15～35 Radix Sanguisorbaes 15～35
Cortex Phellodendri 20～45 Radix Saposhnikoviae 8～25 Fructus Cnidii 20～45 Gypsum Fibrosum 8～25.
The Chinese medicine preparation for the treatment of eczematous dermitis of young pigs of the present invention, its preferred version is to be prepared from by the raw material that comprises following weight portion:
Flos Carthami 25～40 Rhizoma Smilacis Glabrae 25～40 Radix Et Rhizoma Rhei 20～30 Radix Sanguisorbaes 20～30
Cortex Phellodendri 25～40 Radix Saposhnikoviae 10～20 Fructus Cnidii 25～40 Gypsum Fibrosum 10～20.
The Chinese medicine preparation for the treatment of eczematous dermitis of young pigs of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:
Flos Carthami 33 Rhizoma Smilacis Glabrae 30 Radix Et Rhizoma Rhei 27 Radix Sanguisorbae 23 Cortex Phellodendris 28
Radix Saposhnikoviae 18 Fructus Cnidii 35 Gypsum Fibrosum 16.
The Chinese medicine for the treatment of eczematous dermitis of young pigs of the present invention, its preparation method is:
Poria, Radix Et Rhizoma Rhei, Radix Sanguisorbae, Cortex Phellodendri, Radix Saposhnikoviae, the dry medical material of Fructus Cnidii in proportion fetch earth, pulverized 50 mesh sieves, add and be equivalent to the ethanol that the percent by volume of 8～12 times of these medical material gross weights is 50% and infiltrate 1～3 hour, ultrasonic extraction 0.5 hour, proceed to diafiltration cylinder and leave standstill 12 hours, coutroi velocity is collected percolate, and the ethanol in reclaim under reduced pressure percolate, obtains medicinal liquid A;
Get Flos Carthami, heating extraction 2 times at 75 DEG C, 1.5 hours for the first time, 1 hour for the second time, add the water that is equivalent to 10 times of flos carthami weight at every turn, filter, merge extractive liquid,, is cooled to room temperature, obtains medical liquid B.
Get Gypsum Fibrosum powder and be broken into coarse powder, cross 100 mesh sieves, decoct with water 2 times, add the decocting that is equivalent to 8 times of Gypsum Fibrosum medical material weight to boil at every turn 1 hour, decocting liquid merges, and filters, and at 50 DEG C, being concentrated into relative density is 1.06, obtains Gypsum Fibrosum decoction liquor C;
Medicinal liquid A, B, C are described active component.
(1) merge medicinal liquid A, B and Gypsum Fibrosum decoction liquor C, filter, be evaporated to relative density and be 1.21～1.25 extractum D; Extractum D be dry, pulverize into micropowder under 60 DEG C～75 DEG C conditions, add and be equivalent to the starch of micropowder gross weight 10%～25% and 5%～10% sucrose, mix homogeneously obtains Chinese medicine powder of the present invention.
(2) merge medicinal liquid A, B and Gypsum Fibrosum decoction liquor C, boil, cross while hot 30 μ m filter membranes, cooling, add 0.8%～1.5% sorbic acid, mix homogeneously, cold preservation left standstill after 12 hours, added water to and was equivalent to 8 times of medical material gross weight, stir evenly, fill, sterilizing, to obtain final product.
Chinese medicine provided by the present invention can use with feedstuff or drinking-water allotment, and the effect such as have heat clearing away, sterilization, antiinflammatory, invigorate blood circulation has good therapeutic effect to eczematous dermitis of young pigs, also can improve piglet disease-resistant ability simultaneously, safe and reliable.
In the present invention, the details of each medical material is as follows:
Flos Carthami, claims again Flos Carthami, and dicotyledonous feverfew is the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Premium, orange, yellow, all have cultivation on China Henan, Xinjiang, Yunnan, Anhui and other places.Flos Carthami is warm in nature, and acrid in the mouth, for amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury etc.
Rhizoma Smilacis Glabrae, the dry rhizome of liliaceous plant smilacis glabra Smilax glabra Roxb..Be born in hillside or sylvan life more, be distributed in the provinces such as China Anhui, Zhejiang, Jiangxi, Fujian, Hunan, Hubei, Guangdong, Guangxi, Sichuan, Yunnan.This moral character is sweet light, and taste is flat, returns Liver Channel, stomach warp, spleen channel.Function: removing toxic substances, dehumidifying, sharp joint.Cure mainly: control syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, treats furuncle, carbuncle, scrofula etc.
Radix Et Rhizoma Rhei, the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim. ex Balf. or Rheum officinale Rheum officinale Baill..Nature and flavor: hardship, cold.Cure mainly: excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, pyretic toxicity carbuncle and ulcer, erysipelas, scald etc.
Radix Sanguisorbae, the dry root of rosaceous plant Radix Sanguisorbae Sanguisorba officinalis L. or Radix Sanguisorbae Sanguisorba officinalis L. var. longifolia (Bert.) the Y ü et Li that comes into leaves.SHENGCAO is former, in grassy marshland, patana, shrubbery, under sparse woods, Huo Tian limit, roadside.The property of medicine: picric acid, cold, return liver, lung, kidney, large intestine channel.Effect: cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.
Cortex Phellodendri is the dry bark of rutaceae wampee or Cortex Phellodendri.Nature and flavor bitter cold, has heat clearing and damp drying, and pathogenic fire purging removes steams, effect of detoxification sore treatment, and for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity is warded off, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus etc.
Radix Saposhnikoviae, the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk., main product in Heilungkiang, the ground such as Sichuan, the Inner Mongol.Radix Saposhnikoviae acrid in the mouth, slightly warm in nature, has expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, the effect such as antipruritic, for affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint ache, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus etc.
Fructus Cnidii, the dry mature fruit of samphire cnidium monnieri Cnidium monnieri (L.) Cuss., warm in nature, acrid in the mouth, hardship, return kidney channel.Function cures mainly: warming the kidney to invigorate YANG, dampness, dispels the wind, parasite killing.For sexual impotence, cold womb, cold-damp leukorrhagia, arthralgia chiefly caused by damp pathogen lumbago; External treatment vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis.
Gypsum Fibrosum, main chemical compositions: CaSO
4nH
2o, heat clearing and fire purging medicine, acrid in the mouth, sweet, is slightly cold, and attaches to the lung and stomach meridians.Have clearing away heat-fire, relieving restlessness is quenched the thirst, and effect of convergence granulation promoting, can be used for eczema, and skin infection is not held back after bursting, burn due to hot liquid or fire.
Detailed description of the invention
Embodiment 1
Take Rhizoma Smilacis Glabrae 200g, Radix Et Rhizoma Rhei 150g, Radix Sanguisorbae 150g, Cortex Phellodendri 200g, Radix Saposhnikoviae 80g, the dry medical material of Fructus Cnidii 200g, pulverized 50 mesh sieves, add 7.84L percent by volume and be 50% ethanol and infiltrate 2 hours, ultrasonic extraction 0.5 hour, proceed to diafiltration cylinder and leave standstill 12 hours, coutroi velocity is collected percolate, and the ethanol in reclaim under reduced pressure percolate, obtains medicinal liquid A;
Get Flos Carthami 200g, add the water of 2L times of weight, heating extraction 2 times at 75 DEG C, 1.5 hours for the first time, 1 hour for the second time, filter, merge extractive liquid,, is cooled to room temperature, obtains medical liquid B.
Get Gypsum Fibrosum 80g and be ground into coarse powder, cross 100 mesh sieves, decoct with water 2 times, add 160ml decocting at every turn and boil 1 hour, decocting liquid merges, and filters, and at 50 DEG C, being concentrated into relative density is 1.06, obtains Gypsum Fibrosum decoction liquor C;
Merge medicinal liquid A, B and Gypsum Fibrosum decoction liquor C, filter, be evaporated to relative density and be 1.22 extractum D; Extractum D be dry, pulverize into micropowder under 60 DEG C～75 DEG C conditions, add the starch of gross weight 13% and 5% sucrose, mix homogeneously obtains Chinese medicine powder of the present invention.
Embodiment 2
Take Rhizoma Smilacis Glabrae 450g, Radix Et Rhizoma Rhei 450g, Radix Sanguisorbae 350g, Cortex Phellodendri 450g, Radix Saposhnikoviae 250g, the dry medical material of Fructus Cnidii 450g, pulverized 50 mesh sieves, the ethanol that is 50% by 24L percent by volume infiltrates 3 hours, ultrasonic extraction 0.5 hour, proceed to diafiltration cylinder and leave standstill 12 hours, coutroi velocity is collected percolate, and the ethanol in reclaim under reduced pressure percolate, obtains medicinal liquid A;
Get Flos Carthami 400g, add 4L water, heating extraction 2 times at 65 DEG C, 1.5 hours for the first time, 1 hour for the second time, filter, merge extractive liquid,, is cooled to room temperature, obtains medical liquid B.
Get Gypsum Fibrosum 200g and be ground into coarse powder, cross 100 mesh sieves, decoct with water 2 times, each 1600ml decocting boils 1 hour, and decocting liquid merges, and filters, and at 50 DEG C, being concentrated into relative density is 1.06, obtains Gypsum Fibrosum decoction liquor C;
Merge medicinal liquid A, B and Gypsum Fibrosum decoction liquor C, filter, be evaporated to relative density and be 1.23 extractum D; Extractum D be dry, pulverize into micropowder under 75 DEG C of conditions, add the starch of gross weight 13% and 8% sucrose, mix homogeneously obtains Chinese medicine powder of the present invention.
Embodiment 3
Take Rhizoma Smilacis Glabrae 300g, Radix Et Rhizoma Rhei 270g, Radix Sanguisorbae 230g, Cortex Phellodendri 280g, Radix Saposhnikoviae 180g, the dry medical material of Fructus Cnidii 350g, pulverized 50 mesh sieves, add 13L percent by volume and be 50% ethanol and infiltrate 3 hours, ultrasonic extraction 0.5 hour, proceed to diafiltration cylinder and leave standstill 12 hours, coutroi velocity is collected percolate, and the ethanol in reclaim under reduced pressure percolate, obtains medicinal liquid A;
Get Flos Carthami 330g, add the water of 3.3L, heating extraction 2 times at 65 DEG C, 1.5 hours for the first time, 1 hour for the second time, filter, merge extractive liquid,, is cooled to room temperature, obtains medical liquid B.
Get Gypsum Fibrosum 160g and be ground into coarse powder, cross 100 mesh sieves, decoct with water 2 times, every 1280ml decocting boils 1 hour, and decocting liquid merges, and filters, and at 50 DEG C, being concentrated into relative density is 1.06, obtains Gypsum Fibrosum decoction liquor C;
Merge medicinal liquid A, B and Gypsum Fibrosum decoction liquor C, filter, be evaporated to relative density and be 1.23 extractum D; Extractum D be dry, pulverize into micropowder under 75 DEG C of conditions, add the starch of gross weight 13% and 5% sucrose, mix homogeneously obtains Chinese medicine powder of the present invention.
Embodiment 4
Take Rhizoma Smilacis Glabrae 250g, Radix Et Rhizoma Rhei 200g, Radix Sanguisorbae 200g, Cortex Phellodendri 250g, Radix Saposhnikoviae 100g, the dry medical material of Fructus Cnidii 250g, pulverized 50 mesh sieves, add 11.25L percent by volume and be 50% ethanol and infiltrate 3 hours, ultrasonic extraction 0.5 hour, proceed to diafiltration cylinder and leave standstill 12 hours, coutroi velocity is collected percolate, and the ethanol in reclaim under reduced pressure percolate, obtains medicinal liquid A;
Get Flos Carthami 250g, add 2.5L water, heating extraction 2 times at 65 DEG C, 1.5 hours for the first time, 1 hour for the second time, filter, merge extractive liquid,, is cooled to room temperature, obtains medical liquid B.
Get Gypsum Fibrosum 100g and be ground into coarse powder, cross 100 mesh sieves, decoct with water 2 times, each 1280ml decocting boils 1 hour, and decocting liquid merges, and filters, and at 50 DEG C, being concentrated into relative density is 1.06, obtains Gypsum Fibrosum decoction liquor C;
Merge medicinal liquid A, B and Gypsum Fibrosum decoction liquor C, boil, cross while hot 30 μ m filter membranes, cooling, add 1.0% sorbic acid, mix homogeneously, cold preservation left standstill after 12 hours, added as required the water of 1050ml amount, stir evenly, fill, sterilizing, obtains Chinese medicine oral liquid of the present invention.
Embodiment 5
The clinical trial situation of the Chinese medicine for the treatment of eczematous dermitis of young pigs provided by the invention:
(1) 79 of 45 days piglets of pig farm, Liujiang County, Liuzhou City birth, there are the red rash pieces of different sizes in back, abdominal part, and part transfers blister to, festers, and pig lethargy, is judged as eczematoid dermatitis.Get the embodiment of the present invention 4 Chinese medicine oral liquid, convert 3 times of drinking waters, mixed feed is fed.After three days, the overall state of an illness turns gently, 47 recoveries from illness after five days, and 76 recoveries from illness after seven days, cure rate reaches 96.2%.
(2) Liucheng County, Liuzhou City raiser land, supports and has totally 27 of 2 nest piglets, is born 38 days, and paralysis has eczematoid dermatitis in various degree.Get the invention process 4 Chinese medicine oral liquid and feed with drinking-water allotment by 1:100, all recoveries from illness afterwards in seven days, cure rate reaches 100%.
(3) Luzhai County, Liuzhou City Liu raiser, supports and has totally 66 of 5 nest piglets, is born 43 days, and paralysis has eczematoid dermatitis in various degree.Get the invention process 3 Chinese medicine powders and allocate feeding by 1:500 weight portion and feedstuff, 64 recoveries from illness after seven days, cure rate reaches 97.0%.
(4) Luzhai County, Liuzhou City raiser river, supports and has totally 25 of 2 nest piglets, is born 40 days, and paralysis has eczematoid dermatitis in various degree.Get the invention process 1 Chinese medicine powder and allocate feeding by 1:500 weight portion and feedstuff, 24 recoveries from illness after seven days, cure rate reaches 96.0%.
Claims (6)
1. treat a Chinese medicine for eczematous dermitis of young pigs, it is characterized in that it is to be prepared from by the raw material of following weight portion:
Flos Carthami 20～45 Rhizoma Smilacis Glabrae 20～45 Radix Et Rhizoma Rhei 15～35 Radix Sanguisorbaes 15～35
Cortex Phellodendri 20～45 Radix Saposhnikoviae 8～25 Fructus Cnidii 20～45 Gypsum Fibrosum 8～25.
2. the Chinese medicine for the treatment of eczematous dermitis of young pigs as claimed in claim 1, is characterized in that it is to be prepared from by the raw material of following weight portion:
Flos Carthami 25～40 Rhizoma Smilacis Glabrae 25～40 Radix Et Rhizoma Rhei 20～30 Radix Sanguisorbaes 20～30
Cortex Phellodendri 25～40 Radix Saposhnikoviae 10～20 Fructus Cnidii 25～40 Gypsum Fibrosum 10～20.
3. the Chinese medicine for the treatment of eczematous dermitis of young pigs as claimed in claim 2, is characterized in that it is to be prepared from by the raw material of following weight portion:
Flos Carthami 33 Rhizoma Smilacis Glabrae 30 Radix Et Rhizoma Rhei 27 Radix Sanguisorbae 23 Cortex Phellodendris 28
Radix Saposhnikoviae 18 Fructus Cnidii 35 Gypsum Fibrosum 16.
4. as the Chinese medicine of the treatment eczematous dermitis of young pigs of claim 1～3 as described in any one, it is characterized in that, the preparation method of its active component is:
Poria, Radix Et Rhizoma Rhei, Radix Sanguisorbae, Cortex Phellodendri, Radix Saposhnikoviae, the dry medical material of Fructus Cnidii in proportion fetch earth, pulverized 50 mesh sieves, add and be equivalent to the ethanol that the percent by volume of 8～12 times of these medical material gross weights is 50% and infiltrate 1～3 hour, ultrasonic extraction 0.5 hour, proceed to diafiltration cylinder and leave standstill 12 hours, coutroi velocity is collected percolate, and the ethanol in reclaim under reduced pressure percolate, obtains medicinal liquid A;
Get Flos Carthami, heating extraction 2 times at 75 DEG C, 1.5 hours for the first time, 1 hour for the second time, add the water that is equivalent to 10 times of flos carthami weight at every turn, filter, merge extractive liquid,, is cooled to room temperature, obtains medical liquid B;
Get gypsum powder and be broken into coarse powder, cross 100 mesh sieves, decoct with water 2 times, add the decocting that is equivalent to 8 times of Gypsum Fibrosum medical material weight to boil at every turn 1 hour, decocting liquid merges, and filters, and at 50 DEG C, being concentrated into relative density is 1.06, obtains Gypsum Fibrosum decoction liquor C;
Medicinal liquid A, B and decoction liquor C are described active component.
5. the Chinese medicine for the treatment of eczematous dermitis of young pigs as claimed in claim 4, is characterized in that, the preparation method of its powder is:
Merge medicinal liquid A, B and Gypsum Fibrosum decoction liquor C, filter, be evaporated to relative density and be 1.21～1.25 extractum D; Extractum D be dry, pulverize into micropowder under 60 DEG C～75 DEG C conditions, add and be equivalent to the starch of micropowder gross weight 10%～25% and 5%～10% sucrose, mix homogeneously and get final product.
6. the Chinese medicine for the treatment of eczematous dermitis of young pigs as claimed in claim 4, is characterized in that, the preparation method of its oral liquid is:
Merge medicinal liquid A, B and Gypsum Fibrosum decoction liquor C, boil, cross while hot 30 μ m filter membranes, cooling, add 0.8%～1.5% sorbic acid, mix homogeneously, cold preservation left standstill after 12 hours, added water to and was equivalent to 8 times of medical material gross weight, stir evenly, fill, sterilizing, to obtain final product.
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| CN1876144A (en) * | 2006-04-24 | 2006-12-13 | 高祝兰 | A Chinese medicine for treating skin disease of fur-bearing animal and preparation process thereof |
| CN102552498A (en) * | 2010-12-08 | 2012-07-11 | 新晃侗族自治县中医院 | Medicament for alleviating swelling and easing pain and preparation method of same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1876144A (en) * | 2006-04-24 | 2006-12-13 | 高祝兰 | A Chinese medicine for treating skin disease of fur-bearing animal and preparation process thereof |
| CN102552498A (en) * | 2010-12-08 | 2012-07-11 | 新晃侗族自治县中医院 | Medicament for alleviating swelling and easing pain and preparation method of same |
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