CN103142855B - Chinese herbal medicine for treating raccoon pyloric duodenal ulcer and gastric perforation - Google Patents
Chinese herbal medicine for treating raccoon pyloric duodenal ulcer and gastric perforation Download PDFInfo
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Abstract
The invention relates to a Chinese herbal medicine for treating raccoon pyloric duodenal ulcer and gastric perforation. The Chinese herbal medicine is powder prepared from the following raw materials in parts by weight: 4-6 parts of licorice roots, 2-4 parts of forged concha arcae, 2-4 parts of fried cuttlebone, 0.5-1 part of bletilla, 1-2 parts of rhizoma corydalis, 2-3 parts of costus roots, 2-4 parts of baical skullcap roots, 1-2 parts of Chinese rhubarb and 0.5-1 part of henbane. The Chinese herbal medicine is used for treating raccoon pyloric duodenal ulcer and gastric perforation, and has the characteristics of short course of treatment, low cost, high curing rate, security and no toxic and side effect, and is convenient for orally taking.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine for the treatment of Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation.
Background technology
Nyctereutes procyonoides peptic ulcer is a kind of common digestive system disease that spreads all over the world.In recent years, on veterinary clinic, run into a large amount of Nyctereutes procyonoides pylorus duodenal ulcers and gastric perforation case, its reason is the irrational feedstuff of Long-term Feeding nutrition arrangement or feedstuff overlong time, occur rotten, as feed oxide (fat rancidity), or the long-time not high protein of feeding stage by stage, high-fat feedstuff, cause high gastric acid to form ulcer, also have in addition fewer antibacterial also easily to cause this disease as helicobacter pylori, escherichia coli, pasteurellosis bacillus.The rule for the treatment of of effectively treating Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation is: relieving gastric hyperacidity to alleviate stomachache, convergence granulation promoting, anti-inflammation.At present, treatment primary disease is mainly the Western medicine kinds such as cimetidine, omeprazole, amoxicillin, all exists to some extent toxic and side effects and interim medication and do not reach the drawback of ideal effect.Chinese herbal medicine belongs to natural, Green medicament, to animal and human security, have no side effect, scalable body's immunity.Adopt Chinese herbal medicine effectively to treat Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation disease, there is not yet report.
Summary of the invention
The object of the invention is to for the problems referred to above, a kind of Chinese herbal medicine that can effectively treat Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation is provided.
Technical scheme of the present invention is: a kind of Chinese herbal medicine for the treatment of Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation, it is the powder of being made up of the raw material of following weight proportioning: Radix Glycyrrhizae 4-6 part, Concha Arcae (calcined) 2-4 part, fry Endoconcha Sepiae 2-4 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 0.5-1 part, Rhizoma Corydalis 1-2 part, Saussurea lappa Clarke 2-3 part, Radix Scutellariae 2-4 part, Radix Et Rhizoma Rhei 1-2 part, Semen Hyoscyami 0.5-1 part.
The preferred raw material weight proportioning of the present invention is: 6 parts, Radix Glycyrrhizae, 3 parts of Concha Arcae (calcined), fry 3 parts of Endoconcha Sepiaes, 0.5 part of the Pseudobulbus Bletillae (Rhizoma Bletillae), 2 parts of Rhizoma Corydalis, 2 parts of Saussurea lappa Clarke, 2 parts of Radix Scutellariaes, 1 part of Radix Et Rhizoma Rhei, 0.5 part of Semen Hyoscyami.
In prescription of the present invention, each component pharmacological effect is:
1. Radix Glycyrrhizae effect: Radix Glycyrrhizae another name Glycyrrhizae, close sweet, close grass, state are old, Herba Hedyotis cantonensis, leather and fur.Property is put down, and sweet in the mouth, returns 12 warps.Containing compositions such as glycyrrhizic acids, glycyrrhizin, 24-hydroxyl enoxolone, licoflavone, glycyrrhizin, isoliquiritigenin, Angelica Polysaccharide, there is antiulcer, promote pancreatic secretion, protect the liver, the effect such as the phagocytic function of blood fat reducing, adjusting macrophage.For weakness of the spleen and stomach, fatigue and weakness, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
2. Concha Arcae (calcined) effect: Concha Arcae has another name called Concha Meretricis Seu Cyclinae, watt room, row of tiles on a roof, row of tiles on a roof clam skin, blood clam fur Carnis Arca inflata skin.For the shell of Carnis Arca inflata section animal Scapharca broughtonii, Tegillarca granosa and Scapharca subcrenata.Nature and flavor are salty, flat.Return lung, stomach, Liver Channel.Shell contains a large amount of calcium carbonate, a small amount of magnesium, ferrum, sulfate and chloride and organic matter, still silicate and inorganic elements aluminum, chlorine, chromium, copper, potassium, manganese, sodium, nickel, phosphorus, sulfur, silicon, strontium, zinc.After calcining, Decomposition of Calcium Carbonate, produces calcium chloride etc.Fire is controlled vim and vigour after forging, and disease is adjoined, and the clot that disappears reduces phlegm long-pending, gastric acid processed.There is expectorant blood stasis dispelling, hard masses softening and resolving, effect of relieving gastric hyperacidity to alleviate stomachache, for the long-pending knot of pertinacious phlegm, thickness difficulty is coughed up, goiter, scrofula, abdominal mass mass in the abdomen, stomachache pantothenic acid etc.
3. fry Endoconcha Sepiae effect: Endoconcha Sepiae different name Os Sepiae, cuttlebone.For the inner shell of Sepiidae animal sepiella maindroni de Rochebrune or golden cuttlefish.Salty in the mouth, puckery, slightly warm in nature.Return liver, kidney channel.Containing calcium carbonate, conchiolin, phlegmatic temperament, and containing a small amount of sodium chloride, calcium phosphate, magnesium salt etc.It is smelly that Endoconcha Sepiae is fried rear taste masking, and the property of astringent therapy strengthens, and is longer than astringing to arrest bleeding, leukorrhagia stopping, sore.There is effect of astringing to arrest bleeding, antacid sore.
4. Pseudobulbus Bletillae (Rhizoma Bletillae) effect: the Pseudobulbus Bletillae (Rhizoma Bletillae) have another name called Pseudobulbus Bletillae (Rhizoma Bletillae), give free of charge, connect and, be the dry tuber of orchid Pseudobulbus Bletillae (Rhizoma Bletillae).Nature and flavor hardship, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Mucous matter, wherein containing Pseudobulbus Bletillae (Rhizoma Bletillae) glucomannoglycan, biphenyl class, the luxuriant and rich with fragrance compounds of two hydrogen, dihydro phenanthro-pyran compounds, Pseudobulbus Bletillae (Rhizoma Bletillae) alcohol A, B, C, and contain the compounds such as steroid class, terpenoid, esters, ethers.
toolhemostasis, granulation promoting, effect of sore.For epistaxis, swollen ulcer drug, ulcer pain etc.
5. Rhizoma Corydalis effect: Rhizoma Corydalis has another name called Rhizoma Corydalis, Rhizoma Corydalis is Papaveraceae Corydalis herbaceos perennial.Warm in nature, acrid in the mouth hardship, GUIXIN, spleen, liver, lung meridian.Rhizoma Corydalis contains multiple alkaloid as d-corydaline, dl-Tetrahydropalmatine, protopine, l-Tetrahydrocoptisine, d1-Tetrahydrocoptisine, coptisine etc.For pain of the each portion of whole body qi depression to blood stasis.Cure mainly the diseases such as stomachache.
6. Saussurea lappa Clarke effect: the Saussurea lappa Clarke another name Radix Aucklandiae, Radix Aucklandiae (Radix Vladimiriae).For the root of feverfew Saussurea lappa Clarke.Acrid in the mouth, hardship, warm in nature.Return spleen, stomach, liver, large intestine channel.Saussurea lappa Clarke is containing volatile oil, saussurine, inulin.In oil, main component is constuslactone, dihydrocostulactone, α-costol, α-costic acid, Saussurea Lactone, dehydrocostuslactone and aplotaxene, α and β-costen etc., and containing approximately 20 kinds, aminoacid.There are stomach invigorating relieving distension, promoting the flow of QI for relieving the stagnancy, promoting the circulation of QI to relieve pain, effect of warming middle-JIAO for easing the stomach.Can promoting qi circulation, resolving food retention, soothing the liver, stomach invigorating, control all pain due to disorder of QI, stop eating gather, fullness in the chest abdominal distention etc.For chest and abdomen swelling and pain, vomiting, tenesmus.
7. Radix Scutellariae effect: Radix Scutellariae another name Radix Scutellariae, scutellaria tea, tsuchikane tea root etc.For labiate Radix Scutellariae, be used as medicine with root.Bitter in the mouth, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Scutellariae,radix contains flavone compound: baicalin, and neobaicalein, baicalin, wogonin, wogonoside, oroxylin A, 7-methoxyl group baicalin, dihydro oroxylin, chrysin, in addition also containing cupreol, the effective ingredient such as campesterol and stigmasterol.Dysentery bacterium, escherichia coli etc. are had to inhibitory action.There is heat clearing and damp drying, effect of removing toxic substances.Cure mainly the diseases such as antibacterial infection, damp and hot jaundice, dysentery.
8. Radix Et Rhizoma Rhei effect: Radix Et Rhizoma Rhei another name general, Huang Liang, fire ginseng, Radix Et Rhizoma Rhei etc.For the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum.Nature and flavor hardship, cold.Return spleen, stomach, large intestine, liver, pericardium channel.In conjunction with shape anthraquinone derivative, there is catharsis effect containing chrysophanic acid, emodin, chrysophanol, aloe-emodin, physcione etc.The chrysophanic acid, emodin, the aloe-emodin that contain have the effects such as anti-inflammation.Radix Et Rhizoma Rhei has staphylococcus, dysentery bacterium etc. to responsive antibacterial.When low dose is taken, there is effect of stomach invigorating, convergence.The contained tannin of Radix Et Rhizoma Rhei has good antioxidation, and anthraquinone derivative can suppress non-specific immunity.
9. Semen Hyoscyami effect: Semen Hyoscyami has another name called gelsemium henbane, little Semen daturae, mountain cigarette, wild opium.For the dry mature seed of plant of Solanaceae hyoscyami.Warm in nature, bitter in the mouth is pungent.GUIXIN, stomach, Liver Channel, containing hyoscyamine, atropine, scopolamine, l-scopolamine, fatty wet goods.There is effect of the epilepsy of determining, pain relieving.Be used for the treatment of the diseases such as stomachache, chronic dysentery, carbuncle, malignant boil.
Prescription foundation of the present invention: this prescription, with relieving gastric hyperacidity to alleviate stomachache, is restrained granulation promoting, and anti-inflammation is principle.Concha Arcae (calcined) in side, frying Endoconcha Sepiae can hard masses softening and resolving, astringing to arrest bleeding, antacid sore; Pseudobulbus Bletillae (Rhizoma Bletillae) hemostasis, granulation promoting, sore; Rhizoma Corydalis, Semen Hyoscyami, Saussurea lappa Clarke stomach invigorating relieving distension, promoting the circulation of QI to relieve pain; Radix Scutellariae, Radix Et Rhizoma Rhei anti-inflammation; Radix Glycyrrhizae antiulcer, promotion pancreatic secretion, cushion toxicity, strong.All medicine phases and, the effect of playing altogether relieving gastric hyperacidity to alleviate stomachache, convergence granulation promoting, anti-inflammation.
The present invention is applicable to Nyctereutes procyonoides by the irrational feedstuff of the nutrition arrangement of feeding or feedstuff fat rancidity, or the infection of the long-time not high protein of feeding, high-fat feedstuff and antibacterial stage by stage the pylorus duodenal ulcer and the gastric perforation that cause.For convenience of application aborning, make powder.
Energy antacid granulation promoting of the present invention, promoting the circulation of QI to relieve pain, anti-inflammation, treatment Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation, have good effect.
The present invention treats the Chinese herbal medicine of Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation, to carry out on the basis of a large amount of practical applications, according to traditional medicine ancient prescription, form in conjunction with modern nutriology, etiologic theoretical screening, be used for the treatment of Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation, short treating period, cost is low, cure rate is high, safely, have no side effect, taking convenience.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment:
Take respectively raw material (decoction pieces): Radix Glycyrrhizae 300 g, Concha Arcae (calcined) 150 g, fry Endoconcha Sepiae 150 g, the Pseudobulbus Bletillae (Rhizoma Bletillae) 25 g, Rhizoma Corydalis 100 g, Saussurea lappa Clarke 100 g, Radix Scutellariae 100 g, Radix Et Rhizoma Rhei 50 g, Semen Hyoscyami 25 g.Above-mentioned raw materials is ground into respectively to Chinese herbal medicine coarse powder, mixes, packaging, obtains the present invention and treats the Chinese herbal medicine of Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation.
Some test situation that the Chinese herbal medicine that utilizes the present invention to treat Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation carries out are as follows:
1, the impact of Chinese herbal medicine of the present invention on rat model ulcer index
1.1 laboratory animal groupings are divided into 6 groups at random by 48 male Wistar rats, i.e. 8 of normal group, 8 of model group, each 8 of the basic, normal, high dosage group of Chinese herbal treatment group of the present invention, 8 of chemotherapy group cimetidine groups; Chinese herbal medicine group of the present invention is pressed prescription preparation Chinese herbal medicine powder 200g, adds pure water 500mL, and slow fire boiling, to 200mL, boils twice, and 30min/ time, merge to obtain suspension, make medicinal liquid be equivalent to crude drug 1g/mL.According to clinical common dose and pharmacopeia regulation, set the high, medium and low dosage of Chinese herbal medicine group of the present invention and be respectively 6g, 3g, 1g; Chemotherapy group cimetidine group gives respectively cimetidine 0.01 g; Normal control rat gives 5 mL distilled water.Equal administration every day of each group 1 time.
1.2 gastric ulcer model preparations and ulcer index are respectively organized according to above grouping administration, administration every day 1 time, successive administration 6d.After 5d administration, fasting 24h, prohibits water 12h, after last administration 3h, and every rats gavaged 75% ethanol 1mL, normal group gives equal-volume pure water, and after lh, de-cervical vertebra method is put to death.The rat of execution is cut open the belly, cut off cardia upper end and pylorus lower end, isolate body of stomach, along greater gastric curvature, place cuts off, with its content of normal saline flushing, the mucosa injury degree of perusal stomach, by ruler measurement ulcer length, calculate Gastric mucosal injury index integration, to be confined to the erosion of Weishang skin, ulcer, the length scores accumulated of hemorrhagic focus etc., be normally 0 point, 1 point of the rotten to the corn meter of speckle, 2 points of rotten to the corn length L EssT.LTssT.LT 1mm meters, 3 points of 1-2mm meters, 4 points of 3-4mm meters, 5 points of > 4mm meters, each score value adds up to the damage index total score of this animal.Each group rat ulcer index is in table 1.Experimental result shows, the basic, normal, high dosage group of Chinese herbal medicine of the present invention, cimetidine group all have antiulcer action in various degree, have good therapeutical effect for 75% ethanol induced Acute gastric ulcer.Between the each group of Chinese herbal medicine group and cimetidine group, relatively there is remarkable significant difference, but observe and find from concrete numerical value trend, in Chinese herbal medicine group, the ulcer index of dosage group is closer to normally, and Chinese herbal medicine of the present invention the results are shown in Table 1 to the impact of rat model ulcer index.
The impact of table 1 Chinese herbal medicine of the present invention on rat model ulcer index
1.3 gastric mucosa of rat perusal normal rats gastric mucosas present rose pink, gastric mucosa pleat is orderly, smooth surface, without ulcer, erosion, edema, hemorrhage, model group and administration group all occur that the red petechia to pitchy varying degree is to streak damage, more on the whole, administration group curing ulcer erosion situation is compared with model group mild degree for naked eyes, and edema degree is also lighter.
2, the therapeutic effect of Chinese herbal medicine of the present invention to Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation
2.1 GP THs: the laboratory diagnosis of learning from else's experience is that sick 15 of the Nyctereutes procyonoidess of Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation are divided into 3 groups, be respectively Chinese herbal treatment group of the present invention (5), with Chinese herbal medicine powder spice administration 2g of the present invention, chemicals cimetidine treatment group (5) spice administration 0.05 g; Equal medication every day of each group 2 times, is used in conjunction 5 d above.Separately there is blank matched group (5), not administration.
2.2 efficacy determinations: observe disease Nyctereutes procyonoides spirit, search for food, body temperature, breathing, vomiting and diarrhoea and the situation such as dead, judge curative effect by following standard.Cure: after medication, breathe steadily, spirit, diet, temperature recovery are normal, do not vomit, and do not suffer from diarrhoea.Take a turn for the better: after medication, vomiting, symptom of diarrhea obviously alleviate, breathing, spirit, body temperature, diet take a turn for the better.Invalid: after medication, vomiting, symptom of diarrhea do not alleviate, even symptom increases the weight of or is dead.Total effective rate=cure rate+improvement rate.
2.3 therapeutic outcomes: the therapeutic effect of each group is in table 2.
The therapeutic effect (%) of the each group of table 2
| Project | Cure rate | Improvement rate | Total effective rate |
| This Chinese herbal treatment group | 60%(3/5) | 20% (1/5) | 80%(4/20) |
| Cimetidine treatment group | 40% (2/5) | 20%(1/5) | 60%(3/5) |
| Blank group | 0%(0/5) | 0% (0/5) | 0%(0/5) |
The blank group that the cure rate of Chinese herbal treatment group of the present invention and total effective rate are all significantly higher than cimetidine treatment group and do not treat, shows that Chinese herbal medicine of the present invention is effective in cure to Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation.
Claims (2)
1. treat the Chinese herbal medicine of Nyctereutes procyonoides pylorus duodenal ulcer and gastric perforation for one kind, it is characterized in that it is the powder of being made up of the raw material of following weight proportioning: Radix Glycyrrhizae 4-6 part, Concha Arcae (calcined) 2-4 part, fry Endoconcha Sepiae 2-4 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 0.5-1 part, Rhizoma Corydalis 1-2 part, Saussurea lappa Clarke 2-3 part, Radix Scutellariae 2-4 part, Radix Et Rhizoma Rhei 1-2 part, Semen Hyoscyami 0.5-1 part.
2. the Chinese herbal medicine for the treatment of Nyctereutes procyonoides pylorus duodenal ulcer according to claim 1 and gastric perforation, it is characterized in that it is the powder of being made up of the raw material of following weight proportioning: 6 parts, Radix Glycyrrhizae, 3 parts of Concha Arcae (calcined), fry 3 parts of Endoconcha Sepiaes, 0.5 part of the Pseudobulbus Bletillae (Rhizoma Bletillae), 2 parts of Rhizoma Corydalis, 2 parts of Saussurea lappa Clarke, 2 parts of Radix Scutellariaes, 1 part of Radix Et Rhizoma Rhei, 0.5 part of Semen Hyoscyami.
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| CN101439172A (en) * | 2007-11-23 | 2009-05-27 | 北京亚东生物制药有限公司 | Chinese medicinal composition and preparation method thereof and quality control method |
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|---|---|---|---|---|
| CN101439172A (en) * | 2007-11-23 | 2009-05-27 | 北京亚东生物制药有限公司 | Chinese medicinal composition and preparation method thereof and quality control method |
| CN101279072B (en) * | 2008-05-30 | 2010-12-22 | 连德峰 | Chinese medicine capsule for curing digestive system disease |
| CN101683470A (en) * | 2008-09-22 | 2010-03-31 | 赵保云 | Preparation method of powder containing unio margarita and rhizoma corydalis |
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