CN103120719B - Pure traditional Chinese medicine composition for treating sacbrood virus of bees and preparation method thereof - Google Patents
Pure traditional Chinese medicine composition for treating sacbrood virus of bees and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pure traditional Chinese medicine composition for treating sacbrood virus of bees and a preparation method thereof. The pure traditional Chinese medicine composition comprises the following components mixed and extracted in parts by weight: 25-45 parts of cyrtomium rhizome, 25-35 parts of honeysuckle flower, 15-35 parts of licorice root, 15-35 parts of slenderstyle acanthopanax bark, 25-35 parts of bearded scutellaria, 15-35 parts of forsythia fruit and 15-35 parts of giant knotweed rhizome. The pure traditional Chinese medicine composition has the beneficial effects that the components are reasonable, the preparation is simple, the traditional Chinese medicine composition is pure without drug residue, drug resistance or toxic and side effects; and the pure traditional Chinese medicine composition treats both the symptoms and the causes of the disease, the treatment effect is very obvious, and the pure traditional Chinese medicine composition is clinically proven to be effective on the treatment of the sacbrood virus of the bees.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of Apis sac brood and preparation method thereof, belong to field of animal, be particularly a kind ofly specifically designed to pure Chinese medicine composition for the treatment of Apis sac brood and preparation method thereof.
Background technology
The cause of disease of Apis sac brood is sac brood virus, and virus is mainly invaded by digestive tract, and the propagation between bee colony brings healthy bee colony by Apis contacting with each other in collection activity by virus.Its generation and weather, nectar source are relevant with honeybee kind.It is dead that its main infection larva makes it cause a disease, and also can breed in one-tenth honeybee body, but not reveal any symptoms.Honeybee in this sick many harm, body colour becomes dark brown or black from filbert, and the later stage is a dry tablet, like dragon-boat shape.Bee colony morbidity often has two types, and one usually occurs nearly hundred dead larvae in bee colony, and worker honeybees foraging activity is movable normal, is called " chronic type "; Another kind is early spring or late fall, ill during swarm breeding, occurs large quantities of dead larvae in bee colony, and worker bee performance is uneasy, and collection power obviously declines, and even cluster flies to escape, and is called " acute ".Primary disease mortality rate is high, and spring of being everlasting, season in summer two are popular.
This disease spreads all over more than 100 countries of five continents, is widely distributed.At present, treat this disease the most frequently used be various antiviral drugs, though receive certain effect, because its toxic and side effects is strong, easily produce the problem such as drug resistance and drug residue, clinical practice is very limited or prohibits the use.At present, treat the most frequently used Chinese medicine of this disease due to its prescription unreasonable, clinical effectiveness is not fine.
Therefore researching and developing a kind of specific medicament for the treatment of Apis sac brood is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, prepare simple, successful, the pure Chinese medicine composition of effectively treating Apis sac brood and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of Apis sac brood, and by following component, mixed extraction is formulated by weight: Rhizoma Osmundae 25-45 part, Flos Lonicerae 25-35 part, Radix Glycyrrhizae 15-35 part, Cortex Acanthopancis 15-35 part, Herba Scutellariae Barbatae 25-35 part, Fructus Forsythiae 15-35 part, Rhizoma Polygoni Cuspidati 15-35 part.
Described various component optimum ratio amount is: Rhizoma Osmundae 35 parts, Flos Lonicerae 30 parts, 25 parts, Radix Glycyrrhizae, Cortex Acanthopancis 25 parts, Herba Scutellariae Barbatae 30 parts, Fructus Forsythiae 25 parts, Rhizoma Polygoni Cuspidati 25 parts.
Treat a preparation method for the pure Chinese medicine composition of Apis sac brood, carry out as follows:
(1) the various compositions in prescription are pulverized rear mistake 50 mesh sieve respectively;
(2) Rhizoma Osmundae 25-45 part, Flos Lonicerae 25-35 part, Radix Glycyrrhizae 15-35 part, Cortex Acanthopancis 15-35 part, Herba Scutellariae Barbatae 25-35 part, Fructus Forsythiae 15-35 part, Rhizoma Polygoni Cuspidati 15-35 part is taken by weight, mix homogeneously;
(3) the 8 times amount water temperatures adding medical material total amount described in (2) are by weight soaked 1 hour (60 DEG C ~ 80 DEG C), then decoct 60 minutes, filter; Gained filtering residue adds 4 times of soak by water 30 minutes again, and filter, merging filtrate, is evaporated to 750 parts, embedding, sterilizing, obtains final product.
The medicinal property of each component is as follows:
Rhizoma Osmundae: bitter, cold, returns liver, stomach warp, has the function of heat-clearing and toxic substances removing, cooling blood for hemostasis, anthelmintic; Cure mainly epidemic disease flu, maculae caused by violent heat pathogen, sore swollen toxin, abdominal pain due to worm stagnation etc.
Flos Lonicerae: sweet, cold, attaches to the lung and stomach meridians, and has the function of heat-clearing and toxic substances removing, heat radiation dispelling wind; Cure mainly cough due to lung-heat, epidemic febrile disease heating, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Cortex Acanthopancis: bitter, pungent, warm, returns liver, kidney channel, has the function of expelling wind and removing dampness, bone and muscle strengthening, liver and kidney tonifying, inducing diuresis to remove edema; Cure mainly anemofrigid-damp arthralgia, waist flaccidity be soft, the deficiency of vital energy is weak, edema etc.
Herba Scutellariae Barbatae: pungent, bitter, cold, returns lung, liver, kidney channel, has the function of heat-clearing and toxic substances removing, blood stasis dispersing and deswelling, diuresis; Cure mainly diarrhea due to damp-heat, furuncle swelling toxin, laryngopharynx swelling and pain, edema, jaundice, honeybee sac brood etc.
Fructus Forsythiae: bitter, cold, returns lung, the heart, small intestine meridian, has the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Cure mainly epidemic febrile disease heating, skin ulcer general edema with yellowish skin poison etc.
Rhizoma Polygoni Cuspidati: bitter, cold, returns liver, gallbladder, lung meridian, has the function of heat-clearing and toxic substances removing, dampness removing jaundice eliminating, analgesic therapy of invigorating blood circulation, relieving cough and resolving phlegm; Cure mainly jaundice due to damp-heat, puerperal blood stasis, stranguria with turbid discharge, rheumatic arthralgia, carbuncle sore tumefacting virus, cough due to lung-heat etc.
All taste Chinese medicine is according to the theoretical compatible combination of Chinese veterinarian above, for pathogenic microorganism and the clinical symptoms of Apis sac brood, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, Chinese medicine extraction, and cost is low, draws materials wide, drug residue free, has no drug resistance, has no side effect, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, and optimize this seven tastes Chinese medicine, and make them extract pure Chinese medicine according to optimum ratio, clinical practice proves, has specially good effect to treatment Apis sac brood.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of Apis sac brood and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are pulverized rear mistake 50 mesh sieve respectively;
(2) Rhizoma Osmundae 250 parts, Flos Lonicerae 250 parts, 150 parts, Radix Glycyrrhizae, Cortex Acanthopancis 150 parts, Herba Scutellariae Barbatae 250 parts, Fructus Forsythiae 150 parts, Rhizoma Polygoni Cuspidati 150 parts is taken by weight, mix homogeneously;
(3) the 8 times amount water temperatures adding medical material total amount described in (2) are by weight soaked 1 hour (60 DEG C ~ 80 DEG C), then decoct 60 minutes, filter; Gained filtering residue adds 4 times of soak by water 30 minutes again, and filter, merging filtrate, is evaporated to 7500 parts, embedding, sterilizing, obtains final product.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of Apis sac brood and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are pulverized rear mistake 50 mesh sieve respectively;
(2) Rhizoma Osmundae 350 parts, Flos Lonicerae 300 parts, 250 parts, Radix Glycyrrhizae, Cortex Acanthopancis 250 parts, Herba Scutellariae Barbatae 300 parts, Fructus Forsythiae 250 parts, Rhizoma Polygoni Cuspidati 250 parts is taken by weight, mix homogeneously;
(3) the 8 times amount water temperatures adding medical material total amount described in (2) are by weight soaked 1 hour (60 DEG C ~ 80 DEG C), then decoct 60 minutes, filter; Gained filtering residue adds 4 times of soak by water 30 minutes again, and filter, merging filtrate, is evaporated to 7500 parts, embedding, sterilizing, obtains final product.
Embodiment 3
A kind of pure Chinese medicine composition for the treatment of Apis sac brood and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in prescription are pulverized rear mistake 50 mesh sieve respectively;
(2) Rhizoma Osmundae 450 parts, Flos Lonicerae 350 parts, 350 parts, Radix Glycyrrhizae, Cortex Acanthopancis 350 parts, Herba Scutellariae Barbatae 350 parts, Fructus Forsythiae 350 parts, Rhizoma Polygoni Cuspidati 350 parts is taken by weight, mix homogeneously;
(3) the 8 times amount water temperatures adding medical material total amount described in (2) are by weight soaked 1 hour (60 DEG C ~ 80 DEG C), then decoct 60 minutes, filter; Gained filtering residue adds 4 times of soak by water 30 minutes again, and filter, merging filtrate, is evaporated to 7500 parts, embedding, sterilizing, obtains final product.
Clinical trial:
Clinical experiment animal selects Laboratory Diagnosed to be the ill middle honeybee of Apis sac brood.Ill honeybee isolation raised separately, be divided into 3 groups at random, often organize 3 casees totally 15 spleen honeybees, 3 groups of feeding environments are identical, and experimental period carries out 5 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; The ratio of product of the present invention (compositions obtained by the embodiment of the present invention 1) in 1: 1 is mixed hello honeybee with sucrose solution by present composition group, is used in conjunction 3-5 day.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 5th day) at the end of experiment.
Table is that the applicable cases that the present invention and other medicines treat Apis sac brood contrasts:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 26 | 45 | 29 |
| II | Compound recipe Herba Scutellariae Barbatae syrup group | 10 | 73 | 17 |
| III | Present composition group | 6 | 85 | 9 |
This clinical effectiveness statistical analysis, present composition treatment group and compound recipe Herba Scutellariae Barbatae syrup group in cure rate compared with difference extremely significantly (P < 0.01).
Safety testing:
Choose honeybee 1 case 5 spleen in health, feed 5 days according to 5 times of the made compositions recommended dose of the embodiment of the present invention 1, during medication, healthy Apis is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and difference is not remarkable compared with blank group (i.e. health not administration group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment Apis sac brood and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (2)
1. treat the pure Chinese medicine composition of Apis sac brood for one kind, it is characterized in that by following component by weight mixed extraction form: Rhizoma Osmundae 25-45 part, Flos Lonicerae 25-35 part, Radix Glycyrrhizae 15-35 part, Cortex Acanthopancis 15-35 part, Herba Scutellariae Barbatae 25-35 part, Fructus Forsythiae 15-35 part, Rhizoma Polygoni Cuspidati 15-35 part, concrete preparation method is carried out as follows:
(1) the various compositions in prescription are pulverized rear mistake 50 mesh sieve respectively;
(2) Rhizoma Osmundae 25-45 part, Flos Lonicerae 25-35 part, Radix Glycyrrhizae 15-35 part, Cortex Acanthopancis 15-35 part, Herba Scutellariae Barbatae 25-35 part, Fructus Forsythiae 15-35 part, Rhizoma Polygoni Cuspidati 15-35 part is taken by weight, mix homogeneously;
(3) add 8 times of water gagings, 60 DEG C ~ 80 DEG C warm macerating 1 hour of medical material total amount described in (2) by weight, then decoct 60 minutes, filter; Gained filtering residue adds 4 times of soak by water 30 minutes again, and filter, merging filtrate, is evaporated to 750 parts, embedding, sterilizing, obtains final product.
2. the pure Chinese medicine composition for the treatment of Apis sac brood according to claim 1, it is characterized in that by following component by weight mixed extraction form: Rhizoma Osmundae 35 parts, Flos Lonicerae 30 parts, 25 parts, Radix Glycyrrhizae, Cortex Acanthopancis 25 parts, Herba Scutellariae Barbatae 30 parts, Fructus Forsythiae 25 parts, Rhizoma Polygoni Cuspidati 25 parts.
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Cited By (1)
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| CN109045117A (en) * | 2018-10-11 | 2018-12-21 | 道真仡佬族苗族自治县珍珍园中蜂养殖场 | A kind of herbal composite and preparation method thereof for preventing and treating Chinese bee sacbrood |
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| CN104257720B (en) * | 2014-08-29 | 2017-12-19 | 长兴意蜂蜂业科技有限公司 | A kind of formula for treating bee larva vesicular disease |
| CN104524055A (en) * | 2014-12-12 | 2015-04-22 | 青川县唐家河野生资源开发有限责任公司 | Medicine for treating Chinese bee sacbrood and preparation method and application thereof |
| CN104756958A (en) * | 2015-04-16 | 2015-07-08 | 广西容县梁丰养蜂专业合作社 | Method for preventing and treating bee diseases |
| CN105708946A (en) * | 2016-04-19 | 2016-06-29 | 廖为平 | Traditional Chinese medicine composition used for preventing and controlling bee foulbrood and application method thereof |
| CN105998128A (en) * | 2016-05-19 | 2016-10-12 | 梁在贤 | Composition for preventing and curing bee sacbrood and application method of composition |
| CN107596079A (en) * | 2017-10-13 | 2018-01-19 | 山西恒达蕾傲生物科技有限公司 | A kind of Chinese medicine preparation and its application process for preventing and treating honeybee sac brood |
| CN108498587A (en) * | 2018-04-26 | 2018-09-07 | 思南县稻花香蜂业有限责任公司 | A kind of composition and preparation method thereof for treating Chinese bee sacbrood |
| CN113730483B (en) * | 2020-05-29 | 2023-03-17 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine composition for inhibiting 2019 novel coronavirus and application thereof |
| CN112843153A (en) * | 2021-03-22 | 2021-05-28 | 达州市农业科学研究院 | Nutrient solution for preventing and treating bee rotten son disease, unifying group taste and enhancing feeding capacity, and preparation method and application thereof |
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| CN109045117A (en) * | 2018-10-11 | 2018-12-21 | 道真仡佬族苗族自治县珍珍园中蜂养殖场 | A kind of herbal composite and preparation method thereof for preventing and treating Chinese bee sacbrood |
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