CN102775368A - 一类噻唑类化合物及其制备方法和用途 - Google Patents
一类噻唑类化合物及其制备方法和用途 Download PDFInfo
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- CN102775368A CN102775368A CN2011101202079A CN201110120207A CN102775368A CN 102775368 A CN102775368 A CN 102775368A CN 2011101202079 A CN2011101202079 A CN 2011101202079A CN 201110120207 A CN201110120207 A CN 201110120207A CN 102775368 A CN102775368 A CN 102775368A
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- 235000020679 tap water Nutrition 0.000 description 1
- SUTRDULVNIPNLW-SFHVURJKSA-N tert-butyl n-[(2s)-6-acetamido-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxohexan-2-yl]carbamate Chemical compound CC1=CC(=O)OC2=CC(NC(=O)[C@@H](NC(=O)OC(C)(C)C)CCCCNC(=O)C)=CC=C21 SUTRDULVNIPNLW-SFHVURJKSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 150000003549 thiazolines Chemical group 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 description 1
- 229960000237 vorinostat Drugs 0.000 description 1
- 229960000641 zorubicin Drugs 0.000 description 1
- FBTUMDXHSRTGRV-ALTNURHMSA-N zorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(\C)=N\NC(=O)C=1C=CC=CC=1)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 FBTUMDXHSRTGRV-ALTNURHMSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/58—Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Description
Claims (11)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
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CN201110120207.9A CN102775368B (zh) | 2011-05-10 | 2011-05-10 | 一类噻唑类化合物及其制备方法和用途 |
JP2014509592A JP6236382B2 (ja) | 2011-05-10 | 2012-05-07 | チアゾール系化合物、その調製方法及び用途 |
BR112013028894-9A BR112013028894B1 (pt) | 2011-05-10 | 2012-05-07 | Compostos de tiazol, métodos para preparação e uso do mesmo |
NZ617505A NZ617505B2 (en) | 2011-05-10 | 2012-05-07 | Thiazole compound and preparation method and use thereof |
US14/116,944 US9216962B2 (en) | 2011-05-10 | 2012-05-07 | Thiazole compounds, methods for preparation and use thereof |
AU2012253019A AU2012253019B2 (en) | 2011-05-10 | 2012-05-07 | Thiazole compound and preparation method and use thereof |
EP12781747.6A EP2708534B1 (en) | 2011-05-10 | 2012-05-07 | Thiazole compound and preparation method and use thereof |
PCT/CN2012/075142 WO2012152208A1 (zh) | 2011-05-10 | 2012-05-07 | 一类噻唑类化合物及其制备方法和用途 |
KR1020137031882A KR101577520B1 (ko) | 2011-05-10 | 2012-05-07 | 티아졸계 화합물 및 그 제조 방법 |
CA2835705A CA2835705C (en) | 2011-05-10 | 2012-05-07 | Thiazole compounds, methods for preparation and use thereof |
MX2013013048A MX343540B (es) | 2011-05-10 | 2012-05-07 | Compuesto de tiazol y metodo de preparacion y uso del mismo. |
Applications Claiming Priority (1)
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CN201110120207.9A CN102775368B (zh) | 2011-05-10 | 2011-05-10 | 一类噻唑类化合物及其制备方法和用途 |
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CN102775368A true CN102775368A (zh) | 2012-11-14 |
CN102775368B CN102775368B (zh) | 2016-08-17 |
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CN201110120207.9A Active CN102775368B (zh) | 2011-05-10 | 2011-05-10 | 一类噻唑类化合物及其制备方法和用途 |
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US (1) | US9216962B2 (zh) |
EP (1) | EP2708534B1 (zh) |
JP (1) | JP6236382B2 (zh) |
KR (1) | KR101577520B1 (zh) |
CN (1) | CN102775368B (zh) |
AU (1) | AU2012253019B2 (zh) |
BR (1) | BR112013028894B1 (zh) |
CA (1) | CA2835705C (zh) |
MX (1) | MX343540B (zh) |
WO (1) | WO2012152208A1 (zh) |
Cited By (3)
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WO2015149656A1 (zh) * | 2014-04-04 | 2015-10-08 | 中国科学院上海药物研究所 | 一类2,2'-串联双噻唑类化合物及其制备方法和用途 |
CN105315226A (zh) * | 2014-07-11 | 2016-02-10 | 中国科学院生态环境研究中心 | 一种以羧酸为底物一锅法合成2,4-二取代噻唑的新方法 |
WO2018041004A1 (zh) * | 2016-08-31 | 2018-03-08 | 中国科学院上海药物研究所 | 一类芳基-2,2'-串联双噻唑类化合物及其制备方法和用途 |
Families Citing this family (3)
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JP6276378B2 (ja) * | 2013-03-14 | 2018-02-07 | セルジーン クオンティセル リサーチ,インク. | ヒストンデメチラーゼ阻害剤 |
CA2951026A1 (en) * | 2014-06-02 | 2015-12-10 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
US11420950B2 (en) * | 2015-05-22 | 2022-08-23 | Chong Kun Dang Pharmaceutical Corp. | Heterocyclicalkyl derivative compounds as selective histone deacetylase inhibitors and pharmaceutical compositions comprising the same |
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- 2012-05-07 CA CA2835705A patent/CA2835705C/en active Active
- 2012-05-07 AU AU2012253019A patent/AU2012253019B2/en active Active
- 2012-05-07 US US14/116,944 patent/US9216962B2/en active Active
- 2012-05-07 MX MX2013013048A patent/MX343540B/es active IP Right Grant
- 2012-05-07 EP EP12781747.6A patent/EP2708534B1/en active Active
- 2012-05-07 KR KR1020137031882A patent/KR101577520B1/ko active IP Right Grant
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Cited By (9)
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WO2015149656A1 (zh) * | 2014-04-04 | 2015-10-08 | 中国科学院上海药物研究所 | 一类2,2'-串联双噻唑类化合物及其制备方法和用途 |
CN104974108A (zh) * | 2014-04-04 | 2015-10-14 | 中国科学院上海药物研究所 | 一类2,2’-串联双噻唑类化合物及其制备方法和用途 |
US9643941B2 (en) | 2014-04-04 | 2017-05-09 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | 2,2′-tandem dithiazole compound, preparation method therefor, and use thereof |
CN104974108B (zh) * | 2014-04-04 | 2017-11-17 | 中国科学院上海药物研究所 | 一类2,2’‑串联双噻唑类化合物及其制备方法和用途 |
CN105315226A (zh) * | 2014-07-11 | 2016-02-10 | 中国科学院生态环境研究中心 | 一种以羧酸为底物一锅法合成2,4-二取代噻唑的新方法 |
WO2018041004A1 (zh) * | 2016-08-31 | 2018-03-08 | 中国科学院上海药物研究所 | 一类芳基-2,2'-串联双噻唑类化合物及其制备方法和用途 |
CN109641888A (zh) * | 2016-08-31 | 2019-04-16 | 中国科学院上海药物研究所 | 一类芳基2,2’-串联双噻唑类化合物及其制备方法和用途 |
US10766889B2 (en) | 2016-08-31 | 2020-09-08 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Aryl-2,2′-tandem bisthiazole compound and preparation method and use thereof |
CN109641888B (zh) * | 2016-08-31 | 2022-07-22 | 中国科学院上海药物研究所 | 一类芳基-2,2′-串联双噻唑类化合物及其制备方法和用途 |
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BR112013028894B1 (pt) | 2021-06-29 |
KR101577520B1 (ko) | 2015-12-14 |
KR20140028046A (ko) | 2014-03-07 |
MX343540B (es) | 2016-11-08 |
JP6236382B2 (ja) | 2017-11-22 |
BR112013028894A2 (pt) | 2016-09-06 |
AU2012253019B2 (en) | 2016-03-03 |
CA2835705A1 (en) | 2012-11-15 |
EP2708534A1 (en) | 2014-03-19 |
NZ617505A (en) | 2015-11-27 |
WO2012152208A1 (zh) | 2012-11-15 |
JP2014517831A (ja) | 2014-07-24 |
CA2835705C (en) | 2016-01-19 |
AU2012253019A1 (en) | 2013-11-28 |
EP2708534A4 (en) | 2015-02-18 |
US20140148600A1 (en) | 2014-05-29 |
EP2708534B1 (en) | 2017-07-12 |
CN102775368B (zh) | 2016-08-17 |
US9216962B2 (en) | 2015-12-22 |
MX2013013048A (es) | 2014-09-25 |
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