CN102755631B - 预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物 - Google Patents

预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物 Download PDF

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Publication number
CN102755631B
CN102755631B CN201210211368.3A CN201210211368A CN102755631B CN 102755631 B CN102755631 B CN 102755631B CN 201210211368 A CN201210211368 A CN 201210211368A CN 102755631 B CN102755631 B CN 102755631B
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protein
acid sequence
seq
amino acid
strain
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CN102755631A (zh
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G·W·泽洛特尼克
L·D·弗莱切
J·法利
L·A·伯恩非尔德
R·J·扎古斯基
B·J·麦特卡尔夫
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Wyeth Holdings LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
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    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
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    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
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    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
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    • C12N9/2468—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on beta-galactose-glycoside bonds, e.g. carrageenases (3.2.1.83; 3.2.1.157); beta-agarase (3.2.1.81)
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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CN201210211368.3A 2001-10-11 2002-10-11 预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物 Expired - Lifetime CN102755631B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32810101P 2001-10-11 2001-10-11
US60/328,101 2001-10-11
US40693402P 2002-08-30 2002-08-30
US60/406,934 2002-08-30
CN028233301A CN1578785B (zh) 2001-10-11 2002-10-11 预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物

Related Parent Applications (1)

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CN028233301A Division CN1578785B (zh) 2001-10-11 2002-10-11 预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物

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CN102755631A CN102755631A (zh) 2012-10-31
CN102755631B true CN102755631B (zh) 2015-11-25

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CN201210209882.3A Expired - Lifetime CN102836426B (zh) 2001-10-11 2002-10-11 预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物
CN201210211368.3A Expired - Lifetime CN102755631B (zh) 2001-10-11 2002-10-11 预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物
CN201511028093.XA Pending CN105617372A (zh) 2001-10-11 2002-10-11 预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物
CN028233301A Expired - Lifetime CN1578785B (zh) 2001-10-11 2002-10-11 预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物

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CN201210209882.3A Expired - Lifetime CN102836426B (zh) 2001-10-11 2002-10-11 预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物

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Application Number Title Priority Date Filing Date
CN201511028093.XA Pending CN105617372A (zh) 2001-10-11 2002-10-11 预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物
CN028233301A Expired - Lifetime CN1578785B (zh) 2001-10-11 2002-10-11 预防和治疗脑膜炎球菌性疾病的新型免疫原性组合物

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US (13) US8101194B2 (online.php)
EP (14) EP2348035B1 (online.php)
JP (6) JP2005515771A (online.php)
KR (4) KR101099916B1 (online.php)
CN (4) CN102836426B (online.php)
AU (3) AU2009213040C1 (online.php)
BE (3) BE2017C056I2 (online.php)
BR (1) BRPI0212999B8 (online.php)
CA (5) CA2849427C (online.php)
DK (10) DK2343308T3 (online.php)
ES (14) ES2549765T3 (online.php)
FR (4) FR15C0056I2 (online.php)
IL (5) IL161052A0 (online.php)
LU (4) LU92786I2 (online.php)
MX (3) MX339524B (online.php)
NL (4) NL300755I2 (online.php)
PT (10) PT2351767E (online.php)
WO (1) WO2003063766A2 (online.php)

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EP1226253A2 (en) 1999-10-29 2002-07-31 Chiron S.P.A. Neisserial antigenic peptides
CA2871789C (en) 2000-01-17 2017-04-04 Novartis Vaccines And Diagnostics S.R.L. Outer membrane vesicle (omv) vaccine comprising n. meningitidis serogroup b outer membrane proteins
DK1947187T5 (da) 2000-02-28 2011-10-24 Novartis Vaccines & Diagnostic Hybrid ekspression af neisserial-proteiner
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
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MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
CN1809380B (zh) 2002-10-11 2010-05-12 启龙有限公司 广泛防御高毒性脑膜炎球菌谱系的多肽-疫苗
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ES2461350T3 (es) 2003-01-30 2014-05-19 Novartis Ag Vacunas inyectables contra múltiples serogrupos de meningococos
BRPI0409459A (pt) * 2003-04-16 2006-05-02 Wyeth Corp novas composições imunogênicas para a prevenção e tratamento de doença meningocócica
NZ546430A (en) 2003-10-02 2009-04-30 Novartis Vaccines & Diagnostic Liquid vaccines for multiple meningococcal serogroups
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
GB0419408D0 (en) 2004-09-01 2004-10-06 Chiron Srl 741 chimeric polypeptides
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US7709001B2 (en) 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
LT2351578T (lt) * 2005-06-27 2017-04-10 Glaxosmithkline Biologicals S.A. Vakcinų gavimo būdas
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